Integrin

Integrin阻害剤の選択性比較

Integrinシグナル伝達経路

Integrinシグナル伝達経路

Integrin製品

  • All (18)
  • Integrin阻害剤 (11)
  • Integrin拮抗剤(5)
  • Integrin作動薬(2)
  • 新製品
製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
Adv Sci (Weinh), 2022, e2200053
J Clin Invest, 2022, e126155
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Immunity, 2021, S1074-7613(21)00289-2
J Extracell Vesicles, 2021, 10(8):e12091
Nat Commun, 2020, 11(1):282
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Nat Commun, 2022, 13(1):3117
Nat Methods, 2021, 18(1):84-91
Anal Chim Acta, 2021, 1151:338222
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
J Clin Invest, 2022, e126155
Acta Neuropathol Commun, 2022, 10(1):65
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Int J Mol Sci, 2021, 22(16)8410
Cell Death Dis, 2020, 14;11(4):230
Elife, 2019, 8
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cancers (Basel), 2022, 14(10)2430
Sci Rep, 2022, 12(1):9062
Stem Cell Res Ther, 2021, 12(1):523
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
S8454 ATN-161 (Ac-PHSCN-NH2) ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Oncogene, 2022, 10.1038/s41388-022-02333-7
Bioact Mater, 2021, 6(7):2039-2057
Eur Rev Med Pharmacol Sci, 2021, 25(3):1233-1241
S3714 Lifitegrast Lifitegrast (SAR1118) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
J Biomol Struct Dyn, 2020, 1-14
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
J Inflamm Res, 2021, 14:1341-1356
Research Square, 2021, 10.21203/rs.3.rs-870799/v1
bioRxiv, 2020, 10.1101/2020.11.25.398701
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
Adv Sci (Weinh), 2022, e2200053
J Clin Invest, 2022, e126155
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
Immunity, 2021, S1074-7613(21)00289-2
J Extracell Vesicles, 2021, 10(8):e12091
Nat Commun, 2020, 11(1):282
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Nat Commun, 2022, 13(1):3117
Nat Methods, 2021, 18(1):84-91
Anal Chim Acta, 2021, 1151:338222
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
Nat Mater, 2022, 10.1038/s41563-022-01259-5
J Clin Invest, 2022, e126155
Acta Neuropathol Commun, 2022, 10(1):65
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Int J Mol Sci, 2021, 22(16)8410
Cell Death Dis, 2020, 14;11(4):230
Elife, 2019, 8
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cancers (Basel), 2022, 14(10)2430
Sci Rep, 2022, 12(1):9062
Stem Cell Res Ther, 2021, 12(1):523
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
S8454 ATN-161 (Ac-PHSCN-NH2) ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Oncogene, 2022, 10.1038/s41388-022-02333-7
Bioact Mater, 2021, 6(7):2039-2057
Eur Rev Med Pharmacol Sci, 2021, 25(3):1233-1241
S3714 Lifitegrast Lifitegrast (SAR1118) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
J Biomol Struct Dyn, 2020, 1-14
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
J Inflamm Res, 2021, 14:1341-1356
Research Square, 2021, 10.21203/rs.3.rs-870799/v1
bioRxiv, 2020, 10.1101/2020.11.25.398701
A2045New Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
E0790New ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
E0462New Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
Tags: Integrin inhibitor|Integrin agonist|Integrin activator|Integrin inducer|Integrin antagonist|Integrin signaling pathway|Integrin assay kit