phosphatase

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1949 Menadione <1 mg/mL 34 mg/mL 34 mg/mL
S1857 Etidronate 41 mg/mL <1 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S4007 Pentamidine isethionate 100 mg/mL 100 mg/mL <1 mg/mL
S7437 Sal003 <1 mg/mL 93 mg/mL <1 mg/mL
S5452 Sanguinarine chloride <1 mg/mL 5 mg/mL <1 mg/mL
S5431 L-Homoarginine hydrochloride 44 mg/mL <1 mg/mL -1 mg/mL
S5441 1-Naphthyl phosphate potassium salt -1 mg/mL 20 mg/mL -1 mg/mL
S7639 3PO <1 mg/mL 42 mg/mL 42 mg/mL
S3678 PTP Inhibitor II <1 mg/mL 45 mg/mL 45 mg/mL
S4013 Sodium Monofluorophosphate 29 mg/mL <1 mg/mL <1 mg/mL
S3696 PTP Inhibitor I <1 mg/mL 43 mg/mL 43 mg/mL
S7485 CCT007093 <1 mg/mL 1 mg/mL <1 mg/mL
S7537 LB-100 53 mg/mL <1 mg/mL <1 mg/mL
S8278 SHP099 2 mg/mL 77 mg/mL <1 mg/mL
S7573 GSK2830371 <1 mg/mL 92 mg/mL 92 mg/mL
S3670 Cefsulodin sodium 100 mg/mL 100 mg/mL <1 mg/mL
S3620 β-Glycerophosphate sodium salt hydrate 61 mg/mL <1 mg/mL <1 mg/mL
S8182 NSC87877 100 mg/mL 100 mg/mL <1 mg/mL
S8248 IQ-1 <1 mg/mL 72 mg/mL 7 mg/mL
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1949

Menadione

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

S1857

Etidronate

Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.

S1514

Cyclosporine

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

S4007

Pentamidine isethionate

Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.

S7437

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S5431

L-Homoarginine hydrochloride

L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.

S5441

1-Naphthyl phosphate potassium salt

1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.

S7639

3PO

3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.

S3678

PTP Inhibitor II

PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.

S4013

Sodium Monofluorophosphate

Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

S3696

PTP Inhibitor I

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.

S7485

CCT007093

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

S7537

LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.

S8278

SHP099

SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.

S7573

GSK2830371

GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.

S3670

Cefsulodin sodium

Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.

S3620

β-Glycerophosphate sodium salt hydrate

β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.

S8182

NSC87877

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

S8248

IQ-1

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

Tags: phosphatase inhibition | phosphatase inhibitor drugs | phosphatase activation | phosphatase targets | phosphatase inhibitor cancer | phosphatase assay | phosphatase signaling pathway | phosphatase inhibitor clinical trial | phosphatase inhibitor review
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