Adalimumab (anti-TNF-alpha)

製品コードA2010 別名: LU200134, D2E7

For research use only.
Not for use in humans.

Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.

Adalimumab (anti-TNF-alpha)
サイズ 価格(税別)
5mg JPY 103700

代表番号: 03-5615-9297|電子メール:[email protected]
よく尋ねられる質問

文献中Selleckの製品使用例(4)

質量管理及び製品安全説明書

TNF-alpha阻害剤の選択性比較

生物活性

製品説明 Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
同型 Human IgG1
ターゲット
TNF-α [1]
体外試験

Adalimumab treatment alters the secretion of cytokines.[1]

体内試験

We injected adalimumab intraductally into the MG of adult mice;this was found to stimulate BSC multipotency.[2]

お薦めの試験操作(参考用のみ)

細胞試験:
  • Fa2N-4 cells were co-cultivated (CC) with monocyte derived macrophages (MDMs) for 24 h. Physiological (15%) and pro-inflammatory (50%) MDM-to-Fa2N-4 ratios were used. All measured cytokine concentrations were related to the corresponding control (fold change) to analyse (A) the IL-8 neutralising antibody (αIL-8, 100 ng/ml) specific effect and (B) the TNF-α neutralising effect of Adalimumab.

動物試験:
  • Animal Models: K5CreER, K8rtTA, TetO-DTA mice
    Dosages: 0.15 mg
    Administration: i.d.
    Reference: https://pubmed.ncbi.nlm.nih.gov/32848220/
     

製品説明

CAS No. 331731-18-1
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source CHO cells
Storage Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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Handling Instructions

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よくある質問(FAQ)

質問:1:
How to store the antibody?

回答:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.

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