MLL
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S7265 | MM-102 | 100 mg/mL | 100 mg/mL | '100 mg/mL |
| S7816 | MI-463 | <1 mg/mL | 96 mg/mL | 22 mg/mL |
| S7817 | MI-503 | <1 mg/mL | 100 mg/mL | 15 mg/mL |
| S7619 | MI-3 (Menin-MLL Inhibitor) | <1 mg/mL | 19 mg/mL | 19 mg/mL |
| S8934 | VTP50469 | <1 mg/mL | 100 mg/mL | '''100 mg/mL |
| S8996 | SNDX-5613 | ' mg/mL | ||
| S7618 | MI-2 (Menin-MLL Inhibitor) | <1 mg/mL | 75 mg/mL | 75 mg/mL |
| S7815 | MI-136 | <1 mg/mL | 94 mg/mL | 94 mg/mL |
亜型選択性的な製品
MLL製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7265 |
MM-102MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
Immunofluorescence staining of H3K4me2/3 (red) in the IVF, SCNT and MM-102-NT embryos. The nuclei (blue) were stained with DAPI. The merged images of H3K4me2/3 and DNA were purple. Scale bars: 50 μm.
|
|
| S7816 |
MI-463MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
||
| S7817 |
MI-503MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
||
| S7619 |
MI-3 (Menin-MLL Inhibitor)MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. |
||
| S8934 |
VTP50469VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
||
| S8996新 |
SNDX-5613SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM. |
||
| S7618 |
MI-2 (Menin-MLL Inhibitor)MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
||
| S7815 |
MI-136MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S7265 |
MM-102MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
Immunofluorescence staining of H3K4me2/3 (red) in the IVF, SCNT and MM-102-NT embryos. The nuclei (blue) were stained with DAPI. The merged images of H3K4me2/3 and DNA were purple. Scale bars: 50 μm.
|
|
| S7816 |
MI-463MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
||
| S7817 |
MI-503MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
||
| S7619 |
MI-3 (Menin-MLL Inhibitor)MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. |
||
| S8934 |
VTP50469VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
||
| S8996新 |
SNDX-5613SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM. |
||
| S7618 |
MI-2 (Menin-MLL Inhibitor)MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
||
| S7815 |
MI-136MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
