MLL

亜型選択性的な製品

MLL製品

  • All (8)
  • MLL阻害剤 (8)
  • 新製品
製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7265 MM-102 MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.
Life Sci Alliance, 2023, 6(5)e202201619
Cell Stem Cell, 2022, S1934-5909(22)00417-9
Cell Rep, 2022, 39(7):110836
S7618 MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
Cell Stem Cell, 2022, S1934-5909(22)00417-9
Life Sci Alliance, 2022, 5(4)e202101187
J Immunol, 2021, ji1901348
S7817 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
Nat Cell Biol, 2023, 25(2):258-272
J Clin Invest, 2023, 133(13)e169993
Breast Cancer Res, 2022, 24(1):52
S7619 MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
Nat Commun, 2023, 14(1):3062
Nature, 2021, 10.1038/s41586-021-04116-8
Clin Epigenetics, 2019, 11(1):137
S7816 MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
J Clin Invest, 2023, 133(13)e169993
iScience, 2023, 26(10):107726
Front Oncol, 2020, 10:524922
S7815 MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
Breast Cancer Res, 2022, 24(1):52
Cancer Cell Int, 2022, 22(1):336
J Med Chem, 2020, 31
S8934 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
Cell Rep, 2023, 42(6):112547
bioRxiv, 2023, 10.1101/2023.03.17.533231
S8996 Revumenib (SNDX-5613) Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
S7265 MM-102 MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.
Life Sci Alliance, 2023, 6(5)e202201619
Cell Stem Cell, 2022, S1934-5909(22)00417-9
Cell Rep, 2022, 39(7):110836
S7618 MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
Cell Stem Cell, 2022, S1934-5909(22)00417-9
Life Sci Alliance, 2022, 5(4)e202101187
J Immunol, 2021, ji1901348
S7817 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
Nat Cell Biol, 2023, 25(2):258-272
J Clin Invest, 2023, 133(13)e169993
Breast Cancer Res, 2022, 24(1):52
S7619 MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
Nat Commun, 2023, 14(1):3062
Nature, 2021, 10.1038/s41586-021-04116-8
Clin Epigenetics, 2019, 11(1):137
S7816 MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
J Clin Invest, 2023, 133(13)e169993
iScience, 2023, 26(10):107726
Front Oncol, 2020, 10:524922
S7815 MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
Breast Cancer Res, 2022, 24(1):52
Cancer Cell Int, 2022, 22(1):336
J Med Chem, 2020, 31
S8934 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
Cell Rep, 2023, 42(6):112547
bioRxiv, 2023, 10.1101/2023.03.17.533231
S8996 Revumenib (SNDX-5613) Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.

MLL阻害剤の選択性比較

Tags: MLL inhibitor | MLL modulator | MLL regulation| MLL interaction | MLL inhibition