PORCN

PORCN製品

All (6)
PORCN阻害剤 (6)
新製品

製品コード	製品名称	製品説明	文献中Selleckの製品使用例
S7037	Wnt-C59 (C59)	Wnt-C59 (C59) はルシフェラーゼ (luciferase) を駆動する多量体 TCF 結合部位の Wnt3A を介した活性化に対する PORCN 阻害剤 (HEK293 細胞での IC50= 74 pM) です。	Nat Commun, 2024, 15(1):1487 Small Methods, 2024, e2301197. Cell Rep, 2024, 43(3):113927
S7143	LGK-974	LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.	Nat Commun, 2023, 14(1):110 Nat Commun, 2023, 14(1):2262 J Exp Med, 2023, 220(1)e20220503
S7301	IWP-L6	IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.	iScience, 2022, 25(10):105182 Sci Rep, 2022, 12(1):7 Carcinogenesis, 2020, 41(7):993-1004
S6616	ETC-159	ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.	Nat Commun, 2023, 14(1):2402 J Pathol, 2022, 10.1002/path.5868
S8645	IWP-O1	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.	Cancer Cell, 2022, S1535-6108(21)00662-0
S8644	GNF-6231	GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
S7037	Wnt-C59 (C59)	Wnt-C59 (C59) はルシフェラーゼ (luciferase) を駆動する多量体 TCF 結合部位の Wnt3A を介した活性化に対する PORCN 阻害剤 (HEK293 細胞での IC50= 74 pM) です。	Nat Commun, 2024, 15(1):1487 Small Methods, 2024, e2301197. Cell Rep, 2024, 43(3):113927
S7143	LGK-974	LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.	Nat Commun, 2023, 14(1):110 Nat Commun, 2023, 14(1):2262 J Exp Med, 2023, 220(1)e20220503
S7301	IWP-L6	IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.	iScience, 2022, 25(10):105182 Sci Rep, 2022, 12(1):7 Carcinogenesis, 2020, 41(7):993-1004
S6616	ETC-159	ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.	Nat Commun, 2023, 14(1):2402 J Pathol, 2022, 10.1002/path.5868
S8645	IWP-O1	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.	Cancer Cell, 2022, S1535-6108(21)00662-0
S8644	GNF-6231	GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.

PORCN阻害剤の選択性比較