Leronlimab (anti-CCR5)

製品コードA2040 別名: PRO 140; Vyrologix

製品コード：A2040 純度：99%

Leronlimab (anti-CCR5)(PRO 140; Vyrologix) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.

サイズ	価格(税別)	在庫状況
1mg	JPY 44500	国内在庫あり
1mg*5	JPY 146500	お問い合わせ
1mg*25	JPY 445500	お問い合わせ

代表番号: 045-509-1970\|電子メール：[email protected] よく尋ねられる質問

質量管理及び製品安全説明書

現在のバッチを見る：純度： 99% タンパク質濃度： 3.19mg/ml 内毒素：＜1EU/mg

CCR阻害剤の選択性比較

生物活性

製品説明	Leronlimab (anti-CCR5)(PRO 140; Vyrologix) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.

In Vitro
In Vitro	Leronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca^+ 2 signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.^[1]
細胞実験	Equal numbers of cells were plated, and after 72 h of exposure to the drugs, cells were incubated with 1 mg/mL of MTT for 90 min. The reduced (insoluble and colored) formazan was dissolved in 0.04 N HCl acidified isopropanol and measured spectrophotometrically at 570 nm.

In Vivo
In Vivo	In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.^[1]
動物試験	AnimalModels:Female NCI Athymic nu/nu nude mice injected with MB-MDA-231 cells expressing Luc2-eGFP Dosages:2 mg/mouse Administration:i.p.^[1]

In Vivo

In xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis.^[1]

動物試験

AnimalModels:Female NCI Athymic nu/nu nude mice injected with MB-MDA-231 cells expressing Luc2-eGFP
Dosages:2 mg/mouse
Administration:i.p.^[1]

参考
[1] Jiao X, et al. Breast Cancer Res. 2021 Jan 23;23(1):11.

参考

[1] Jiao X, et al. Breast Cancer Res. 2021 Jan 23;23(1):11.

製品説明

CAS No.	674782-26-4
Formulation	PBS Buffer, PH 7.4
Isotype	Human IgG4
Application	Leronlimab (anti-CCR5)
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Shipping	Shipped under low temperature conditions
Sterility	1.94mg/ml

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