GABA受容体

シグナル伝達経路

研究分野

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1168	Valproic acid sodium salt (Sodium valproate)	33 mg/mL	33 mg/mL	33 mg/mL
S3018	Niflumic acid	<1 mg/mL	56 mg/mL	<1 mg/mL
S4661	Tiagabine hydrochloride	11 mg/mL	82 mg/mL	82 mg/mL
S1969	Nefiracetam	5 mg/mL	49 mg/mL	49 mg/mL
S1332	Flumazenil	<1 mg/mL	5 mg/mL	<1 mg/mL
S5049	Thiocolchicoside	100 mg/mL	100 mg/mL	2 mg/mL
S7071	(+)-Bicuculline	<1 mg/mL	21 mg/mL	<1 mg/mL
S2026	Ginkgolide A	<1 mg/mL	81 mg/mL	2 mg/mL
S4587	Pentylenetetrazol	27 mg/mL	27 mg/mL	27 mg/mL
S4197	Bemegride	<1 mg/mL	31 mg/mL	31 mg/mL
S1338	Gabapentin HCl	42 mg/mL	<1 mg/mL	<1 mg/mL
S1329	Etomidate	<1 mg/mL	49 mg/mL	49 mg/mL
S2133	Gabapentin	34 mg/mL	<1 mg/mL	<1 mg/mL
S4840	Baclofen	0.1 mg/mL	<1 mg/mL	<1 mg/mL
S4892	Phenibut	-1 mg/mL	35 mg/mL	-1 mg/mL
S3786	Glabridin	-1 mg/mL	64 mg/mL	-1 mg/mL
S3748	Acamprosate Calcium	40 mg/mL	<1 mg/mL	<1 mg/mL
S3072	(R)-baclofen	8 mg/mL	<1 mg/mL	<1 mg/mL
S4574	Piperazine	17 mg/mL	8 mg/mL	17 mg/mL
S3634	6-Hydroxyflavone (6-HF)	<1 mg/mL	47 mg/mL	<1 mg/mL
S2269	Baicalin	<1 mg/mL	89 mg/mL	<1 mg/mL
S2399	Dihydromyricetin	<1 mg/mL	64 mg/mL	64 mg/mL
S3663	Afloqualone	<1 mg/mL	56 mg/mL	28 mg/mL
S4270	Oxiracetam	31 mg/mL	31 mg/mL	<1 mg/mL
S4700	4-Aminobutyric acid	20 mg/mL	<1 mg/mL	<1 mg/mL

亜型選択性的な製品

GABA Receptor阻害剤(31)
新GABA Receptor製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1168	Valproic acid sodium salt (Sodium valproate) Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.	Nat Biotechnol, 2015, 10.1038/nbt.3130 J Neurosci, 2013, 33(17):7535-47 Cell Death Dis, 2016, 7:e2221	(A,B) Wild-type C57BL/6 male mice were treated with vehicle (saline) or 10 mg/kg of paraquat (PQ) for 3 days, and mice received VPA (3.5 mg/kg) or anacardic acid (5 mg/kg) starting 24 and 1 h before PQ injection. IL-6 mRNA expression was determined by real-time PCR.
S3018	Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
S4661	Tiagabine hydrochloride Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
S4675	Tiagabine Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
S1969	Nefiracetam Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
S1332	Flumazenil Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
S9249^新	Securinine Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
S9176^新	Pimpinellin Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.
S9065^新	Songorine Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S5049^新	Thiocolchicoside Thiocolchicoside is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.
S7071	(+)-Bicuculline (+)-Bicuculline is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.	Br J Pharmacol, 2016, 173(10):1693-702 Sci Rep, 2016, 6: 19266 Sci Rep, 2014, 4:7270	Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine.
S2026	Ginkgolide A Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a K_i of 14.5 μM.
S4587	Pentylenetetrazol Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
S4197	Bemegride Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
S1338	Gabapentin HCl Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
S1329	Etomidate Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
S2133	Gabapentin Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
S2023^新	Propofol Propofol (Diprivan) is a short-acting, intravenously administered hypnotic agent.
S4840^新	Baclofen Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors.
S4892^新	Phenibut Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
S3786^新	Glabridin Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.
S3748^新	Acamprosate Calcium Acamprosate, calcium acetylhomotaurinate, is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
S3072	(R)-baclofen (R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.
S4574	Piperazine Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis.
S3634	6-Hydroxyflavone (6-HF) 6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors.
S2269	Baicalin Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.	J Nutr Biochem, 2013, 24(11):1953-62
S2399	Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.	Food Chem Toxicol, 2012, 50(7):2508-14 Oncotarget, 2016, 10.18632/oncotarget.10836	A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.
S3663	Afloqualone Afloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
S4270	Oxiracetam Oxiracetam, a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.
S4700	4-Aminobutyric acid Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.
S5131^新	Homotaurine Homotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.

研究分野別

製品類型

GABA受容体

シグナル伝達経路

研究分野

亜型選択性的な製品

Valproic acid sodium salt (Sodium valproate)

Niflumic acid

Tiagabine hydrochloride

Tiagabine

Nefiracetam

Flumazenil

Securinine

Pimpinellin

Songorine

Thiocolchicoside

(+)-Bicuculline

Ginkgolide A

Pentylenetetrazol

Bemegride

Gabapentin HCl

Etomidate

Gabapentin

Propofol

Baclofen

Phenibut

Glabridin

Acamprosate Calcium

(R)-baclofen

Piperazine

6-Hydroxyflavone (6-HF)

Baicalin

Dihydromyricetin

Afloqualone

Oxiracetam

4-Aminobutyric acid

Homotaurine