- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S8388 | ML-7 HCl | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S8465 | GSK'872 (GSK2399872A) | <1 mg/mL | 76 mg/mL | 40 mg/mL |
| S8215 | BAY 1217389 | <1 mg/mL | 100 mg/mL | 3 mg/mL |
| S8366 | CRT0066101 | 82 mg/mL | 25 mg/mL | 2 mg/mL |
| S8358 | WNK463 | <1 mg/mL | 92 mg/mL | 92 mg/mL |
| S7188 | CID755673 | <1 mg/mL | 43 mg/mL | <1 mg/mL |
- Serine/threonin kinase阻害剤(6)
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S8388 |
ML-7 HClML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. |
Representative Hoechst 33342 (blue) and phosphorylated MLC (red) stained images of SK-LMS-1 cells. Scale bar, 200 μm.
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| S8465 |
GSK'872 (GSK2399872A)GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity. |
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| S8215 |
BAY 1217389BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile. |
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| S8366 |
CRT0066101CRT0066101 is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple. |
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| S8358 |
WNK463WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4). |
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| S7188 |
CID755673CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs. |
