MG-132

製品コードS2619

MG-132化学構造

分子量(MW):475.62

MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.

サイズ 価格(税別)  
JPY 8300.00
JPY 28220.00
JPY 78020.00

Selleckは効果が一番いいである(S,R,S)-(-)-2のコンフィギュレーションを採用しましたので、MG-132プロテアソームの抑制効果はSigmaの同類製品の効果より著しく高くなります

正常には、p21蛋白はユビキチン化で分解されますが、MG-132はプロテアソームの活性を抑制することを通じて、p21蛋白の貯まりを引き起こします。だから、MG-132の抑制効果は強ければ強いほど、p21蛋白の貯まりは多くなってきます。(検査された蛋白:p21  細胞株:HeLa细胞株 処理条件:濃度5μM 処理時間:6h)

文献中Selleckの製品使用例(48)

カスタマーフィードバック(11)

  • Western blot of IκBζ expression in BMDMs treated with DI and stimulated with LPS for 1 h. MG132 or bafilomycin A (BafA) were added 30 min before LPS stimulation.

    Nature, 2018, 556(7702):501-504. MG-132 purchased from Selleck.

    MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

  • HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

    HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  •  

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

    JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

  • LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

    Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

  • Nek2A impedes SuFu ubiquitination. HEK293T cells transfected with Nek2A-Myc and Flag-SuFu for 48 h were treated with MG-132 to enrich ubiquitinated proteins, and subsequently subjected to co-immunoprecipitation assay. Precipitated proteins were probed using anti-Ub antibody.

    Int J Oncol, 2017, 50(2):373-380. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

質量管理及び製品安全説明書

Proteasome阻害剤の選択性比較

生物活性

製品説明 MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.
ターゲット
20S proteasome [9]
(Cell-free assay)
100 nM
体外試験

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells NX7DWm9kTnWwY4Tpc44hSXO|YYm= Mof3NlUh|ryP M2SzZmROW09? NWnzS45CUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMTFOwG0> MVWyOFY6PzR7Nh?=
HL-60 M{\ITWN6fG:2b4jpZ{BCe3OjeR?= M1TueFQxKM7:TR?= MVu0PEBp NFGxemRFVVOR NGnPR29KSzVyPEGwJO69VQ>? NGjTcZgzPDZ7N{S5Oi=>
SMMC-7721 MVfDfZRwfG:6aXOgRZN{[Xl? MXK0NEDPxE1? MVy0PEBp NYX0NpdMTE2VTx?= M{ftcGlEPTB;Nz6xJO69VQ>? MXGyOFY6PzR7Nh?=
A-549 Ml:4R5l1d3SxeHnjJGF{e2G7 MWi0NEDPxE1? NYDtfIxiPDhiaB?= MVjEUXNQ NFnFe4lKSzVyPEGwJO69VQ>? M33h[lI1Pjl5NEm2
MCF-7 MlLyR5l1d3SxeHnjJGF{e2G7 NW\pS3F[PDBizszN MlPOOFghcA>? MoHKSG1UVw>? NGPtXGJKSzVyPUeuN{DPxE1? M2LvSVI1Pjl5NEm2
SW-480 M1LCS2N6fG:2b4jpZ{BCe3OjeR?= M33oNFQxKM7:TR?= NVjmZYJNPDhiaB?= NFWyVFBFVVOR M3zJdmlEPTB;NDFOwG0> MXWyOFY6PzR7Nh?=
NCI-H929 NFLmdYFEgXSxdH;4bYMhSXO|YYm= NIjke5MyKM7:TR?= M{T1U|czKGh? NWrkcndWTE2VTx?= NVr0Uo9SUUN3ME2wMlE4KM7:TR?= NYe2bFJ4OjR4MkWwPFg>
293T NGD4NGJEgXSxdH;4bYMhSXO|YYm= MnXsNVAh|ryP NWTEXYFFPzJiaB?= NGDXOW1FVVOR NUfwNXZ4UUN3MEyyJO69VQ>? M2[3e|I1PjJ3MEi4
293T MlOwSpVv[3Srb36gRZN{[Xl? NYG4Z25LOTBizszN MVGyOEBp M1;UUmROW09? Mln5UY9l\XKjdHXsfUBqdmS3Y3XzJIhm[XRvc3jvZ4shKA>? NIjGW2ozPDZ{NUC4PC=>
HeLa M{W5SWtqdmG|ZTDBd5NigQ>? MnnrNVAh|ryP NUjFb2ptOSCq MVHEUXNQ MkP6TY5lfWOnczDQRXJRKGOuZXH2ZYdmKGK7IHnubIljcXSrbnegdJJwe2Wjc3;t[UBi[3Srdnn0fS=> MkjxNlQ{OjF6M{O=
MDA-MB-231 M2LrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxJO69VQ>? Mo\lO|IhcA>? M3fz[2ROW09? M1XNRWlEPTB;MD6xPEDPxE1? NFPwNWwzPDF3M{KwOi=>
MCF-7 M1vPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjDOWJSOSEQvF2= MY[3NkBp MlvpSG1UVw>? MX3JR|UxRTBwMUOg{txO NIDqbZozPDF3M{KwOi=>
MCF10A NEP2WodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXixJO69VQ>? MnnvO|IhcA>? MY\EUXNQ M4jzPWlEPTB;MD6yPUDPxE1? MWWyOFE2OzJyNh?=
HEK-293 NUDRSXF7U2mwYYPlJGF{e2G7 NISwb4MzKGGwZDCyNEDPxE1? M3G0NVIhcA>? NIT0VnZFVVOR M3juR2lvcGmkaYTzJGNpXC2OIHHjeIl3cXS7IIfpeIghUUN3MDDv[kA6KG6PIB?= NGO0c2gzOzV2MEe5NC=>
Calu6 NXTvR3c3TnWwY4Tpc44hSXO|YYm= MV6xNEDPxE1? M2DNclE5KGh? NWDXeFFJTE2VTx?= M33aXnNq\26rZnnjZY51dHliYXPjeY12dGG2ZYOg[pJifGG6aX6gdJJm[3W{c3;y NF3hNoczOzVyNkS4Oi=>
IFN-gamma-induced RAW264.7 NYj1NIlMTnWwY4Tpc44hSXO|YYm= M4ixe2ROW09? MUPJcohq[mm2czDubZRzcWNib4jp[IUheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE4xPzdizszN MUeyNlI4PzJ5Nx?=
IPC227F NVTIe2RMS3m2b4TvfIlkKEG|c3H5 NXzhOoZ7OSEQvF2= NU\4W4hxPDhiaB?= NFe5ToFFVVOR MYjJR|UxRTBwMEe3JO69VQ>? Mn[yNlE6OjR3Mki=
Hepa-1c1c7 MoXHSpVv[3Srb36gRZN{[Xl? NXLOPWQ1OjVizszN NHj2XZI3KGh? MVvEUXNQ MUPJcoNz\WG|ZYOgUpJnOiCycn;0[YlvKGyndnXs MV6yNFM6OjV2NB?=
COS-7 MVXDfZRwfG:6aXOgRZN{[Xl? NXTJNm9YOTBizszN M4nGVWROW09? MVrJR|UxRDFyIN88US=> MYqxPFA5QDB7Nx?=
HuH-7 M2DEOmN6fG:2b4jpZ{BCe3OjeR?= MlLVNVAh|ryP NEXFdnBFVVOR NYjpdI5{UUN3MEyxNEDPxE1? NX3he5V4OThyOEiwPVc>
OCI-Ly3 M1;wUmZ2dmO2aX;uJGF{e2G7 M1vBeFExKM7:TdMg NYXqV2l6PCCq NH3kVndFVVOR MmOzTY5lfWOnczDoeY1idiCLa3HwdIFD[WyyaHGgd5Ri[mmuaYrheIlwdiC5aYToJGVEPTBib3[gNUDPxE1? MnLPNVgxOjRzMUO=
A2780 cDDP MV7BdI9xfG:|aYOgRZN{[Xl? NGTIXYwzPCCq NEfBPZJFVVOR NHnUT2tKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? MlXQNVc3QDRyMUi=
LPS-stimulated RAW264.7 cells MXLGeY5kfGmxbjDBd5NigQ>? MYXEUXNQ MYHJcohq[mm2czDOSk1s[XCyYVKgSG5CKGKrbnTpcoc> MnzINVc1ODd{N{e=
PC12 MYHGeY5kfGmxbjDBd5NigQ>? MUKxNFAh|ryPwrC= NGfmNFEzPCCq NYTUbopwTE2VTx?= NHK0VJZKdmirYnn0d{A3NU:KRFGtJIFv\CCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 MXyxO|E2QDR3NB?=
PC3 NX7nUWtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljONlAh|ryP NHm3foQ1QCCq MkTpSG1UVw>? NUjJPIl[UUN3ME2wMlYh|ryP M{TuXFE3Pjh4NUO3
LP-1 MVXBdI9xfG:|aYOgRZN{[Xl? NUn5TZI6OzByIH7N M361T|I1KGh? MmC2SG1UVw>? NWDVRotLUW6mdXPld{BieG:ydH;zbZMh[nliaX7jdoVie2mwZzDjcIVifmWmIGDBVnAhdGW4ZXygZY5lKHKnZIXjbY5oKE2lbD2xJJBzd3SnaX6gcIV3\Wx? MojFNVU6PTh3OEm=
ES6 M36xZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknVTWM2OD1yLkCxN|A3KM7:TR?= NUDEbGczW0GQR1XS
A101D NUL1UJhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzQWWxpUUN3ME2wMlA{Ojd7IN88US=> M2jBfnNCVkeHUh?=
OCUB-M NEDCflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjVd|NKSzVyPUCuNFM4OzdizszN NELwVYZUSU6JRWK=
LB2518-MEL M3LG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfWTWM2OD1yLkCzO|Yh|ryP NGGwVppUSU6JRWK=
SH-4 NGjkdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\sd2lEPTB;MD6wOFMyKM7:TR?= NVjGcGtZW0GQR1XS
KNS-42 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\wPZZxUUN3ME2wMlA1PDRzIN88US=> MVXTRW5ITVJ?
DSH1 NXThbG9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEWyPFkh|ryP MV3TRW5ITVJ?
NTERA-S-cl-D1 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrxR5ZKSzVyPUCuNFU4PzJizszN NF7CR2lUSU6JRWK=
D-542MG NYm3T49VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELyTlZKSzVyPUCuNFU6PTdizszN Mn\hV2FPT0WU
KS-1 M4rZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3MZY5KSzVyPUCuNFY1PThizszN NYPJdG5bW0GQR1XS
BL-41 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jrUGlEPTB;MD6wOlk1PyEQvF2= M1O2PXNCVkeHUh?=
LXF-289 NYPwbWpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\DTYdKSzVyPUCuNFcxPjZizszN MVHTRW5ITVJ?
D-247MG NV7mPXpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmxNVZKSzVyPUCuNFczODlizszN M4rkcHNCVkeHUh?=
MMAC-SF NEj4NYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXoTWM2OD1yLkC3NlY5KM7:TR?= M161V3NCVkeHUh?=
CP66-MEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPvTWM2OD1yLkC3OUDPxE1? NUn3RlI1W0GQR1XS
LB771-HNC NVfkcHdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLCdYNKSzVyPUCuNFgxOzZizszN NX7XfopMW0GQR1XS
no-10 M4PTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEi5NFkh|ryP NWPLTXlHW0GQR1XS
A388 M1rkTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HDVWlEPTB;MD6wPVA3PSEQvF2= MnzJV2FPT0WU
OPM-2 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDwOpFNUUN3ME2wMlExPDd2IN88US=> NHfFOoJUSU6JRWK=
OVCAR-4 NVi4XGx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH0cmJ3UUN3ME2wMlExQTN6IN88US=> NWjpbmhHW0GQR1XS
HOP-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPpenpVUUN3ME2wMlExQTR7IN88US=> NWC5T3l6W0GQR1XS
ML-2 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMUG4NFYh|ryP MnqxV2FPT0WU
UACC-257 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi3TWM2OD1yLkGxPVI4KM7:TR?= NWi0T|RIW0GQR1XS
NEC8 NFL5SHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHBTWM2OD1yLkGxPVk2KM7:TR?= NEjyNmFUSU6JRWK=
ONS-76 NULqcpp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm4TnBKSzVyPUCuNVI6OzVizszN MVPTRW5ITVJ?
KE-37 NI\hU2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nlV2lEPTB;MD6xN|I4QCEQvF2= NWjmboJjW0GQR1XS
HT-144 M{XnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfUfJppUUN3ME2wMlE{QDl3IN88US=> MUfTRW5ITVJ?
LB2241-RCC Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW4[44yUUN3ME2wMlE1OjR5IN88US=> NX[xZW1qW0GQR1XS
TE-5 MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEflWIRKSzVyPUCuNVQzPzhizszN NWXyO2NrW0GQR1XS
KINGS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlexTWM2OD1yLkG0O|kh|ryP Mn3WV2FPT0WU
NCI-H69 NFHBZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P3T2lEPTB;MD6xOVE1OSEQvF2= NGjNSYVUSU6JRWK=
CAS-1 NEHR[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HnV2lEPTB;MD6xOVQ5OiEQvF2= M1n0NHNCVkeHUh?=
D-263MG NFrVOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnEUXRVUUN3ME2wMlE3ODB4IN88US=> MWPTRW5ITVJ?
A253 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvGe4ZKSzVyPUCuNVYyOjhizszN NVy4SJE{W0GQR1XS
PF-382 NXHSbIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zZT2lEPTB;MD6xOlcxPiEQvF2= NV6xSHNUW0GQR1XS
CESS M17LW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[xTWM2OD1yLkG3NFYh|ryP NYn2VolLW0GQR1XS
MZ2-MEL MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\6ZpVKSzVyPUCuNVc2PTlizszN MYrTRW5ITVJ?
HEL MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn1TWM2OD1yLkG4OVE4KM7:TR?= MU\TRW5ITVJ?
D-392MG NF\N[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6wZYFJUUN3ME2wMlE6OTF3IN88US=> MniwV2FPT0WU
SK-LMS-1 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nyPGlEPTB;MD6xPVMxOyEQvF2= MkjHV2FPT0WU
GI-ME-N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTXTXdKSzVyPUCuNVk{ODZizszN NXPiVVZ5W0GQR1XS
LB831-BLC MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf3TWM2OD1yLkG5N|Qh|ryP NIH6XZZUSU6JRWK=
DU-4475 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2GxTWlEPTB;MD6xPVY2QCEQvF2= NF7MeGNUSU6JRWK=
IST-SL1 M4H1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvtTWM2OD1yLkKwNFk1KM7:TR?= MkTTV2FPT0WU
GAK NFLuflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoThTWM2OD1yLkKwOVM1KM7:TR?= M1vpXnNCVkeHUh?=
EW-1 M4P6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX2TWM2OD1yLkKxNFQ4KM7:TR?= M17LTXNCVkeHUh?=
LAMA-84 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf4V3lIUUN3ME2wMlIyQDVzIN88US=> MXjTRW5ITVJ?
SK-UT-1 NFXvWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMkKwOFkh|ryP NFTQeohUSU6JRWK=
VA-ES-BJ NIrJWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjFPI5KSzVyPUCuNlIzPTdizszN NEHKNZpUSU6JRWK=
ACN M{nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDrTWM2OD1yLkKyOlM5KM7:TR?= M{TnOXNCVkeHUh?=
SK-PN-DW MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPFfWdKSzVyPUCuNlMyQSEQvF2= NXnFRW82W0GQR1XS
HD-MY-Z NH61OXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17YVWlEPTB;MD6yN|MxOyEQvF2= MXLTRW5ITVJ?
LB373-MEL-D NX7pOJVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW4fpBzUUN3ME2wMlI1OTl6IN88US=> Ml;UV2FPT0WU
COLO-829 NILYSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXPblQ6UUN3ME2wMlI1OjV5IN88US=> MVjTRW5ITVJ?
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SIMA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M376O2lEPTB;NT6zNFc3PSEQvF2= Mn[yV2FPT0WU
RL NFHEdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLWcFBKSzVyPUWuN|c2PDFizszN M4niWXNCVkeHUh?=
GCIY M4DBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH24RZpKSzVyPUWuOFczOzZizszN NXXzUZV2W0GQR1XS
Calu-6 M17mWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XnfWlEPTB;NT62NlIh|ryP MlzvV2FPT0WU
ALL-PO NHeyeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjSXW1OUUN3ME21MlY{Pzl3IN88US=> M{jGdHNCVkeHUh?=
ARH-77 NFqxeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTVwNkewPFch|ryP MkPiV2FPT0WU
A4-Fuk M2rCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTZwMEixNVgh|ryP NIezfHVUSU6JRWK=
NCI-H1581 NVvqN29iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDwTWM2OD14LkKzPFQ6KM7:TR?= MWDTRW5ITVJ?
HUTU-80 M3fOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTZwM{[4PVch|ryP MoLjV2FPT0WU
TGW MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLyTWM2OD14LkS1OVk{KM7:TR?= NX\3ZZRtW0GQR1XS
SK-N-FI Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ZTWM2OD14LkS1PFU1KM7:TR?= MYfTRW5ITVJ?
U-266 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTZwNUG5NlYh|ryP MYDTRW5ITVJ?
EM-2 M1jiZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTvTlU5UUN3ME22MlY4ODl7IN88US=> NETFd5BUSU6JRWK=
NMC-G1 NYP2b2F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOcWlEPTB;Nj63NVg6PSEQvF2= NETBS3dUSU6JRWK=
KASUMI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfjTWM2OD14Lki0O|g4KM7:TR?= M2DCWHNCVkeHUh?=
NALM-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTZwOE[3OVQh|ryP M1fuTXNCVkeHUh?=
OCI-AML2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\5TWM2OD15LkCwN|I3KM7:TR?= MXLTRW5ITVJ?
SHP-77 M2LlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTdwMkK0N{DPxE1? NV;QWnQ6W0GQR1XS
NOMO-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HlR2lEPTB;Nz6yOFI2PCEQvF2= NY[yWYhTW0GQR1XS
SK-N-DZ NHezboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn30TWM2OD15LkexNFg6KM7:TR?= NIDhN2RUSU6JRWK=
LB1047-RCC NVvnN2RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLCV3NKSzVyPUeuO|IzOzFizszN NH3MSldUSU6JRWK=
MZ1-PC Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnCUZVKSzVyPUeuPFY2PThizszN NFnITIZUSU6JRWK=
NB10 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\hTWM2OD15Lkm5OVU3KM7:TR?= NYTuUXhTW0GQR1XS
RL95-2 M1vTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jLNGlEPTB;OD6xNFg1OiEQvF2= NIjyXJVUSU6JRWK=
OMC-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvQTWM2OD16LkWyNVkyKM7:TR?= Mm\ZV2FPT0WU
D-283MED MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjV[JFKSzVyPUiuPVE4OTlizszN NV7GUY42W0GQR1XS
MC116 NVvLNFlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrpTXVKSzVyPUiuPVc6PCEQvF2= M{DVenNCVkeHUh?=
SJSA-1 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHsTWM2OD17LkC5NFkyKM7:TR?= MWDTRW5ITVJ?
JiyoyeP-2003 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTlwMkmzNVch|ryP NWrTVWFlW0GQR1XS
IST-MEL1 NU\6WXJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHFTWM2OD17Lke0NVk5KM7:TR?= NV;Bfm1NW0GQR1XS
CTV-1 NGLKWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFyLkC5O|kh|ryP Mn[zV2FPT0WU
NH-12 M{fS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITUXVlKSzVyPUGwMlI1OzNizszN M4XKUXNCVkeHUh?=
CA46 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFyLkO2NUDPxE1? NYLDc2tlW0GQR1XS
NCI-SNU-1 MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrDcHVoUUN3ME2xNE41QTZ7IN88US=> NVnEb|l{W0GQR1XS
SCLC-21H Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFyLk[1PVYh|ryP M{LGO3NCVkeHUh?=
EC-GI-10 NFHhdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFyLkewN|Eh|ryP MXzTRW5ITVJ?
SR M17wXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPNdYVVUUN3ME2xNU4xOTh3IN88US=> M2DqS3NCVkeHUh?=
NCI-H1648 NXP5cIlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC4WI9KSzVyPUGxMlA6PjVizszN NEO2dplUSU6JRWK=
TGBC1TKB Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\hOWlEPTB;MUGuOFExOiEQvF2= MnvvV2FPT0WU
EW-11 NESyb2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13lWmlEPTB;MUGuOVE5PiEQvF2= M4jrbHNCVkeHUh?=
SK-MM-2 NETndmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT2TWM2OD1zMT64NFYyKM7:TR?= M1PKPHNCVkeHUh?=
NCI-H524 M1vQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTD[I5KSzVyPUGxMlk5OjJizszN MWjTRW5ITVJ?
NOS-1 M17UOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LIXmlEPTB;MUKuNFM1PSEQvF2= NULH[YM3W0GQR1XS
AM-38 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF{LkW2N|Mh|ryP NHPD[pFUSU6JRWK=
A498 NWLvO4pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i5fmlEPTB;MUKuO|A3QSEQvF2= MW\TRW5ITVJ?
KARPAS-422 NVPrXmlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7qRVRMUUN3ME2xNk44PDl4IN88US=> MYXTRW5ITVJ?
LU-139 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HYPGlEPTB;MUKuPVAzPiEQvF2= NV3tVYlWW0GQR1XS
COR-L88 NXvaVmZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LIVGlEPTB;MUKuPVM5OiEQvF2= MoOyV2FPT0WU
K5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n0bGlEPTB;MUKuPVQ3OiEQvF2= MlLrV2FPT0WU
NB13 NEjLNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTYZohKSzVyPUGyMlk4QDNizszN NYOyXlJbW0GQR1XS
MRK-nu-1 NVTmbGRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XTS2lEPTB;MUOuNVk2KM7:TR?= NHnsXYlUSU6JRWK=
MHH-NB-11 Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[1TWM2OD1zMz6yPVAzKM7:TR?= NEDzdG9USU6JRWK=
KU812 NXPx[VRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3voR2lEPTB;MUOuOlEzPCEQvF2= MXvTRW5ITVJ?
TE-12 NFfuN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP0TWM2OD1zMz62PVk1KM7:TR?= MW\TRW5ITVJ?
NCI-N87 NFzh[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3afFlYUUN3ME2xN{44OzZizszN MVvTRW5ITVJ?
EB2 NVPRNolVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTF|Lki1NFUh|ryP M4LKZnNCVkeHUh?=
DB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\vWXRXUUN3ME2xN{46QDh3IN88US=> MnvtV2FPT0WU
697 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPpbI1KSzVyPUG0MlQ2OTFizszN MkTEV2FPT0WU
MSTO-211H NHrZOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDwNoxTUUN3ME2xOE44PDR6IN88US=> NUHXWFV6W0GQR1XS
JVM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfkbJVKSzVyPUG0Mlc4OzVizszN M4CzNXNCVkeHUh?=
COLO-824 M3PBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF2Lke5PVQh|ryP NELOOHdUSU6JRWK=
BC-3 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF3LkO5PEDPxE1? MnP2V2FPT0WU
BOKU M4LueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS0U4NKSzVyPUG1Mlk3ODhizszN NX3reotJW0GQR1XS
GOTO MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnsXnhKSzVyPUG2Mlk3OTdizszN MknuV2FPT0WU
HCC2157 NUDqVIM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF5LkS3OVUh|ryP NI\LSHRUSU6JRWK=
LS-1034 M4e3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF5Lk[4NVgh|ryP M2C0R3NCVkeHUh?=
CAL-148 MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF5Lkm3PVYh|ryP NFS4dYpUSU6JRWK=
MOLT-4 NH7Td5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTF6LkiyNFgh|ryP NVW3W2NuW0GQR1XS
Daudi M3rXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\0ZWlEPTB;MUiuPVI{OSEQvF2= MkfoV2FPT0WU
J-RT3-T3-5 M2S3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLaTWM2OD1zOT60NFY3KM7:TR?= NV[y[Xc1W0GQR1XS
KMOE-2 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P5dmlEPTB;MUmuOlQ5OiEQvF2= NIHtdYJUSU6JRWK=
HL-60 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDDbFhKSzVyPUKwMlE6PjVizszN M3P1VnNCVkeHUh?=
P31-FUJ M1G3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG0TWM2OD1{MD60O|U{KM7:TR?= M2i1bXNCVkeHUh?=
IM-9 NVHReVJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELpc41KSzVyPUKwMlYzOjRizszN NWnScFRUW0GQR1XS
HDLM-2 NY\ncFN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFTWM2OD1{MD64PFIyKM7:TR?= MY\TRW5ITVJ?
NCI-H1304 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP2TWM2OD1{MT6wN|EyKM7:TR?= NVTWd|VGW0GQR1XS
NCI-H345 Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfpPWtKSzVyPUKxMlA3PDNizszN NELZPHRUSU6JRWK=
RPMI-6666 NHvnc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTyTWM2OD1{MT6zOlAzKM7:TR?= NGD2eolUSU6JRWK=
GR-ST MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTyTWM2OD1{MT60NVch|ryP MUjTRW5ITVJ?
CHP-126 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHCcZVKSzVyPUKxMlYyQDFizszN NWjFR45IW0GQR1XS
EHEB M3e4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jMdWlEPTB;MkGuOlc{OSEQvF2= Mn:5V2FPT0WU
CPC-N NUXibYUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJ2LkCyNFEh|ryP M3;QdXNCVkeHUh?=
NB1 NHfvWpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInF[m1KSzVyPUK0MlY6OzlizszN NVHmOWFSW0GQR1XS
LS-123 M1fQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ2LkmwNVIh|ryP MVTTRW5ITVJ?
ST486 M1\LV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJ3LkGxNVMh|ryP MXHTRW5ITVJ?
NCI-H1963 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHJU5pKSzVyPUK2MlA3OjNizszN M3rHPXNCVkeHUh?=
U-87-MG MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLzTWM2OD1{Nj63OlQ1KM7:TR?= NInGOGRUSU6JRWK=
COR-L279 M{TBd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ4Lke5NlIh|ryP NVHlcmtsW0GQR1XS
LU-165 NEHHRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;z[o1ZUUN3ME2yPE4xQDZzIN88US=> NGHHSnFUSU6JRWK=
COLO-800 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7XTpV3UUN3ME2yPE4zQTV4IN88US=> NYDncIVJW0GQR1XS
ETK-1 M{nSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPxN45KSzVyPUK4MlM1PDZizszN MVXTRW5ITVJ?
LNCaP-Clone-FGC MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ7LkmyPFEh|ryP MY\TRW5ITVJ?
SIG-M5 NWOyU3RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTNyLke5OVIh|ryP MWjTRW5ITVJ?
NB6 NWXjSpE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXmTWM2OD1|MD65OVA{KM7:TR?= M1XNNHNCVkeHUh?=
NCI-H2107 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPWN405UUN3ME2zNU4zOzN6IN88US=> NEj5Xo9USU6JRWK=
SNU-C1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr2boRKSzVyPUOxMlMyOjZizszN M2fIPHNCVkeHUh?=
JAR NYnWXVdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ydGlEPTB;M{GuN|c6QSEQvF2= M{\GVHNCVkeHUh?=
L-363 MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDIdJFKSzVyPUOyMlIyPDRizszN NH;kZ|lUSU6JRWK=
EW-24 NUTTTnlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrIeWFKSzVyPUOyMlM1PzRizszN NWrjcIdLW0GQR1XS
NB69 NFrYVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnHN3FKSzVyPUOzMlY1PTRizszN MWPTRW5ITVJ?
EW-13 NV7xdpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXkZmJKSzVyPUOzMlg6PjlizszN MYDTRW5ITVJ?
Ramos-2G6-4C10 M3;xOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnIPFZKSzVyPUO0MlI6QTNizszN MlHkV2FPT0WU
TE-11 NYOwZpNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DYeGlEPTB;M{SuOFgzOiEQvF2= M1\yRnNCVkeHUh?=
L-428 NYPLWGg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXGTHdKSzVyPUO0Mlc2OzZizszN M2LQWXNCVkeHUh?=
KP-N-YN M1q3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2raNGlEPTB;M{SuPVA2PyEQvF2= M{LsXHNCVkeHUh?=
CGTH-W-1 NGL3dINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvxTFFKSzVyPUO2MlkxPDhizszN NH3MT|JUSU6JRWK=
K-562 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TTWM2OD1|Nz6wPFY1KM7:TR?= M4jvXHNCVkeHUh?=
NCI-H1299 Mlm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTN6LkG2NFMh|ryP NXfZZppzW0GQR1XS
RCC10RGB NFjSeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13KT2lEPTB;M{iuNlA5OyEQvF2= MnXPV2FPT0WU
NCI-SNU-16 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHvTWM2OD1|OD61OlU{KM7:TR?= NXvjN3luW0GQR1XS
LC-2-ad NE[zZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jidmlEPTB;M{muOFM{PyEQvF2= MmLkV2FPT0WU
MHH-PREB-1 M2X6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[0U2lEPTB;M{muO|M5QCEQvF2= NIO4VGRUSU6JRWK=
NCI-H64 Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq3S2JyUUN3ME20NE4xQTR6IN88US=> NHvxfGpUSU6JRWK=
LB996-RCC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjD[|BtUUN3ME20NE45PzF4IN88US=> NUTVbpRWW0GQR1XS
DEL MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRzLkS0NFUh|ryP NFTkcGpUSU6JRWK=
MLMA MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITlZXFKSzVyPUSxMlc2QTVizszN NYjQcW5sW0GQR1XS
SBC-1 M2nXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR{LkG4NFYh|ryP MV7TRW5ITVJ?
MPP-89 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fG[2lEPTB;NEKuOVg4PSEQvF2= MkG5V2FPT0WU
MV-4-11 NEnYVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXZTWM2OD12Mj65NFY4KM7:TR?= MX\TRW5ITVJ?
EoL-1- NX3meXVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\pTWM2OD12ND6xOVY5KM7:TR?= MmHNV2FPT0WU
CW-2 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXzTWM2OD12ND64N|QzKM7:TR?= MnPJV2FPT0WU
HT M4XFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPvZ|l5UUN3ME20OU44ODB5IN88US=> MY\TRW5ITVJ?
SW954 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\kWGlEPTB;NEeuOFEzQCEQvF2= MljmV2FPT0WU
A3-KAW M1jRc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ToZWlEPTB;NEmuPFA3OSEQvF2= NYP5T2ZqW0GQR1XS
TC-YIK NWnyPJlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fSNWlEPTB;NUCuNFM3OyEQvF2= MWLTRW5ITVJ?
SW962 NV\tRplMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHpTZhbUUN3ME21OE45OzV5IN88US=> MoL1V2FPT0WU
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NCI-H1395 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonpTWM2OD13OD64NVczKM7:TR?= MnzEV2FPT0WU
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SCH MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i3UWlEPTB;NkCuPVY{QCEQvF2= NHTueVJUSU6JRWK=
NCI-H2196 M1vXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLK[5RKSzVyPU[xMlI{OSEQvF2= MnjGV2FPT0WU
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NCI-H1522 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrsW4FKSzVyPU[5MlAxPDdizszN Mn75V2FPT0WU
UACC-812 M2rv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:2cWlEPTB;NkmuOVIxQSEQvF2= Mo\KV2FPT0WU
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NCI-H1694 NF:1SoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\UbWlEPTB;N{GuNFMzKM7:TR?= NF;CSZNUSU6JRWK=
NCI-H82 M3z1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD15MT65OVA4KM7:TR?= MXHTRW5ITVJ?
SCC-15 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX73SoxvUUN3ME23Nk4{PCEQvF2= NYfwS2JZW0GQR1XS
NCI-H1436 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SwV2lEPTB;N{KuO|Q2PiEQvF2= NWf4eWFjW0GQR1XS
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HCC1599 M3;XTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTd2Lki3N|Ih|ryP M1PkUXNCVkeHUh?=
NCI-H1155 M4Ty[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Cx[2lEPTB;N{SuPVM3PyEQvF2= NF[2TWRUSU6JRWK=
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HCC1187 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;wc5BKSzVyPUe3MlYyOjJizszN M2r4ZXNCVkeHUh?=
NCI-H322M M1nVTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;WTGlEPTB;N{iuN|cxQSEQvF2= NHvQcYlUSU6JRWK=
NCI-H526 NHuxb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTd6LkW4O|ch|ryP MljQV2FPT0WU
NCI-H2171 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHPVYhwUUN3ME23PU41OTN4IN88US=> M{POU3NCVkeHUh?=
COLO-668 M3;wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn6cZhtUUN3ME24NU42QDh2IN88US=> MlG0V2FPT0WU
RS4-11 NWT4Z4pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu1eGFKSzVyPUiyMlI2ODVizszN M2rWW3NCVkeHUh?=
NCI-H716 M4THbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTh{LkmwO|Uh|ryP M3\CXXNCVkeHUh?=
LU-134-A MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\BTWM2OD16Mz6xN|UyKM7:TR?= MnTyV2FPT0WU
RPMI-8226 M3HHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzwNHpKSzVyPUi0MlIyODdizszN Mn\TV2FPT0WU
KY821 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTlzLk[1OVEh|ryP MVfTRW5ITVJ?
ECC4 NWjxXmRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTl|LkiyOlkh|ryP NXLYbWpFW0GQR1XS
EW-3 NXjYRm9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37Te2lEPTB;OUSuPVA5OSEQvF2= MlnCV2FPT0WU
NB7 NVLSNJJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTl3Lke3PFYh|ryP MYrTRW5ITVJ?
NCI-H720 NH\HRphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTNXHdKSzVyPUm4MlQxPjFizszN NVL3TG54W0GQR1XS
NCI-H446 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTl7Lke1PFgh|ryP MYHTRW5ITVJ?
NCI-H889 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;kfmlEPTB;MUC0MlI1OiEQvF2= NUXoPI1GW0GQR1XS
EW-22 NUTxO29xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWwVFBKSzVyPUGwOk4yQSEQvF2= M2fH[3NCVkeHUh?=
BV-173 NG\Ec2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFyOD63Nlgh|ryP M2HaUnNCVkeHUh?=
WSU-NHL M4n6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrGTWM2OD1zMEmuOlcyKM7:TR?= M4T6bHNCVkeHUh?=
MN-60 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIemJrUUN3ME2xNFkvPjlizszN MkHDV2FPT0WU
DG-75 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPxNFNtUUN3ME2xNVMvOzV{IN88US=> Mn;VV2FPT0WU
DMS-79 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFzNz6zPFIh|ryP MULTRW5ITVJ?
SK-MEL-1 M{\Nemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmzT5JpUUN3ME2xNVgvODB7IN88US=> NFrGU5BUSU6JRWK=
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NCI-H510A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HMZWlEPTB;MUK3MlMzKM7:TR?= M3PzSnNCVkeHUh?=
BE-13 M4DWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jlT2lEPTB;MUO0MlA1PCEQvF2= M1f5S3NCVkeHUh?=
KP-N-YS M2XUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnDTWM2OD1zM{muO|M3KM7:TR?= M1nSZ3NCVkeHUh?=
SUP-T1 NUPDOYw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe0TWM2OD1zNEOuO|A5KM7:TR?= NHfxT|VUSU6JRWK=
EW-12 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrJfmJKSzVyPUG0OE43QTlizszN MW\TRW5ITVJ?
NB14 M{SzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn4dmJKSzVyPUG0O{4xQDJizszN NVnzXFZMW0GQR1XS
MDA-MB-134-VI NUG4[opXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PjW2lEPTB;MUS4MlI3QCEQvF2= NYfmSGxzW0GQR1XS
NCI-H1770 NX3Z[4V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjwWWJ1UUN3ME2xOVYvOjd7IN88US=> MmT6V2FPT0WU
TUR NWrMZ5h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[yTWM2OD1zNkeuPFch|ryP MoTSV2FPT0WU
NCI-H1417 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLOTWM2OD1zOECuN|MyKM7:TR?= NWLye2o5W0GQR1XS
IMR-5 NF20UXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfxTWM2OD1zOEGuOVcyKM7:TR?= NHGyU5VUSU6JRWK=
NCI-H226 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LwOGlEPTB;MUi4Mlg3PiEQvF2= MXXTRW5ITVJ?
NCI-H187 NX;NNWdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDETWM2OD1zOUCuNFY1KM7:TR?= MWHTRW5ITVJ?
SF539 NFvtO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTETWM2OD1zOUKuO|I5KM7:TR?= MVzTRW5ITVJ?
TALL-1 NFTINWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ZTWM2OD1zOUiuN|A1KM7:TR?= NGPMWJhUSU6JRWK=
TE-441-T MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPwTWM2OD1zOUmuO|M6KM7:TR?= NVvQeINYW0GQR1XS
REH NVH4VINPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT1RXpKSzVyPUKzOk43OjZizszN NXH4UXp1W0GQR1XS
MS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XMV2lEPTB;MkO5MlEzOSEQvF2= NEH2fmJUSU6JRWK=
THP-1 M4XafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELFN2lKSzVyPUK2OE44OzhizszN NUnsWmJEW0GQR1XS
NCI-H1838 M3HqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLTWM2OD1{N{GuOFU3KM7:TR?= NF3hO3VUSU6JRWK=
P30-OHK MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fjfmlEPTB;MkizMlg1PyEQvF2= M1TGNnNCVkeHUh?=
C8166 NEfrN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTN2NT6zN|gh|ryP MlT4V2FPT0WU

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

体内試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

お薦めの試験操作(参考用のみ)

キナーゼ試験:

[1]

+ 展開

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
細胞試験:

[3]

+ 展開
  • 細胞株: KIM-2, HC11, and ES
  • 濃度: Dissolved in DMSO, final concentrations ~25 μM
  • 反応時間: 24 and 48 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (参考用のみ)
動物試験:

[7]

+ 展開
  • 動物モデル: Male mdx (C57BL/10ScSn DMD mdx) mice
  • 製剤: Dissolved in DMSO, and diluted in PBS
  • 投薬量: ~10 μg/kg/day
  • 投与方法: Injection
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 90 mg/mL (189.22 mM)
Ethanol 25 mg/mL (52.56 mM)
Water Insoluble
体内 左から(NMPから)右の順に溶剤を製品に加えます(文献ではなく、Selleckの実験によるデータ):
4% DMSO+30% PEG 300+20% propylene glycol+ddH2O
混合させたのち直ちに使用することを推奨します。
2mg/mL

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (g) = 濃度 (mol/L) x 体積 (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

よくある質問(FAQ)

  • 質問1:

    I want to know whether it contains EDTA or other chelating agent in this product(S2619)?

  • 回答:

    Our S2619 MG-132 doesn't contain EDTA or other chelating agent.

Proteasomeシグナル伝達経路

Proteasome Inhibitors with Unique Features

相関Proteasome製品

Tags: MG-132を買う | MG-132 ic50 | MG-132供給者 | MG-132を購入する | MG-132費用 | MG-132生産者 | オーダーMG-132 | MG-132化学構造 | MG-132分子量 | MG-132代理店
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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID