炭酸脱水酵素

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1375	Dorzolamide HCl	14 mg/mL	<1 mg/mL	<1 mg/mL
S1438	Topiramate	<1 mg/mL	68 mg/mL	68 mg/mL
S2866	U-104	<1 mg/mL	62 mg/mL	<1 mg/mL
S2603	Tioxolone	<1 mg/mL	34 mg/mL	34 mg/mL
S1736	Methocarbamol	2 mg/mL	48 mg/mL	48 mg/mL
S4998	2-Aminobenzenesulfonamide	-1 mg/mL	34 mg/mL	-1 mg/mL
S2177	Dichlorphenamide	<1 mg/mL	61 mg/mL	33 mg/mL
S3178	Brinzolamide	<1 mg/mL	77 mg/mL	<1 mg/mL
S4039	Methazolamide	<1 mg/mL	47 mg/mL	3 mg/mL
S3697	Mafenide hydrochloride	44 mg/mL	44 mg/mL	8 mg/mL
S3647	Mafenide Acetate	49 mg/mL	49 mg/mL	3 mg/mL
S4506	Acetazolamide	<1 mg/mL	44 mg/mL	<1 mg/mL
S4725	Benzenesulfonamide	<1 mg/mL	31 mg/mL	31 mg/mL

亜型選択性的な製品

Carbonic Anhydrase製品

All (13) Carbonic Anhydrase阻害剤(13) 新Carbonic Anhydrase製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1375	Dorzolamide HCl Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
S1438	Topiramate Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
S2866	U-104 U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Lab Invest, 2016, 10.1038/labinvest.2016.103 Biomaterials, 2018, 156:121-133 Int J Oncol, 2018, 53(1):189-202	Regression coefficients from the second-order stepwise linear regression model are provided based on the data obtained from Search 2.1 (B) The results allow the least effective compounds to be eliminated. Red is used to highlighted drug contributions that do not help to inhibit cell viability, orange bars are used to indicate minimal contributions and green highlights synergistic drug interactions. The inset in B shows the linear fit of modelled data with theoretical quartiles versus standardized residuals and the corresponding R2-values for each model. Significance is indicated by asterisks, *p < 0.01 and p < 0.05.
S2603	Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S4998^新	2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is an inhibitor of carbonic anhydrase IX.
S2177	Dichlorphenamide Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S3178	Brinzolamide Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	J Drug Deliv Sci Tec, 2017, 10.1016/j.jddst.2017.05.005
S4039	Methazolamide Methazolamide is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3697	Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S3647	Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4506	Acetazolamide Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
S4725	Benzenesulfonamide Benzenesulfonamide ia an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1375	Dorzolamide HCl Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
S1438	Topiramate Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
S2866	U-104 U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Lab Invest, 2016, 10.1038/labinvest.2016.103 Biomaterials, 2018, 156:121-133 Int J Oncol, 2018, 53(1):189-202	Regression coefficients from the second-order stepwise linear regression model are provided based on the data obtained from Search 2.1 (B) The results allow the least effective compounds to be eliminated. Red is used to highlighted drug contributions that do not help to inhibit cell viability, orange bars are used to indicate minimal contributions and green highlights synergistic drug interactions. The inset in B shows the linear fit of modelled data with theoretical quartiles versus standardized residuals and the corresponding R2-values for each model. Significance is indicated by asterisks, *p < 0.01 and p < 0.05.
S2603	Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S4998^新	2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is an inhibitor of carbonic anhydrase IX.
S2177	Dichlorphenamide Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S3178	Brinzolamide Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	J Drug Deliv Sci Tec, 2017, 10.1016/j.jddst.2017.05.005
S4039	Methazolamide Methazolamide is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3697	Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S3647	Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4506	Acetazolamide Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
S4725	Benzenesulfonamide Benzenesulfonamide ia an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32

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