GABA受容体
シグナル伝達経路
研究分野
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1168 | Valproic Acid (NSC 93819) sodium salt | 33 mg/mL | 33 mg/mL | ''33 mg/mL |
| S3018 | Niflumic acid | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S2996 | L-DAB HBR | 23 mg/mL | <1 mg/mL | '''<1 mg/mL |
| S4661 | Tiagabine hydrochloride | 11 mg/mL | 82 mg/mL | 82 mg/mL |
| S4675 | Tiagabine | ' mg/mL | ||
| S6470 | Fluralaner | <1 mg/mL | 100 mg/mL | 25 mg/mL |
| S1969 | Nefiracetam | 5 mg/mL | 49 mg/mL | 49 mg/mL |
| S4772 | alpha-Asarone | -1 mg/mL | 41 mg/mL | -1 mg/mL |
| S5319 | AWD 131-138 | <1 mg/mL | 30 mg/mL | '2 mg/mL |
| S4423 | Emamectin Benzoate | <1 mg/mL | 100 mg/mL | ''100 mg/mL |
| S4494 | Methionine | 29 mg/mL | <1 mg/mL | ''<1 mg/mL |
| S1332 | Flumazenil (RO 15-1788) | <1 mg/mL | 5 mg/mL | '<1 mg/mL |
| S6100 | Picrotoxin | <1 mg/mL | 100 mg/mL | '100 mg/mL |
| S7071 | (+)-Bicuculline | <1 mg/mL | 21 mg/mL | '<1 mg/mL |
| S0303 | CGP52432 | 2.5 mg/mL | 5 mg/mL | 5 mg/mL |
| S9249 | Securinine | -1 mg/mL | 44 mg/mL | -1 mg/mL |
| S2026 | Ginkgolide A | <1 mg/mL | 81 mg/mL | 2 mg/mL |
| S4587 | Pentylenetetrazol | 27 mg/mL | 27 mg/mL | '27 mg/mL |
| S5194 | Furosemide sodium | 71 mg/mL | 71 mg/mL | '''<1 mg/mL |
| S6008 | p-Hydroxybenzaldehyde | -1 mg/mL | 24 mg/mL | -1 mg/mL |
| S9065 | Songorine | -1 mg/mL | 71 mg/mL | -1 mg/mL |
| S4197 | Bemegride | <1 mg/mL | 31 mg/mL | 31 mg/mL |
| S5049 | Thiocolchicoside | 100 mg/mL | 100 mg/mL | 2 mg/mL |
| S6094 | Imidazole-4(5)-acetic Acid Hydrochloride | -1 mg/mL | 10 mg/mL | -1 mg/mL |
| S9176 | Pimpinellin | -1 mg/mL | 49 mg/mL | -1 mg/mL |
| S1338 | Gabapentin HCl | 42 mg/mL | <1 mg/mL | <1 mg/mL |
| S1329 | Etomidate | <1 mg/mL | 49 mg/mL | 49 mg/mL |
| S2133 | Gabapentin | 34 mg/mL | <1 mg/mL | <1 mg/mL |
| S3072 | (R)-baclofen | 8 mg/mL | <1 mg/mL | <1 mg/mL |
| S4574 | Piperazine | 17 mg/mL | 8 mg/mL | 17 mg/mL |
| S4840 | Baclofen | 0.1 mg/mL | <1 mg/mL | '''<1 mg/mL |
| S3634 | 6-Hydroxyflavone (6-HF) | <1 mg/mL | 47 mg/mL | <1 mg/mL |
| S4892 | Phenibut | -1 mg/mL | 35 mg/mL | -1 mg/mL |
| S4724 | Etomidate hydrochloride | 56 mg/mL | 56 mg/mL | ''56 mg/mL |
| S2269 | Baicalin (NSC-661431) | <1 mg/mL | 89 mg/mL | <1 mg/mL |
| S4961 | 3,4,5-Trimethoxycinnamic acid | -1 mg/mL | 47 mg/mL | -1 mg/mL |
| S3786 | Glabridin | -1 mg/mL | 64 mg/mL | -1 mg/mL |
| S2399 | Dihydromyricetin | <1 mg/mL | 64 mg/mL | 64 mg/mL |
| S3663 | Afloqualone | <1 mg/mL | 56 mg/mL | 28 mg/mL |
| S4270 | Oxiracetam | 31 mg/mL | 31 mg/mL | '<1 mg/mL |
| S4700 | 4-Aminobutyric acid (GABA) | 20 mg/mL | <1 mg/mL | <1 mg/mL |
| S3748 | Acamprosate Calcium | 40 mg/mL | <1 mg/mL | '<1 mg/mL |
| S5612 | Isonipecotic acid | 26 mg/mL | <1 mg/mL | '-1 mg/mL |
| S5131 | Homotaurine | ' mg/mL | ||
| S3959 | (+)-Borneol | -1 mg/mL | 30 mg/mL | -1 mg/mL |
| S5805 | Allopregnanolone | <1 mg/mL | 64 mg/mL | 31 mg/mL |
| S6611 | Cyclothiazide | ' mg/mL | ||
| S9409 | Kavain | -1 mg/mL | 46 mg/mL | -1 mg/mL |
| S3977 | (-)-Borneol | -1 mg/mL | 30 mg/mL | -1 mg/mL |
| S6755 | NS 11394 | <1 mg/mL | 71 mg/mL | 71 mg/mL |
GABA Receptor製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1168 |
Valproic Acid (NSC 93819) sodium saltValproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. |
Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
| S3018 |
Niflumic acidNiflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain. |
||
| S2996 |
L-DAB HBRL-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity. |
||
| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
||
| S4675 |
TiagabineTiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
||
| S6470 |
FluralanerFluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls). |
||
| S1969 |
NefiracetamNefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2. |
||
| S4772 |
alpha-AsaroneAlpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
||
| S5319 |
AWD 131-138AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. |
||
| S4423 |
Emamectin BenzoateEmamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis. |
||
| S4494 |
MethionineMethionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity. |
||
| S1332 |
Flumazenil (RO 15-1788)Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
||
| S6100新 |
PicrotoxinPicrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors. |
||
| S7071 |
(+)-Bicuculline(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
-Bicuculline-S707101X0320161109.gif)
-Bicuculline-S707101X0320161109.gif)
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
|
| S0303 |
CGP52432CGP52432 is a potent and selective antagonist of GABAB autoreceptor with IC50 of 0.085 μM. |
||
| S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
| S2026 |
Ginkgolide AGinkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. |
||
| S4587 |
PentylenetetrazolPentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. |
||
| S5194 |
Furosemide sodiumFurosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor. |
||
| S6008 |
p-Hydroxybenzaldehydep-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. |
||
| S9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
| S4197 |
BemegrideBemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
||
| S5049 |
ThiocolchicosideThiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor. |
||
| S6094 |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. |
||
| S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
||
| S1338 |
Gabapentin HClGabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
||
| S1329 |
EtomidateEtomidate (R16659) is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative. |
||
| S2133 |
GabapentinGabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
||
| S3072 |
(R)-baclofen(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. |
||
| S4574 |
PiperazinePiperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine), GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis. |
||
| S4840 |
BaclofenBaclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors. |
||
| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors. |
||
| S4892 |
PhenibutPhenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
||
| S4724 |
Etomidate hydrochlorideEtomidate (Amidate, R 16659) hydrochloride is a general anesthetic that produces its effects by enhancing GABA(A) receptor activity. |
||
| S2269 |
Baicalin (NSC-661431)Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors. |
||
| S4961 |
3,4,5-Trimethoxycinnamic acid3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
||
| S3786 |
GlabridinGlabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
||
| S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
| S3663 |
AfloqualoneAfloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
||
| S4270 |
OxiracetamOxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning. |
||
| S4700 |
4-Aminobutyric acid (GABA)4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. |
||
| S3748 |
Acamprosate CalciumAcamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine. |
||
| S5612 |
Isonipecotic acidIsonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist. |
||
| S5131 |
HomotaurineHomotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
||
| S3959 |
(+)-Borneol(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
||
| S5596 |
(1S)-(-)-α-Pineneα-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. |
||
| S5805 |
AllopregnanoloneAllopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor. |
||
| S6611 |
CyclothiazideCyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function. |
||
| S9409 |
KavainKavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. |
||
| S3977 |
(-)-Borneol(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. |
||
| S6755 |
NS 11394NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1168 |
Valproic Acid (NSC 93819) sodium saltValproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. |
Western blot analysis of Acetylated Histone and Histone. 0-10μM sodium valproate was added.
|
|
| S3018 |
Niflumic acidNiflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain. |
||
| S2996 |
L-DAB HBRL-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity. |
||
| S4661 |
Tiagabine hydrochlorideTiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
||
| S4675 |
TiagabineTiagabine (Gabitril, NO050328, NO328, TGB) is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
||
| S6470 |
FluralanerFluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls). |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1969 |
NefiracetamNefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2. |
||
| S4772 |
alpha-AsaroneAlpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
||
| S5319 |
AWD 131-138AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. |
||
| S4423 |
Emamectin BenzoateEmamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis. |
||
| S4494 |
MethionineMethionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1332 |
Flumazenil (RO 15-1788)Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
2018, 107:1674-1681 2017, 31(3):193-203 |
|
| S6100新 |
PicrotoxinPicrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors. |
||
| S7071 |
(+)-Bicuculline(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
2022, 10.1038/s41401-021-00854-7 2021, 156:105407 2021, 11(1):9300 |
-Bicuculline-S707101X0320161109.gif)
-Bicuculline-S707101X0320161109.gif)
Effects of antagonists on the anti-hyperalgesic effects of sinomenine in CCI rats. * P<0.05 as compared to vehicle control group (N=8 per group). The GABAA receptor antagonist bicuculline but not the opioid receptor antagonist naltrexone nor the 5-HT1A receptor antagonist WAY100635 blocked the antinociceptive effects of 40 mg/kg sinomenine. |
| S0303 |
CGP52432CGP52432 is a potent and selective antagonist of GABAB autoreceptor with IC50 of 0.085 μM. |
2022, 10.1002/jcb.30231 2021, 15:741214 |
|
| S9249 |
SecurinineSecurinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
||
| S2026 |
Ginkgolide AGinkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM. |
2020, 21;31(3):107521 |
|
| S4587 |
PentylenetetrazolPentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist. |
||
| S5194 |
Furosemide sodiumFurosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor. |
||
| S6008 |
p-Hydroxybenzaldehydep-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. |
||
| S9065 |
SongorineSongorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
||
| S4197 |
BemegrideBemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
||
| S5049 |
ThiocolchicosideThiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor. |
||
| S6094 |
Imidazole-4(5)-acetic Acid HydrochlorideImidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. |
||
| S9176 |
PimpinellinPimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1338 |
Gabapentin HClGabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain. |
2022, 101(4):236-245 2018, 11(12):5536-5546 2017, 5:1 |
|
| S1329 |
EtomidateEtomidate (R16659) is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative. |
||
| S2133 |
GabapentinGabapentin is a GABA analogue, used to treat seizures and neuropathic pain. |
2022, 101(4):236-245 2020, 11(9):764 2018, 11(12):5536-5546 |
|
| S3072 |
(R)-baclofen(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity. |
2022, 10.1002/jcb.30231 |
|
| S4574 |
PiperazinePiperazine (1,4-Diazacyclohexane, Diethylenediamine, exahydropyrazine, Piperazidine), GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis. |
||
| S4840 |
BaclofenBaclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates GABA receptors, specifically the GABAB receptors. |
||
| S3634 |
6-Hydroxyflavone (6-HF)6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors. |
||
| S4892 |
PhenibutPhenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. |
||
| S4724 |
Etomidate hydrochlorideEtomidate (Amidate, R 16659) hydrochloride is a general anesthetic that produces its effects by enhancing GABA(A) receptor activity. |
||
| S2269 |
Baicalin (NSC-661431)Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors. |
2021, 26(5)1210 2021, 27(7-8):533-542 2019, 31(5):983-992 |
|
| S4961 |
3,4,5-Trimethoxycinnamic acid3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
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| S3786 |
GlabridinGlabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
2021, S0024-3205(20)31752-5 |
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| S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. |
2021, 26(5)1210 2020, 65:109431 2019, 91(8):1440-1447 |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
| S3663 |
AfloqualoneAfloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor. |
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| S4270 |
OxiracetamOxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning. |
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| S4700 |
4-Aminobutyric acid (GABA)4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. |
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| S3748 |
Acamprosate CalciumAcamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine. |
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| S5612 |
Isonipecotic acidIsonipecotic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid) is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S5131 |
HomotaurineHomotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy. |
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| S3959 |
(+)-Borneol(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
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| S5596 |
(1S)-(-)-α-Pineneα-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. |
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| S5805 |
AllopregnanoloneAllopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor. |
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| S6611 |
CyclothiazideCyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function. |
2021, e2004846 2021, 7(1):201 2021, 406(1):112735 |
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| S9409 |
KavainKavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. |
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| S3977 |
(-)-Borneol(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. |
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| S6755 |
NS 11394NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes. |
