Tyrosinase

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene)	<1 mg/mL	39 mg/mL	<1 mg/mL
S1652	Monobenzone	<1 mg/mL	40 mg/mL	40 mg/mL
S4132	Deoxyarbutin	<1 mg/mL	39 mg/mL	39 mg/mL
S6237	2-Ketoglutaric acid	-1 mg/mL	29 mg/mL	-1 mg/mL
S4571	Hexylresorcinol	<1 mg/mL	38 mg/mL	'38 mg/mL
S6272	Glycolic acid	-1 mg/mL	15 mg/mL	-1 mg/mL
S2375	Aloin	83 mg/mL	83 mg/mL	2 mg/mL
S2263	Arbutin	55 mg/mL	55 mg/mL	<1 mg/mL
S4739	Oxyresveratrol	1 mg/mL	48 mg/mL	48 mg/mL
S9284	Aloesin	-1 mg/mL	78 mg/mL	-1 mg/mL
S4997	4-Butylresorcinol	-1 mg/mL	34 mg/mL	'-1 mg/mL
S3691	4-Chlorosalicylic acid	<1 mg/mL	34 mg/mL	34 mg/mL
S9089	Magnoflorine	-1 mg/mL	93 mg/mL	-1 mg/mL
S5174	Kojic acid	-1 mg/mL	28 mg/mL	-1 mg/mL
S9111	Isorhamnetin	-1 mg/mL	63 mg/mL	-1 mg/mL
S9376	Benzylacetone			' mg/mL
S6221	Methyl cinnamate	-1 mg/mL	32 mg/mL	-1 mg/mL
S3783	Echinacoside	-1 mg/mL	100 mg/mL	-1 mg/mL

Tyrosinase製品

All (18) Tyrosinase阻害剤(17) Tyrosinase活性剤(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.	J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Phytomedicine, 2019, 61:152859 Toxicol Res (Camb), 2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S1652	Monobenzone Monobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.
S4132	Deoxyarbutin DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
S6237	2-Ketoglutaric acid 2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle.
S4571	Hexylresorcinol Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.
S6272	Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel.
S2375	Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.	Drug Des Devel Ther, 2020, 14:145-155 J Sci Food Agric, 2020, 10.1002/jsfa.10650 Cancer Med, 2019, 10.1002/cam4.2723
S2263	Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.	G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S4739	Oxyresveratrol Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
S9284	Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid 4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde.
S9089	Magnoflorine Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S9111	Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S9376	Benzylacetone Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
S3783	Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S4921	MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.	J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133 Phytomedicine, 2019, 61:152859 Toxicol Res (Camb), 2016, 5(1):188-196	WT mouse primary macrophages were untreated as control (lane 1) or treated with 0.1μg/ml E. coli LPS (lane 5-8), 10μM E-64 (lane 2 and 6), 250μM PMSF (lane 3 and 7), or 20μM MNS (lane 4 and 8). The cells were continuously cultured for 16 hrs. Extracts from whole cells or nuclei were separately purified and subjected to WB analysis with antibody against pERK2, LITAF, or actin/tubulin as control.
S1652	Monobenzone Monobenzone is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.
S4132	Deoxyarbutin DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
S6237	2-Ketoglutaric acid 2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle.
S4571	Hexylresorcinol Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.
S6272	Glycolic acid Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel.
S2375	Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.	Drug Des Devel Ther, 2020, 14:145-155 J Sci Food Agric, 2020, 10.1002/jsfa.10650 Cancer Med, 2019, 10.1002/cam4.2723
S2263	Arbutin Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.	G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S4739	Oxyresveratrol Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
S9284	Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S4997	4-Butylresorcinol 4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.
S3691	4-Chlorosalicylic acid 4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde.
S9089	Magnoflorine Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S9111	Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S9376	Benzylacetone Benzylacetone (4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone) is an attractant compound in flowers.
S6221	Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S3783	Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.	Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S3783

Echinacoside

Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.

Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w

研究分野別

製品類型

Tyrosinase

阻害剤の選択性比較

Tyrosinase製品