PAK

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S8032 PRT062607 (P505-15) HCl 86 mg/mL 86 mg/mL '<1 mg/mL
S7093 IPA-3 <1 mg/mL 70 mg/mL 7 mg/mL
S7094 PF-3758309 <1 mg/mL 98 mg/mL 98 mg/mL
S8444 KPT 9274 ( ATG-019) <1 mg/mL 100 mg/mL 100 mg/mL
S7271 FRAX597 <1 mg/mL 14 mg/mL 1 mg/mL
E2380 GNE 2861 <1 mg/mL 81 mg/mL 40 mg/mL
S7807 FRAX486 <1 mg/mL 22 mg/mL <1 mg/mL
S1976 LCH-7749944 <1 mg/mL 70 mg/mL ''70 mg/mL
S7989 FRAX1036 <1 mg/mL <1 mg/mL 20 mg/mL

亜型選択性的な製品

PAK製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8032

PRT062607 (P505-15) HCl

PRT062607 (P505-15, BIIB057, PRT-2607) is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.

S7093

IPA-3

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

S7094

PF-3758309

PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with IC50 of 1.3 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.

S8444

KPT 9274 ( ATG-019)

KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

S7271

FRAX597

FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

E2380

GNE 2861

GNE 2861, a PAK inhibitor that displays group II selectivity, inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

S7807

FRAX486

FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.

S1976

LCH-7749944

LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.

S7989

FRAX1036

FRAX-1036 is a potent and selective PAK1 inhibitor.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8032

PRT062607 (P505-15) HCl

PRT062607 (P505-15, BIIB057, PRT-2607) is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.

S7093

IPA-3

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

S7094

PF-3758309

PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with IC50 of 1.3 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.

S8444

KPT 9274 ( ATG-019)

KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

S7271

FRAX597

FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

E2380

GNE 2861

GNE 2861, a PAK inhibitor that displays group II selectivity, inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

S7807

FRAX486

FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.

S1976

LCH-7749944

LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.

S7989

FRAX1036

FRAX-1036 is a potent and selective PAK1 inhibitor.

Tags: PAK inhibitor|PAK agonist|PAK activator|PAK inducer|PAK antagonist|PAK signaling pathway|PAK assay kit