HIVプロテアーゼ

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1030 Panobinostat (LBH589) <1 mg/mL 69 mg/mL ''<1 mg/mL
S1185 Ritonavir <1 mg/mL 100 mg/mL '''3 mg/mL
S1380 Lopinavir <1 mg/mL 126 mg/mL '''126 mg/mL
S3013 Plerixafor 8HCl (AMD3100 8HCl) 100 mg/mL <1 mg/mL ''<1 mg/mL
S1457 Atazanavir Sulfate <1 mg/mL 104 mg/mL '<1 mg/mL
S3287 Rosamultin -1 mg/mL 100 mg/mL ''-1 mg/mL
S0076 ABX464 <1 mg/mL 68 mg/mL ''''68 mg/mL
S6625 Temsavir (BMS-626529) <1 mg/mL 95 mg/mL <1 mg/mL
S6581 Fosamprenavir calcium salt <1 mg/mL 100 mg/mL 3 mg/mL
S1620 Darunavir Ethanolate <1 mg/mL 100 mg/mL ''<1 mg/mL
S1639 Amprenavir <1 mg/mL 16 mg/mL '100 mg/mL
S5250 Darunavir <1 mg/mL 100 mg/mL ''11 mg/mL
S9010 Bevirimat -1 mg/mL 100 mg/mL -1 mg/mL
S2319 Limonin <1 mg/mL 44 mg/mL <1 mg/mL
S4662 Atazanavir <1 mg/mL 71 mg/mL '32 mg/mL
S9567 Indinavir Sulfate -1 mg/mL 100 mg/mL '-1 mg/mL
S4282 Nelfinavir Mesylate <1 mg/mL 100 mg/mL ''100 mg/mL
S7381 Pepstatin A <1 mg/mL 57 mg/mL ''1 mg/mL

HIV Protease製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1030

Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir

Ritonavir (ABT-538, A 84538) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir

Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S3013

Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100, JM 3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.

S1457

Atazanavir Sulfate

Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S3287

Rosamultin

Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.

S0076

ABX464

ABX464 is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

S6625

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S6581

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir (141W94, VX-478, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S5250

Darunavir

Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

S9567

Indinavir Sulfate

Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1030

Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.

S1185

Ritonavir

Ritonavir (ABT-538, A 84538) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

S1380

Lopinavir

Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S3013

Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100, JM 3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.

S1457

Atazanavir Sulfate

Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S3287

Rosamultin

Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.

S0076

ABX464

ABX464 is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

S6625

Temsavir (BMS-626529)

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.

S6581

Fosamprenavir calcium salt

Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir (141W94, VX-478, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S5250

Darunavir

Darunavir (TMC114) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S9010

Bevirimat

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4662

Atazanavir

Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.

S9567

Indinavir Sulfate

Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.

S7381

Pepstatin A

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.