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Microtubule Associated
Microtubule Associated製品
- All (84)
- Microtubule Associated阻害剤 (59)
- Microtubule Associated抗体(3)
- Microtubule Associatedモジュレータ(4)
- 新製品
| 製品コード | 製品名称 | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|---|
| S1150 | Paclitaxel | パクリタキセル (Paclitaxel (NSC 125973, PTX)) は微小管を安定化することで脱重合を阻害します。ヒト血管内皮細胞における IC50 は 0.1 pM です。 |
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| S1148 | Docetaxel | Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
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| S1241 | Vincristine sulfate | Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis. |
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| S2775 | Nocodazole | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis. |
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| S1233 | 2-Methoxyestradiol (2-MeOE2) | 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. |
-S123306W0220150907.gif)
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| S7787 | Docetaxel Trihydrate | Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
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| S4505 | Vinblastine sulfate | Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis. | ||
| S4269 | Vinorelbine ditartrate | Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation. |
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| S3022 | Cabazitaxel | Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway. |
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| S2284 | Colchicine | Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. | ||
| S1364 | Patupilone (Epothilone B) | Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2. |
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| S7930 | Ixabepilone | Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. | ||
| S7204 | Fosbretabulin (Combretastatin A4 Phosphate) Disodium | Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3. |
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| S2195 | Lexibulin (CYT997) | Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2. |
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| S1640 | Albendazole | Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. |
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| S7336 | CW069 | CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP. |
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| S7721 | MMAE (Monomethyl auristatin E) | MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent. | ||
| S1165 | ABT-751 (E7010) | ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. |
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| S1176 | Plinabulin | Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2. | ||
| S7783 | Combretastatin A4 | Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3. | ||
| S7497 | CK-636 | CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | ||
| S1297 | Epothilone A | Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. | ||
| S7495 | TAI-1 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. | ||
| S0360 | EGFR Inhibitor | EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics. | ||
| S4535 | Methylene Blue | Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | ||
| S5256 | Benproperine phosphate | Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of actin polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis. | ||
| S3970 | Vindoline | Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly. | ||
| S9695 | iHAP1 | iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells. | ||
| S2254 | 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) | 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. | ||
| S0328 | MMAF | MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A. | ||
| E1068 | Nab-Paclitaxel | Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared. | ||
| S7762 | TRx0237 (LMTX) mesylate | TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | ||
| S7493 | INH1 | INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. | ||
| S0444 | Indibulin | Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis. | ||
| S3220 | Trigonelline | Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells. | ||
| F0167 | β-Tubulin Antibody [C23L2] | β-Tubulin Rabbit mAb recognizes endogenous levels of total β-Tubulin protein. | ||
| F0110 | Vinculin Antibody [M20M17] | Vinculin Rabbit mAb recognizes endogenous levels of total Vinculin protein. | ||
| F0063 | α-Tubulin Antibody [A15C7] | α-Tubulin Rabbit mAb detects endogenous levels of total α-tubulin protein, and does not cross-react with recombinant β-tubulin. | ||
| F0368 | βIII-Tubulin Antibody [L16E10] | β3-Tubulin Rabbit mAb recognizes endogenous levels of total β3-Tubulin protein. | ||
| F0059 | Phospho-Tau (Ser202/ Thr205) Antibody [C18J10] | Phospho-Tau (Ser202/ Thr205) Mouse mAb recognizes a phosphatase-senstive epitope on PHF-Tau. No cross reactivity with normal Tau has been observed. The epitope of this antibody contains the phosphorylated Ser202 (4,5) residue (numbering according to human Tau40). Phospho-Tau (Ser202, Thr205) Mouse mAb detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa | ||
| F1566 | Tubulin Antibody [G9A12] | |||
| F0928 | Tau Antibody [A12M24] | Tau Mouse mAb recognizes normal Tau from human and bovine brain and PHF-Tau. No cross reactivity with Tau from rat brain has been observed. The epitope of this antibody has been mapped on human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK | ||
| F2311 | Neuron-specific β-III Tubulin Antibody [P18E21] | |||
| F0620 | Acetyl-α-Tubulin (Lys40) Antibody [C17M7] | |||
| F3020New | Phospho-Tau (Ser416) Antibody [H22B7] | |||
| F1675 | β IV Tubulin Antibody [M17P6] | |||
| F1411 | TPX2 Antibody [H20H1] | |||
| F2614New | Phospho-Tau (Ser199) Antibody [F2N9] | |||
| F2118 | Plectin Antibody [G16H14] | |||
| F2687New | γ-Tubulin Antibody [J9F14] | |||
| F2472 | TPPP Antibody [F20K21] | |||
| S1836 | Albendazole Oxide | Albendazole Oxide (Ricobendazole,Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. | ||
| S2440 | Vindesine sulfate | Vindesine sulfate, a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. | ||
| S0510 | Myoseverin | Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM. | ||
| S9969 | RMC-4630 | Vociprotafib (RMC-4630) is a potent, selective, orally bioavailable allosteric inhibitor of SHP2 with potential anti-tumor activity. RMC-4630 targets, binds to and inhibits the activity of SHP2, thereby inhibiting the activation of the RAS-RAF-MEK-ERK signaling pathway. | ||
| F0548New | MAP2 Antibody [G20G3] | MAP2 Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total MAP2 protein. Non-specific labeling of the pancreas and macrophages in mouse liver tissue may be observed by immunofluorescence. | ||
| S4114 | Triclabendazole | Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. | ||
| S3374 | Verubulin hydrochloride | Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals. | ||
| E8284New | PM534 | PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer. | ||
| S6954 | CK-869 | CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo. | ||
| S8789 | SSE15206 | SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. | ||
| E7058New | DM4 | DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies. | ||
| E1426 | EAPB02303 | EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts. | ||
| D4003 | Trastuzumab Emtansine（T-DM1） | Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. | ||
| S0561New | Auristatin E | Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity. | ||
| S2447 | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. | ||
| E4897 | Estramustine | Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules. | ||
| S4071 | Griseofulvin | Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function. | ||
| S3725 | ELR-510444 | ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. | ||
| A2692 | Gosuranemab (Anti-Tau) | Gosuranemab (Anti-Tau) is a humanized monoclonal antibody against the extracellular N-terminal of tau in the interstitial fluid (ISF) and CSF released by neurons. It has the potential for research of alzheimer’s disease (AD). MW : 150 kD. | ||
| A2693 | Semorinemab (Anti-Tau) | Semorinemab (Anti-Tau) is a humanized IgG4 monoclonal antibody that targets the N-terminal domain of tau (amino acid residues 6-23). Semorinemab has the potential to be used in research on Alzheimer's disease. MW : 150 kD. | ||
| S6661 | VcMMAE | VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity. | ||
| S6772New | VERU-111 | Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines. | ||
| S6773 | DM1 (Mertansine) | DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are unstable and should be fresh-prepared. | ||
| S7494 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. | ||
| S3206 | 5a-Pregnane-3,20-dione | 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules. | ||
| E2402 | T-1101 tosylate | T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. | ||
| S8912 | Eribulin Mesylate | Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor. | ||
| S2441 | Estramustine phosphate sodium | Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects. | ||
| S2444 | Parbendazole | Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules. | ||
| S9555 | Vincristine | Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM. | ||
| E2851 | Trastuzumab-Emtansine（T-DM1） | Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.This product is supplied as 10mg/ml PBS solution. | ||
| A2341 | Zagotenemab (Anti-Tau) | Zagotenemab (Anti-Tau) is a humanised anti-tau antibody that selectively binds and neutralises tau deposits in the brain. It has the potential to be used in Alzheimer's disease research. MW : 145.5 KD | ||
| S5919 | KHS101 hydrochloride | KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks. | ||
| S1148 | Docetaxel | Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
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| S1241 | Vincristine sulfate | Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis. |
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| S2775 | Nocodazole | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis. |
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| S7787 | Docetaxel Trihydrate | Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. |
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| S4505 | Vinblastine sulfate | Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis. | ||
| S4269 | Vinorelbine ditartrate | Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation. |
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| S3022 | Cabazitaxel | Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway. |
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| S2284 | Colchicine | Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. | ||
| S1364 | Patupilone (Epothilone B) | Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2. |
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| S7930 | Ixabepilone | Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. | ||
| S7204 | Fosbretabulin (Combretastatin A4 Phosphate) Disodium | Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3. |
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| S2195 | Lexibulin (CYT997) | Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2. |
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| S1640 | Albendazole | Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. |
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| S7336 | CW069 | CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP. |
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| S7721 | MMAE (Monomethyl auristatin E) | MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent. | ||
| S1165 | ABT-751 (E7010) | ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. |
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| S7783 | Combretastatin A4 | Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3. | ||
| S7497 | CK-636 | CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | ||
| S1297 | Epothilone A | Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM. | ||
| S7495 | TAI-1 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. | ||
| S4535 | Methylene Blue | Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | ||
| S5256 | Benproperine phosphate | Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of actin polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis. | ||
| S3970 | Vindoline | Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly. | ||
| S9695 | iHAP1 | iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells. | ||
| S2254 | 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) | 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. | ||
| S0328 | MMAF | MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A. | ||
| E1068 | Nab-Paclitaxel | Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1:9. It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared. | ||
| S7762 | TRx0237 (LMTX) mesylate | TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | ||
| S7493 | INH1 | INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. | ||
| S0444 | Indibulin | Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis. | ||
| S3220 | Trigonelline | Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells. | ||
| S1836 | Albendazole Oxide | Albendazole Oxide (Ricobendazole,Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. | ||
| S2440 | Vindesine sulfate | Vindesine sulfate, a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. | ||
| S0510 | Myoseverin | Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM. | ||
| S9969 | RMC-4630 | Vociprotafib (RMC-4630) is a potent, selective, orally bioavailable allosteric inhibitor of SHP2 with potential anti-tumor activity. RMC-4630 targets, binds to and inhibits the activity of SHP2, thereby inhibiting the activation of the RAS-RAF-MEK-ERK signaling pathway. | ||
| S4114 | Triclabendazole | Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. | ||
| E8284New | PM534 | PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer. | ||
| S6954 | CK-869 | CK-869 (CK 0157869) is a small molecule inhibitor of actin-related protein 2/3 (Arp2/3) complex with an IC50 of 7 μM. CK-869 can directly suppresses microtubule assembly both in vitro and in vivo. | ||
| S8789 | SSE15206 | SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. | ||
| E7058New | DM4 | DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies. | ||
| E1426 | EAPB02303 | EAPB02303 is a second-generation imiqualine that acts as a microtubule -disruptingagent and demonstrates anti-tumor effects and reduces tumor size in human melanoma xenografts. | ||
| D4003 | Trastuzumab Emtansine（T-DM1） | Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. | ||
| S0561New | Auristatin E | Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity. | ||
| S2447 | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. | ||
| E4897 | Estramustine | Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules. | ||
| S4071 | Griseofulvin | Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function. | ||
| S3725 | ELR-510444 | ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. | ||
| S6661 | VcMMAE | VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity. | ||
| S6772New | VERU-111 | Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines. | ||
| S6773 | DM1 (Mertansine) | DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC). Solutions are unstable and should be fresh-prepared. | ||
| S7494 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. | ||
| S3206 | 5a-Pregnane-3,20-dione | 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules. | ||
| E2402 | T-1101 tosylate | T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. | ||
| S8912 | Eribulin Mesylate | Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor. | ||
| S2441 | Estramustine phosphate sodium | Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects. | ||
| S2444 | Parbendazole | Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules. | ||
| S9555 | Vincristine | Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM. | ||
| E2851 | Trastuzumab-Emtansine（T-DM1） | Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.This product is supplied as 10mg/ml PBS solution. | ||
| S5919 | KHS101 hydrochloride | KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks. | ||
| A2692 | Gosuranemab (Anti-Tau) | Gosuranemab (Anti-Tau) is a humanized monoclonal antibody against the extracellular N-terminal of tau in the interstitial fluid (ISF) and CSF released by neurons. It has the potential for research of alzheimer’s disease (AD). MW : 150 kD. | ||
| A2693 | Semorinemab (Anti-Tau) | Semorinemab (Anti-Tau) is a humanized IgG4 monoclonal antibody that targets the N-terminal domain of tau (amino acid residues 6-23). Semorinemab has the potential to be used in research on Alzheimer's disease. MW : 150 kD. | ||
| A2341 | Zagotenemab (Anti-Tau) | Zagotenemab (Anti-Tau) is a humanised anti-tau antibody that selectively binds and neutralises tau deposits in the brain. It has the potential to be used in Alzheimer's disease research. MW : 145.5 KD | ||
| S1233 | 2-Methoxyestradiol (2-MeOE2) | 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. |
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| S1176 | Plinabulin | Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2. | ||
| S0360 | EGFR Inhibitor | EGFR inhibitor, a cell permeable, 4,6-disubstituted pyrimidine compound, is a highly selevtive inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics. | ||
| S3374 | Verubulin hydrochloride | Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals. | ||
| F3020New | Phospho-Tau (Ser416) Antibody [H22B7] | |||
| F2614New | Phospho-Tau (Ser199) Antibody [F2N9] | |||
| F2687New | γ-Tubulin Antibody [J9F14] | |||
| F0548New | MAP2 Antibody [G20G3] | MAP2 Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total MAP2 protein. Non-specific labeling of the pancreas and macrophages in mouse liver tissue may be observed by immunofluorescence. | ||
| E8284New | PM534 | PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer. | ||
| E7058New | DM4 | DM4 is a potent maytansinoid and potent inhibitor of tubulin. It binds to α/β-tubulin heterodimers and inhibits tubulin polymerization and microtubule assembly, leading to enhanced microtubule destabilization. This strong antimitotic activity results in suppressed microtubule dynamics, causing mitotic arrest and apoptotic cell death, making it valuable for studying acute myeloid leukemia (AML) therapies. | ||
| S0561New | Auristatin E | Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity. | ||
| S6772New | VERU-111 | Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines. |
Microtubule Associatedシグナル伝達経路
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