p53

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2929 Pifithrin-α (PFTα) HBr <1 mg/mL 67 mg/mL <1 mg/mL
S5791 Cyclic Pifithrin-α hydrobromide <1 mg/mL 27 mg/mL 3 mg/mL
S2930 Pifithrin-μ <1 mg/mL 36 mg/mL 36 mg/mL
S9235 Didymin -1 mg/mL 100 mg/mL -1 mg/mL
S8149 NSC348884 <1 mg/mL 100 mg/mL 100 mg/mL
S8187 ReACp53 100 mg/mL -1 mg/mL -1 mg/mL
S1172 JNJ-26854165 (Serdemetan) <1 mg/mL 66 mg/mL 2 mg/mL
S2678 NSC 207895 <1 mg/mL 0.4 mg/mL <1 mg/mL
S2781 RITA (NSC 652287) <1 mg/mL 58 mg/mL 8 mg/mL
S8000 Tenovin-1 <1 mg/mL 74 mg/mL <1 mg/mL
S7149 NSC 319726 <1 mg/mL 19 mg/mL <1 mg/mL
S8580 COTI-2 <1 mg/mL 73 mg/mL <1 mg/mL
S7649 MI-773 (SAR405838) <1 mg/mL 100 mg/mL 31 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S7724 APR-246 (PRIMA-1MET) 40 mg/mL 40 mg/mL 40 mg/mL
S8106 NSC59984 <1 mg/mL 53 mg/mL 53 mg/mL
S8483 CBL0137 (CBL-0137) 24 mg/mL 38 mg/mL <1 mg/mL
S7723 PRIMA-1 37 mg/mL 37 mg/mL 37 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S8728 PK11007 47 mg/mL 47 mg/mL 23 mg/mL

p53製品

新p53製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2929

Pifithrin-α (PFTα) HBr

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

S5791

Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.

S2930

Pifithrin-μ

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

S9235

Didymin

Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.

S8149

NSC348884

NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.

S8187

ReACp53

ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).

S1172

JNJ-26854165 (Serdemetan)

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.

S2678

NSC 207895

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

S2781

RITA (NSC 652287)

RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.

S8000

Tenovin-1

Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

S7149

NSC 319726

NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.

S8580

COTI-2

COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.

S7649

MI-773 (SAR405838)

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

S4900

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

S7724

APR-246 (PRIMA-1MET)

APR-246, also known as PRIMA-1MET, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

S8106

NSC59984

NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.

S8483

CBL0137 (CBL-0137)

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).

S7723

PRIMA-1

PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.

S2341

(-)-Parthenolide

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

S8728

PK11007

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2929

Pifithrin-α (PFTα) HBr

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

S5791

Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.

S2930

Pifithrin-μ

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

S9235

Didymin

Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.

S8149

NSC348884

NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.

S8187

ReACp53

ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1172

JNJ-26854165 (Serdemetan)

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.

2019, 36(2):179-193

2019, 36(2):179-193

2017, 18(1):40

S2678

NSC 207895

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

2018, 15(2):1673-1679

2016, 7(6):1140-1151

S2781

RITA (NSC 652287)

RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.

2019, 35(2):191-203

2015, 10.1038/nchembio.1986

2014, 10.1038/onc.2014.37

S8000

Tenovin-1

Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

2019, 17(1):76

S7149

NSC 319726

NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.

S8580

COTI-2

COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.

S7649

MI-773 (SAR405838)

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

2016, 7(50):82757-82769

S4900

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

2015, 10.1038/nbt.3130

S7724

APR-246 (PRIMA-1MET)

APR-246, also known as PRIMA-1MET, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

S8106

NSC59984

NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.

S8483

CBL0137 (CBL-0137)

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).

S7723

PRIMA-1

PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.

S2341

(-)-Parthenolide

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

2019, 187(1):49-64

2018, 501(1):246-252

2018, 39(3):1181-1190

S8728

PK11007

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.

Tags: p53 apoptosis | p53 inhibition | p53 cancer | p53 mutation | p53 protein | p53 pathway | p53 activation | p53 phosphorylation | p53 activity | p53-dependent apoptosis | p53 apoptosis pathway | p53 cancer therapy | p53-independent apoptosis | p53-mdm2 interaction | p53-p21 pathway | p53-mdm2 pathway | p53 protein structure | p53 protein function | p53 cleavage | p53 inhibitor review