COX

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1261	Celecoxib	<1 mg/mL	76 mg/mL	33 mg/mL
S1396	Resveratrol	<1 mg/mL	45 mg/mL	''<1 mg/mL
S1255	Nepafenac	<1 mg/mL	50 mg/mL	<1 mg/mL
S1638	Ibuprofen	<1 mg/mL	41 mg/mL	41 mg/mL
S1723	Indomethacin	<1 mg/mL	72 mg/mL	24 mg/mL
S2121	Licofelone	<1 mg/mL	19 mg/mL	4 mg/mL
S6615	ATB 346	<1 mg/mL	73 mg/mL	'''<1 mg/mL
S2595	FK-3311	<1 mg/mL	68 mg/mL	8 mg/mL
S6780	TFAP	<1 mg/mL	56 mg/mL	56 mg/mL
S6686	SC-560	<1 mg/mL	70 mg/mL	70 mg/mL
S6685	Mavacoxib	<1 mg/mL	77 mg/mL	77 mg/mL
S4360	Tolmetin Sodium	63 mg/mL	<1 mg/mL	10 mg/mL
S2007	Sulindac	<1 mg/mL	71 mg/mL	9 mg/mL
S3043	Rofecoxib	<1 mg/mL	63 mg/mL	<1 mg/mL
S1734	Meloxicam	<1 mg/mL	30 mg/mL	<1 mg/mL
S4028	Dexamethasone Sodium Phosphate	103 mg/mL	<1 mg/mL	<1 mg/mL
S3023	Bufexamac	<1 mg/mL	45 mg/mL	3 mg/mL
S1204	Melatonin	<1 mg/mL	47 mg/mL	'47 mg/mL
S3017	Aspirin	<1 mg/mL	36 mg/mL	'36 mg/mL
S1761	Suprofen	<1 mg/mL	52 mg/mL	52 mg/mL
S1713	Piroxicam	<1 mg/mL	66 mg/mL	1 mg/mL
S1328	Etodolac	<1 mg/mL	58 mg/mL	58 mg/mL
S1645	Ketoprofen	<1 mg/mL	51 mg/mL	51 mg/mL
S1903	Diclofenac Sodium	14 mg/mL	64 mg/mL	64 mg/mL
S1518	Ibuprofen Lysine	71 mg/mL	<1 mg/mL	<1 mg/mL
S2047	Lornoxicam	<1 mg/mL	3 mg/mL	<1 mg/mL
S1646	Ketorolac	<1 mg/mL	75 mg/mL	75 mg/mL
S1626	Naproxen Sodium	50 mg/mL	3 mg/mL	<1 mg/mL
S1576	Sulfasalazine	<1 mg/mL	80 mg/mL	'''<1 mg/mL
S2903	Lumiracoxib	<1 mg/mL	59 mg/mL	<1 mg/mL
S2531	Asaraldehyde	<1 mg/mL	39 mg/mL	16 mg/mL
S1960	Pranoprofen	<1 mg/mL	51 mg/mL	6 mg/mL
S3008	Zaltoprofen	<1 mg/mL	60 mg/mL	31 mg/mL
S2602	Acemetacin	<1 mg/mL	83 mg/mL	58 mg/mL
S1959	Tolfenamic Acid	<1 mg/mL	52 mg/mL	<1 mg/mL
S4049	Valdecoxib	<1 mg/mL	63 mg/mL	18 mg/mL
S2577	Phenacetin	<1 mg/mL	36 mg/mL	36 mg/mL
S2040	Nimesulide	<1 mg/mL	62 mg/mL	<1 mg/mL
S4149	Amfenac Sodium Monohydrate	59 mg/mL	59 mg/mL	4 mg/mL
S4248	Bromfenac Sodium	71 mg/mL	71 mg/mL	2 mg/mL
S4051	Nabumetone	<1 mg/mL	46 mg/mL	25 mg/mL
S3018	Niflumic acid	<1 mg/mL	56 mg/mL	<1 mg/mL
S3173	Antipyrine	38 mg/mL	38 mg/mL	38 mg/mL
S3200	Triflusal	<1 mg/mL	50 mg/mL	50 mg/mL
S4011	Ampiroxicam	<1 mg/mL	90 mg/mL	<1 mg/mL
S9208	Ginsenoside Rb3	-1 mg/mL	100 mg/mL	-1 mg/mL
S5177	Naproxen	-1 mg/mL	46 mg/mL	-1 mg/mL
S5418	Parecoxib Sodium	-1 mg/mL	78 mg/mL	-1 mg/mL
S8433	NS-398 (NS398)	<1 mg/mL	62 mg/mL	<1 mg/mL
S4032	Bismuth Subsalicylate	<1 mg/mL	0.04 mg/mL	<1 mg/mL
S5698	Ketorolac tromethamine salt	75 mg/mL	75 mg/mL	8 mg/mL
S4628	(+/-)-Sulfinpyrazone	<1 mg/mL	80 mg/mL	64 mg/mL
S4136	Carprofen	<1 mg/mL	55 mg/mL	55 mg/mL
S3063	Diclofenac Diethylamine	<1 mg/mL	74 mg/mL	74 mg/mL
S3974	(+)-Catechin hydrate	-1 mg/mL	58 mg/mL	-1 mg/mL
S4656	Parecoxib	<1 mg/mL	74 mg/mL	2 mg/mL
S4609	Diflunisal	<1 mg/mL	50 mg/mL	20 mg/mL
S4176	Trometamol	24 mg/mL	2 mg/mL	<1 mg/mL
S5520	Phenidone	-1 mg/mL	32 mg/mL	-1 mg/mL
S9029	Prim-o-glucosylcimifugin	-1 mg/mL	93 mg/mL	-1 mg/mL
S3931	Ginsenoside Rd	-1 mg/mL	90 mg/mL	-1 mg/mL
S5019	Indobufen	-1 mg/mL	59 mg/mL	-1 mg/mL
S4078	Mefenamic Acid	<1 mg/mL	48 mg/mL	<1 mg/mL
S4651	Etoricoxib	<1 mg/mL	71 mg/mL	46 mg/mL
S9386	Polygalacic acid	-1 mg/mL	100 mg/mL	-1 mg/mL
S6073	Diclofenac acid	-1 mg/mL	59 mg/mL	-1 mg/mL
S4765	Syringaldehyde	-1 mg/mL	36 mg/mL	-1 mg/mL
S5010	Indometacin Sodium	-1 mg/mL	87 mg/mL	-1 mg/mL
S4230	Oxaprozin	<1 mg/mL	59 mg/mL	27 mg/mL
S2349	Rutaecarpine	<1 mg/mL	24 mg/mL	<1 mg/mL
S2351	Salicin	24 mg/mL	57 mg/mL	<1 mg/mL
S4526	Fenbufen	<1 mg/mL	50 mg/mL	50 mg/mL
S3899	Hederagenin	-1 mg/mL	94 mg/mL	-1 mg/mL
S4539	Salicylic acid	<1 mg/mL	27 mg/mL	27 mg/mL
S9149	Benzoylpaeoniflorin	-1 mg/mL	100 mg/mL	-1 mg/mL
S4509	4-Aminoantipyrine	40 mg/mL	40 mg/mL	40 mg/mL
S3872	Guaiacol	-1 mg/mL	24 mg/mL	-1 mg/mL
S5309	Propyphenazone (4-Isopropylantipyrine)	-1 mg/mL	46 mg/mL	-1 mg/mL
S7889	Xanthohumol	<1 mg/mL	70 mg/mL	70 mg/mL
S2108	Flunixin Meglumin	98 mg/mL	98 mg/mL	8 mg/mL
S5711	Deracoxib	<1 mg/mL	80 mg/mL	20 mg/mL
S3925	(-)-Epicatechin gallate	-1 mg/mL	88 mg/mL	-1 mg/mL
S4295	Meclofenamate Sodium	63 mg/mL	63 mg/mL	63 mg/mL
S2272	Indoprofen	<1 mg/mL	52 mg/mL	<1 mg/mL
S9190	Oroxin B	-1 mg/mL	100 mg/mL	-1 mg/mL

亜型選択性的な製品

COX製品

All (90) COX阻害剤(88) COX活性剤(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1261	Celecoxib Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.	J Clin Invest, 2020, 26;132417 Cell Death Differ, 2020, 20 Nanotoxicology, 2020, 14(2):162-180	Reduced hepatic lipid contents and alleviated liver injury in EC-AMPK mice treated with selective COX-2 inhibitors. Wild-type and EC-AMPK mice given a high fat diet were treated with vehicle, celecoxib or nimesulide for a period of 4 weeks. At the end of treatment, parameters including body weight and circulating glucose (A), serum triglyceride and cholesterol levels (B were measured and presented as percentage comparisons against those from vehicle-treated wild-type mice. *P < 0.05 versus wild-type mice treated with vehicle; #P < 0.05 versus EC-AMPK mice treated with vehicle, n = 3-5.
S1396	Resveratrol Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Bone, 2020, 133:115252 J Biol Chem, 2020, 13;295(11):3485-3496 Oncol Lett, 2020, 19(4):3269-3277	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
S1255	Nepafenac Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.
S1638	Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.	Immunity, 2020, 52(2):328-341 Anticancer Drugs, 2020, 31(1):27-34 Nat Commun, 2017, 8(1):573
S1723	Indomethacin Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.	Front Immunol, 2020, 11:1125 Mol Cancer Ther, 2020, 19;molcanther00152020 Nat Commun, 2019, 10(1):2427	Indicated PN and MES spheres were shown expressing GFP under the control of a 7 × TCF/LEF optimal promoter cassette (7 × TOP) and constitutively expressed nuclear mCherry. PN 84 and MES 1123 were treated with Wnt3a (200 ng/ml), indomethacin (Indo; 20 μM), or a control (vehicle). Scale bar, 100 μm. Bar graph, quantification of fluorescent signal of GFP (TOP-GFP) versus mCherry (PGK-H2BmCherry). The percentage of GFP- and mCherry-positive spheres was determined by FACS.
S2121^新	Licofelone Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
S6615^新	ATB 346 ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.
S2595^新	FK-3311 FK-3311 is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.
S6780^新	TFAP TFAP is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.
S6686^新	SC-560 SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.
S6685^新	Mavacoxib Mavacoxib is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).
S4360^新	Tolmetin Sodium Tolmetin is a non-steroidal anti-inflammatory drug of the arylalkanoic acids.
S2007	Sulindac Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.	Cancer Cell Int, 2020, 19;20:58 Oncogene, 2017, 36(6):787-796 Oncogene, 2016, 10.1038/onc.2016.247	(d) Parental and regorafenib-resistant HCT116 cells were treated with 40 μM regorafenib, 20 μM sorafenib, 1 μM UCN-01, 1 μM YM-155, 10 μM roscovitine, 15 μM sunitinib, 10 μM crizotinib, 10 nM TRAIL, 10 μM VX680, 20 μM etoposide, 20 μM temsirolimus or 120 μM sulindac sulfide for 48 h. Apoptosis was analyzed as in b. (e) Western blotting of Mcl-1 in parental and regorafenib-resistant HCT116 cells treated with indicated agents as in d for 24 h. Results in (b-d) represent the means±s.d. of three independent experiments. NS, P>0.05; P<0.05; *P<0.01.
S3043	Rofecoxib Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.	Toxicol Appl Pharmacol, 2015, 285(1):51-60
S1734	Meloxicam Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.	PLoS One, 2020, 13;15(3):e0230272 Oncol Lett, 2017, 14(2):2198-2206	Meloxicam (0.25 μg/ml) decreases the migration of CF41.Mg cells. Incubation with 0.25 μg/ml meloxicam for 24 and 48 h inhibited the migration of cells compared with the DMSO‑treated control cells in a wound healing assay. A total of 6 repeats were performed and results are presented as the mean ± standard deviation. Representative images of the wound healing assay and quantification if the results are presented. Scale bar, 90 μm. *P<0.05 vs. the control group.
S4028	Dexamethasone Sodium Phosphate Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.	Blood Cancer J, 2020, 10(6):72 Leuk Lymphoma, 2020, 1-10 Nat Commun, 2015, 6:8481	Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.
S3023	Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.	Autophagy, 2016, 12(10):1738-1758 Oncotarget, 2016, 7(37):59388-59401 Nat Biotechnol, 2015, 10.1038/nbt.3130	(a) Treatment of HeLa cells with 1 mM bufexamac results in the induction of HIF1-α, as determined by immunoblotting. The known hypoxia mimetics CPX and DFX were used as positive controls; vinculin served as loading control. (b) Verification of bufexamac-specific upregulation of HIF1-α. HIF1-α protein expression was analyzed 4 h after treatment of cells with the indicated compounds. Ac, acetylated. (c) Time-course analysis of HIF1-α induction by bufexamac. The induction of HIF1-α protein was analyzed by immunoblotting. The graph shows rapid stabilization of HIF1-α upon bufexamac treatment with half-maximal intensity I1/2 of about 75 min. Error bars represent s.d. of three independent experiments. (d) HIF1-α is stabilized only at higher concentrations of bufexamac and accumulates in the nucleus. Induction of endogenous HIF1-α and its nuclear accumulation was analyzed using immunofluorescence microscopy; scale bar, 10 μm.
S1204	Melatonin Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.	Reprod Sci, 2020, 27(1):75-86 Theranostics, 2019, 9(13):3768-3779 Redox Biol, 2019, 25:101197	TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3).
S3017	Aspirin Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.	Immunity, 2020, 52(2):328-341 PLoS Pathog, 2020, 16;16(3):e1008341 Nanotoxicology, 2020, 14(2):162-180
S1761	Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
S1713	Piroxicam Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
S1328	Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
S1645	Ketoprofen Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
S1903	Diclofenac Sodium Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.	Arch Toxicol, 2018, 92(6):1953-1967 Cell, 2016, 167(7):1803-1813 Head Neck, 2014, 10.1002/hed.23822
S1518	Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
S2047	Lornoxicam Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
S1646	Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.	J Virol, 2020, 6;94(2):e01679-19 Life Sci, 2020, 15;251:117604
S1626	Naproxen Sodium Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
S1576	Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.	PLoS Pathog, 2020, 16;16(3):e1008341 Platelets, 2019, 10.1080/09537104.2019.1609665
S2903	Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with K_i of 0.06 μM. It also inhibits COX1 with K_i of 3 μM.	J Am Heart Assoc, 2020, 9(1):e013470 Cell Rep, 2019, 29(1):135-150 Cancer Lett, 2019, 442:453-463	(A) Western blot analysis of MITF expression in MelIM. One representative experiment out of two is shown. (B) Proliferation of MelIM cells under diclofenac or lumiracoxib (0.1 mM) for 3 vs. 30 days. Results are given as percentage of untreated controls.
S2531	Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
S1960	Pranoprofen Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.	Mol Med Rep, 2017, 15(6):4305-4311
S3008	Zaltoprofen Zaltoprofen is an inhibitor of COX-1 and COX-2 for treatment of arthritis.
S2602	Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
S1959	Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.	Front Microbiol, 2020, 10:2936 Oncotarget, 2017, 8(57):96865-96884
S4049	Valdecoxib Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.	Biochem Bioph Res Co, 2015, 460(2):198-204	(B) HeLa and SACC-83 cells were treated with radiation, valdecoxib, or both radiation and valdecoxib. Cells were lysed or extracted for membrane proteins and then subjected to Western blot.
S2577	Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
S2040	Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.	Front Microbiol, 2020, 10:2936 Viruses, 2015, 7(5):2268-87	Nimesulide has no effect on KSHV lytic replication in BCBL-1 cells. The cells induced with TPA for 3 h were treated with the test compounds for 72 h. Then, the effect of nimesulide on cell viability (C) and the number of DNA copies (D) were measured as described in the Methods. CDV (20 µM) is a positive control for inhibiting viral DNA replication. Data were normalized as the fold change compared with the no-TPA induced control. The results are presented as the mean values with standard deviations (n = 3).
S4149	Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
S4248	Bromfenac Sodium Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
S4051	Nabumetone Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S3018	Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
S3173	Antipyrine Antipyrine is an analgesic and antipyretic agent; selective COX-3 inhibitor.
S3200	Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.	J Am Heart Assoc, 2020, 9(1):e013470
S4011	Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
S9208	Ginsenoside Rb3 Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).
S5177	Naproxen Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.	Biogerontology, 2016, 17(5-6):907-920
S5418	Parecoxib Sodium Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).
S3816	Dehydroevodiamine Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.
S8433	NS-398 (NS398) NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.	Front Microbiol, 2020, 17;11:708 Stem Cells Int, 2020, 17;2020:2803747 J Hematol Oncol, 2019, 12(1):31	(C)Percentage of TUNEL-positive cell in B were calculated. Data are mean ± SEM; ** P < 0.01 versus the Sham group; # P < 0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group. (D-G) ELISA of cytokines IL-1α (D), IL-1β (E), IL-6 (F), and TNF-α (G) in tSCI rats with or without NS-398 treatment. Data are mean ± SEM; * P < 0.05 or P < 0.01 versus the Sham group; # P <0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group. (H) The mean CBS score in tSCI rats was improved by NS-398 treatment. Data are mean ± SEM; P < 0.05 versus the Sham group; # P < 0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group.
S4032	Bismuth Subsalicylate Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
S5698	Ketorolac tromethamine salt Ketorolac is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.
S4628	(+/-)-Sulfinpyrazone Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
S4136	Carprofen Carprofen inhibits canine COX2 with IC50 of 30 nM.
S3063	Diclofenac Diethylamine Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
S3974	(+)-Catechin hydrate Catechins are a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.
S4656	Parecoxib Parecoxib is a selective COX2 inhibitor.	Theranostics, 2020, 10(8):3366-3381
S4609	Diflunisal Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.
S4176	Trometamol Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.
S5520	Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
S9029	Prim-o-glucosylcimifugin Prim-O-glucosylcimifugin is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.
S3931	Ginsenoside Rd Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.
S5019	Indobufen Indobufen is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.
S4078	Mefenamic Acid Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.	Brain Res, 2020, 20;1740:146846
S4651	Etoricoxib Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
S9386	Polygalacic acid Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
S4686	Vitamin E Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.	Biosci Biotechnol Biochem, 2020, 18;1-8 Cell Death Dis, 2019, 10(5):358
S6073	Diclofenac acid Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
S4765	Syringaldehyde Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.
S5010	Indometacin Sodium Indomethacin Sodium is the sodium salt of indomethacin, which is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects.	Mol Cancer Ther, 2020, 19;molcanther00152020
S4230	Oxaprozin Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
S5595	3-Carene 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.
S2349	Rutaecarpine Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.	Theranostics, 2020, 10(8):3366-3381
S2351	Salicin Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.	Biochem Biophys Res Commun, 2019, 508(3):682-689
S4526	Fenbufen Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.	Gastroenterology, 2019, 10.1053/j
S3899	Hederagenin Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.
S5551	6-Paradol 6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities.
S4539	Salicylic acid Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
S9149	Benzoylpaeoniflorin Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.
S6457	Flurbiprofen Axetil Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.
S4509	4-Aminoantipyrine 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S3872	Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin.
S5309	Propyphenazone (4-Isopropylantipyrine) Propyphenazone(4-Isopropylantipyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.
S7889	Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.	J-Cancer, 2020, 6;11-14-:4047-4058 Int J Biol Sci, 2019, 15(11):2497-2508 PLoS One, 2019, 14(3):e0213776
S2108	Flunixin Meglumin Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.
S5711	Deracoxib Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).
S3925	(-)-Epicatechin gallate (-)-Epicatechin gallate ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.	Cell Death Dis, 2018, 9(2):205 PLoS One, 2018, 13(10):e0205123 J Fish Dis, 2018, 10.1111/jfd.12819
S4295	Meclofenamate Sodium Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.	Nature, 2019, 573(7775):539-545
S2272^新	Indoprofen Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.
S9190	Oroxin B Oroxin B, one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.

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S1261	Celecoxib Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.	J Clin Invest, 2020, 26;132417 Cell Death Differ, 2020, 20 Nanotoxicology, 2020, 14(2):162-180	Reduced hepatic lipid contents and alleviated liver injury in EC-AMPK mice treated with selective COX-2 inhibitors. Wild-type and EC-AMPK mice given a high fat diet were treated with vehicle, celecoxib or nimesulide for a period of 4 weeks. At the end of treatment, parameters including body weight and circulating glucose (A), serum triglyceride and cholesterol levels (B were measured and presented as percentage comparisons against those from vehicle-treated wild-type mice. *P < 0.05 versus wild-type mice treated with vehicle; #P < 0.05 versus EC-AMPK mice treated with vehicle, n = 3-5.
S1396	Resveratrol Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Bone, 2020, 133:115252 J Biol Chem, 2020, 13;295(11):3485-3496 Oncol Lett, 2020, 19(4):3269-3277	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
S1255	Nepafenac Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.
S1638	Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.	Immunity, 2020, 52(2):328-341 Anticancer Drugs, 2020, 31(1):27-34 Nat Commun, 2017, 8(1):573
S1723	Indomethacin Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.	Front Immunol, 2020, 11:1125 Mol Cancer Ther, 2020, 19;molcanther00152020 Nat Commun, 2019, 10(1):2427	Indicated PN and MES spheres were shown expressing GFP under the control of a 7 × TCF/LEF optimal promoter cassette (7 × TOP) and constitutively expressed nuclear mCherry. PN 84 and MES 1123 were treated with Wnt3a (200 ng/ml), indomethacin (Indo; 20 μM), or a control (vehicle). Scale bar, 100 μm. Bar graph, quantification of fluorescent signal of GFP (TOP-GFP) versus mCherry (PGK-H2BmCherry). The percentage of GFP- and mCherry-positive spheres was determined by FACS.
S2121^新	Licofelone Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
S6615^新	ATB 346 ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.
S2595^新	FK-3311 FK-3311 is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.
S6780^新	TFAP TFAP is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.
S6686^新	SC-560 SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.
S6685^新	Mavacoxib Mavacoxib is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).
S4360^新	Tolmetin Sodium Tolmetin is a non-steroidal anti-inflammatory drug of the arylalkanoic acids.
S2007	Sulindac Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.	Cancer Cell Int, 2020, 19;20:58 Oncogene, 2017, 36(6):787-796 Oncogene, 2016, 10.1038/onc.2016.247	(d) Parental and regorafenib-resistant HCT116 cells were treated with 40 μM regorafenib, 20 μM sorafenib, 1 μM UCN-01, 1 μM YM-155, 10 μM roscovitine, 15 μM sunitinib, 10 μM crizotinib, 10 nM TRAIL, 10 μM VX680, 20 μM etoposide, 20 μM temsirolimus or 120 μM sulindac sulfide for 48 h. Apoptosis was analyzed as in b. (e) Western blotting of Mcl-1 in parental and regorafenib-resistant HCT116 cells treated with indicated agents as in d for 24 h. Results in (b-d) represent the means±s.d. of three independent experiments. NS, P>0.05; P<0.05; *P<0.01.
S3043	Rofecoxib Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.	Toxicol Appl Pharmacol, 2015, 285(1):51-60
S1734	Meloxicam Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.	PLoS One, 2020, 13;15(3):e0230272 Oncol Lett, 2017, 14(2):2198-2206	Meloxicam (0.25 μg/ml) decreases the migration of CF41.Mg cells. Incubation with 0.25 μg/ml meloxicam for 24 and 48 h inhibited the migration of cells compared with the DMSO‑treated control cells in a wound healing assay. A total of 6 repeats were performed and results are presented as the mean ± standard deviation. Representative images of the wound healing assay and quantification if the results are presented. Scale bar, 90 μm. *P<0.05 vs. the control group.
S4028	Dexamethasone Sodium Phosphate Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.	Blood Cancer J, 2020, 10(6):72 Leuk Lymphoma, 2020, 1-10 Nat Commun, 2015, 6:8481	Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.
S3023	Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.	Autophagy, 2016, 12(10):1738-1758 Oncotarget, 2016, 7(37):59388-59401 Nat Biotechnol, 2015, 10.1038/nbt.3130	(a) Treatment of HeLa cells with 1 mM bufexamac results in the induction of HIF1-α, as determined by immunoblotting. The known hypoxia mimetics CPX and DFX were used as positive controls; vinculin served as loading control. (b) Verification of bufexamac-specific upregulation of HIF1-α. HIF1-α protein expression was analyzed 4 h after treatment of cells with the indicated compounds. Ac, acetylated. (c) Time-course analysis of HIF1-α induction by bufexamac. The induction of HIF1-α protein was analyzed by immunoblotting. The graph shows rapid stabilization of HIF1-α upon bufexamac treatment with half-maximal intensity I1/2 of about 75 min. Error bars represent s.d. of three independent experiments. (d) HIF1-α is stabilized only at higher concentrations of bufexamac and accumulates in the nucleus. Induction of endogenous HIF1-α and its nuclear accumulation was analyzed using immunofluorescence microscopy; scale bar, 10 μm.
S1204	Melatonin Melatonin is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.	Reprod Sci, 2020, 27(1):75-86 Theranostics, 2019, 9(13):3768-3779 Redox Biol, 2019, 25:101197	TUNEL staining of treated adipocytes and flow cytometry analysis of positive TUNEL cells (n=3).
S3017	Aspirin Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.	Immunity, 2020, 52(2):328-341 PLoS Pathog, 2020, 16;16(3):e1008341 Nanotoxicology, 2020, 14(2):162-180
S1761	Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
S1713	Piroxicam Piroxicam is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.
S1328	Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
S1645	Ketoprofen Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
S1903	Diclofenac Sodium Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.	Arch Toxicol, 2018, 92(6):1953-1967 Cell, 2016, 167(7):1803-1813 Head Neck, 2014, 10.1002/hed.23822
S1518	Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
S2047	Lornoxicam Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
S1646	Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.	J Virol, 2020, 6;94(2):e01679-19 Life Sci, 2020, 15;251:117604
S1626	Naproxen Sodium Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
S1576	Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.	PLoS Pathog, 2020, 16;16(3):e1008341 Platelets, 2019, 10.1080/09537104.2019.1609665
S2903	Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with K_i of 0.06 μM. It also inhibits COX1 with K_i of 3 μM.	J Am Heart Assoc, 2020, 9(1):e013470 Cell Rep, 2019, 29(1):135-150 Cancer Lett, 2019, 442:453-463	(A) Western blot analysis of MITF expression in MelIM. One representative experiment out of two is shown. (B) Proliferation of MelIM cells under diclofenac or lumiracoxib (0.1 mM) for 3 vs. 30 days. Results are given as percentage of untreated controls.
S2531	Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
S1960	Pranoprofen Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.	Mol Med Rep, 2017, 15(6):4305-4311
S3008	Zaltoprofen Zaltoprofen is an inhibitor of COX-1 and COX-2 for treatment of arthritis.
S2602	Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
S1959	Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.	Front Microbiol, 2020, 10:2936 Oncotarget, 2017, 8(57):96865-96884
S4049	Valdecoxib Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.	Biochem Bioph Res Co, 2015, 460(2):198-204	(B) HeLa and SACC-83 cells were treated with radiation, valdecoxib, or both radiation and valdecoxib. Cells were lysed or extracted for membrane proteins and then subjected to Western blot.
S2577	Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
S2040	Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.	Front Microbiol, 2020, 10:2936 Viruses, 2015, 7(5):2268-87	Nimesulide has no effect on KSHV lytic replication in BCBL-1 cells. The cells induced with TPA for 3 h were treated with the test compounds for 72 h. Then, the effect of nimesulide on cell viability (C) and the number of DNA copies (D) were measured as described in the Methods. CDV (20 µM) is a positive control for inhibiting viral DNA replication. Data were normalized as the fold change compared with the no-TPA induced control. The results are presented as the mean values with standard deviations (n = 3).
S4149	Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
S4248	Bromfenac Sodium Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
S4051	Nabumetone Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S3018	Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
S3173	Antipyrine Antipyrine is an analgesic and antipyretic agent; selective COX-3 inhibitor.
S3200	Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.	J Am Heart Assoc, 2020, 9(1):e013470
S4011	Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
S9208	Ginsenoside Rb3 Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).
S5177	Naproxen Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.	Biogerontology, 2016, 17(5-6):907-920
S5418	Parecoxib Sodium Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).
S3816	Dehydroevodiamine Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.
S8433	NS-398 (NS398) NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.	Front Microbiol, 2020, 17;11:708 Stem Cells Int, 2020, 17;2020:2803747 J Hematol Oncol, 2019, 12(1):31	(C)Percentage of TUNEL-positive cell in B were calculated. Data are mean ± SEM; ** P < 0.01 versus the Sham group; # P < 0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group. (D-G) ELISA of cytokines IL-1α (D), IL-1β (E), IL-6 (F), and TNF-α (G) in tSCI rats with or without NS-398 treatment. Data are mean ± SEM; * P < 0.05 or P < 0.01 versus the Sham group; # P <0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group. (H) The mean CBS score in tSCI rats was improved by NS-398 treatment. Data are mean ± SEM; P < 0.05 versus the Sham group; # P < 0.05 versus the Vehicle group; unpaired two-tailed Student’s t-test. n = 5 per group.
S4032	Bismuth Subsalicylate Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
S5698	Ketorolac tromethamine salt Ketorolac is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.
S4628	(+/-)-Sulfinpyrazone Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
S4136	Carprofen Carprofen inhibits canine COX2 with IC50 of 30 nM.
S3063	Diclofenac Diethylamine Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
S3974	(+)-Catechin hydrate Catechins are a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.
S4656	Parecoxib Parecoxib is a selective COX2 inhibitor.	Theranostics, 2020, 10(8):3366-3381
S4609	Diflunisal Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.
S4176	Trometamol Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.
S5520	Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
S9029	Prim-o-glucosylcimifugin Prim-O-glucosylcimifugin is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.
S3931	Ginsenoside Rd Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.
S5019	Indobufen Indobufen is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.
S4078	Mefenamic Acid Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.	Brain Res, 2020, 20;1740:146846
S4651	Etoricoxib Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
S9386	Polygalacic acid Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
S4686	Vitamin E Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.	Biosci Biotechnol Biochem, 2020, 18;1-8 Cell Death Dis, 2019, 10(5):358
S6073	Diclofenac acid Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
S4765	Syringaldehyde Syringaldehyde is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.
S5010	Indometacin Sodium Indomethacin Sodium is the sodium salt of indomethacin, which is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects.	Mol Cancer Ther, 2020, 19;molcanther00152020
S4230	Oxaprozin Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
S5595	3-Carene 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.
S2349	Rutaecarpine Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.	Theranostics, 2020, 10(8):3366-3381
S2351	Salicin Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.	Biochem Biophys Res Commun, 2019, 508(3):682-689
S4526	Fenbufen Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.	Gastroenterology, 2019, 10.1053/j
S3899	Hederagenin Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.
S5551	6-Paradol 6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities.
S4539	Salicylic acid Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
S9149	Benzoylpaeoniflorin Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.
S6457	Flurbiprofen Axetil Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.
S4509	4-Aminoantipyrine 4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
S3872	Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin.
S5309	Propyphenazone (4-Isopropylantipyrine) Propyphenazone(4-Isopropylantipyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.
S7889	Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Phase 1.	J-Cancer, 2020, 6;11-14-:4047-4058 Int J Biol Sci, 2019, 15(11):2497-2508 PLoS One, 2019, 14(3):e0213776
S2108	Flunixin Meglumin Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.
S5711	Deracoxib Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).
S3925	(-)-Epicatechin gallate (-)-Epicatechin gallate ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.	Cell Death Dis, 2018, 9(2):205 PLoS One, 2018, 13(10):e0205123 J Fish Dis, 2018, 10.1111/jfd.12819
S4295	Meclofenamate Sodium Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.	Nature, 2019, 573(7775):539-545

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S2272^新	Indoprofen Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.

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S2272^新

Indoprofen

Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S9190	Oroxin B Oroxin B, one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.

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S9190

Oroxin B

Oroxin B, one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.

研究分野別

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COX

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COX製品