LSD1

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S7237 OG-L002 <1 mg/mL 45 mg/mL 19 mg/mL
S7574 GSK-LSD1 2HCl 57 mg/mL 57 mg/mL -1 mg/mL
S7795 Iadademstat (ORY-1001) 2HCl 61 mg/mL 5 mg/mL '4 mg/mL
S6722 Seclidemstat (SP-2577) ˂1 mg/mL 90 mg/mL ˂1 mg/mL
S0356 LSD1-IN-7 benzenesulfonate <1 mg/mL 100 mg/mL ''''<1 mg/mL
S7796 GSK2879552 2HCl 44 mg/mL 29 mg/mL '<1 mg/mL
S7680 SP2509 <1 mg/mL 38 mg/mL '<1 mg/mL
S8438 T-3775440 HCl 22 mg/mL 69 mg/mL ''<1 mg/mL

LSD1製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7237

OG-L002

OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.

S7574

GSK-LSD1 2HCl

GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).

S7795

Iadademstat (ORY-1001) 2HCl

Iadademstat 2HCl (ORY-1001, RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.

S6722

Seclidemstat (SP-2577)

Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 127 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.

S0356

LSD1-IN-7 benzenesulfonate

LSD1-IN-7 benzenesulfonate is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.

S7796

GSK2879552 2HCl

GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.

S7680

SP2509

SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.

S8438

T-3775440 HCl

T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7237

OG-L002

OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.

S7574

GSK-LSD1 2HCl

GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).

S7795

Iadademstat (ORY-1001) 2HCl

Iadademstat 2HCl (ORY-1001, RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.

S6722

Seclidemstat (SP-2577)

Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 127 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.

S0356

LSD1-IN-7 benzenesulfonate

LSD1-IN-7 benzenesulfonate is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.

S7796

GSK2879552 2HCl

GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.

S7680

SP2509

SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.

S8438

T-3775440 HCl

T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.

Tags: LSD1 inhibitor | LSD1 modulator | LSD1 chemical