Tyrosinase
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
---|---|---|---|---|
水 | DMSO | アルコール | ||
S4921 | MNS (3,4-Methylenedioxy-β-nitrostyrene) | <1 mg/mL | 39 mg/mL | <1 mg/mL |
S1652 | Monobenzone | <1 mg/mL | 40 mg/mL | 40 mg/mL |
S4132 | Deoxyarbutin | <1 mg/mL | 39 mg/mL | 39 mg/mL |
S6237 | 2-Ketoglutaric acid | -1 mg/mL | 29 mg/mL | '-1 mg/mL |
S4571 | Hexylresorcinol | <1 mg/mL | 38 mg/mL | '38 mg/mL |
S6272 | Glycolic acid | -1 mg/mL | 15 mg/mL | -1 mg/mL |
S2375 | Aloin | 83 mg/mL | 83 mg/mL | 2 mg/mL |
S2263 | Arbutin | 55 mg/mL | 55 mg/mL | <1 mg/mL |
S4739 | Oxyresveratrol | 1 mg/mL | 48 mg/mL | 48 mg/mL |
S9284 | Aloesin | -1 mg/mL | 78 mg/mL | -1 mg/mL |
S4997 | 4-Butylresorcinol | -1 mg/mL | 34 mg/mL | '-1 mg/mL |
S3691 | 4-Chlorosalicylic acid | <1 mg/mL | 34 mg/mL | 34 mg/mL |
S9089 | Magnoflorine | -1 mg/mL | 93 mg/mL | -1 mg/mL |
S5174 | Kojic acid | -1 mg/mL | 28 mg/mL | -1 mg/mL |
S9111 | Isorhamnetin | -1 mg/mL | 63 mg/mL | -1 mg/mL |
S9376 | Benzylacetone | ' mg/mL | ||
S6221 | Methyl cinnamate | -1 mg/mL | 32 mg/mL | -1 mg/mL |
S3783 | Echinacoside | -1 mg/mL | 100 mg/mL | -1 mg/mL |
Tyrosinase製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
---|---|---|---|
S4921 |
MNS (3,4-Methylenedioxy-β-nitrostyrene)MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. |
![]() ![]() WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
|
|
S1652 |
MonobenzoneMonobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase. |
||
S4132 |
DeoxyarbutinDeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM. |
||
S6237 |
2-Ketoglutaric acid2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. |
||
S4571 |
HexylresorcinolHexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM. |
||
S6272 |
Glycolic acidGlycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. |
||
S2375 |
AloinAloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. |
||
S2263 |
ArbutinArbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively. |
||
S4739 |
OxyresveratrolOxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis. |
||
S9284 |
AloesinAloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
||
S4997 |
4-Butylresorcinol4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. |
||
S3691 |
4-Chlorosalicylic acid4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. |
||
S9089 |
MagnoflorineMagnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
||
S5174 |
Kojic acidKojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
||
S9111 |
IsorhamnetinIsorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity. |
||
S9376 |
BenzylacetoneBenzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers. |
||
S6221 |
Methyl cinnamateMethyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes. |
||
S3783 |
EchinacosideEchinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
---|---|---|---|
S4921 |
MNS (3,4-Methylenedioxy-β-nitrostyrene)MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. |
![]() ![]() WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
|
|
S1652 |
MonobenzoneMonobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase. |
||
S4132 |
DeoxyarbutinDeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM. |
||
S6237 |
2-Ketoglutaric acid2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. |
||
S4571 |
HexylresorcinolHexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM. |
||
S6272 |
Glycolic acidGlycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. |
||
S2375 |
AloinAloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. |
||
S2263 |
ArbutinArbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively. |
||
S4739 |
OxyresveratrolOxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis. |
||
S9284 |
AloesinAloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
||
S4997 |
4-Butylresorcinol4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. |
||
S3691 |
4-Chlorosalicylic acid4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. |
||
S9089 |
MagnoflorineMagnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
||
S5174 |
Kojic acidKojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
||
S9111 |
IsorhamnetinIsorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity. |
||
S9376 |
BenzylacetoneBenzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers. |
||
S6221 |
Methyl cinnamateMethyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
---|---|---|---|
S3783 |
EchinacosideEchinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. |
2020, 10.1007/s00210-020-02022-w |