Celecoxib (SC 58635)

Licensed by Pfizer 製品コード:S1261

For research use only.

Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.

Celecoxib (SC 58635)化学構造

CAS No. 169590-42-5

サイズ 価格(税別)
10mM (1mL in DMSO) JPY 15900
JPY 18100

代表番号: 03-5615-9297|電子メール:[email protected]
よく尋ねられる質問

文献中Selleckの製品使用例(85)

製品安全説明書

COX阻害剤の選択性比較

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生物活性

製品説明 Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.
ターゲット
COX-2 [1]
(Sf9 cells)
40 nM
体外試験

Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 NF;rZ5RHfW6ldHnvckBCe3OjeR?= MmnENE4yNTNyIN88US=> NFfyU|Y1QCCq NYjJNXVNcW6mdXPld{BKS0GPLUGg[ZhxemW|c3nvckBwdiCkb4ToJJBzd3SnaX6gZY5lKG2UTlGgcIV3\Wx? M1P4elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NUGzNVczLz5{NkWxN|E4OjxxYU6=
H460 NWXYO|RkTnWwY4Tpc44hSXO|YYm= M{K3b|AvOS1|MDFOwG0> MnXLOFghcA>? MknLbY5lfWOnczDJR2FONTFiZYjwdoV{e2mxbjDvckBjd3SqIIDyc5RmcW5iYX7kJI1TVkFibHX2[Yw> MnywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3MUOxO|IoRjJ4NUGzNVczRC:jPh?=
HKESC-2 NIW3TGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jRXlIxyqEQvF2= NVvr[m5bPDkEoHlCpC=> Mo\Ed4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJGlEPTEEoI\hcJVmeyCxZjDvfIFtcXCuYYTpcuKh Mo\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
CaES-17 NYLqZ3lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOyNOKh|ryP M3S1TFQ5yqCqwrC= M1qyRZNq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBKSzVywrD2ZYx2\XNib3[gc5hidGmybHH0bY7DqA>? Mk\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2N{S2PVMoRjJ4NEe0Olk{RC:jPh?=
HKESC-2 NFX1PVBCeG:ydH;zbZMhSXO|YYm= NHjRfnIzOMLizszN MVi0POKhcMLi M2jNc5Jm\HWlZYOgc5hidGmybHH0bY4ucW6mdXPl[EBieG:ydH;zbZM> NIi2[GM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS3OFY6Oyd-Mk[0O|Q3QTN:L3G+
CaES-17 M4\HTmFxd3C2b4Ppd{BCe3OjeR?= Mk[4NlDDqM7:TR?= NEf0TpE1QMLiaNMg NIPKW2lz\WS3Y3XzJI95[WyrcHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR5NE[5N{c,OjZ2N{S2PVM9N2F-
A549 M3T6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj1OU0yPjBizszN NV;nR2xTPDkEoHlCpC=> MVTEUXNQ NHz2UXdKSzVyPUG2N{41KM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4NE[0N{c,OjZ2NkS2OFM9N2F-
HCC827 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJOU0yPjBizszN NF;3Sm01QMLiaNMg M2H5cmROW09? NV7HVI86UUN3ME22PU4zKM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR4NE[0N{c,OjZ2NkS2OFM9N2F-
A549 MV3BdI9xfG:|aYOgRZN{[Xl? MYq4NEDDvU1? MmjLOFjDqGkEoB?= NIjmb4ZFVVOR M17Ob4lv\HWlZYOgZZBweHSxc3nz NXfjU49LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlQ3PDNpPkK2OFY1PjR|PD;hQi=>
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LMeC  NYnxOG9OTnWwY4Tpc44hSXO|YYm= MofWNlAwPTBizszN MmHGOFghcA>? M1;5bIRm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDv[kBEV1hvMjDwdo91\Wmw NHnSZW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
CMeC-1 MoXzR4VtdCCYaXHibYxqfHliQYPzZZk> M2jncVIxNzVyIN88US=> M{m2fVQ5KGh? M1TkOolvcGmkaYTzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
LMeC M2\jOmNmdGxiVnnhZoltcXS7IFHzd4F6 M1[0eVIxNzVyIN88US=> MljPOFghcA>? MUjpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ3Nke0Okc,OjR4NU[3OFY9N2F-
CMeC-1 Ml3YSpVv[3Srb36gRZN{[Xl? MnTMNlAwPTBizszN MUe0PEBp MoDObY5lfWOnczDHNU1UKGG{cnXzeC=> MnrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
LMeC NUjDZYxpTnWwY4Tpc44hSXO|YYm= MWmyNE82OCEQvF2= Ml7yOFghcA>? M1rSOIlv\HWlZYOgS|EuWyCjcoLld5Q> M1W4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
CMeC-1 MoC1SpVv[3Srb36gRZN{[Xl? M1\PPFIxNzVyIN88US=> M13odlQ5KGh? NWjjNYJK\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gZ5lkdGmwIFSxJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NVK5cFlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY4PDZpPkK0OlU3PzR4PD;hQi=>
LMeC MYDGeY5kfGmxbjDBd5NigQ>? NWDSR3JMOjBxNUCg{txO M37VUVQ5KGh? NHXWcHRl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjfYNtcW5iREGgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MkLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[3OFYoRjJ2NkW2O|Q3RC:jPh?=
CMeC-1 NGjSV4pHfW6ldHnvckBCe3OjeR?= MX:yNE82OCEQvF2= Mnv6OFghcA>? NXPVVohxcW6mdXPld{Bk[XOyYYPlMVMh[WO2aY\heIlwdg>? M3f5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkW2O|Q3Lz5{NE[1Olc1PjxxYU6=
LMeC MkWySpVv[3Srb36gRZN{[Xl? MXKyNE82OCEQvF2= M4\EUVQ5KGh? MYHpcoR2[2W|IHPhd5Bie2VvMzDhZ5RqfmG2aX;u NGi2V5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[1Olc1Pid-MkS2OVY4PDZ:L3G+
OVCAR-3 M{K5bmNmdGxiVnnhZoltcXS7IFHzd4F6 NUPGWJU5OTBiwsXN NIDMdmkyKGh? NX\QXZJC\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKG:4YYLpZY4h[2GwY3XyJINmdGxiZHXheIjDqA>? M4S2TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 MVnBdI9xfG:|aYOgRZN{[Xl? M334ZVExKML3TR?= NEntd2wyKGh? NVHZdJpFeHKxbX;0[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKGGyb4D0c5Nqe8Li MnvPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkCyNlcoRjJ2NUKwNlI4RC:jPh?=
OVCAR-3 NGDDdXZHfW6ldHnvckBCe3OjeR?= M13LUlExKML3TR?= MVyxJIg> NIKycJJmdmijbnPld{Bx[WOuaYThfIVtNWmwZIXj[YQh[WO2aY\heIlwdiCxZjDjZZNx[XOnLUpCpC=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MEKyO{c,OjR3MkCyNlc9N2F-
OVCAR-3 M1zqS2Z2dmO2aX;uJGF{e2G7 MWCxNEDDvU1? NFjTZnIyKGh? MoT4[I94di2{ZXf1cIF1\XNiTl[t{tpDKGGldHn2ZZRqd25iaX7keYNm\CCkeTDwZYNtcXSjeHXs M{iwb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKwNlI4Lz5{NEWyNFIzPzxxYU6=
OVCAR-3 MnThSpVv[3Srb36gRZN{[Xl? NYf6UIVIOTBiwsXN NUTmfmZ4OSCq NXu3UYtocW6qaXLpeJMheGGlbHn0ZZhmdC2rbnT1Z4VlKEGtdDDwbI9{eGixconsZZRqd25? NE\FZ5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNFIzPyd-MkS1NlAzOjd:L3G+
CF33 MVfGeY5kfGmxbjDBd5NigQ>? M{npXlExOCEQvF2= M2m5e|I1KGh? M3:5N4lv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gR29ZNTJicILveIVqdiCneIDy[ZN{cW:w NXrCWG9uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NFM4QDJpPkK0OVA{Pzh{PD;hQi=>
CF33 M{PXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13kXFExNTFyMDFOwG0> NWjOZ5R7OC12IHS= MVzpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NE\CZ5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwN|c5Oid-MkS1NFM4QDJ:L3G+
CF33 NEnkVWdHfW6ldHnvckBCe3OjeR?= NEXkRXEyOC1zMECg{txO M3uwR|QuOjRiaB?= M1\uSYRm[3KnYYPld{Bk\WyuczDpckB1cGViUzDwbIF{\SCjbnSgbY5kemWjc3XzJINmdGy|IHnuJGcxN0dzIHHydoV{fA>? M2XheVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCzO|gzLz5{NEWwN|c5OjxxYU6=
LNCaP NH3GW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\SNk82NzFyIN88US=> MoD2PVYhcA>? NWWxT2V5cW6qaXLpeJMh[2WubDDndo94fGhic3nncolncWOjboTsfUBkd22kaX7l[EB4cXSqIHH0c5J3[XO2YYTpci=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ7Nkm3PEc,OjR{OU[5O|g9N2F-
LNCaP MnHKRZBweHSxc3nzJGF{e2G7 NVi0N|Z5Oi93L{GwJO69VQ>? MVO5OkBp NYHnOVJVcW6mdXPld{BieG:ydH;zbZMh[2:vYnnu[YQhf2m2aDDheI9zfmG|dHH0bY4> NGHucmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK5Olk4QCd-MkSyPVY6Pzh:L3G+
PC-3  NX;Md|MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nQcVAuPTBizszN NY\afpV4PDkkgJno NG\1S21qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? Ml76QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMke4PFIoRjJ2MUK3PFgzRC:jPh?=
PC-3  NEHiZ3JE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MVOwMVExOCEQvF2= MmPmO|IhcA>? NV\uUYtx\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NF3aTWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyO|g5Oid-MkSxNlc5QDJ:L3G+
HCA-7 MoHESpVv[3Srb36gZZN{[Xl? NF21bFM4OiCqcoO= MX;Jcohq[mm2aX;uJI9nKEmOLUHi[ZRiNWmwZIXj[YQhWEeHMjDwdo9lfWO2aX;uJIlvKGi3bXHuJGhESS15IHPlcIx{KGGodHXyJFczKGi{czDifUBGUUFuIFXDOVAhRSByLkCwNVE2KM7:TT6= MoriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3MU[yPFIoRjJ{NUG2NlgzRC:jPh?=
CHO MkToSpVv[3Srb36gZZN{[Xl? NW[3O2tvUW5idnn0do8hcW6qaXLpeI9zgSCyb4TlcoN6KGGpYXnud5QhcHWvYX6gR29ZNTJiaX6gd5Ri[my7IITyZY5{\mWldHXkJINpcW6nc3WgbIFue3SncjDveoFzgSBqQ1jPLUBk\WyuczygTWM2OCB;IECuNFAzKM7:TT6= M1LDe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNUe2Olg1Lz5zMEW3OlY5PDxxYU6=
CHO M{LEUWZ2dmO2aX;uJIF{e2G7 NIfKdoRKdmirYnn0bY9vKG:oIGDHSU0zKHC{b3T1Z5Rqd25iaX6gR2hQKGOnbHzzJIV5eHKnc4PpcochcHWvYX6gR29ZNTJuIFnDOVAhRSByLkCwNkDPxE1w NH;T[5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEW3OlY5PSd-MUC1O|Y3QDV:L3G+
CHO MXvGeY5kfGmxbjDhd5NigQ>? MofvTY4hfmm2cn:gdI91\W6leTDh[4FqdnO2IHj1cYFvKFC{b4P0ZYdt[W6maX6gS{9JKHO7boToZZNmKDJiaX6geJJidnOoZXP0[YQhS0iRIHPlcIx{NCCLQ{WwJF0hOC5yMEKg{txONg>? NX3UZ4pLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCxPVc6PzBpPkGwNVk4QTdyPD;hQi=>
CHO Ml7zSpVv[3Srb36gZZN{[Xl? NVrjNYdjUW6qaXLpeI9zgSCxZjDoeY1idiCScn;zeIFodGGwZHnuJGcwUCC|eX70bIF{\SB{IHX4dJJme3OnZDDpckBEUE9iY3XscJMtKEmFNUCgQUAxNjByMjFOwG0v NUnDdJVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2OFM6PDJpPkGyOlQ{QTR{PD;hQi=>
synovial cells MYrGeY5kfGmxbjDhd5NigQ>? NYTsSoRXUW6qaXLpeI9zgSCnZn\lZ5Qhd25icILv[JVkfGmxbjDv[kBkgWOub3;4fYdmdmG|ZT2yJEhEV1hvMjmgdJJwe3SjZ3zhcoRqdiCHMjCoVGdGOiliaX6gbJVu[W5iSVyxMYJmfGFic4TpcZVt[XSnZDDzfY5wfmmjbDDj[YxteyxiSVO1NEA:KDBwMEC3PUDPxE1w MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh{MUexOkc,OTB6MkG3NVY9N2F-
RAW264.7 M3HvZ2Z2dmO2aX;uJIF{e2G7 MWHJcohq[mm2aX;uJI9nKEORWD2yJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEySUz3pcoR2[2WmIGDHSVIheHKxZIXjeIlwdiC2cnXheIVlKHC{aX;yJJRwKEySUzDjbIFtdGWwZ3WgZpkh\W68eX3lJIludXWwb3Hzd4F6NCCLQ{WwJF0hOC5yMEi3JO69VS5? MmLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4NU[2OlIoRjJ2NkW2OlYzRC:jPh?=
HEK293 M2HST2Z2dmO2aX;uJIF{e2G7 MYLJcohq[mm2aX;uJI9nKGOub37l[EBUfHmub4Doc5JiKHCrc4TpcIxifGFiYXzwbIEuS0FiZYjwdoV{e2WmIHnuJIh2dWGwIFjFT|I6OyClZXzsd{BjgSC|dH;wdIVlNW[ub4egR28zKGG|c3H5MEBMcSB;IECuNFM1OiEQvF2u M2fvWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUKwOVc4Lz5zOUWyNFU4PzxxYU6=
SF9 NVvocGpxTnWwY4Tpc44h[XO|YYm= MY\Jcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUILvd5Ri\2yjbnTpckBIN0hic4nueIhie2ViMjDlfJBz\XO|ZXSgbY4he2ZvOTDj[YxteyCrbn\lZ5Rm\CC5aYToJIJi[3Wub4\pdpV{NCCLQ{WwJF0hOC5yM{[g{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDZ7OEG5NEc,OTR4OUixPVA9N2F-
SF9 MojsSpVv[3Srb36gZZN{[Xl? M3vkTmlvKH[rdILvJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDy[YNwdWKrbnHueEBxem:|dHHncIFv\GmwIFevTEB{gW62aHHz[UAzKGW6cILld5Nm\CCrbjDz[k06KGOnbHzzJIlv\mWldHXkJJdqfGhiYnHjeYxwfmm{dYOsJGlEPTBiPTCwMlA{PiEQvF2u NHPDVW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUCyOlA2OCd-MUWwNlYxPTB:L3G+
CHO M4LVWWZ2dmO2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKEORWEKg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGG{YXPobYRwdmmlIHHjbYQue3SrbYXsZZRm\CCSR1WyJJBzd2S3Y4Tpc44h[nliZX76fY1mKGmvbYXuc4F{e2G7LDDJR|UxKD1iMD6wN|Yh|ryPLh?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkK5NEc,OTV3Nk[yPVA9N2F-
insect cells MlX4SpVv[3Srb36gZZN{[Xl? NYj1bIhROSCvaX6= MYLJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEORWEKg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczD1d4lv\yCjcnHjbIlld26rYzDhZ4llKGG|IIP1ZpN1emG2ZTDpcoN2[mG2ZXSg[o9zKDFibXnuJJBzcW:{IITvJJN2[nO2cnH0[UBi\GSrdHnvckBu\WG|dYLl[EBnd3JiMkWgd4VkeyCkeTDUUXBFNWKjc3XkJINpem:vb3flcolkKGG|c3H5MEBKSzVyIE2gNE4xPDJizszNMi=> NXKzb4NORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNVAzPzBpPkKzNFExOjdyPD;hQi=>
HNSCC 1483 NITqRnhHfW6ldHnvckBie3OjeR?= M2jXZVMxKG2rboO= NVzrfIdrUW6qaXLpeIlwdiCxZjDDU3guOiCrbjDoeY1idiCKTmPDR{AyPDh|IHPlcIx{KHW|aX7nJHsyPEOfIHHyZYNpcWSxbnnjJIFkcWRiYYOgd5Vje3S{YYTlJJBz\WmwY4XiZZRm\CCob4KgN|AhdWmwczDi[YZwemVic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMtKEmFNUCgQUAxNjB3NDFOwG0v NYPtV454RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlM5QTRpPkKyNlY{QDl2PD;hQi=>
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アッセイ
Methods Test Index PMID
Western blot Fibronectin / Vimentin / N-cadherin / E-cadherin ; COX-2 ; pAKT / AKT / PPARγ / PTEN 28978083 29515134 24721996
Immunofluorescence PPARγ / PTEN 24721996
Growth inhibition assay Cell viability 28521485
体内試験 Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3]

お薦めの試験操作(参考用のみ)

キナーゼ試験:[1]
  • COX enzyme assay in vitro:

    Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 μM). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Celecoxib are preincubated with crude 1% CHAPS homogenates (2-10 μg of protein) for 10 minutes before addition of arachidonic acid. PGE2 formed is detected by ELISA after 10 minute incubation.

細胞試験:[2]
  • 細胞株:HNE1 and CNE1-LMP1
  • 濃度: 0-75 μM
  • 反応時間:48 hours
  • 実験の流れ:The antiproliferative effect of Celecoxib on NPC cells is assessed using an MTT assay. Cells are seeded into 96-well plates and allowed to attach for 24 hours. The cells are then treated with increasing concentrations of Celecoxib (0 to 75 μM) dissolved in DMSO (final concentration ≤0.1%) and incubated for up to 48 hours. After the incubation, 20 μL of MTT dye (5 mg/mL) are added to each well and cells are incubated at 37 °C for 4 hours. After removing the supernatants, the crystals are dissolved in DMSO and the absorbance is measured at 490 nm. The half-maximal inhibitory concentration (IC50) values and the 95% confidence intervals are calculated using probit regression using SPSS 15.0 software. The experiment is performed in triplicate and repeated at least three times.
動物試験:[1]
  • 動物モデル:A 0.1 mL aliquot of a 1% solution of carrageenan in 0.9% sterile saline or 1 mg of Mycobacterium butyricum in 50 μL of mineral oil is administered to the right hind foot pad of male Sprague−Dawley rats.
  • 投薬量:≤200 mg/kg
  • 投与方法:Administered via p.o.

溶解度 (25°C)

体外

体内

左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
混合させたのち直ちに使用することを推奨します。

5mg/mL

化学情報

分子量 381.37
化学式

C17H14F3N3O2S

CAS No. 169590-42-5
Storage 3年 -20°C
2年 -80°C in solvent
Smiles CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

便利ツール

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01344200 Not yet recruiting Drug: Celecoxib|Drug: Placebo Pharmacokinetics of Celecoxib in Children Children''s Hospital of Eastern Ontario January 2023 Phase 2
NCT05256823 Recruiting Drug: Celecoxib|Drug: nucleos(t)ide analogue To Evaluate the Safety and Efficacy of Celecoxib Plus Nucleos(t)Ide Analogues in Nucleos(t)Ide-treated Patients With Chronic Hepatitis B Lai Wei|Beijing Tsinghua Chang Gung Hospital February 24 2022 Phase 2
NCT05324163 Recruiting Drug: X0002 Spray|Drug: Celecoxib capsules|Drug: placebo KNEE OSTEOARTHRITIS Jiangsu XinChen-Techfields Pharma Co. LTD. September 29 2021 Phase 3
NCT04526197 Completed Drug: ALXN1840|Drug: Celecoxib Wilson Disease Alexion Pharmaceuticals July 8 2020 Phase 1
NCT04447261 Completed Drug: BI 1356225|Drug: Placebo Obesity Boehringer Ingelheim June 30 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

* 必須

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よくある質問(FAQ)

質問1:
I am doing an animal experiment with mice and planning to administrate S1261 via oral gavage. what are your recommendations for diluting the compound?

回答
For oral administration, Celecoxib can be dissolved in vehicle one: "0.5% methyl cellulose and 0.025% Tween-20", or the vehicle 2 "2% DMSO/30% PEG 300/5% Tween 80/ ddH2O".

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