トロンビン
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S2196 | Dabigatran (BIBR 953) | <1 mg/mL | 0.5 mg/mL | 0.01 mg/mL |
| S2154 | Dabigatran Etexilate | <1 mg/mL | 126 mg/mL | 12 mg/mL |
| S2069 | Argatroban | <1 mg/mL | 9 mg/mL | 6 mg/mL |
| S5252 | Ozagrel sodium | 50 mg/mL | 1 mg/mL | <1 mg/mL |
| S3200 | Triflusal | <1 mg/mL | 50 mg/mL | 50 mg/mL |
| S4740 | Sodium ferulate | 43 mg/mL | 2 mg/mL | <1 mg/mL |
| S5074 | Argatroban hydrate|Argipidine | <1 mg/mL | 100 mg/mL | 40 mg/mL |
| S4502 | Eltrombopag | <1 mg/mL | 26 mg/mL | <1 mg/mL |
| S5286 | Ramatroban | <1 mg/mL | 83 mg/mL | 83 mg/mL |
| S2229 | Eltrombopag Olamine | <1 mg/mL | 89 mg/mL | <1 mg/mL |
| S1346 | Heparin sodium | 100 mg/mL | <1 mg/mL | <1 mg/mL |
Thrombin製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S2196 |
Dabigatran (BIBR 953)Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay. |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of (C) dabigatran. Each dose-response curve was fitted to the Hill equation, and these curves are shown in red for thrombin inhibitors (B,C).
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| S2154 |
Dabigatran EtexilateDabigatran Etexilate is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule. |
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| S2069 |
ArgatrobanArgatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant. |
||
| S5252新 |
Ozagrel sodiumSodium ozagrel (ozagrel) is a thromboxane A2 synthase inhibitor with neuroprotective properties. |
||
| S3200 |
TriflusalTriflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. |
||
| S4740 |
Sodium ferulateSodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis. |
||
| S5074 |
Argatroban hydrate|ArgipidineArgatroban is a direct, selective thrombin inhibitor with anticoagulant effects. |
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| S4502 |
EltrombopagEltrombopag, a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP). |
32D‐MPL cells were treated with hetrombopag (10 nmol/L), eltrombopag (100 nmol/L) or rhTPO (10 ng/mL) for the indicated time. Whole‐cell lysates were analysed by Western blotting using the indicated antibodies.
|
|
| S5286新 |
RamatrobanRamatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells. |
||
| S2229 |
Eltrombopag OlamineEltrombopag Olamine is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). |
||
| S1346 |
Heparin sodiumHeparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins, used as an anticoagulant. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S2196 |
Dabigatran (BIBR 953)Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay. |
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of (C) dabigatran. Each dose-response curve was fitted to the Hill equation, and these curves are shown in red for thrombin inhibitors (B,C).
|
|
| S2154 |
Dabigatran EtexilateDabigatran Etexilate is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule. |
|
|
| S2069 |
ArgatrobanArgatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant. |
||
| S5252新 |
Ozagrel sodiumSodium ozagrel (ozagrel) is a thromboxane A2 synthase inhibitor with neuroprotective properties. |
||
| S3200 |
TriflusalTriflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. |
||
| S4740 |
Sodium ferulateSodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis. |
||
| S5074 |
Argatroban hydrate|ArgipidineArgatroban is a direct, selective thrombin inhibitor with anticoagulant effects. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S4502 |
EltrombopagEltrombopag, a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP). |
2015, 44(3):398-408 2018, 22(11):5367-5377 2016, 44(3):398-408 |
32D‐MPL cells were treated with hetrombopag (10 nmol/L), eltrombopag (100 nmol/L) or rhTPO (10 ng/mL) for the indicated time. Whole‐cell lysates were analysed by Western blotting using the indicated antibodies.
|
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S5286新 |
RamatrobanRamatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S2229 |
Eltrombopag OlamineEltrombopag Olamine is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). |
2018, 22(11):5367-5377 |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1346 |
Heparin sodiumHeparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins, used as an anticoagulant. |
