グルココルチコイド受容体

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1322	Dexamethasone	<1 mg/mL	79 mg/mL	6 mg/mL
S2606	Mifepristone	<1 mg/mL	85 mg/mL	19 mg/mL
S6608	AL082D06	<1 mg/mL	10 mg/mL	<1 mg/mL
S1696	Hydrocortisone (cortisol)	<1 mg/mL	73 mg/mL	'23 mg/mL
S1737	Prednisolone	<1 mg/mL	72 mg/mL	''10 mg/mL
S1622	Prednisone	<1 mg/mL	71 mg/mL	<1 mg/mL
S1669	Loteprednol etabonate	<1 mg/mL	93 mg/mL	4 mg/mL
S1987	Mometasone furoate	<1 mg/mL	6 mg/mL	<1 mg/mL
S1992	Fluticasone propionate	<1 mg/mL	100 mg/mL	5 mg/mL
S1733	Methylprednisolone	<1 mg/mL	75 mg/mL	2 mg/mL
S1286	Budesonide	<1 mg/mL	86 mg/mL	19 mg/mL
S1628	Triamcinolone Acetonide	<1 mg/mL	87 mg/mL	13 mg/mL
S1689	Meprednisone	<1 mg/mL	75 mg/mL	4 mg/mL
S1888	Deflazacort	<1 mg/mL	88 mg/mL	12 mg/mL
S2470	Fluocinolone Acetonide	<1 mg/mL	90 mg/mL	12 mg/mL
S1688	Betamethasone Dipropionate	<1 mg/mL	100 mg/mL	66 mg/mL
S1690	Betamethasone Valerate	<1 mg/mL	95 mg/mL	58 mg/mL
S2570	Prednisolone Acetate	<1 mg/mL	81 mg/mL	<1 mg/mL
S1500	Betamethasone	<1 mg/mL	79 mg/mL	10 mg/mL
S4088	Flumethasone	<1 mg/mL	82 mg/mL	6 mg/mL
S1701	Desonide	<1 mg/mL	83 mg/mL	30 mg/mL
S2608	Fluocinonide	<1 mg/mL	99 mg/mL	<1 mg/mL
S2584	Clobetasol propionate	<1 mg/mL	93 mg/mL	20 mg/mL
S1933	Triamcinolone	<1 mg/mL	78 mg/mL	1 mg/mL
S3078	Beclomethasone dipropionate	<1 mg/mL	104 mg/mL	18 mg/mL
S2559	Cortisone acetate	<1 mg/mL	7 mg/mL	<1 mg/mL
S5685	Desoximetasone	<1 mg/mL	75 mg/mL	75 mg/mL
S3617	(20S)-Protopanaxatriol	<1 mg/mL	95 mg/mL	'95 mg/mL
S4752	Corticosterone	<1 mg/mL	69 mg/mL	69 mg/mL
S4646	Ciclesonide	<1 mg/mL	100 mg/mL	''100 mg/mL
S5486	Fluorometholone	<1 mg/mL	75 mg/mL	'5 mg/mL
S4228	Fluorometholone Acetate	<1 mg/mL	83 mg/mL	1 mg/mL
S4775	Cortodoxone	-1 mg/mL	69 mg/mL	-1 mg/mL

Glucocorticoid Receptor製品

All (33) Glucocorticoid Receptor阻害剤(1) Glucocorticoid Receptor拮抗剤(2) Glucocorticoid Receptor作動薬(30)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1322	Dexamethasone Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.	Proc Natl Acad Sci U S A, 2020, 202021450 Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-1315 Blood Cancer J, 2020, 10(6):72	Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.
S2606	Mifepristone Mifepristone (RU486, C-1073) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.	Proc Natl Acad Sci U S A, 2020, 202021450 Cell Death Discov, 2020, 20;6:24 Sci Rep, 2020, 24;10(1):5363	Myogenic differentiation assay to determine the GR specificity of DEX by using RU-486 (10 uM). Immunofluorescence detection of MyHC (red) and DAPI counterstaining of nuclei (blue) was used to detect myotubes. The scale bar is 50 um.
S6608	AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
S1696	Hydrocortisone (cortisol) Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Biochem Pharmacol, 2020, 175:113865 Biochem Biophys Res Commun, 2020, 21;526(1):267-272 FASEB J, 2020, 10.1096/fj.202000045R
S1737	Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	Ther Adv Hematol, 2020, 11:2040620719898373 Drug Test Anal, 2020, 10.1002/dta.2917 Int J Biol Sci, 2020, 16(13):2382-2391	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	Drug Test Anal, 2020, 10.1002/dta.2917 PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987	Mometasone furoate Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.	Drug Test Anal, 2020, 10.1002/dta.2917 Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.	Sci Rep, 2020, 24;10(1):5363 Drug Test Anal, 2020, 10.1002/dta.2917
S1628	Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.	Theranostics, 2020, 10(1):247-264 Drug Test Anal, 2020, 10.1002/dta.2917
S1689	Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1888	Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.	Drug Test Anal, 2020, 10.1002/dta.2917
S2470	Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688	Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690	Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2570	Prednisolone Acetate Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	Int J Biol Sci, 2020, 16(13):2382-2391 J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S4088	Flumethasone Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.	Drug Test Anal, 2020, 10.1002/dta.2917
S1701	Desonide Desonide is a low potency topical corticosteroid.	Drug Test Anal, 2020, 10.1002/dta.2917
S2608	Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S2584	Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.	Drug Test Anal, 2020, 10.1002/dta.2917
S3078	Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S2559	Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S5685	Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
S4752	Corticosterone Corticosterone (17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.	Drug Test Anal, 2020, 10.1002/dta.2917
S5486	Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.	Drug Test Anal, 2020, 10.1002/dta.2917
S4228	Fluorometholone Acetate Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775	Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S1322

Dexamethasone

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.

Proc Natl Acad Sci U S A, 2020, 202021450

Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-1315

Blood Cancer J, 2020, 10(6):72

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S2606	Mifepristone Mifepristone (RU486, C-1073) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.	Proc Natl Acad Sci U S A, 2020, 202021450 Cell Death Discov, 2020, 20;6:24 Sci Rep, 2020, 24;10(1):5363	Myogenic differentiation assay to determine the GR specificity of DEX by using RU-486 (10 uM). Immunofluorescence detection of MyHC (red) and DAPI counterstaining of nuclei (blue) was used to detect myotubes. The scale bar is 50 um.
S6608	AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

製品コード

製品説明

文献中Selleckの製品使用例

お客様のフィードバック

S2606

Mifepristone

Mifepristone (RU486, C-1073) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.

Proc Natl Acad Sci U S A, 2020, 202021450

Cell Death Discov, 2020, 20;6:24

Sci Rep, 2020, 24;10(1):5363

S6608

AL082D06

AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1696	Hydrocortisone (cortisol) Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.	Biochem Pharmacol, 2020, 175:113865 Biochem Biophys Res Commun, 2020, 21;526(1):267-272 FASEB J, 2020, 10.1096/fj.202000045R
S1737	Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.	Ther Adv Hematol, 2020, 11:2040620719898373 Drug Test Anal, 2020, 10.1002/dta.2917 Int J Biol Sci, 2020, 16(13):2382-2391	Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from 0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.	Drug Test Anal, 2020, 10.1002/dta.2917 PLoS One, 2018, 13(8):e0200725
S1669	Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
S1987	Mometasone furoate Mometasone Furoate (SCH-32088) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
S1992	Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Nat Med, 2017, 23(4):424-428
S1733	Methylprednisolone Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.	Drug Test Anal, 2020, 10.1002/dta.2917 Nat Med, 2017, 23(4):424-428 Trop J Pharm Res, 2014, 13 (1): 53-59	Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
S1286	Budesonide Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.	Sci Rep, 2020, 24;10(1):5363 Drug Test Anal, 2020, 10.1002/dta.2917
S1628	Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.	Theranostics, 2020, 10(1):247-264 Drug Test Anal, 2020, 10.1002/dta.2917
S1689	Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1888	Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.	Drug Test Anal, 2020, 10.1002/dta.2917
S2470	Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
S1688	Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
S1690	Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2570	Prednisolone Acetate Prednisolone Acetate (Omnipred) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	Int J Biol Sci, 2020, 16(13):2382-2391 J Int Med Res, 2019, 47(6):2655-2665
S1500	Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S4088	Flumethasone Flumethasone (RS-2177, NSC-54702) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.	Drug Test Anal, 2020, 10.1002/dta.2917
S1701	Desonide Desonide is a low potency topical corticosteroid.	Drug Test Anal, 2020, 10.1002/dta.2917
S2608	Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S2584	Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.	Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.	Drug Test Anal, 2020, 10.1002/dta.2917
S3078	Beclomethasone dipropionate Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S2559	Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S5685	Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
S3617	(20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
S4752	Corticosterone Corticosterone (17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.	Neuroscience, 2019, 411:11-22 Xenobiotica, 2016, 46(10):948-52
S4646	Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.	Drug Test Anal, 2020, 10.1002/dta.2917
S5486	Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.	Drug Test Anal, 2020, 10.1002/dta.2917
S4228	Fluorometholone Acetate Fluorometholone Acetate (NSC 47438) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
S4775	Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

研究分野別

製品類型

グルココルチコイド受容体

阻害剤の選択性比較

Glucocorticoid Receptor製品