Lamivudine (BCH-189)

For research use only. Not for use in humans.

製品コードS1706 別名:GR109714X

Lamivudine (BCH-189)化学構造

CAS No. 134678-17-4

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 23500
JPY 13300
JPY 21400
JPY 33000
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バルク問合せ

カスタマーフィードバック(1)

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine (BCH-189) purchased from Selleck.

製品安全説明書

Reverse Transcriptase阻害剤の選択性比較

生物活性

製品説明 Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
ターゲット
Reverse transcriptase [1]
体外試験

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT-4 MlG2SpVv[3Srb36gZZN{[Xl? MV3Dc45k\W62cnH0bY9vKHKncYXpdoVlKHSxIHnubIljcXRic4nueIlk[SCob4LtZZRqd25iYomgOVAmKGmwIFjJWk0yKGmwZnXjeIVlKE2WLUSgZ4VtdHNuIFnDOVA:OC5zzszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85ODN3NEK5K|45ODN3NEK5QE9iRg>?
PBMC Moj4SpVv[3Srb36gZZN{[Xl? M1rPemNwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJIFvfGm4aYLhcEBi[3Srdnn0fUBqdiCSQl3DJEhpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy|KTDpcoZm[3SnZDD3bZRpKEiLVj2xJJN1emGrbjDMRXYtKEWFNUC9NE4xODF6zszN MorXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDRzMEm3OUc,QDRzMEm3OVww[T5?
PBMC NWnKZncxTnWwY4Tpc44h[XO|YYm= M2DFe2NwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJIFvfGm4aYLhcEBi[3Srdnn0fUBqdiCSQl3DJEhpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy|KTDpcoZm[3SnZDD3bZRpKEiLVj2xJJN1emGrbjDMRXYtKEWFNUC9NE4zOc7:TR?= NWe5eGo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESxNFk4PSd-OESxNFk4PTxxYU6=
PBMC NFjvSFFCdnSrLVjJWk0yKGG|c3H5 MVHBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5yMEG4{txO MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDJ|NUmxK|45PDJ|NUmxQE9iRg>?
PBMC M{THOmFvfGlvSFnWMVEh[XO|YYm= NIrQSXdCdnSrLVjJWk0yKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyCrbn\lZ5Rm\CC5aYToJGhKXi1zIIP0doFqdiCOQW[sJGVEPTB;MD6wOu69VQ>? MlzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDR{M{W5NUc,QDR{M{W5NVww[T5?
PBMC NFzX[W1CdnSrLVjJWk0yKGG|c3H5 MYXBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OC5{Md88US=> Mm[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDR{M{W5NUc,QDR{M{W5NVww[T5?
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PBMC Mn\hRY51cS2KSW[tNUBie3OjeR?= NWrndI5[UW5idnn0do8h[W62aT3ITXYh[WO2aY\peJkhcW5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiRVO1NF0xNjB5zszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86OzBzNkW5K|46OzBzNkW5QE9iRg>?
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PBMC Ml\XSpVv[3Srb36gZZN{[Xl? NV2z[Y9lSWO2aY\peJkh[WejaX7zeEBN[W2rdoXkbY5mNXKnc3nzeIFvfCC4aYL1d{ApUEmYLUHYXGJTXSliaX6gbJVu[W5iUFLNJINmdGy|LDDlfJBz\XO|ZXSgZZMhTUN3MDygSWM2OD1yLkCzOe69VQ>? M3vKTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyO|U2Lz5zMki1Nlc2PTxxYU6=
PBMC MUHGeY5kfGmxbjDhd5NigQ>? MmDITY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBJUVZvMTDMRVEhemWybHnjZZRqd25ib36gVGJOS3NiY3XscEApeGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{ktKEWFNUC9NE4xOc7:TR?= M123SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyPVQ{Lz5zMki1Nlk1OzxxYU6=
PBMC M1zGXWZ2dmO2aX;uJIF{e2G7 NVfMUoY4TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBJUVZvMTDMRWkh[3m2b4DheIhq[2m2eTDpckBRSk2FIHPlcIx{KHejczDk[ZRmem2rbnXkJIlvKH[rdILvMEBGSzVyPUCuNFEyPs7:TR?= NY\0fI5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5O|E5QThpPkG0PVcyQDl6PD;hQi=>
HepG2.2.15 Ml\jSpVv[3Srb36gZZN{[Xl? NIC5R2VG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JIhmeGG2aYTpd{BDKH[rcoXzJIN6fG:yYYTobYNqfHliaX6gTIVxTzJwMj6xOUBk\WyuczD3ZZMh\GW2ZYLtbY5m\CCrbjD2bZRzdyxiRVO1NF0xNjMQvF2= M{PFXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUexPFk5Lz5zNEm3NVg6QDxxYU6=
MT-4 M17RSmZ2dmO2aX;uJIF{e2G7 NH\LeHVG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JGhKXi1zIFnJTWIh[3m2b4DheIhq[2m2eTDpckBOXC12IHPlcIx{KHejczDk[ZRmem2rbnXkJIlvKH[rdILvMEBGSzVyPUCuOe69VQ>? M2nzbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUexPFk5Lz5zNEm3NVg6QDxxYU6=
PBMC MkTkRY51cX[rcnHsJIF{e2G7 NYLH[lZtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVjD2bZJ2eyi6eFLSWUkhcW5iSIXtZY4heGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiBqUFLNLUBk\WyuczygSWM6OD1yLkC4{txO M12zblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MEK3PFU1Lz5zNUCyO|g2PDxxYU6=
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2.2.15 M37NXGZ2dmO2aX;uJIF{e2G7 NFjnRVhG\m[nY4TpeoUh[2:wY3XueJJifGmxboOgZZQhf2irY3igNVAu\m:uZDDk[ZBz\XO|aX;uJI9nKGmwdILhZ4VtdHWuYYKgbY51\XKvZXTpZZRmeyCxZjDIRnYhTE6DIIfhd{Bw[nOnco\l[EBqdiB{LkKuNVUhS2WubIOsJGVEQTB;MD62Pe69VQ>? MmTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{OyPFMoRjF4MEOzNlg{RC:jPh?=
2.2.15 NXjNNWMyTnWwY4Tpc44h[XO|YYm= MnLxTY5pcWKrdHnvckBw\iC|eX70bIV{cXNib3[g[Zh1emGlZXzseYxieiC4aYLpc44hTE6DIILlcIVie2ViaX6gZ5VtfHW{ZXSgbJVu[W5iaHXwZZRw[myjc4TvcYEhOi5{LkG1JINmdGy|LDDFR|UxRTBwMES4{txO M1T1[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MkGzO|E{Lz5zNkKxN|cyOzxxYU6=
2.2.15 M4HMRWZ2dmO2aX;uJIF{e2G7 M3H6WWlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIV5fHKjY3XscJVt[XJidnnybY9vKESQQTDy[Yxm[XOnIHnuJIN2dHS3cnXkJIh2dWGwIHjldIF1d2KuYYP0c41iKDJwMj6xOUBk\WyuczygSWM6OD1yLkG1Ne69VQ>? M2XtSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MkGzO|E{Lz5zNkKxN|cyOzxxYU6=
2.2.15 NYL4O29lTnWwY4Tpc44h[XO|YYm= M{G2NWlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGm4ZTDpcpRmem2nZHnheIV{KGmwIHP1cJR2emWmIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0xNjJ3Md88US=> Mnr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ{MUO3NVMoRjF4MkGzO|E{RC:jPh?=
2.2.15 MXHGeY5kfGmxbjDhd5NigQ>? MnjRTY5pcWKrdHnvckBw\iC|eX70bIV{cXNib3[gbY51emGlZXzseYxieiCKQm[gSG5CKHKncHzpZ4F1cX[nIHnueIVzdWWmaXH0[ZMhcW5iY4XseJVz\WRiaIXtZY4hcGWyYYTvZoxie3SxbXGgNk4zNjF3IHPlcIx{NCCHQ{mwQVAvPjR6zszN M13DSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MkGzO|E{Lz5zNkKxN|cyOzxxYU6=
2.2.15 MonXSpVv[3Srb36gZZN{[Xl? MljnTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViSFLWJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO1NF0zNjIQvF2= NH\rPGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM6Oyd-MU[1N|k{QTN:L3G+
hepatoma 2.2.15 MkfCRY51cX[rcnHsJIF{e2G7 NGK1bGdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEKYIHnuJIh2dWGwIHjldIF1d22jIEKuNk4yPSClZXzsd{whTUN3ME2yMlHPxE1? MoPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NUmxNVIoRjF4N{W5NVEzRC:jPh?=
2.2.15 NESzbllHfW6ldHnvckBie3OjeR?= NXfPeFFbUW6qaXLpeIlwdiCxZjDIRnYhemWybHnjZZRqd25iaX6gNk4zNjF3IHPlcIx{KGK7IFTORUBpgWK{aXTpfoF1cW:wIHHzd4F6NCCHQ{WwQVAvODMQvF2= Mmj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NlYoRjF5MEC0O|I3RC:jPh?=
MDCK2 MYLGeY5kfGmxbjDhd5NigQ>? NXfYZmZjOTBidV2= NGrOd5lKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEKg[ZhxemW|c3XkJIlvKE2GQ1uyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR21HKG[udX;y[ZNk\W6lZTDheEAyOCC3TTDifUBEVU[GQTDhd5NigQ>? NELofno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3NlMyOSd-MUexO|I{OTF:L3G+
MDCK2 MlOzSpVv[3Srb36gZZN{[Xl? NYfpbppoOTBidV2= MlHZTY5pcWKrdHnvckBw\iCqdX3hckBOWlB|IHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IFPNSkBndHWxcnXzZ4Vv[2ViYYSgNVAhfU1iYomgR21HTEFiYYPzZZk> NILtR3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G3NlMyOSd-MUexO|I{OTF:L3G+
MDCK2 NFfZPYVHfW6ldHnvckBie3OjeR?= NInYTnAyOCC3TR?= NXrjVZBUUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCxJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5MkOxNUc,OTdzN{KzNVE9N2F-
Huh7 MnTzSpVv[3Srb36gZZN{[Xl? NFPJdItKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDIRnYhemWybHnjZZRqd25iaX6gTJVpPyClZXzsd{whTUN3ME2x{txO MlvNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|N{G4NlcoRjF5M{exPFI4RC:jPh?=
PBMC NW[4bpZFSW62aY\pdoFtKGG|c3H5 M3OyS2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFiTFHJJIlvKGi3bXHuJHBDVSClZXzsd{whTUN3ME2wMlAzPs7:TR?= NVTOOYdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NFM6QTZpPkG3OFA{QTl4PD;hQi=>
PBMC M2\pVWFvfGm4aYLhcEBie3OjeR?= NXPYU5V2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDMRWkhcW5iaIXtZY4hWEKPIHPlcIx{NCCHQ{mwQVAvOTMQvF2= MmnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MEO5PVYoRjF5NECzPVk3RC:jPh?=
HepG2.2.15 MWLBcpRqfmm{YXygZZN{[Xl? MlnsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIFjldGczNjJwMUWgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h\Xi2cnHj[YxtfWyjcjD2bZJidCCGTlGgcIV3\WxiYomgVnQuWEOULDDFR|UxRTBwMd88US=> NEe5OGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SwOFAxPid-MUe0NFQxODZ:L3G+
Huh7 MWnBcpRqfmm{YXygZZN{[Xl? M2KyXFUh\GG7cx?= NX76XY5VSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHflco91gXCnIFSge4l1cCC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFgxUSCvdYTheIlwdiCrbjDoeY1idiCKdXi3JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPSCmYYnzMEBGSzVyPUCuNFPPxE1? Ml;CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOFcoRjF5NEO4NFQ4RC:jPh?=
Huh7 NXPRWHcySW62aY\pdoFtKGG|c3H5 MVG1JIRigXN? M4XiOmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhD\UGpLXTl[olkcWWwdDDIRnYh\2Wwb4T5dIUhTCC5aYToJJBz\WOxcnWgS|E5QT[DIH31eIF1cW:wIHHu[EBz\X[ncoPlJJRz[W6|Y4LpdJRie2ViTEiwTUBufXSjdHnvckBqdiCqdX3hckBJfWh5IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgOUBl[Xm|LDDFR|UxRTBwMEROwG0> M3r5d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
Huh7 NVvsWGpkSW62aY\pdoFtKGG|c3H5 NFywTXk2KGSjeYO= NGPuUJdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiZ3Xuc5R6eGViRDDpckBpfW2jbjDIeYg4KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNTDkZZl{NCCHQ{WwQVAvPDIQvF2= MnvWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOFcoRjF5NEO4NFQ4RC:jPh?=
Huh7 NYnXSGs3SW62aY\pdoFtKGG|c3H5 NG\rTGY2KGSjeYO= M3jTbGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhD\UGpLXTl[olkcWWwdDDIRnYh\2Wwb4T5dIUhTCC5aYToJJBz\WOxcnWgS|E5QT[DIH31eIF1cW:wIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMtKEWFNUC9NE41Ps7:TR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
HepG2(2.2.15) NX;FWHNtSW62aY\pdoFtKGG|c3H5 MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iYYn3JJdqdGRidInw[UBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygSG5CKHKncHzpZ4F1cW:wLDDJR|UxRTBwMEZOwG0> NUXINZZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepG2(2.2.15) MkX1SpVv[3Srb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKEiEVjDwdo9ud3SncjDpckBpfW2jbjDI[ZBIOih{LkKuNVUqKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkC4{txO M3eyXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEi4PFE4Lz5zN{S4PFgyPzxxYU6=
HepW10 NEnkT|hCdnSrdnnyZYwh[XO|YYm= NV3pVpo{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnuJIFlemmjbYnjbY4uemW|aYP0ZY51KHerbHSgeJlx\SCKZYDXNVAh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCGTlGgdoVxdGmlYYTpc44tKEmFNUC9NE4y|ryP MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEi4NVcoRjF5NEi4PFE4RC:jPh?=
HBV-Met MXTBcpRqfmm{YXygZZN{[Xl? NFniflZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX6gcY92e2ViYYn3JJdqdGRidInw[UBJSlZvTXX0JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uMEBKSzVyPUCuNu69VQ>? M3vpclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEi4PFE4Lz5zN{S4PFgyPzxxYU6=
HepG2.2.15 MYHGeY5kfGmxbjDhd5NigQ>? NH3UcnQ5KGSjeYO= MYLJcohq[mm2aX;uJI9nKGO7dH;wcIF{dWmlIFjCWkBFVkFic4nueIhme2m|IHnuJGhmeEd{LkKuNVUh[2WubIOgZYZ1\XJiODDkZZl{NCCLQ{WwQVAvOzkQvF2= M2TaNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm5PFg6Lz5zN{S5PVg5QTxxYU6=
PBMC NYrUOlVVTnWwY4Tpc44h[XO|YYm= MXuzNFAhdWd? MoXsO{Bl[Xm| NEDGZ3FEdWG6IHnuJGhKXi2rbn\lZ5Rm\CCqdX3hckBie3Onc4Pl[EBieyCOYX3pepVlcW6nIH3vco9xcG:|cHjheIUhdGW4ZXygbY4hWEKPQzDheEA{ODBibXegVWQh\m:{IEeg[IF6eyCvZXHzeZJm\CCyZYKgNVAoPiClZXzsd{BqdiCycnXz[Y5k\SCxZjD6bYRwfnWmaX7lMEBEdWG6PUCuNFAxODByON88US=> MkLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkSzNlgoRjF5Nk[0N|I5RC:jPh?=
PBMC MVzGeY5kfGmxbjDhd5NigQ>? MXezNFAhdWd? NITGSmc4KGSjeYO= M2q1cWNu[XhiaX6gTGlXNWmwZnXjeIVlKGi3bXHuJIF{e2W|c3XkJIF{KEyjbXn2eYRqdmViZHnwbI9{eGijdHWgcIV3\WxiaX6gVGJOSyCjdDCzNFAhdWdiUVSg[o9zKDdiZHH5d{Bu\WG|dYLl[EBx\XJiMUCnOkBk\WyuczDpckBxemW|ZX7j[UBw\iC8aXTvepVlcW6nLDDDcYF5RTBwMECwNFA1PM7:TR?= NUD2UYJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2OlQ{OjhpPkG3OlY1OzJ6PD;hQi=>
PBMC Mm\6SpVv[3Srb36gZZN{[Xl? M3LTNlMxOCCvZx?= Mm\KO{Bl[Xm| NVHRWY1kS22jeDDpckBJUVZvaX7m[YN1\WRiaIXtZY4h[XO|ZYPz[YQh[XNiTHHtbZZ2\GmwZTD0dolxcG:|cHjheIUhdGW4ZXygbY4hWEKPQzDheEA{ODBibXegVWQh\m:{IEeg[IF6eyCvZXHzeZJm\CCyZYKgNVAoPiClZXzsd{BqdiCycnXz[Y5k\SCxZjD6bYRwfnWmaX7lMEBEdWG6PUCuNFAxODB2ON88US=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ4NEOyPEc,OTd4NkSzNlg9N2F-
MAGIC-5A NXzEOWpOSW62aY\pdoFtKGG|c3H5 M3vXd|QxKGi{cx?= NUXMWIlLSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiLVkGgUmw1NTNicILv[JVk\WRiZoLvcUBnfWyuIHzlcod1cCCyUknk[Yx1[UGyYTDpcoZm[3SnZDDpckBpfW2jbjDNRWdKSy13QTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEyjYzug[o9kcSCneIDy[ZN{cW:wIHHmeIVzKDRyIHjyd{whTUN3ME2wMlg5|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4N{mxN{c,OTd7Nke5NVM9N2F-
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MT2 NIG5[25CdnSrdnnyZYwh[XO|YYm= NFTkRWc2KGSjeYO= NHHtO3BCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjB3IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjCyJIhzNXC{ZYTy[YF1\WRiaIXtZY4hVVR{IHPlcIx{KG2nYYP1doVlKGGodHXyJFUh\GG7czDifUBTXCCVUFGsJGVEPTB;Mj60O:69VQ>? MoLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MU[1NlEoRjF6M{G2OVIyRC:jPh?=
MT2 MnLMRY51cX[rcnHsJIF{e2G7 NGnHRZg2KGSjeYO= NHKybpJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjB3IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjCyJIhzNXC{ZYTy[YF1\WRiaIXtZY4hVVR{IHPlcIx{KG2nYYP1doVlKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9N{4zPDgQvF2= M3zieFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{G2OVIyLz5zOEOxOlUzOTxxYU6=
HepG2(2.2.15) M4rndmFvfGm4aYLhcEBie3OjeR?= MW[yOEBpenN? M3TJPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbjDoeY1idiCKZYDHNkgzNjJwMUWpJINmdGy|IHHzd4V{e2WmIHHzJIV5fHKjY3XscJVt[XJiSFLWJJZqemmxbjDEUmEhdGW4ZXygZYZ1\XJiMkSgbJJ{NCCHQ{WwQVAvODR6zszN MljzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
HepG2(2.2.15) MXrBcpRqfmm{YXygZZN{[Xl? NWLiWoZ6OjRiaILz Ml3TRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwIHj1cYFvKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVxdGmlYYTpc44hcW62ZYLt[YRq[XSnczDh[pRmeiB{NDDodpMtKEWFNUC9NE4yPc7:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 M3XhdmFvfGm4aYLhcEBie3OjeR?= MWi0JIRigXN? MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDsZY1qfnWmaX7lMZJme2m|dHHueEB4cWymIIT5dIUhUEKYIHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2wMlLPxE1? NGfYbmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 NFLqfIRCdnSrdnnyZYwh[XO|YYm= M3nZPVQh\GG7cx?= MkKwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UAzOz[WIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MD6z{txO MoG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 NHf0[FlCdnSrdnnyZYwh[XO|YYm= NFrTOHY1KGSjeYO= M2fOPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEB4cWymIIT5dIUhUEKYIHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2xMlPPxE1? M4O5R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 MoP1RY51cX[rcnHsJIF{e2G7 NUjHRmh6PCCmYYnz MUTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDNNlA1XiCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTFwNd88US=> MljNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 NH6wcnBCdnSrdnnyZYwh[XO|YYm= MUi0JIRigXN? NFHJOVNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GWob4\pdk1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UBNOThyTTDteZRidnRiaX6gbJVu[W5iSIXoO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliaX70doFk\WyudXzhdkBJSlZiRF7BJJJmeGyrY3H0bY9vKGG|c3H5MEBGSzVyPUGuOu69VQ>? NFXNTHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 Ml\KRY51cX[rcnHsJIF{e2G7 NVO5XVZkPCCmYYnz MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMUU9z\X[ncoPlJJRz[W6|Y4LpdJRie2ViTW[g[I92[mynIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT62{txO MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 M1nIOWFvfGm4aYLhcEBie3OjeR?= MXK0JIRigXN? MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDNNlA1USCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTFwON88US=> NXGxSFlHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
Huh7 NWHWR2xXSW62aY\pdoFtKGG|c3H5 NITsemI1KGSjeYO= NFvoXVhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GWob4\pdk1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UAzOz[WIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;Nz63{txO NGOwfZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 MnH1RY51cX[rcnHsJIF{e2G7 NWLMTo1{PCCmYYnz MYrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDsZY1qfnWmaX7lMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJGwyQDCPIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MUFOwG0> MljUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
HuH7 NGr3d2tCdnSrdnnyZYwh[XO|YYm= M2XjZ|I1KGi{cx?= NU\zPIo3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBpfW2jbjDIeWg4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKHS{YX7zbYVvfCC2cnHud4Zm[3Srb36gZYZ1\XJiMkSgbJJ{NCCHQ{WwQVAvOs7:TR?= NVXMfVB2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVg3PDhpPkG5N|k5PjR6PD;hQi=>
HuH7 MmLLRY51cX[rcnHsJIF{e2G7 NUeyZmRyOjRiaILz MmjjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGijcnLvdolv\yCUTlGgdI9tgW2ncnHz[UBPOjN4VDDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqemGuIITyZY5{cWWwdDD0doFve2[nY4Tpc44h[W[2ZYKgNlQhcHK|LDDFR|UxRTBwM988US=> M4\FfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m4OlQ5Lz5zOUO5PFY1QDxxYU6=
HuH7 M{Lhb2FvfGm4aYLhcEBie3OjeR?= NFHiUYYzPCCqcoO= M{PO[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVjJ|NmSgcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM6OD1zLkZOwG0> MkjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
HuH7 NFrDdVlCdnSrdnnyZYwh[XO|YYm= MXKyOEBpenN? NWO2WGw3SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhf2muZDD0fZBmKEiEVjDpcoZm[3SnZDDpckBpfW2jbjDIeWg4KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwII\pdoFtKHS{YX7zbYVvfCC2cnHud4Zm[3Srb36gZYZ1\XJiMkSgbJJ{NCCHQ{mwQVPPxE1? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7OE[0PEc,OTl|OUi2OFg9N2F-
HuH7 MWfBcpRqfmm{YXygZZN{[Xl? M4i5PVI1KGi{cx?= Ml\KRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGijcnLvdolv\yCUTlGgdI9tgW2ncnHz[UBNOThyTTDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqemGuIITyZY5{cWWwdDD0doFve2[nY4Tpc44h[W[2ZYKgNlQhcHK|LDDFR|UxRTF4zszN MmHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
HuH7 M{mwdWFvfGm4aYLhcEBie3OjeR?= MmHwNlQhcHK| M{LSb2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCqYYLic5JqdmdiUl7BJJBwdHmvZYLhd4UhVDF6MF2gcZV1[W62IHflcoUhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDD0doFve2mnboSgeJJidnOoZXP0bY9vKGGodHXyJFI1KGi{czygSWM6OD12Md88US=> MoXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
MT2 NV\MO21oSW62aY\pdoFtKGG|c3H5 Mn\yRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCrbn\lZ5Rm\CCrbjDoeY1idiCPVEKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdixiSVO1NF0xNjcQvF2= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7Nki4OUc,OTl3OU[4PFU9N2F-
HeLa P4/R5 MWDBcpRqfmm{YXygZZN{[Xl? NXHiNm41SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKFB2L2K1JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25uIFnDOVA:OC55ON88US=> M1:4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUm2PFg2Lz5zOUW5Olg5PTxxYU6=
TZM-bl NH2wSIhCdnSrdnnyZYwh[XO|YYm= NELqbFI4OiCqcoO= M1q2eGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFicF7MOE0{KGijcnLvdolv\yCUZY\ldpNmKHS{YX7zZ5JqeHSjc3WgVFEyQVNibYX0ZY51KGenbnWgbY5n\WO2ZXSgbY4hXFqPLXLsJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVAvPDgQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN|E9N2F-
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TZM-bl NHnDblRCdnSrdnnyZYwh[XO|YYm= MU[3NkBpenN? NHrDbFhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIDOUFQuOyCqYYLic5JqdmdiUnX2[ZJ{\SC2cnHud4NzcXC2YYPlJHQyPjWDIH31eIFvfCCpZX7lJIlv\mWldHXkJIlvKFScTT3icEBk\WyuczDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG|ZTDhd5NigSxiRVO1NF0yNjB6zszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN|E9N2F-
TZM-bl MnfVRY51cX[rcnHsJIF{e2G7 M{\hd|czKGi{cx?= NHPifYtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIIDOUFQuOyCqYYLic5JqdmdiUnX2[ZJ{\SC2cnHud4NzcXC2YYPlJHAyOTmVL2SxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2yMlHPxE1? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyNEGzNUc,OTl5MESxN|E9N2F-
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HepG2(2.2.15) NX\USmRjSW62aY\pdoFtKGG|c3H5 NITGSoc3KGSjeYO= M{e4d2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCneITyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZpkhemWjbD30bY1mKHGSQ2KgcYV1cG:mLDDFR|UxRTBwMEJOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5NEc,Ojd5NEi1PVA9N2F-
MT4 NV3ZZWFkSW62aY\pdoFtKGG|c3H5 MWO1JIRigXN? NYDzeYxYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2II\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgOUBl[Xm|IHL5JG1VXCCjc4PhfUwhTUN3ME2yMlIz|ryP MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5NEc,Ojd5NEi1PVA9N2F-
MT4 MkjQRY51cX[rcnHsJIF{e2G7 M1rBVlUh\GG7cx?= NY\HNI9USW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMjDSU2QhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5Rm[3Srb36gZYdicW6|dDD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEWFNUC9PE45Oc7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5NEc,Ojd5NEi1PVA9N2F-
Huh7 MUnBcpRqfmm{YXygZZN{[Xl? Ml34RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhf2muZDD0fZBmKGincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKHOnY4LleIVlKESQQTDs[ZZmdHNibXXhd5Vz\WRib36g[IF6KDdiYomgdoVidC22aX3lJHBEWiCjbnHsfZNqeyxiRVO1NF0xNjB3Nd88US=> NHu4c3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
HepG2.215 MorVRY51cX[rcnHsJIF{e2G7 Mlj1RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJwMkG1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBFVkFicnXwcIlk[XSrb36gcYVie3W{ZXSgc44h\GG7IEegZpkhemWjbDD0bY1mKFCFUjDhcoFtgXOrczygSWM2OD1yLkJOwG0> NGr5ZVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
Huh7 NEPacIJCdnSrdnnyZYwh[XO|YYm= MkfhRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhf2muZDD0fZBmKGincHH0bZRqeyCEII\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGmwdILhZ4VtdHWuYYKgSG5CKGyndnXsd{Bu\WG|dYLl[EBwdiCmYYmgO{BjgSC{ZXHsMZRqdWViUFPSJIFv[Wy7c3nzMEBGSzVyPUCuNlM4|ryP NE[0UIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC4NlA3QCd-MkiwPFIxPjh:L3G+
HepG2.215 NV7pZXJZSW62aY\pdoFtKGG|c3H5 M4T0OWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm|aYOsJGVEQTB;Mt88US=> NVL5WXJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPFIxPjhpPkK4NFgzODZ6PD;hQi=>
HepAD38 M{nOdWFvfGm4aYLhcEBie3OjeR?= MVi1JIRigXN? NVPMdY9mSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGFFOzhiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFVkFicnXwcIlk[XSrb36gZYZ1\XJiNTDkZZl{KGK7IGLUMXBEWiCvZYToc4QtKEWFNUC9NE4xPM7:TR?= NVjlPYR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPVQyPzlpPkK4NFk1OTd7PD;hQi=>
P4R5 MAGI M{S5[mZ2dmO2aX;uJIF{e2G7 MmL1NkBpenN? MmXKTY5pcWKrdHnvckBw\iCKSW[xJGJiVCCmaX71Z4xmd3OrZHWgdoV3\XK|ZTD0doFve2O{aYD0ZZNmKGmwZnXjeIVlKGmwIHj1cYFvKFB2UkWgUWFIUSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxiaX7m[YN1cW:wIHHmeIVzKDJiaILzJIJ6KEejbHHjeI8uW3SjcjDi[ZRiNWejbHHjeI9{cWSjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2xNU4{|ryP M2X1SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{WxOVg5Lz5{OEO1NVU5QDxxYU6=
P4R5 MAGI NWfQZVF1TnWwY4Tpc44h[XO|YYm= MUWyJIhzew>? NYf2eFF5UW6qaXLpeIlwdiCxZjDITXYyKDOEIHTpcpVkdGWxc3nk[UBz\X[ncoPlJJRz[W6|Y4LpdJRie2ViaX7m[YN1\WRiaX6gbJVu[W5iUETSOUBOSUeLIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDpcoZm[3Srb36gZYZ1\XJiMjDodpMh[nliR3HsZYN1dy2VdHHyJIJmfGFvZ3HsZYN1d3OrZHHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVMzNjgQvF2= M3nE[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{WxOVg5Lz5{OEO1NVU5QDxxYU6=
HepG2.2.15 MV\BcpRqfmm{YXygZZN{[Xl? NIe5NVE5KGSjeYO= MlK2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTIVx[XSrdHnzJGIhfmm{dYOgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKESQQTDy[ZBtcWOjdHnvckBi\nSncjC4JIRigXNiYomgdoVidCC2aX3lJIZtfW:{ZYPj[Y51KFCFUjDt[ZRpd2RuIFnDOVA:OC53zszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR7NEK1Nkc,Ojh2OUSyOVI9N2F-
MT4 NUnqeW1KSW62aY\pdoFtKGG|c3H5 MWm1JIRigXN? MmnsRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhKXjFiM1KgbY5n\WO2ZXSgbY4hcHWvYX6gUXQ1KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVIvPTUQvF2= MkX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUmyOFYoRjJ6NkW5NlQ3RC:jPh?=
HepG2(2.2.15) MmDuRY51cX[rcnHsJIF{e2G7 MWS2JIRigXN? NWfHTmF[SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHH5e|EhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXygdoVxdGmlYYTpc44h[nlibXXhd5VzcW6pIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGOxcImgcpVu[mW{IHHmeIVzKDZiZHH5d{BjgXJiYomgdoVidC22aX3lJJFRS1JiYYPzZZktKEWFNUC9NE4xODh6N988US=> NFXuW2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4NlA3Pyd-Mki2PFIxPjd:L3G+
HepG2(2.2.15) M{exS2FvfGm4aYLhcEBie3OjeR?= M1XJXlYh\GG7cx?= NGPENmpCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiYYn3NUBqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDy[ZBtcWOjdHnvckBjgSCvZXHzeZJqdmdiZYj0doFk\WyudXzhdkB3cXKjbDDEUmEh[2:yeTDueY1j\XJiYX\0[ZIhPiCmYYnzJIJ6KHKnYXyteIlu\SCzUFPSJI1mfGixZDygSWM2OD1yLkCy{txO NVnTN|RFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFIxPjdpPkK4OlgzODZ5PD;hQi=>
HepAD38 MWnBcpRqfmm{YXygZZN{[Xl? MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyQVSzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkB3cXKjbDDEUmEhdGW4ZXygZpkhWlRvUFPSJI1mfGixZDygSWM2ODxyLkCx{txO MoC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 NYnweHNnSW62aY\pdoFtKGG|c3H5 MnTJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHL5JHJVNVCFUjDt[ZRpd2RuIFXDOVA:OC5yNN88US=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 M13acGFvfGm4aYLhcEBie3OjeR?= M4PBXmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDlfJRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcEBjgSCUVD3QR3IhdWW2aH;kMEBGSzVyPUCuNFTPxE1? MnvsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 M4HoNWFvfGm4aYLhcEBie3OjeR?= MorjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHL5JHJVNVCFUjDt[ZRpd2RuIFXDPVA:OC5|zszN MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
HepAD38 MWPBcpRqfmm{YXygZZN{[Xl? NXi5Vod6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFjldGFFOzhiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIV5fHKjY3XscJVt[XJidnnyZYwhTE6DIHzleoVtKGK7IGLUMXBEWiCvZYToc4QtKEWFOUC9NE4{|ryP M{nvWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 MXzBcpRqfmm{YXygZZN{[Xl? MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyQVSzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkB3cXKjbDDEUmEhdGW4ZXygZpkhWlRvUFPSJI1mfGixZDygSWM6OD1yLkhOwG0> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OEK4NEc,Ojh4OEiyPFA9N2F-
SupT1 NHrCNWlCdnSrdnnyZYwh[XO|YYm= MXK0PEBpenN? MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDWV3YuTyCyc3X1[I91gXCnZDDITXYyKGmwZnXjeIVlKGmwIHj1cYFvKFO3cGSxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6x{txO MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTBzNkGzNUc,OjlyMU[xN|E9N2F-
HepG2(2.2.15) NIPRT2xCdnSrdnnyZYwh[XO|YYm= MoDEOkBl[Xm| M3rV[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDHNkgzNjJwMUWpJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IE[g[IF6eyCkeTDSWE1RS1JibXX0bI9lNCCLQ{WwQFAvOc7:TR?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEm0N{c,Ojl{OEi5OFM9N2F-
A549 M2XIR2FvfGm4aYLhcEBie3OjeR?= MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKH[rcnnvcpMh\GW{aY\l[EBnem:vIFjJWk9XW0dvRzDvdkBJUVZxSFGgeolzcW:wczDpcoZm[3SnZDCyPVNVKGOnbHzzJJV{cW6pIHj1cYFvKEF3NEmgZ4VtdHNiYYOgeIFz\2W2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44hfXOrbnegZ49ueG:3bnSgdJJmNW2reHXkJJZqemmxboOg[o9tdG:5ZXSgZpkhcW6ldXLheIlwdiC5aYToJJRiemendDDj[YwtKEmFNUC9NE42Oc7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ7OUmyOEc,Ojl4OUm5NlQ9N2F-
HepG2.2.15 M{HUeWFvfGm4aYLhcEBie3OjeR?= MVO2JIRigXN? M1LEeWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKuNVUh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHX4eJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsd{Bi\nSncjC2JIRigXNiYomgdXBEWi:WYYHNZY4h[XO|YYmsJGlEPTB;MD6wNlXPxE1? NUTaT5lPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPFYzQTJpPkOwNlg3Ojl{PD;hQi=>
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他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 229.26
化学式

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
別名 GR109714X
Smiles C1C(OC(S1)CO)N2C=CC(=NC2=O)N

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

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モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT04034862 Not yet recruiting Drug: Treatment simplification (dolutegravir lamivudine) HIV Infections University of Liege October 1 2019 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

Reverse Transcriptaseシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID