Lamivudine (BCH-189)

For research use only. Not for use in humans.

製品コードS1706 別名:GR109714X

Lamivudine (BCH-189)化学構造

CAS No. 134678-17-4

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

サイズ 価格(税別)  
10mM (1mL in DMSO) JPY 23500
JPY 13300
JPY 21400
JPY 33000
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バルク問合せ

カスタマーフィードバック(1)

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine (BCH-189) purchased from Selleck.

製品安全説明書

Reverse Transcriptase阻害剤の選択性比較

生物活性

製品説明 Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
ターゲット
Reverse transcriptase [1]
体外試験

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MT-4 NEPhXJNHfW6ldHnvckBie3OjeR?= NYW4TXVtS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJN6dnSrY3Gg[o9zdWG2aX;uJIJ6KDVyJTDpckBJUVZvMTDpcoZm[3SnZDDNWE01KGOnbHzzMEBKSzVyPUCuNe69VQ>? MoDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDB|NUSyPUc,QDB|NUSyPVww[T5?
PBMC Mmf0SpVv[3Srb36gZZN{[Xl? M2LqcWNwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJIFvfGm4aYLhcEBi[3Srdnn0fUBqdiCSQl3DJEhpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy|KTDpcoZm[3SnZDD3bZRpKEiLVj2xJJN1emGrbjDMRXYtKEWFNUC9NE4xODF6zszN M1r4SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MUC5O|UoRjh2MUC5O|U9N2F-
PBMC NVr3OlR1TnWwY4Tpc44h[XO|YYm= MWLDc45k\W62cnH0bY9vKHKncYXpdoVlKG[xcjDhcpRqfmm{YXygZYN1cX[rdImgbY4hWEKPQzCobJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyliaX7m[YN1\WRid3n0bEBJUVZvMTDzeJJicW5iTFHWMEBGSzVyPUCuNlHPxE1? NHTNV4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEGwPVc2Lz56NEGwPVc2RC:jPh?=
PBMC M1TuNGFvfGlvSFnWMVEh[XO|YYm= MojNRY51cS2KSW[tNUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIIDldolxcGW{YXygZoxwd2RibX;uc452[2ynYYKgLHBDVSliY3XscJMhcW6oZXP0[YQhf2m2aDDITXYuOSC|dILhbY4hVEGYLDDFR|UxRTBwMECxPO69VQ>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PDJ|NUmxK|45PDJ|NUmxQE9iRg>?
PBMC MoP2RY51cS2KSW[tNUBie3OjeR?= M4DqVWFvfGlvSFnWMVEh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{KGmwZnXjeIVlKHerdHigTGlXNTFic4TyZYlvKEyDVjygSWM2OD1yLkC2{txO M1rCbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh2MkO1PVEoRjh2MkO1PVE9N2F-
PBMC MX\BcpRqNUiLVj2xJIF{e2G7 NYO5O|J6SW62aT3ITXYuOSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIhMFCETTmgZ4VtdHNiaX7m[YN1\WRid3n0bEBJUVZvMTDzeJJicW5iTFHWMEBGSzVyPUCuNlHPxE1? MoizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDR{M{W5NUc,QDR{M{W5NVww[T5?
PBMC Mn[xRY51cS2KSW[tNUBie3OjeR?= MWTBcpRqNUiLVj2xJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjCoVGJOMSClZXzsd{Bqdm[nY4Tl[EB4cXSqIFjJWk0yKHO2cnHpckBNSVZuIFXDOVA:OTBwMd88US=> NYj0VmxPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOESyN|U6OSd-OESyN|U6OTxxYU6=
2.2.15 MX;GeY5kfGmxbjDhd5NigQ>? NWqxVI1iUW5idnn0do8h\W[oZXP0bZZmKGOxbnPlcpRz[XSrb36gZYdicW6|dDDo[ZBifGm2aYOgRkB3cXK3czD3ZZMh\GW2ZYLtbY5m\CCrbjCyMlIvOTViY3XscJMtKEWFNUC9NE4xODkQvF2= MoHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTNyMU[1PUc,QTNyMU[1PVww[T5?
PBMC M{jSWWFvfGlvSFnWMVEh[XO|YYm= M2XiT2lvKH[rdILvJIFvfGlvSFnWJIFkfGm4aYT5JIlvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiY3XscJMtKEWFNUC9NE4xP87:TR?= MnH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTNyMU[1PUc,QTNyMU[1PVww[T5?
2.2.15 NUW2RpI4SW62aY\pdoFtKGG|c3H5 NEPlNI1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XCjdHn0bZMhSiC4aYL1d{ApUEKYKTDpckAzNjJwMUWgZ4VtdHNuIFXDOVA:OC5yMElOwG0> M2nRZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k2Lz5zMUC1Nlc6PTxxYU6=
PBMC NF\reWFCdnSrdnnyZYwh[XO|YYm= MVzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcY12dm:mZX\pZ4lmdmO7II\pdpV{KHS7cHWtNUApUEmYLUGpJIlvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiY3XscJMtKEWFNUC9NE4xP87:TR?= M3rLOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEWyO|k2Lz5zMUC1Nlc6PTxxYU6=
H9 M{\jRmFvfGm4aYLhcEBie3OjeR?= NYfN[mxxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTCzRkBqdiCqdX3hckBJQSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYomg[o9zdWG8YX6tZoF{\WRiY3;ueoVvfGmxbnHsJINwdG:{aX3leJJq[yC2ZXPocolyfWVuIFXDOVA:OC5yNt88US=> NHLLOWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUSzNFAyQSd-MUG0N|AxOTl:L3G+
H9 NUDNfHBESW62aY\pdoFtKGG|c3H5 NITsNZJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIGLGJIlvKGi3bXHuJGg6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDmc5Ju[Xqjbj3iZZNm\CClb372[Y51cW:wYXygZ49td3KrbXX0dolkKHSnY3jubZF2\SxiRVO1NF0xNjB4zszN M3LCXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEOwNFE6Lz5zMUSzNFAyQTxxYU6=
PBMC MXjBcpRqfmm{YXygZZN{[Xl? MYDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYuOXi6QmLVJI12fGGwdDDzeJJicW5iaX6gbJVu[W5iUFLNJINmdGy|LDDFR|kxRTBwMElOwG0> M1zicVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{M{izNFE1Lz5zMkO4N|AyPDxxYU6=
PBMC NGrTXWxHfW6ldHnvckBie3OjeR?= MYXBZ5Rqfmm2eTDh[4FqdnO2IFzhcYl3fWSrbnWtdoV{cXO2YX70JJZqenW|IDjITXYuOVi[QmLVLUBqdiCqdX3hckBRSk1iY3XscJMtKGW6cILld5Nm\CCjczDFR|UxNCCHQ{WwQVAvODN3zszN NF\jZnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMki1Nlc2PSd-MUK4OVI4PTV:L3G+
PBMC M{HJbmZ2dmO2aX;uJIF{e2G7 NWLJVGdsUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJRp\SCKSW[tNUBNSTFicnXwcIlk[XSrb36gc44hWEKPQ4OgZ4VtdCBqcHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyluIFXDOVA:OC5yMd88US=> M17VRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyPVQ{Lz5zMki1Nlk1OzxxYU6=
PBMC M3XlOmZ2dmO2aX;uJIF{e2G7 NGD6WYNG\m[nY4TpeoUh[2:wY3XueJJifGmxbjD0c{BqdmirYnn0JGhKXi1zIFzBTUBkgXSxcHH0bIlkcXS7IHnuJHBDVUNiY3XscJMhf2G|IHTleIVzdWmwZXSgbY4hfmm2cn:sJGVEPTB;MD6wNVE3|ryP NF7UTlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QCd-MUS5O|E5QTh:L3G+
HepG2.2.15 MYnGeY5kfGmxbjDhd5NigQ>? MYfF[oZm[3SrdnWgZ49v[2WwdILheIlwdiC2bzDpcohq[mm2IHjldIF1cXSrczDCJJZqenW|IHP5eI9x[XSqaXPpeJkhcW5iSHXwS|IvOi5zNTDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlLPxE1? M{jVfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUexPFk5Lz5zNEm3NVg6QDxxYU6=
MT-4 MV;GeY5kfGmxbjDhd5NigQ>? NX\JVZE{TW[oZXP0bZZmKGOxbnPlcpRz[XSrb36geI8hcW6qaXLpeEBJUVZvMTDJTWlDKGO7dH;wZZRpcWOrdImgbY4hVVRvNDDj[YxteyC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{whTUN3ME2wMlXPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl5MUi5PEc,OTR7N{G4PVg9N2F-
PBMC NVrMNVM3SW62aY\pdoFtKGG|c3H5 MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGlXKH[rcoXzLJh5SlKXKTDpckBJfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJEhRSk1rIHPlcIx{NCCHQ{mwQVAvODkQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB{N{i1OEc,OTVyMke4OVQ9N2F-
PBMC NWnpPHZGTnWwY4Tpc44h[XO|YYm= M3rJZWVn\mWldHn2[UBkd26lZX70doF1cW:wIHHnZYlve3RiV3ns[EBVgXCnIFjJWk0yKH[rcoXzJIlvKGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOsJGVEPTB;MD6wOFHPxE1? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTF6OUCzOkc,OTVzOEmwN|Y9N2F-
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2.2.15 M3T6ZWZ2dmO2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKHO7boTo[ZNqeyCxZjDlfJRz[WOnbHz1cIFzKH[rcnnvckBFVkFicnXs[YF{\SCrbjDjeYx1fXKnZDDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDOVA:OC5yNElOwG0> NUjrTHVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yNVM4OTNpPkG2NlE{PzF|PD;hQi=>
2.2.15 NXnmUGFkTnWwY4Tpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKHO7boTo[ZNqeyCxZjDlfJRz[WOnbHz1cIFzKH[rcnnvckBFVkFicnXs[YF{\SCrbjDjeYx1fXKnZDDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDPVA:OC5zNUJOwG0> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJzM{exN{c,OTZ{MUO3NVM9N2F-
2.2.15 MkT1SpVv[3Srb36gZZN{[Xl? MlrlTY5pcWKrdHnvckBw\iC|eX70bIV{cXNib3[gbY51emGlZXzseYxieiCKQm[gSG5CKHKncHzpZ4F1cX[nIHnueIVzdWWmaXH0[ZMhcW5iY4XseJVz\WRiaIXtZY4hcGWyYYTvZoxie3SxbXGgNk4zNjF3IHPlcIx{NCCHQ{WwQVAvOjVzzszN NW\xcXg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yNVM4OTNpPkG2NlE{PzF|PD;hQi=>
2.2.15 NICwPZZHfW6ldHnvckBie3OjeR?= M4fQNGlvcGmkaYTpc44hd2Zic4nueIhme2m|IH;mJIlvfHKjY3XscJVt[XJiSFLWJGRPSSC{ZYDsbYNifGm4ZTDpcpRmem2nZHnheIV{KGmwIHP1cJR2emWmIHj1cYFvKGincHH0c4Jt[XO2b33hJFIvOi5zNTDj[YxteyxiRVO5NF0xNjZ2ON88US=> M37MU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MkGzO|E{Lz5zNkKxN|cyOzxxYU6=
2.2.15 MXHGeY5kfGmxbjDhd5NigQ>? M3nOcGlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFjCWkB1emGwc3\lZ5Rm\CCrbjDoeY1idiCqZYDheI9jdGG|dH;tZUAzNjJwMUWgZ4VtdHNuIFXDOVA:Oi5zzszN NYXxWYlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{QTNpPkG2OVM6Ozl|PD;hQi=>
hepatoma 2.2.15 MWTBcpRqfmm{YXygZZN{[Xl? MoTKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\CC2eYDlJGhDXiCrbjDoeY1idiCqZYDheI9u[SB{LkKuNVUh[2WubIOsJGVEPTB;Mj6x{txO M1XWN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{W5NVEzLz5zNke1PVEyOjxxYU6=
2.2.15 NWnVNXE4TnWwY4Tpc44h[XO|YYm= MlPpTY5pcWKrdHnvckBw\iCKQm[gdoVxdGmlYYTpc44hcW5iMj6yMlE2KGOnbHzzJIJ6KESQQTDofYJzcWSrenH0bY9vKGG|c3H5MEBGSzVyPUCuNFLPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzByNEeyOkc,OTdyMES3NlY9N2F-
MDCK2 M1XJeWZ2dmO2aX;uJIF{e2G7 NIPLOIEyOCC3TR?= M4rIZ2lvcGmkaYTpc44hd2ZiaIXtZY4hVVKSMjDlfJBz\XO|ZXSgbY4hVUSFS{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDDUWYh\my3b4Lld4NmdmOnIHH0JFExKHWPIHL5JGNOTkSDIHHzd4F6 MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5MkOxNUc,OTdzN{KzNVE9N2F-
MDCK2 MUTGeY5kfGmxbjDhd5NigQ>? MV2xNEB2VQ>? M{nqVmlvcGmkaYTpc44hd2ZiaIXtZY4hVVKSMzDlfJBz\XO|ZXSgbY4hVUSFS{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDDUWYh\my3b4Lld4NmdmOnIHH0JFExKHWPIHL5JGNOTkSDIHHzd4F6 NWPTRlVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexO|I{OTFpPkG3NVczOzFzPD;hQi=>
MDCK2 NUOyN3F{TnWwY4Tpc44h[XO|YYm= NIrTR3oyOCC3TR?= NX21Z4VZUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCxJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNOTiCobIXvdoV{[2WwY3WgZZQhOTBidV2gZpkhS02IRFGgZZN{[Xl? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF5MkOxNUc,OTdzN{KzNVE9N2F-
Huh7 NGDLR4lHfW6ldHnvckBie3OjeR?= M1\idmlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFjCWkBz\XCuaXPheIlwdiCrbjDIeYg4KGOnbHzzMEBGSzVyPUJOwG0> M{LXSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{exPFI4Lz5zN{O3NVgzPzxxYU6=
PBMC NUHQXJdVSW62aY\pdoFtKGG|c3H5 MofrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCOQVmgbY4hcHWvYX6gVGJOKGOnbHzzMEBGSzVyPUCuNFI3|ryP M{KxU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NECzPVk3Lz5zN{SwN|k6PjxxYU6=
PBMC NXrZfHZtSW62aY\pdoFtKGG|c3H5 MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKEyDSTDpckBpfW2jbjDQRm0h[2WubIOsJGVEQTB;MD6xNu69VQ>? NYPYPI85RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NFM6QTZpPkG3OFA{QTl4PD;hQi=>
HepG2.2.15 M{XyVGFvfGm4aYLhcEBie3OjeR?= NHLXOldCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX6gTIVxTzJwMj6xOUBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCneITyZYNmdGy3bHHyJJZqemGuIFTORUBt\X[nbDDifUBTXC2SQ2KsJGVEPTB;MD6x{txO NVLySpZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NFQxODZpPkG3OFA1ODB4PD;hQi=>
Huh7 NGfIOo9CdnSrdnnyZYwh[XO|YYm= MXm1JIRigXN? NVHsXZNJSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHflco91gXCnIFSge4l1cCC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgUFgxUSCvdYTheIlwdiCrbjDoeY1idiCKdXi3JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPSCmYYnzMEBGSzVyPUCuNFPPxE1? M1;VS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO4NFQ4Lz5zN{SzPFA1PzxxYU6=
Huh7 NEnPbplCdnSrdnnyZYwh[XO|YYm= NIPZXWI2KGSjeYO= NW[3d4Y1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKnQXet[IVncWOrZX70JGhDXiCpZX7veJlx\SCGIIfpeIgheHKnY3;y[UBIOTh7NlGgcZV1[XSrb36gZY5lKHKndnXyd4UhfHKjboPjdolxfGG|ZTDMPFBKKG23dHH0bY9vKGmwIHj1cYFvKEi3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA2KGSjeYOsJGVEPTB;MD6wN:69VQ>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
Huh7 MYPBcpRqfmm{YXygZZN{[Xl? NInDbYc2KGSjeYO= M1rBXWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCpZX7veJlx\SCGIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMtKEWFNUC9NE41Oc7:TR?= MnXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2M{iwOFcoRjF5NEO4NFQ4RC:jPh?=
Huh7 NWXMSIxUSW62aY\pdoFtKGG|c3H5 MUe1JIRigXN? M1zNdGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhD\UGpLXTl[olkcWWwdDDIRnYh\2Wwb4T5dIUhTCC5aYToJJBz\WOxcnWgS|E5QT[DIH31eIF1cW:wIHnuJIh2dWGwIFj1bFch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB3IHThfZMtKEWFNUC9NE41Ps7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR|OEC0O{c,OTd2M{iwOFc9N2F-
HepG2(2.2.15) NWPmR5IxSW62aY\pdoFtKGG|c3H5 M1f1UmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbjDhfZchf2muZDD0fZBmKEincFeyLFIvOi5zNTmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBFVkFicnXwcIlk[XSrb36sJGlEPTB;MD6wOe69VQ>? NX;wZVlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepG2(2.2.15) MVXGeY5kfGmxbjDhd5NigQ>? NULwO|NuUW6qaXLpeIlwdiCxZjDIRnYheHKxbX;0[ZIhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4xQM7:TR?= NWrCcYNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HepW10 NYnidpk2SW62aY\pdoFtKGG|c3H5 M3v4O2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbjDh[JJq[W27Y3nuMZJme2m|dHHueEB4cWymIIT5dIUhUGWyV{GwJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uMEBKSzVyPUCuNe69VQ>? NUH3cZFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFg5OTdpPkG3OFg5QDF5PD;hQi=>
HBV-Met NUPy[JpTSW62aY\pdoFtKGG|c3H5 MULBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5ibX;1d4Uh[Xm5IIfpcIQhfHmyZTDIRnYuVWW2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygSG5CKHKncHzpZ4F1cW:wLDDJR|UxRTBwMt88US=> NF7JfYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4PFgyPyd-MUe0PFg5OTd:L3G+
HepG2.2.15 MmfySpVv[3Srb36gZZN{[Xl? MVe4JIRigXN? MVPJcohq[mm2aX;uJI9nKGO7dH;wcIF{dWmlIFjCWkBFVkFic4nueIhme2m|IHnuJGhmeEd{LkKuNVUh[2WubIOgZYZ1\XJiODDkZZl{NCCLQ{WwQVAvOzkQvF2= NX3TSFRRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVk5QDlpPkG3OFk6QDh7PD;hQi=>
PBMC MULGeY5kfGmxbjDhd5NigQ>? MknPN|AxKG2p MUm3JIRigXN? MUPDcYF5KGmwIFjJWk1qdm[nY4Tl[EBpfW2jbjDhd5Nme3OnZDDhd{BN[W2rdoXkbY5mKG2xbn;wbI9{eGijdHWgcIV3\WxiaX6gVGJOSyCjdDCzNFAhdWdiUVSg[o9zKDdiZHH5d{Bu\WG|dYLl[EBx\XJiMUCnOkBk\WyuczDpckBxemW|ZX7j[UBw\iC8aXTvepVlcW6nLDDDcYF5RTBwMECwNFAxQM7:TR?= M1LRb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[0N|I5Lz5zN{[2OFMzQDxxYU6=
PBMC NFjncYZHfW6ldHnvckBie3OjeR?= NYHKc|BvOzByIH3n NXv4eHZEPyCmYYnz NEWyRY1EdWG6IHnuJGhKXi2rbn\lZ5Rm\CCqdX3hckBie3Onc4Pl[EBieyCOYX3pepVlcW6nIHTpdIhwe3CqYYTlJIxmfmWuIHnuJHBDVUNiYYSgN|AxKG2pIGHEJIZweiB5IHThfZMhdWWjc4Xy[YQheGW{IEGwK|Yh[2WubIOgbY4heHKnc3XuZ4Uhd2Ziennkc5Z2\GmwZTygR41igD1yLkCwNFAxPDUQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ4NEOyPEc,OTd4NkSzNlg9N2F-
PBMC MWDGeY5kfGmxbjDhd5NigQ>? MUKzNFAhdWd? NInNV4U4KGSjeYO= NEjONFVEdWG6IHnuJGhKXi2rbn\lZ5Rm\CCqdX3hckBie3Onc4Pl[EBieyCOYX3pepVlcW6nIITybZBpd3OyaHH0[UBt\X[nbDDpckBRSk2FIHH0JFMxOCCvZzDRSEBnd3JiNzDkZZl{KG2nYYP1doVlKHCncjCxNEc3KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIIrp[I93fWSrbnWsJGNu[Xh;MD6wNFAxODR6zszN NGnrN5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2OFMzQCd-MUe2OlQ{Ojh:L3G+
MAGIC-5A MV\BcpRqfmm{YXygZZN{[Xl? MoS5OFAhcHK| NGHSTWdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEmYMTDOUFQuOyCycn;keYNm\CCocn;tJIZ2dGxibHXu[5RpKHCUOXTlcJRiSXCjIHnu[oVkfGWmIHnuJIh2dWGwIF3BS2lENTWDIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVGGlKzDmc4NqKGW6cILld5Nqd25iYX\0[ZIhPDBiaILzMEBGSzVyPUCuPFjPxE1? NIC0b4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m2O|kyOyd-MUe5Olc6OTN:L3G+
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MT2 Mo\SRY51cX[rcnHsJIF{e2G7 MUS1JIRigXN? NV\zWnIxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yNTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gNkBpei2ycnX0doVifGWmIHj1cYFvKE2WMjDj[YxteyCvZXHzeZJm\CCjZoTldkA2KGSjeYOgZpkhWlRiU2DBMEBGSzVyPUKuOFfPxE1? NIixZVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOxOlUzOSd-MUizNVY2OjF:L3G+
MT2 M1fGemFvfGm4aYLhcEBie3OjeR?= NXXOUVZvPSCmYYnz NEn1e4tCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjB3IF3PTUB4cWymIIT5dIUhUEmYMTDOUFQuOyCrbn\lZ5Rm\CCrbjCyJIhzNXC{ZYTy[YF1\WRiaIXtZY4hVVR{IHPlcIx{KG2nYYP1doVlKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9N{4zPDgQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzNkWyNUc,OTh|MU[1NlE9N2F-
HepG2(2.2.15) NHTreHVCdnSrdnnyZYwh[XO|YYm= M1zUN|I1KGi{cx?= MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDlfJRz[WOnbHz1cIFzKEiEVjD2bZJqd25iRF7BJIxmfmWuIHHmeIVzKDJ2IHjyd{whTUN3ME2wMlA1QM7:TR?= NXPVSmVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
HepG2(2.2.15) MVXBcpRqfmm{YXygZZN{[Xl? NF6ySm8zPCCqcoO= MVXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW5iaIXtZY4hUGWyR{KoNk4zNjF3KTDj[YxteyCjc4Pld5Nm\CCjczDy[ZBtcWOjdHnvckBqdnSncn3l[IlifGW|IHHmeIVzKDJ2IHjyd{whTUN3ME2wMlE2|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 NHHl[pJCdnSrdnnyZYwh[XO|YYm= MYK0JIRigXN? MlXNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhf2muZDD0fZBmKEiEVjDpckBpfW2jbjDIeYg4KGOnbHzzJIFnfGW{IESg[IF6eyCkeTDpcpRz[WOnbHz1cIFzKEiEVjDEUmEhemWybHnjZZRqd25iYYPzZZktKEWFNUC9NE4z|ryP M4f3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 MnPURY51cX[rcnHsJIF{e2G7 MkftOEBl[Xm| NHfaV4RCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCCKQm[gdoV3\XK|ZTD0doFve2O{aYD0ZZNmKDJ|NmSgcZV1[W62IHnuJIh2dWGwIFj1bFch[2WubIOgZYZ1\XJiNDDkZZl{KGK7IHnueJJi[2WubIXsZZIhUEKYIFTORUBz\XCuaXPheIlwdiCjc4PhfUwhTUN3ME2wMlPPxE1? NFjVRlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlY6PCd-MUmwO|I3QTR:L3G+
Huh7 M1fqVWFvfGm4aYLhcEBie3OjeR?= MXe0JIRigXN? NXfZPGZUSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSnZn;2bZIuemW|aYP0ZY51KHerbHSgeJlx\SCKQm[gbY4hcHWvYX6gTJVpPyClZXzsd{Bi\nSncjC0JIRigXNiYomgbY51emGlZXzseYxieiCKQm[gSG5CKHKncHzpZ4F1cW:wIHHzd4F6NCCHQ{WwQVEvO87:TR?= M4\QcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
Huh7 M{X5eGFvfGm4aYLhcEBie3OjeR?= NXTjTFlxPCCmYYnz M1jkemFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl\W[xdnnyMZJme2m|dHHueEBJSlZicnX2[ZJ{\SC2cnHud4NzcXC2YYPlJG0zODSYIH31eIFvfCCrbjDoeY1idiCKdXi3JINmdGy|IHHmeIVzKDRiZHH5d{BjgSCrboTyZYNmdGy3bHHyJGhDXiCGTlGgdoVxdGmlYYTpc44h[XO|YYmsJGVEPTB;MT61{txO NWfBUZNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
Huh7 NIftSZVCdnSrdnnyZYwh[XO|YYm= NVvuOZgxPCCmYYnz NGjpZmRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GWob4\pdk1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UBNOThyTTDteZRidnRiaX6gbJVu[W5iSIXoO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliaX70doFk\WyudXzhdkBJSlZiRF7BJJJmeGyrY3H0bY9vKGG|c3H5MEBGSzVyPUGuOu69VQ>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 NXH1TpA1SW62aY\pdoFtKGG|c3H5 M4jBe|Qh\GG7cx?= NUL5fWI2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSnZn;2bZIuemW|aYP0ZY51KEiEVjDy[ZZmenOnIITyZY5{[3KrcIThd4UhVE1xcnX2[ZJ{\SC2cnHud4NzcXC2YYPlJG1XKGSxdXLs[UBufXSjboSgbY4hcHWvYX6gTJVpPyClZXzsd{Bi\nSncjC0JIRigXNiYomgbY51emGlZXzseYxieiCKQm[gSG5CKHKncHzpZ4F1cW:wIHHzd4F6NCCHQ{WwQVEvPs7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5Mk[5OEc,OTlyN{K2PVQ9N2F-
Huh7 MUXBcpRqfmm{YXygZZN{[Xl? MVm0JIRigXN? MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IVnd3[rcj3y[ZNqe3SjboSgTGJXKHKndnXyd4UhfHKjboPjdolxfGG|ZTDNNlA1USCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTFwON88US=> MmHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{K2PVQoRjF7MEeyOlk1RC:jPh?=
Huh7 NFnRe41CdnSrdnnyZYwh[XO|YYm= NIfaN2g1KGSjeYO= MnS2RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRm\m:4aYKtdoV{cXO2YX70JGhDXiC{ZY\ldpNmKHS{YX7zZ5JqeHSjc3WgNlM3XCCvdYThcpQhcW5iaIXtZY4hUHWqNzDj[YxteyCjZoTldkA1KGSjeYOgZpkhcW62cnHj[YxtfWyjcjDIRnYhTE6DIILldIxq[2G2aX;uJIF{e2G7LDDFR|UxRTdwN988US=> NX7obYVNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|I3QTRpPkG5NFczPjl2PD;hQi=>
Huh7 NHjWNIZCdnSrdnnyZYwh[XO|YYm= MkXqOEBl[Xm| MlLNRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgcIFucX[3ZHnu[U1z\XOrc4ThcpQhUEKYIILleoVze2VidILhcpNkemmydHHz[UBNOThyTTDteZRidnRiaX6gbJVu[W5iSIXoO{Bk\WyuczDh[pRmeiB2IHThfZMh[nliaX70doFk\WyudXzhdkBJSlZiRF7BJJJmeGyrY3H0bY9vKGG|c3H5MEBGSzVyPUGw{txO M1TmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyOlk1Lz5zOUC3NlY6PDxxYU6=
HuH7 NH\vUnpCdnSrdnnyZYwh[XO|YYm= MoH3NlQhcHK| MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDD3bYxlKHS7cHWgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEPTB;MD6y{txO NEn5Too9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 MU\BcpRqfmm{YXygZZN{[Xl? M1LqUVI1KGi{cx?= NXr2SHpSSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzVyPUCuN:69VQ>? Mm[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
HuH7 Ml\lRY51cX[rcnHsJIF{e2G7 M{DSUFI1KGi{cx?= NWfhd283SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEKYIHjhdoJwemmwZzDSUmEheG:ueX3ldoF{\SCQMkO2WEBufXSjboSg[4Vv\SCrbn\lZ5Rm\CCrbjDoeY1idiCKdVi3JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKH[rcnHsJJRz[W6|aXXueEB1emGwc3\lZ5Rqd25iYX\0[ZIhOjRiaILzMEBGSzlyPUGuOe69VQ>? MkW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|OUi2OFgoRjF7M{m4OlQ5RC:jPh?=
HuH7 M2[0O2FvfGm4aYLhcEBie3OjeR?= NF;jeowzPCCqcoO= NFy0d5NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEB4cWymIIT5dIUhUEKYIHnu[oVkfGWmIHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idnnyZYwhfHKjboPp[Y51KHS{YX7z[oVkfGmxbjDh[pRmeiB{NDDodpMtKEWFOUC9N:69VQ>? NFnJOVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 M3nvWmFvfGm4aYLhcEBie3OjeR?= MnnzNlQhcHK| NF3udG1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaHHyZo9zcW6pIGLORUBxd2y7bXXyZZNmKExzOEDNJI12fGGwdDDn[Y5mKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEPTB;MUdOwG0> NEm1fZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5PFY1QCd-MUmzPVg3PDh:L3G+
HuH7 M3v5N2FvfGm4aYLhcEBie3OjeR?= M1:weFI1KGi{cx?= NF\ybIJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaHHyZo9zcW6pIGLORUBxd2y7bXXyZZNmKExzOEDNJI12fGGwdDDn[Y5mKGmwZnXjeIVlKGmwIHj1cYFvKEi3SEegZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hfmm{YXygeJJidnOrZX70JJRz[W6|ZnXjeIlwdiCjZoTldkAzPCCqcoOsJGVEQTB;NEJOwG0> M1;scFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m4OlQ5Lz5zOUO5PFY1QDxxYU6=
MT2 Mn61RY51cX[rcnHsJIF{e2G7 NXvzRmg5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDpcoZm[3SnZDDpckBpfW2jbjDNWFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjygTWM2OD1yLkdOwG0> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7Nki4OUc,OTl3OU[4PFU9N2F-
HeLa P4/R5 M2W1NGFvfGm4aYLhcEBie3OjeR?= MoW4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSCrbn\lZ5Rm\CCrbjDoeY1idiCKZVzhJHA1N1J3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44tKEmFNUC9NE44QM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7Nki4OUc,OTl3OU[4PFU9N2F-
TZM-bl Mn7MRY51cX[rcnHsJIF{e2G7 MkLrO|IhcHK| NYfn[nh5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYMTDwUmw1NTNiaHHyZo9zcW6pIGLleoVze2VidILhcpNkemmydHHz[UBROTF7UzDteZRidnRiZ3Xu[UBqdm[nY4Tl[EBqdiCWWl2tZowh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFXDOVA:OC52N988US=> NEXVWGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl MWTBcpRqfmm{YXygZZN{[Xl? MlHrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sge4lt\C22eYDlJGhKXjFicF7MOE0{KGmwZnXjeIVlKGmwIGTaUU1jdCClZXzsd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVAvPjYQvF2= NEXoTWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl M3rXbWFvfGm4aYLhcEBie3OjeR?= M3ztdFczKGi{cx?= MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDITXYyKHCQTEStN{Bp[XKkb4LpcochWmW4ZYLz[UB1emGwc3PybZB1[XOnIGSxOlVCKG23dHHueEBo\W6nIHnu[oVkfGWmIHnuJHRbVS2kbDDj[YxteyCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME2xMlA5|ryP NFn4S489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewOFE{OSd-MUm3NFQyOzF:L3G+
TZM-bl M2WxbmFvfGm4aYLhcEBie3OjeR?= NIf2T2Q4OiCqcoO= M1\qbmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFicF7MOE0{KGijcnLvdolv\yCUZY\ldpNmKHS{YX7zZ5JqeHSjc3WgVFEyQVNxVEG2OWEhdXW2YX70JIdmdmViaX7m[YN1\WRiaX6gWHpONWKuIHPlcIx{KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG|c3H5MEBGSzVyPUKuNe69VQ>? M{fVVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{C0NVMyLz5zOUewOFE{OTxxYU6=
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HepG2(2.2.15) M2DJUWFvfGm4aYLhcEBie3OjeR?= NUDDTXRiPiCmYYnz M2Pu[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCjeYexJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{KEKuNk4yPSliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqemGuIILldIxq[2G2aX;uJIJ6KG2nYYP1dolv\yCneITyZYNmdGy3bHHyJJZqemGuIFTORUBkd3C7IH71cYJmeiCjZoTldkA3KGSjeYOgZpkhemWjbD30bY1mKHGSQ2KgcYV1cG:mLDDFR|UxRTBwMEJOwG0> NUjnPYdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OFg2QTBpPkK3O|Q5PTlyPD;hQi=>
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Huh7 NXLNZ4hOSW62aY\pdoFtKGG|c3H5 NIXXSHRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViaHXwZZRqfGm|IFKgeolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSIXoO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5ic3XjdoV1\WRiRF7BJIxmfmWuczDt[YF{fXKnZDDvckBl[XliNzDifUBz\WGuLYTpcYUhWEOUIHHuZYx6e2m|LDDFR|UxRTBwMEW1{txO Mk\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEKwOlgoRjJ6MEiyNFY5RC:jPh?=
HepG2.215 Mmm4RY51cX[rcnHsJIF{e2G7 M17JNmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm|aYOsJGVEPTB;MD6x{txO M17kN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEiyNFY5Lz5{OEC4NlA3QDxxYU6=
Huh7 MlrHRY51cX[rcnHsJIF{e2G7 NGPLW5FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBt[W2rdoXkbY5mNXKnc3nzeIFvfCC5aXzkJJR6eGViaHXwZZRqfGm|IFKgeolzfXNiaX7m[YN1\WRiaX6gbJVu[W5iSIXoO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkBFVkFibHX2[Yx{KG2nYYP1doVlKG:wIHThfUA4KGK7IILlZYwufGmvZTDQR3Ih[W6jbInzbZMtKEWFNUC9NE4zOzgQvF2= MlrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOEKwOlgoRjJ6MEiyNFY5RC:jPh?=
HepG2.215 MXXBcpRqfmm{YXygZZN{[Xl? M{n6dGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIhmeGG2aYTpd{BDKH[rcoXzJIlv\mWldHXkJIlvKGi3bXHuJGhmeEd{LkKxOUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhTE6DIILldIxq[2G2aX;uJI1m[XO3cnXkJI9vKGSjeTC3JIJ6KHKnYXygeIlu\SCSQ2KgZY5idHm|aYOsJGVEQTB;Mt88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB6MkC2PEc,OjhyOEKwOlg9N2F-
HepAD38 NVm1XXk4SW62aY\pdoFtKGG|c3H5 NEm4cW02KGSjeYO= MnHyRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDEUmEhemWybHnjZZRqd25iYX\0[ZIhPSCmYYnzJIJ6KFKWLWDDVkBu\XSqb3SsJGVEPTB;MD6wOO69VQ>? NIKxTFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5OFE4QSd-MkiwPVQyPzl:L3G+
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HepG2.2.15 NVv4bnMySW62aY\pdoFtKGG|c3H5 MVW4JIRigXN? NUj6PYt{SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KEJidnnyeZMhcW6oZXP0[YQhcW5iaIXtZY4hUGWyR{KuNk4yPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIFTORUBz\XCuaXPheIlwdiCjZoTldkA5KGSjeYOgZpkhemWjbDD0bY1mKG[udX;y[ZNk\W62IGDDVkBu\XSqb3SsJGlEPTB;MD61{txO MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR7NEK1Nkc,Ojh2OUSyOVI9N2F-
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HepG2(2.2.15) NVHteXVvSW62aY\pdoFtKGG|c3H5 NEXlVnA3KGSjeYO= MnfrRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGG7d{GgbY5n\WO2ZXSgbY4hcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhdWWjc4XybY5oKGmwdILhZ4VtdHWuYYKgeolz[WxiRF7BJINweHliboXtZoVzKGGodHXyJFYh\GG7czDifZIh[nlicnXhcE11cW2nIIHQR3Ih[XO|YYmsJGVEPTB;MD6wNFg5P87:TR?= M1nISFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkiyNFY4Lz5{OE[4NlA3PzxxYU6=
HepG2(2.2.15) M1flbmFvfGm4aYLhcEBie3OjeR?= NETSOWE3KGSjeYO= NIDkZ4FCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiYYn3NUBqdm[nY4Tl[EBqdiCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXKjbDDy[ZBtcWOjdHnvckBjgSCvZXHzeZJqdmdiZYj0doFk\WyudXzhdkB3cXKjbDDEUmEh[2:yeTDueY1j\XJiYX\0[ZIhPiCmYYnzJIJ6KHKnYXyteIlu\SCzUFPSJI1mfGixZDygSWM2OD1yLkCy{txO Mn\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEKwOlcoRjJ6NkiyNFY4RC:jPh?=
HepAD38 MVHBcpRqfmm{YXygZZN{[Xl? MXzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyQVSzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iaX70doFk\WyudXzhdkB3cXKjbDDEUmEhdGW4ZXygZpkhWlRvUFPSJI1mfGixZDygSWM2ODxyLkCx{txO MkjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 MlHuRY51cX[rcnHsJIF{e2G7 NEe3PGhCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJSlZiaX7m[YN1\WRiaX6gbJVu[W5iSHXwRWQ{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6geolz[WxicnXwcIlk[XSrb36gZpkhWlRvUFPSJI1mfGixZDygSWM2OD1yLkC0{txO M3jPfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
HepAD38 NVzpdIRzSW62aY\pdoFtKGG|c3H5 M16wSmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDlfJRz[WOnbHz1cIFzKH[rcnHsJGRPSSCuZY\lcEBjgSCUVD3QR3IhdWW2aH;kMEBGSzVyPUCuNFTPxE1? NGTDUJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4PFI5OCd-Mki2PFgzQDB:L3G+
HepAD38 NVTwb5c4SW62aY\pdoFtKGG|c3H5 M2jiTmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDBSFM5KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDifUBTXC2SQ2KgcYV1cG:mLDDFR|kxRTBwM988US=> MnyzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OEiyPFAoRjJ6Nki4NlgxRC:jPh?=
HepAD38 MWDBcpRqfmm{YXygZZN{[Xl? MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIRnYhcW6oZXP0[YQhcW5iaIXtZY4hUGWyQVSzPEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iZYj0doFk\WyudXzhdkB3cXKjbDDEUmEhdGW4ZXygZpkhWlRvUFPSJI1mfGixZDygSWM6OD1yLkROwG0> NI\nO489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[4PFI5OCd-Mki2PFgzQDB:L3G+
HepAD38 MYDBcpRqfmm{YXygZZN{[Xl? Ml\hRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGJXKGmwZnXjeIVlKGmwIHj1cYFvKEincFHEN|gh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHnueJJi[2WubIXsZZIhfmm{YXygSG5CKGyndnXsJIJ6KFKWLWDDVkBu\XSqb3SsJGVEQTB;MD63{txO M{\reVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Nki4NlgxLz5{OE[4PFI5ODxxYU6=
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HepG2(2.2.15) M1n6ZWFvfGm4aYLhcEBie3OjeR?= NHvJc|M3KGSjeYO= M1f1RmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhDXiCrbn\lZ5Rm\CCrbjDoeY1idiCKZYDHNkgzNjJwMUWpJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhTE6DIILldIxq[2G2aX;uJIFnfGW{IE[g[IF6eyCkeTDSWE1RS1JibXX0bI9lNCCLQ{WwQFAvOc7:TR?= NX\abI1FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6PDNpPkK5Nlg5QTR|PD;hQi=>
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MT4 NV\XT3pSSW62aY\pdoFtKGG|c3H5 MmOxOUBl[Xm| NGLXN5NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZvMTCzRkBqdm[nY4Tl[EBqdiCqdX3hckBOXDRiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiaX7jeYJifGWmIH\vdkA2KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVMvQDkQvF2= Ml3XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2M{SwN|koRjNzNEO0NFM6RC:jPh?=
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MT4 MX\BcpRqfmm{YXygZZN{[Xl? Mk\IOUBl[Xm| MoHJRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\yC{ZYPpd5RidnRiSFnWMVEhcGG{Yn;ybY5oKHKndnXyd4UhfHKjboPjdolxfGG|ZTDZNVgySyCvdYThcpQhcW6oZXP0[YQhcW5iaIXtZY4hVVR2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHnuZ5Vj[XSnZDDmc5IhPSCmYYnzJIJ6KE2WVDDhd5NigSxiRVO1NF01NjV2zszN NWqzUGdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0N|QxOzlpPkOxOFM1ODN7PD;hQi=>
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PBMC NWfmSYVISW62aY\pdoFtKGG|c3H5 NFXMO45CdnSrdnnyZYwh[WO2aY\peJkhcW5iUFLNJINmdGy|IHX4dJJme3OnZDDhd{BKSzVyLDDJR|UxRTBwMECy{txO M4TZZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
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HepG2.2.15 NH3oVG1HfW6ldHnvckBie3OjeR?= Mo\ZSYZn\WO2aY\lJINwdmOnboTyZZRqd25ibnXj[ZN{[XK7IITvJIRm[3KnYYPlJIV5fHKjY3XscJVt[XJiSHXwZZRqfGm|IFKgeolzfXNiRF7BJIxmfmWuczDifUA2OCViaX6gbJVu[W5iaHXwZZRw[myjc4TvcYEh[2WubDDsbY5mKCh{LkKuNVUh[2WubIOpJIlvKH[rdILvMEBGSzVyPUCuNFM5|ryP NY\yZVBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>
PBMC M2rzbGZ2dmO2aX;uJIF{e2G7 MYLDc41xd3WwZDD3ZZMhfGW|dHXkJIZweiCrdIOgZY51cS2KSW[gZYN1cX[rdImgZYdicW6|dDDITXYuOSCOQVmgbY4hcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkApWEKPKTDj[YxteyxiRVO1NF0xNjB4zszN NH34PWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDFxJ{7DbGVOSkx:L3G+
HepG2.2.15 M4W4[GZ2dmO2aX;uJIF{e2G7 MkjjSYZn\WO2aY\lJINwdmOnboTyZZRqd25ibnXj[ZN{[XK7IITvJIRm[3KnYYPlJIV5fHKjY3XscJVt[XJiSHXwZZRqfGm|IFKgeolzfXNiRF7BJIxmfmWuczDifUA6OCViaX6gbJVu[W5iaHXwZZRw[myjc4TvcYEh[2WubDDsbY5mKCh{LkKuNVUh[2WubIOpJIlvKH[rdILvMEBGSzlyPUCuNVbPxE1? M4jCdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1OS9pPlPoSW1DVDxxYU6=
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MT-4 MXLBcpRqfmm{YXygZZN{[Xl? NUjiW|JFSW62aY\pdoFtKGGldHn2bZR6KGmwIF3UMVQh[2WubIOg[ZhxemW|c3XkJIF{KEmFNUCsJGlEPTB;MD6zO:69VQ>? NEPjUm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyPDFxJ{7DbGVOSkx:L3G+
MT-4 Ml\ERY51cX[rcnHsJIF{e2G7 M{Lvd2FvfGm4aYLhcEBi[3Srdnn0fUBqdiCPVD20JINmdGy|IHX4dJJme3OnZDDhd{BKSzVyLDDJR|UxRTBwNkJOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFEwLz6FaFXNRmw9N2F-
MT-4 NFT0e|JHfW6ldHnvckBie3OjeR?= M4fUUGNwdXCxdX7kJJdieyC2ZYP0[YQh\m:{IHn0d{BidnSrLVjJWkBi[3Srdnn0fUBqdiCjY4X0[Yx6KGmwZnXjeIVlKE2WLUSgZ4VtdHNuIFXDOVA:P87:TR?= NVvGR2hLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTRzLze+R4hGVUKOPD;hQi=>

他の多くの細胞株試験データをご覧になる場合はこちらをクリックして下さい

お薦めの試験操作(参考用のみ)

溶解度 (25°C)

体外 DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* 溶解度測定はSelleck技術部門によって行われており、その他文献に示されている溶解度と差異がある可能性がありますが、同一ロットの生産工程で起きる正常な現象ですからご安心ください。

化学情報

分子量 229.26
化学式

C8H11N3O3S

CAS No. 134678-17-4
Storage powder
in solvent
別名 GR109714X
Smiles C1C(OC(S1)CO)N2C=CC(=NC2=O)N

投与溶媒組成計算器(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)
投与量 mg/kg 動物平均体重 g 投与体積(動物毎) ul 動物数
ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)
% DMSO % % Tween 80 % ddH2O
計算リセット

便利ツール

モル濃度計算器

モル濃度計算器

求めたい質量、体積または濃度を計算してください。

質量 (mg) = 濃度 (mM) x 体積 (mL) x 分子量 (g/mol)

モル濃度計算器方程式

  • 質量
    濃度
    体積
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備するために必要な希釈率を計算してください。Selleck希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 入力 出力 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

質量 濃度 体積 分子量

臨床試験

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04133012 Recruiting Other: Samplings HIV-1 Infection ANRS Emerging Infectious Diseases|ViiV Healthcare February 10 2020 Not Applicable
NCT03869944 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|Institut National de la Santé Et de la Recherche Médicale France|Centre Muraz December 4 2019 Phase 2
NCT03870438 Recruiting Drug: Lamivudine Oral Solution HIV-1 ANRS Emerging Infectious Diseases|University Teaching Hospital Lusaka Zambia|Centre Muraz|Institut National de la Santé Et de la Recherche Médicale France|University of Bergen December 14 2019 Phase 3

技術サポート

ストックの作り方、阻害剤の保管方法、細胞実験や動物実験の際に注意すべき点など、製品を取扱う時に問い合わせが多かった質問に対しては取扱説明書でお答えしています。

Handling Instructions

他に質問がある場合は、お気軽にお問い合わせください。

  • * 必須

Reverse Transcriptaseシグナル伝達経路

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細胞株 試験類型 濃度 培養時間 溶剤類型 活性叙述 PMID