製品コードA2011 別名: SAR153191, REGN88
For research use only.
Not for use in humans.
Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
|製品説明||Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.|
Sarilumab (SAR153191/REGN88) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity thereby blocking cis and trans IL-6-mediated inflammatory signalling cascade, and with no evidence of complement-dependent or antibody-dependent cell-mediated cytotoxicity. Sarilumab provides partial growth inhibition of a subset of the tumor cell lines tested, e.g., DU145 (prostate), Calu3 (lung) and A549 (lung). Sarilumab bound with high affinity to recombinant monomeric human and monkey IL-6 receptor with a KD value of 61.9 pM and 71.9 pM, respectively. The binding affinity of sarilumab to the dimeric human IL-6 receptor Fc-fusion is 12.8 pM. sarilumab is specific to human and monkey IL-6 receptor and does not cross-react with mouse IL-6R.
|体内試験||Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner.|
|Formulation||PBS buffer, pH 7.2|
|Storage||Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles|
How to store the antibody?
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.