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MLL
MLL阻害剤の選択性比較
亜型選択性的な製品
MLL製品
- All (8)
- MLL阻害剤 (8)
- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|---|
| S7265 | MM-102 | MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
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| S7816 | MI-463 | MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. | ||
| S7817 | MI-503 | MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. | ||
| S7619 | MI-3 (Menin-MLL Inhibitor) | MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. | ||
| S8934 | VTP50469 | VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. | ||
| S7618 | MI-2 (Menin-MLL Inhibitor) | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. | ||
| S8996 | SNDX-5613 | SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM. | ||
| S7815 | MI-136 | MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. | ||
| S7265 | MM-102 | MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay. |
|
|
| S7816 | MI-463 | MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. | ||
| S7817 | MI-503 | MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. | ||
| S7619 | MI-3 (Menin-MLL Inhibitor) | MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. | ||
| S8934 | VTP50469 | VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. | ||
| S7618 | MI-2 (Menin-MLL Inhibitor) | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. | ||
| S8996 | SNDX-5613 | SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM. | ||
| S7815 | MI-136 | MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
Tags: MLL inhibitor | MLL modulator | MLL regulation| MLL interaction | MLL inhibition
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