ホームページ Apoptosis RIP kinase RIP2-kinase 選択性 阻害剤
  • RIP1 kinase
  • RIP2 kinase
  • RIP3 kinase
  • RIP 1 Kinase

RIP2-kinase 選択性 阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S8927 GSK2983559 (compound 3) GSK2983559 (compound 3, RIP2 kinase inhibitor 1, RIPK2-IN-1) is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity. Selective
S9786 BDTX-189 BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity. Selective RIPK2, Kd: 1.2 nM
S2805 LY364947 LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II. Selective RIPK2, IC50: 0.11 μM
S8261 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures. Pan RIP2, IC50: 5 nM