Pembrolizumab (anti-PD-1)

製品コードA2005 別名: MK-3475, lambrolizumab Non-humanized mouse model applicable

For research use only. Not for use in humans.

Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.

サイズ 価格(税別)  
JPY 101799.69

質量管理及び製品安全説明書

PD-1/PD-L1阻害剤の選択性比較

生物活性

製品説明 Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
ターゲット
PD-1 [1]
(Cell-free assay)
体内試験 In addition to Melanoma and Lung carcinoma, pembrolizumab has also demonstrated efficacy in other advanced solid tumors and hematologic malignancies. Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer[2].

お薦めの試験操作(参考用のみ)

細胞試験:
+ 展開
  • Objective: To examine the effect of high-dose steroid therapy on lymphocyte proliferation/functionality after stimulation with anti-CD3 in the presence of pembrolizumab
    Cells: Human PBMCs
    Concentrations: 5 µg/mL
    Incubation Time: --
    Method: Isolated PBMCs were pre-treated with prednisone (1 nM - 1 mM) before anti-CD3 stimulation. Anti-CD3-stimulated cells were then incubated with pembrolizumab and their proliferative capacity and IL-2 secretion ability were measured by carboxyfluorescein succinimidyl ester (CFSE) staining and ELISA.
    Reference: http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e14587

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

動物試験:
+ 展開
  • Objective: To evaluate the pharmacokinetics and biodistribution of 89Zr-labeled Pembrolizumab
    Animal Models: Female ICR (CD-1) mice, Hsd: Sprague-Dawley outbred rats, NSG mice(humanized mice), hu-PBL-SCID mice(humanized mice)
    Formulation: --
    Dosages: --
    Administration: i.v.
    Reference: https://www.ncbi.nlm.nih.gov/pubmed/27493273

    Pembrolizumab can apply to mice, rat, peripheral blood and other related assays (Only for Reference)

製品説明

Formulation PBS buffer, pH 7.2
Isotype Human IgG4
Source CHO cells
Storage Store at -80°C and avoid freeze-thaw cycles.

技術サポート

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須
Tags: Pembrolizumab (anti-PD-1)を買う | Pembrolizumab (anti-PD-1) ic50 | Pembrolizumab (anti-PD-1)供給者 | Pembrolizumab (anti-PD-1)を購入する | Pembrolizumab (anti-PD-1)費用 | Pembrolizumab (anti-PD-1)生産者 | オーダーPembrolizumab (anti-PD-1) | Pembrolizumab (anti-PD-1)化学構造 | Pembrolizumab (anti-PD-1)分子量 | Pembrolizumab (anti-PD-1)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
×

大阪市内で「G20サミット」が開催されることに伴い、大阪府内で大規模な交通規制が行われる影響で、6月26日(水)から7月1日(月)までの間、下記地域へ出荷が行えなくなります。
対象地域
大阪府(全域)、兵庫県(芦屋市、尼崎市、伊丹市、西宮市)
上記地域より西の地域につきましては納期の遅延が予想されます。
また、国際便も遅延が予想されているため国内在庫がない製品の納期が一週間程度遅れる可能性がございます。
ご不便をおかけいたしますが、宜しくお願い申し上げます。