LSD1

LSD1製品

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  • LSD1阻害剤 (8)
  • 新製品
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S7680 SP2509 SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.
MedComm (2020), 2023, 4(3):e269
JCI Insight, 2023, 8(15)e167440
JCI Insight, 2023, 8(15)e167440
S7796 GSK2879552 2HCl GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.
MedComm (2020), 2023, 4(3):e269
Cell Rep, 2023, 10.1016/j.celrep.2023.113477
Int J Mol Sci, 2023, 24(4)3605
S7795 Iadademstat (ORY-1001) 2HCl Iadademstat 2HCl (ORY-1001, RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
Nat Cell Biol, 2023, 10.1038/s41556-023-01281-y
MedComm (2020), 2023, 4(3):e269
Cell Rep, 2023, 10.1016/j.celrep.2023.113477
S7574 GSK-LSD1 2HCl GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).
Cell Death Dis, 2023, 10.1038/s41419-023-06238-5
Front Immunol, 2023,
Cell Death Differ, 2022, 10.1038/s41418-022-00983-4
S7237 OG-L002 OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
Viruses, 2023, 15(1)163
Sci Rep, 2021, 11(1):10285
Nat Genet, 2020, 52(10):1011-1017
S6722 Seclidemstat (SP-2577) Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
Nat Commun, 2023, 10.1038/s41467-023-42850-x
S0356 Pulrodemstat (CC-90011) besylate Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.
S8438 T-3775440 HCl T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.
S7680 SP2509 SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.
MedComm (2020), 2023, 4(3):e269
JCI Insight, 2023, 8(15)e167440
JCI Insight, 2023, 8(15)e167440
S7796 GSK2879552 2HCl GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.
MedComm (2020), 2023, 4(3):e269
Cell Rep, 2023, 10.1016/j.celrep.2023.113477
Int J Mol Sci, 2023, 24(4)3605
S7795 Iadademstat (ORY-1001) 2HCl Iadademstat 2HCl (ORY-1001, RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
Nat Cell Biol, 2023, 10.1038/s41556-023-01281-y
MedComm (2020), 2023, 4(3):e269
Cell Rep, 2023, 10.1016/j.celrep.2023.113477
S7574 GSK-LSD1 2HCl GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).
Cell Death Dis, 2023, 10.1038/s41419-023-06238-5
Front Immunol, 2023,
Cell Death Differ, 2022, 10.1038/s41418-022-00983-4
S7237 OG-L002 OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
Viruses, 2023, 15(1)163
Sci Rep, 2021, 11(1):10285
Nat Genet, 2020, 52(10):1011-1017
S6722 Seclidemstat (SP-2577) Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
Nat Commun, 2023, 10.1038/s41467-023-42850-x
S0356 Pulrodemstat (CC-90011) besylate Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.
S8438 T-3775440 HCl T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.

LSD1阻害剤の選択性比較

Tags: LSD1 inhibitor | LSD1 modulator | LSD1 chemical