PLK1 選択性阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S7720 SBE 13 HCl

SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.

Selective PLK1, IC50: 200 pM
S2235 Volasertib (BI 6727)

Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Phase 3.

Selective PLK1, IC50: 0.87 nM
S2898 MLN0905

MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.

Selective PLK1, IC50: 2 nM
S7255 NMS-P937 (NMS1286937)

NMS-P937 (NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Phase 1.

Selective PLK1, IC50: 2 nM
S2193 GSK461364

GSK461364 inhibits purified Plk1 with Ki of 2.2 nM. It is more than 1000-fold selective against Plk2/3. Phase 1.

Selective PLK1, Ki: 2.2 nM
S7248 Ro3280

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.

Selective PLK1, IC50: 3 nM
S1362 Rigosertib (ON-01910)

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.

Selective PLK1, IC50: 9 nM
S1485 HMN-214

HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.

Selective
S1109 BI 2536

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

Pan PLK1, IC50: 0.83 nM