逆転写酵素

シグナル伝達経路

研究分野

阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1401	Tenofovir	2 mg/mL	4 mg/mL	<1 mg/mL
S1400	Tenofovir Disoproxil Fumarate	<1 mg/mL	100 mg/mL	44 mg/mL
S1704	Emtricitabine	49 mg/mL	49 mg/mL	9 mg/mL
S1252	Entecavir Hydrate	<1 mg/mL	59 mg/mL	<1 mg/mL
S1718	Adefovir Dipivoxil	<1 mg/mL	100 mg/mL	100 mg/mL
S5068	Adefovir	0.1 mg/mL	<1 mg/mL	<1 mg/mL
S5423	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride	-1 mg/mL	52 mg/mL	-1 mg/mL
S5246	Entecavir	<1 mg/mL	55 mg/mL	<1 mg/mL
S5215	Abacavir	-1 mg/mL	57 mg/mL	-1 mg/mL
S4890	Bifendate	-1 mg/mL	83 mg/mL	-1 mg/mL
S1742	Nevirapine	<1 mg/mL	53 mg/mL	<1 mg/mL
S1702	Didanosine	<1 mg/mL	47 mg/mL	<1 mg/mL
S1706	Lamivudine	46 mg/mL	46 mg/mL	<1 mg/mL
S1398	Stavudine (d4T)	<1 mg/mL	45 mg/mL	15 mg/mL
S1651	Telbivudine	48 mg/mL	48 mg/mL	2 mg/mL
S2579	Zidovudine	53 mg/mL	53 mg/mL	18 mg/mL
S1719	Zalcitabine	42 mg/mL	7 mg/mL	<1 mg/mL
S3165	Abacavir sulfate	36 mg/mL	<1 mg/mL	<1 mg/mL
S3076	Foscarnet Sodium	3 mg/mL	7 mg/mL	<1 mg/mL
S4187	Salicylanilide	<1 mg/mL	43 mg/mL	18 mg/mL
S4685	Efavirenz	<1 mg/mL	63 mg/mL	63 mg/mL
S3606	Fangchinoline	<1 mg/mL	100 mg/mL	4 mg/mL
S7856	Tenofovir Alafenamide (GS-7340)	<1 mg/mL	95 mg/mL	95 mg/mL

Reverse Transcriptase阻害剤(23)
新Reverse Transcriptase製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1401	Tenofovir Tenofovir blocks reverse transcriptase and hepatitis B virus infections.	Sci Transl Med, 2014, 6(262):262ra157 Sci Signal, 2015, 8(399):ra104 Retrovirology, 2015, 10.1186/s12977-015-0139-7	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S1400	Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.	Sci Transl Med, 2014, 6(262):262ra157 Retrovirology, 2015, 10.1186/s12977-015-0139-7 Stem Cells Dev, 2015, 24(7):814-23	Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
S1704	Emtricitabine Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.	J Immunol, 2014, 193(7):3577-89
S1252	Entecavir Hydrate Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).	J Hepatol, 2015, 10.1016/j.jhep.2015.02.048
S1718	Adefovir Dipivoxil Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
S5068^新	Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5423^新	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5246^新	Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
S5215^新	Abacavir Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
S4890^新	Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S1742	Nevirapine Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.	Sci Transl Med, 2014, 6(262):262ra157	Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
S1702	Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
S1706	Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.		The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
S1398	Stavudine (d4T) Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
S1651	Telbivudine Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.	Sci Rep, 2013, 3:2105
S2579	Zidovudine Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.
S1719	Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
S3165	Abacavir sulfate Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
S3076	Foscarnet Sodium Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
S4187	Salicylanilide Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
S4685	Efavirenz Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
S3606	Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
S7856	Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

研究分野別

製品類型

逆転写酵素

シグナル伝達経路

研究分野

Tenofovir

Tenofovir Disoproxil Fumarate

Emtricitabine

Entecavir Hydrate

Adefovir Dipivoxil

Adefovir

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

Entecavir

Abacavir

Bifendate

Nevirapine

Didanosine

Lamivudine

Stavudine (d4T)

Telbivudine

Zidovudine

Zalcitabine

Abacavir sulfate

Foscarnet Sodium

Salicylanilide

Efavirenz

Fangchinoline

Tenofovir Alafenamide (GS-7340)