Integrin

亜型選択性的な製品

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Integrinシグナル伝達経路

Integrin製品

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  • Integrin阻害剤 (12)
  • Integrin拮抗剤(5)
  • Integrin作動薬(2)
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S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Adv Sci (Weinh), 2023, e2307206.
Heliyon, 2023, 9(9):e20185
Cell Reports Medicine, 2023, 4(4)
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
NPJ Regen Med, 2024, 9(1):4
Cancer Cell, 2023, 41(8):1480-1497.e9
Nat Mater, 2022, 10.1038/s41563-022-01259-5
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Cancer Lett, 2024, 582:216597
Nat Commun, 2023, 14(1):3251
Neuron, 2023, S0896-6273(23)00623-2
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
iScience, 2024, 27(3):109119
Cell Stem Cell, 2023, 30(6):867-884.e11
Biosens Bioelectron, 2023, 226:115113
S8454 ATN-161 ATN-161 is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Bioact Mater, 2023, 22:75-90
Cancer Commun (Lond), 2023, 10.1002/cac2.12411
Cell Rep, 2023, 42(7):112804
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cell Commun Signal, 2023, 10.1186/s12964-022-01027-7
iScience, 2023, 26(6):106839
Inflammation, 2023, 46(2):739-751
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Oxidative Medicine and Cellular Longevity, 2021, 10.1155/2021/9739977
Oxid Med Cell Longev, 2021, 2021:9739977
Int J Mol Sci, 2021, 22(16)8410
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
International Immunopharmacology, 2023, Volume 118
Int Immunopharmacol, 2023, 118:110024
Front Immunol, 2022, 13:919444
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S3714 Lifitegrast Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
World J Gastroenterol, 2023, 29(20):3103-3118
Med Chem Res, 2022, 31(4):555-579
J Biomol Struct Dyn, 2020, 1-14
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
Exp Eye Res, 2023, 234:109609
E0462 Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
E0790 ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S3408 A286982 A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
A2045 Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
International Immunopharmacology, 2023, Volume 118
Int Immunopharmacol, 2023, 118:110024
Front Immunol, 2022, 13:919444
E0462 Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.
A2045 Vedolizumab (anti-α4β7-integrin) Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
S7077 Cilengitide trifluoroacetate Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Adv Sci (Weinh), 2023, e2307206.
Heliyon, 2023, 9(9):e20185
Cell Reports Medicine, 2023, 4(4)
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.
NPJ Regen Med, 2024, 9(1):4
Cancer Cell, 2023, 41(8):1480-1497.e9
Nat Mater, 2022, 10.1038/s41563-022-01259-5
S7540 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Cancer Lett, 2024, 582:216597
Nat Commun, 2023, 14(1):3251
Neuron, 2023, S0896-6273(23)00623-2
S8008 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
iScience, 2024, 27(3):109119
Cell Stem Cell, 2023, 30(6):867-884.e11
Biosens Bioelectron, 2023, 226:115113
S7844 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Cell Commun Signal, 2023, 10.1186/s12964-022-01027-7
iScience, 2023, 26(6):106839
Inflammation, 2023, 46(2):739-751
S7834 Cyclo (-RGDfK) Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
Oxidative Medicine and Cellular Longevity, 2021, 10.1155/2021/9739977
Oxid Med Cell Longev, 2021, 2021:9739977
Int J Mol Sci, 2021, 22(16)8410
S2885 A-205804 A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.
Stem Cell Res Ther, 2022, 13(1):218
Am J Rhinol Allergy, 2022, 19458924221086061
Cancer Lett, 2018, 438:105-115
S6840 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
Exp Eye Res, 2023, 234:109609
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
E0790 ILK-IN-3 ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.
S3408 A286982 A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
S8454 ATN-161 ATN-161 is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
Bioact Mater, 2023, 22:75-90
Cancer Commun (Lond), 2023, 10.1002/cac2.12411
Cell Rep, 2023, 42(7):112804
S3714 Lifitegrast Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.
World J Gastroenterol, 2023, 29(20):3103-3118
Med Chem Res, 2022, 31(4):555-579
J Biomol Struct Dyn, 2020, 1-14
S3085 Tirofiban Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Food Funct, 2020, 11(1):139-152
S8594 Tirofiban Hydrochloride Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.
Front Cell Infect Microbiol, 2021, 11:783085
S0314 TR-14035 TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
S8306 Leukadherin-1 Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).
International Immunopharmacology, 2023, Volume 118
Int Immunopharmacol, 2023, 118:110024
Front Immunol, 2022, 13:919444
E0462 Pyrintegrin Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival, also enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling.

Integrin阻害剤の選択性比較

Tags: Integrin inhibitor|Integrin agonist|Integrin activator|Integrin inducer|Integrin antagonist|Integrin signaling pathway|Integrin assay kit