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NEDD8

NEDD8製品

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  • NEDD8阻害剤 (3)
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製品コード 製品名称 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S7109 Pevonedistat (MLN4924) MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.
Nature, 2025, 642(8068):785-795
Nat Commun, 2025, 16(1):2526
Nat Commun, 2025, 16(1):3756
Pevonedistat-S710901W0420190221.gif
S0346 NAcM-OPT NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
Cell Death Dis, 2021, 12(9):836
E1953 Pevonedistat hydrochloride Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.
S7109 Pevonedistat (MLN4924) MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.
Nature, 2025, 642(8068):785-795
Nat Commun, 2025, 16(1):2526
Nat Commun, 2025, 16(1):3756
 Pevonedistat-S710901W0420190221.gif
S0346 NAcM-OPT NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
Cell Death Dis, 2021, 12(9):836
E1953 Pevonedistat hydrochloride Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.
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