Acyltransferase

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2187 Avasimibe <1 mg/mL 100 mg/mL ''8 mg/mL
S3021 Rimonabant <1 mg/mL 25 mg/mL ''2 mg/mL
S2674 A922500 <1 mg/mL 86 mg/mL '<1 mg/mL
S4189 Cyclandelate <1 mg/mL 55 mg/mL '55 mg/mL
S9162 Rubimaillin -1 mg/mL 22 mg/mL -1 mg/mL
S7192 PF-04620110 <1 mg/mL 49 mg/mL '<1 mg/mL
S7889 Xanthohumol <1 mg/mL 70 mg/mL '70 mg/mL

Acyltransferase製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2187

Avasimibe

Avasimibe (CI-1011) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

S3021

Rimonabant

Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.

S2674

A922500

A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.

S4189

Cyclandelate

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

S9162

Rubimaillin

Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.

S7192

PF-04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

S7889

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2187

Avasimibe

Avasimibe (CI-1011) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

S3021

Rimonabant

Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.

S2674

A922500

A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.

S4189

Cyclandelate

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

S9162

Rubimaillin

Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.

S7192

PF-04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

S7889

Xanthohumol

Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.

Tags: ACAT