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阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7077 Cilengitide trifluoroacetate 8 mg/mL 100 mg/mL <1 mg/mL
S8008 RGD (Arg-Gly-Asp) Peptides 12 mg/mL <1 mg/mL <1 mg/mL
S2885 A-205804 <1 mg/mL 60 mg/mL <1 mg/mL
S7540 SB273005 <1 mg/mL 90 mg/mL 16 mg/mL
S4513 RGD peptide (GRGDNP) 100 mg/mL <1 mg/mL ''<1 mg/mL
S6840 OSU-T315 ˂1 mg/mL 100 mg/mL '11 mg/mL
S7834 Cyclo (-RGDfK) 84 mg/mL 100 mg/mL <1 mg/mL
S7844 Cyclo(RGDyK) 100 mg/mL 100 mg/mL 20 mg/mL
S3085 Tirofiban <1 mg/mL 0.005 mg/mL <1 mg/mL
S0314 TR-14035 <1 mg/mL 95 mg/mL 20 mg/mL
S8594 Tirofiban Hydrochloride 95 mg/mL 95 mg/mL '95 mg/mL
S8454 ATN-161 (Ac-PHSCN-NH2) 13 mg/mL -1 mg/mL -1 mg/mL
S3714 Lifitegrast <1 mg/mL 100 mg/mL '20 mg/mL
S8306 Leukadherin-1 <1 mg/mL 15 mg/mL '<1 mg/mL

Integrin製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7077

Cilengitide trifluoroacetate

Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

S8008

RGD (Arg-Gly-Asp) Peptides

RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

S2885

A-205804

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

S7540

SB273005

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

S4513

RGD peptide (GRGDNP)

RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.

S6840

OSU-T315

OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.

S7834

Cyclo (-RGDfK)

Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.

S7844

Cyclo(RGDyK)

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

S3085

Tirofiban

Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.

S0314

TR-14035

TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.

S8594

Tirofiban Hydrochloride

Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.

S8454

ATN-161 (Ac-PHSCN-NH2)

ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.

S3714

Lifitegrast

Lifitegrast (SAR1118) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.

S8306

Leukadherin-1

Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7077

Cilengitide trifluoroacetate

Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

S8008

RGD (Arg-Gly-Asp) Peptides

RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

S2885

A-205804

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

S7540

SB273005

SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

S4513

RGD peptide (GRGDNP)

RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.

S6840

OSU-T315

OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.

S7834

Cyclo (-RGDfK)

Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.

S7844

Cyclo(RGDyK)

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S3085

Tirofiban

Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.

2020, 11(1):139-152

S0314

TR-14035

TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.

S8594

Tirofiban Hydrochloride

Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.

S8454

ATN-161 (Ac-PHSCN-NH2)

ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.

2021, 6(7):2039-2057

2021, 25(3):1233-1241

2021, 6(7):2039-2057

S3714

Lifitegrast

Lifitegrast (SAR1118) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.

2020, 1-14

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8306

Leukadherin-1

Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).

2021, 14:1341-1356

2019, 10:215