phosphatase

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S5003 Tacrolimus (FK506) <1 mg/mL 94 mg/mL ''83 mg/mL
S2286 Cyclosporin A <1 mg/mL 100 mg/mL ''100 mg/mL
S1949 Menadione <1 mg/mL 34 mg/mL 34 mg/mL
S1857 Etidronate 41 mg/mL <1 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S2435 Sodium stibogluconate 20 mg/mL <1 mg/mL <1 mg/mL
S0528 Raphin1 ˂1 mg/mL 46 mg/mL 2 mg/mL
S0302 F1063-0967 ˂1 mg/mL 100 mg/mL ˂1 mg/mL
S0119 PTP1B-IN-2 ˂1 mg/mL 100 mg/mL ˂1 mg/mL
S0136 KY-226 <1 mg/mL 96 mg/mL 1.5 mg/mL
S4007 Pentamidine isethionate 100 mg/mL 100 mg/mL <1 mg/mL
S7437 Sal003 <1 mg/mL 93 mg/mL <1 mg/mL
S4013 Sodium Monofluorophosphate 29 mg/mL <1 mg/mL <1 mg/mL
S5452 Sanguinarine chloride <1 mg/mL 5 mg/mL <1 mg/mL
S7639 3PO <1 mg/mL 42 mg/mL 42 mg/mL
S6109 H-HoArg-OH 37 mg/mL <1 mg/mL -1 mg/mL
S3696 PTP Inhibitor I <1 mg/mL 43 mg/mL 43 mg/mL
S8718 RMC-4550 -1 mg/mL 100 mg/mL -1 mg/mL
S3678 PTP Inhibitor II <1 mg/mL 45 mg/mL 45 mg/mL
S7485 CCT007093 <1 mg/mL 1 mg/mL <1 mg/mL
S7537 LB-100 53 mg/mL <1 mg/mL <1 mg/mL
S7383 (-)-p-Bromotetramisole Oxalate 30 mg/mL 74 mg/mL <1 mg/mL
S8278 SHP099 2 mg/mL 77 mg/mL <1 mg/mL
S7573 GSK2830371 <1 mg/mL 92 mg/mL 92 mg/mL
S3670 Cefsulodin sodium 100 mg/mL 100 mg/mL <1 mg/mL
S3620 β-Glycerophosphate sodium salt hydrate 61 mg/mL <1 mg/mL <1 mg/mL
S5525 SodiuM Metatungstate -1 mg/mL 30 mg/mL -1 mg/mL
S5441 1-Naphthyl phosphate potassium salt -1 mg/mL 20 mg/mL -1 mg/mL
S8182 NSC87877 100 mg/mL 100 mg/mL <1 mg/mL
S5431 L-Homoarginine hydrochloride 44 mg/mL <1 mg/mL -1 mg/mL
S8248 IQ-1 <1 mg/mL 72 mg/mL 7 mg/mL
S8774 DT-061(SMAP) <1 mg/mL 100 mg/mL 50 mg/mL

phosphatase製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S5003

Tacrolimus (FK506)

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

S2286

Cyclosporin A

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

S1949

Menadione

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

S1857

Etidronate

Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S2435

Sodium stibogluconate

Sodium stibogluconate, a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.

S0528

Raphin1

Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.

S0302

F1063-0967

F1063-0967 is an inhibitor of Dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM.

S0119

PTP1B-IN-2

PTP1B-IN-2 (MDK3465) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin-stimulated glucose uptake.

S0136

KY-226

KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.

S4007

Pentamidine isethionate

Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

S4013

Sodium Monofluorophosphate

Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S7639

3PO

3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.

S6109

H-HoArg-OH

H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.

S3696

PTP Inhibitor I

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.

S8718

RMC-4550

RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.

S3678

PTP Inhibitor II

PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.

S7485

CCT007093

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.

S7383

(-)-p-Bromotetramisole Oxalate

(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

S8278

SHP099

SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.

S7573

GSK2830371

GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.

S3670

Cefsulodin sodium

Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.

S3620

β-Glycerophosphate sodium salt hydrate

β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.

S5595

3-Carene

3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.

S5525

SodiuM Metatungstate

Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation.

S5441

1-Naphthyl phosphate potassium salt

1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.

S8182

NSC87877

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

S5431

L-Homoarginine hydrochloride

L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.

S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

S8774

DT-061(SMAP)

DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S5003

Tacrolimus (FK506)

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

S2286

Cyclosporin A

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

S1949

Menadione

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

S1857

Etidronate

Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S2435

Sodium stibogluconate

Sodium stibogluconate, a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.

S0528

Raphin1

Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.

S0302

F1063-0967

F1063-0967 is an inhibitor of Dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM.

S0119

PTP1B-IN-2

PTP1B-IN-2 (MDK3465) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin-stimulated glucose uptake.

S0136

KY-226

KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.

S4007

Pentamidine isethionate

Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

S4013

Sodium Monofluorophosphate

Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S7639

3PO

3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.

S6109

H-HoArg-OH

H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.

S3696

PTP Inhibitor I

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.

S8718

RMC-4550

RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.

S3678

PTP Inhibitor II

PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.

S7485

CCT007093

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.

S7383

(-)-p-Bromotetramisole Oxalate

(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

S8278

SHP099

SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.

S7573

GSK2830371

GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.

S3670

Cefsulodin sodium

Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.

S3620

β-Glycerophosphate sodium salt hydrate

β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.

S5595

3-Carene

3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.

S5525

SodiuM Metatungstate

Sodium metatungstate (SMT) solution is an inorganic heavy liquid which is widely used in density fractionation.

S5441

1-Naphthyl phosphate potassium salt

1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.

S8182

NSC87877

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

S5431

L-Homoarginine hydrochloride

L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.

S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S8774

DT-061(SMAP)

DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

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