Chloride Channel

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1698	Torsemide	<1 mg/mL	3 mg/mL	<1 mg/mL
S8279	Shikonin (C.I. 75535)	<1 mg/mL	57 mg/mL	23 mg/mL
S3264	Atractyloside potassium salt	-1 mg/mL	100 mg/mL	-1 mg/mL
S0125	CaCCinh-A01	<1 mg/mL	69 mg/mL	2 mg/mL
S4339	Meticrane	<1 mg/mL	55 mg/mL	'<1 mg/mL
S3807	Dehydroandrographolide	-1 mg/mL	66 mg/mL	-1 mg/mL
S6439	Talniflumate	<1 mg/mL	61 mg/mL	'<1 mg/mL
S0454	Adjudin	<1 mg/mL	67 mg/mL	2 mg/mL
S6470	Fluralaner	<1 mg/mL	100 mg/mL	25 mg/mL
S1203	T16Ainh-A01	<1 mg/mL	83 mg/mL	<1 mg/mL
S1675	Lubiprostone	<1 mg/mL	78 mg/mL	78 mg/mL
S1351	Ivermectin (MK-933)	<1 mg/mL	100 mg/mL	''28 mg/mL

Chloride Channel製品

All (12) Chloride Channel阻害剤(10) Chloride Channel活性剤(2)

製品コード	製品説明	文献中Selleckの製品使用例
S1698	Torsemide Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.	Cell Chem Biol, 2021, S2451-9456(21)00442-6
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	J Cancer, 2021, 12(1):76-88 Cancer Sci, 2021, 112(9):3507-3519 J Cell Mol Med, 2021, 10.1111/jcmm.17007
S3264	Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.
S0125	CaCCinh-A01 CaCCinh-A01 (TMEM16 Blocker I) is a blocker of TMEM16A with IC50 of 2.1 μM. CaCCinh-A01 is also an inhibitor of calcium-activated chloride channel (CaCC) with IC50 of ~ 10 μM.
S4339	Meticrane Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
S3807	Dehydroandrographolide Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
S6439	Talniflumate Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Talniflumate is also an inhibitor of human calcium-activated chloride channels.
S0454	Adjudin Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
S6470	Fluralaner Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls).
S1203	T16Ainh-A01 T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of 1.8 μM.
S1675	Lubiprostone Lubiprostone (RU 0211) is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.
S1351	Ivermectin (MK-933) Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.	J Virol, 2021, JVI0148121 BMC Cancer, 2021, 21(1):1307 Nat Cell Biol, 2020,

製品コード	製品説明	文献中Selleckの製品使用例
S1698	Torsemide Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.	Cell Chem Biol, 2021, S2451-9456(21)00442-6
S8279	Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	J Cancer, 2021, 12(1):76-88 Cancer Sci, 2021, 112(9):3507-3519 J Cell Mol Med, 2021, 10.1111/jcmm.17007
S3264	Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.
S0125	CaCCinh-A01 CaCCinh-A01 (TMEM16 Blocker I) is a blocker of TMEM16A with IC50 of 2.1 μM. CaCCinh-A01 is also an inhibitor of calcium-activated chloride channel (CaCC) with IC50 of ~ 10 μM.
S4339	Meticrane Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
S3807	Dehydroandrographolide Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
S6439	Talniflumate Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Talniflumate is also an inhibitor of human calcium-activated chloride channels.
S0454	Adjudin Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
S6470	Fluralaner Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls).
S1203	T16Ainh-A01 T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of 1.8 μM.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1675	Lubiprostone Lubiprostone (RU 0211) is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.
S1351	Ivermectin (MK-933) Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.	J Virol, 2021, JVI0148121 BMC Cancer, 2021, 21(1):1307 Nat Cell Biol, 2020,

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S1675

Lubiprostone

Lubiprostone (RU 0211) is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.

S1351

Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.

J Virol, 2021, JVI0148121

BMC Cancer, 2021, 21(1):1307

Nat Cell Biol, 2020,

研究分野別

製品類型

Chloride Channel

阻害剤の選択性比較