Sarilumab (anti-IL-6Rα)
製品コードA2011 別名: SAR153191, REGN88
For research use only.
Not for use in humans.
Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
文献中Selleckの製品使用例(1)
質量管理及び製品安全説明書
IL Receptor阻害剤の選択性比較
生物活性
| 製品説明 | Sarilumab is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD. | ||||
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| ターゲット |
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| 体外試験 |
Sarilumab (SAR153191/REGN88) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity thereby blocking cis and trans IL-6-mediated inflammatory signalling cascade, and with no evidence of complement-dependent or antibody-dependent cell-mediated cytotoxicity[1]. Sarilumab provides partial growth inhibition of a subset of the tumor cell lines tested, e.g., DU145 (prostate), Calu3 (lung) and A549 (lung)[2]. Sarilumab bound with high affinity to recombinant monomeric human and monkey IL-6 receptor with a KD value of 61.9 pM and 71.9 pM, respectively. The binding affinity of sarilumab to the dimeric human IL-6 receptor Fc-fusion is 12.8 pM. sarilumab is specific to human and monkey IL-6 receptor and does not cross-react with mouse IL-6R[3]. |
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| 体内試験 | Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner[1]. |
お薦めの試験操作（参考用のみ）
製品説明
| CAS No. | 1189541-98-7 |
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| Formulation | PBS buffer, pH 7.2 |
| Isotype | Human IgG1 |
| Source | CHO cells |
| Storage | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
技術サポート
他に質問がある場合は、お気軽にお問い合わせください。
よくある質問（FAQ）
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質問1：
How to store the antibody?
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回答：
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.
