HIVプロテアーゼ

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1030 Panobinostat (LBH589) <1 mg/mL 69 mg/mL <1 mg/mL
S1185 Ritonavir (ABT-538) <1 mg/mL 100 mg/mL '''3 mg/mL
S1380 Lopinavir (ABT-378) <1 mg/mL 126 mg/mL '126 mg/mL
S1457 Atazanavir (BMS-232632) Sulfate <1 mg/mL 104 mg/mL '<1 mg/mL
S1620 Darunavir Ethanolate <1 mg/mL 100 mg/mL <1 mg/mL
S6999 Chloroquine (NSC-187208) <1 mg/mL 64 mg/mL ''''64 mg/mL
S6929 Dextran sulfate sodium (DSS) 100 mg/mL <1 mg/mL <1 mg/mL
S3287 Rosamultin -1 mg/mL 100 mg/mL -1 mg/mL
S1639 Amprenavir (VX-478) <1 mg/mL 16 mg/mL '100 mg/mL
S6625 Temsavir (BMS-626529) <1 mg/mL 95 mg/mL <1 mg/mL
S5250 Darunavir <1 mg/mL 100 mg/mL 11 mg/mL
S9010 Bevirimat -1 mg/mL 100 mg/mL '-1 mg/mL
S6581 Fosamprenavir calcium salt <1 mg/mL 100 mg/mL 3 mg/mL
S2319 Limonin <1 mg/mL 44 mg/mL <1 mg/mL
S4662 Atazanavir <1 mg/mL 71 mg/mL 32 mg/mL
S9567 Indinavir Sulfate -1 mg/mL 100 mg/mL '-1 mg/mL
S4282 Nelfinavir (AG 1343) Mesylate <1 mg/mL 100 mg/mL ''100 mg/mL
S7381 Pepstatin A <1 mg/mL 57 mg/mL 1 mg/mL

HIV Protease製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1030

Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir (ABT-538)

Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir (ABT-378)

Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir (BMS-232632) Sulfate

Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S6999

Chloroquine (NSC-187208)

Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.

S6929

Dextran sulfate sodium (DSS)

Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.

S3287

Rosamultin

Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.

S1639

Amprenavir (VX-478)

Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S6625

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S5250

Darunavir

Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S6581

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

S9567

Indinavir Sulfate

Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir (AG 1343) Mesylate

Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1030

Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir (ABT-538)

Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir (ABT-378)

Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir (BMS-232632) Sulfate

Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S6999

Chloroquine (NSC-187208)

Chloroquine (NSC-187208, Aralen, CHQ, CQ) is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.

S6929

Dextran sulfate sodium (DSS)

Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.

S3287

Rosamultin

Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.

S1639

Amprenavir (VX-478)

Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S6625

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S5250

Darunavir

Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S6581

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

S9567

Indinavir Sulfate

Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir (AG 1343) Mesylate

Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.