MPS1

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2731 AZ 3146 <1 mg/mL 28 mg/mL 91 mg/mL
S8214 Empesertib (BAY1161909) <1 mg/mL 100 mg/mL <1 mg/mL
S8215 BAY 1217389 <1 mg/mL 100 mg/mL 3 mg/mL
S7488 MPI-0479605 <1 mg/mL 62 mg/mL 2 mg/mL

MPS1製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2731

AZ 3146

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.

S8214

Empesertib (BAY1161909)

Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.

S8215

BAY 1217389

BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.

S8911

BOS172722

BOS-172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 2 nM.

S7488

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

S0426

Pim1/AKK1-IN-1

Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor, MDK-2275) is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2731

AZ 3146

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.

S8214

Empesertib (BAY1161909)

Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.

S8215

BAY 1217389

BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.

S8911

BOS172722

BOS-172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 2 nM.

S7488

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

S0426

Pim1/AKK1-IN-1

Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor, MDK-2275) is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.