PKM2 阻害剤 | 活性剤

製品コード	製品名	製品説明	Selective / Pan	IC50 / Ki
S7302	TEPP-46 (ML265)	TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.	Pan
S8279	Shikonin	Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB)<	Pan	PKM2, IC50: 0.3 μM; PKM2, IC50: 0.8 μM
S8616	PKM2 inhibitor(compound 3k)	PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.	Pan	PKM2, IC50: 2.95 μM
S7928	DASA-58	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.	Pan