炭酸脱水酵素

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研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1375	Dorzolamide HCl	14 mg/mL	<1 mg/mL	<1 mg/mL
S1438	Topiramate	<1 mg/mL	68 mg/mL	68 mg/mL
S2866	U-104	<1 mg/mL	62 mg/mL	<1 mg/mL
S2603	Tioxolone	<1 mg/mL	34 mg/mL	34 mg/mL
S1736	Methocarbamol	2 mg/mL	48 mg/mL	48 mg/mL
S2177	Dichlorphenamide	<1 mg/mL	61 mg/mL	33 mg/mL
S3178	Brinzolamide	<1 mg/mL	77 mg/mL	<1 mg/mL
S4039	Methazolamide	<1 mg/mL	47 mg/mL	3 mg/mL
S3697	Mafenide hydrochloride	44 mg/mL	44 mg/mL	8 mg/mL
S3647	Mafenide Acetate	49 mg/mL	49 mg/mL	3 mg/mL
S4506	Acetazolamide	<1 mg/mL	44 mg/mL	<1 mg/mL
S4998	2-Aminobenzenesulfonamide	-1 mg/mL	34 mg/mL	-1 mg/mL
S4725	Benzenesulfonamide	<1 mg/mL	31 mg/mL	31 mg/mL

亜型選択性的な製品

Carbonic Anhydrase製品

All (13) Carbonic Anhydrase阻害剤(13)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1375	Dorzolamide HCl Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
S1438	Topiramate Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
S2866	U-104 U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Biomaterials, 2018, 156:121-133 Int J Oncol, 2018, 53(1):189-202 Lab Invest, 2016, 10.1038/labinvest.2016.103	(c-f) Effects of the CAIX inhibitor U-104 (75 μM) on cell proliferation by Pt45.P1/asTF+ cells (c, e) or Pt45.P1 cells (d, f) under advanced-stage (c, d) or early-stage conditions (e, f). At the indicated times, WST-1 uptake was measured by colorimetry. The error bars are s.e.m. * Indicates significance at P<0.05.
S2603	Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177	Dichlorphenamide Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S3178	Brinzolamide Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	J Drug Deliv Sci Tec, 2017, 10.1016/j.jddst.2017.05.005
S4039	Methazolamide Methazolamide is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3697	Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S3647	Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4506	Acetazolamide Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
S4998	2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is an inhibitor of carbonic anhydrase IX.
S4725	Benzenesulfonamide Benzenesulfonamide ia an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1375	Dorzolamide HCl Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with K_i of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
S1438	Topiramate Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
S2866	U-104 U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with K_i of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.	Biomaterials, 2018, 156:121-133 Int J Oncol, 2018, 53(1):189-202 Lab Invest, 2016, 10.1038/labinvest.2016.103	(c-f) Effects of the CAIX inhibitor U-104 (75 μM) on cell proliferation by Pt45.P1/asTF+ cells (c, e) or Pt45.P1 cells (d, f) under advanced-stage (c, d) or early-stage conditions (e, f). At the indicated times, WST-1 uptake was measured by colorimetry. The error bars are s.e.m. * Indicates significance at P<0.05.
S2603	Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
S1736	Methocarbamol Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
S2177	Dichlorphenamide Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
S3178	Brinzolamide Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.	J Drug Deliv Sci Tec, 2017, 10.1016/j.jddst.2017.05.005
S4039	Methazolamide Methazolamide is a carbonic anhydrase inhibitor with K_i of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S3697	Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S3647	Mafenide Acetate Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
S4506	Acetazolamide Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
S4998	2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is an inhibitor of carbonic anhydrase IX.
S4725	Benzenesulfonamide Benzenesulfonamide ia an inhibitor of carbonic anhydrases.	Br J Pharmacol, 2016, 173(6):1018-32

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