逆転写酵素
シグナル伝達経路
研究分野
阻害剤の選択性比較
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1401 | Tenofovir | 2 mg/mL | 4 mg/mL | '''<1 mg/mL |
| S1400 | Tenofovir Disoproxil Fumarate | <1 mg/mL | 100 mg/mL | ''44 mg/mL |
| S1704 | Emtricitabine | 49 mg/mL | 49 mg/mL | '9 mg/mL |
| S1252 | Entecavir Hydrate | <1 mg/mL | 59 mg/mL | <1 mg/mL |
| S1718 | Adefovir Dipivoxil | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S3273 | Hypericin | -1 mg/mL | 100 mg/mL | '''-1 mg/mL |
| S6848 | 3'-Fluoro-3'-deoxythymidine (Alovudine) | 20 mg/mL | 49 mg/mL | '40 mg/mL |
| S1742 | Nevirapine | <1 mg/mL | 53 mg/mL | '<1 mg/mL |
| S1702 | Didanosine | <1 mg/mL | 47 mg/mL | <1 mg/mL |
| S1706 | Lamivudine | 46 mg/mL | 46 mg/mL | ''<1 mg/mL |
| S1398 | Stavudine (d4T) | <1 mg/mL | 45 mg/mL | '15 mg/mL |
| S1651 | Telbivudine | 48 mg/mL | 48 mg/mL | 2 mg/mL |
| S3080 | Etravirine (TMC125) | <1 mg/mL | 42 mg/mL | '<1 mg/mL |
| S2579 | Zidovudine | 53 mg/mL | 53 mg/mL | 18 mg/mL |
| S1719 | Zalcitabine | 42 mg/mL | 7 mg/mL | '<1 mg/mL |
| S3165 | Abacavir sulfate | 36 mg/mL | <1 mg/mL | '<1 mg/mL |
| S2914 | Dapivirine (TMC120) | <1 mg/mL | 34 mg/mL | <1 mg/mL |
| S3076 | Foscarnet Sodium | 3 mg/mL | 7 mg/mL | <1 mg/mL |
| S7303 | Rilpivirine | <1 mg/mL | 73 mg/mL | '<1 mg/mL |
| S4890 | Bifendate | -1 mg/mL | 83 mg/mL | -1 mg/mL |
| S5215 | Abacavir | -1 mg/mL | 57 mg/mL | -1 mg/mL |
| S5246 | Entecavir | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| S4187 | Salicylanilide | <1 mg/mL | 43 mg/mL | 18 mg/mL |
| S4685 | Efavirenz | <1 mg/mL | 63 mg/mL | 63 mg/mL |
| S3606 | Fangchinoline | <1 mg/mL | 100 mg/mL | 4 mg/mL |
| S6452 | Delavirdine (mesylate) | <1 mg/mL | 100 mg/mL | 4 mg/mL |
| S7856 | Tenofovir Alafenamide (GS-7340) | <1 mg/mL | 95 mg/mL | 95 mg/mL |
| S5423 | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | -1 mg/mL | 52 mg/mL | -1 mg/mL |
| S5068 | Adefovir | 0.1 mg/mL | <1 mg/mL | <1 mg/mL |
| S6492 | Doravirine (MK-1439) | <1 mg/mL | 85 mg/mL | <1 mg/mL |
Reverse Transcriptase製品
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1401 |
TenofovirTenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
|
| S1400 |
Tenofovir Disoproxil FumarateTenofovir (GS-1278) Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
|
|
| S1704 |
EmtricitabineEmtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
||
| S1252 |
Entecavir HydrateEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S1718 |
Adefovir DipivoxilAdefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
||
| S3273新 |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
||
| S6848新 |
3'-Fluoro-3'-deoxythymidine (Alovudine)3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
||
| S1742 |
NevirapineNevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
|
|
| S1702 |
DidanosineDidanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
||
| S1706 |
LamivudineLamivudine (GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
|
|
| S1398 |
Stavudine (d4T)Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
||
| S1651 |
TelbivudineTelbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection. |
||
| S3080 |
Etravirine (TMC125)Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
1D 19F NMR spectra of RT181tfmF and several RT181tfmF mutants in the absence (black) and presence of NVP (pink), EFV (green), ETR (blue) and RPV (orange). (A) Superposition of the 19F spectra of apo-RT181tfmF and the 19F spectra of RT181tfmF in the presence of each NNRTI, (B) Superposition of the 19F spectra of apo-RT181tfmF-V108I and the 19F spectra of RT181tfmF in the presence of each NNRTI, (C) Superposition of the 19F spectra of apo-RT181tfmF-K103N and the 19F spectra of RT181tfmF-K103N in the presence of each NNRTI, (D) Superposition of the 19F spectra of apo-RT181tfmF-E138K(p51) and the 19F spectra of RT181tfmF-E138K(p51) in the presence of each NNRTI. The 19F spectra in the presence of each NNRTI at 1:1 and 1:5 molar ratios are shown in light and dark colors, respectively. Chemical formulae for each inhibitor are depicted in the individual panels.
|
|
| S2579 |
ZidovudineZidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. |
||
| S1719 |
ZalcitabineZalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
||
| S3165 |
Abacavir sulfateAbacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
||
| S2914 |
Dapivirine (TMC120)Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
||
| S3076 |
Foscarnet SodiumFoscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
||
| S7303 |
RilpivirineRilpivirine (R278474, TMC27) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
||
| S4890 |
BifendateBifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
||
| S5215 |
AbacavirAbacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
||
| S5246 |
EntecavirEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S4187 |
SalicylanilideSalicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
||
| S4685 |
EfavirenzEfavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
||
| S3606 |
FangchinolineFangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities. |
||
| S6452 |
Delavirdine (mesylate)Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
||
| S7856 |
Tenofovir Alafenamide (GS-7340)Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. |
||
| S5423 |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
||
| S5068 |
AdefovirAdefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
||
| S6492 |
Doravirine (MK-1439)Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1401 |
TenofovirTenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; **** p<0.0001; *** p<0.001 (unpaired t-test). |
|
| S1400 |
Tenofovir Disoproxil FumarateTenofovir (GS-1278) Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
|
|
| S1704 |
EmtricitabineEmtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
||
| S1252 |
Entecavir HydrateEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S1718 |
Adefovir DipivoxilAdefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
||
| S3273新 |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
||
| S6848新 |
3'-Fluoro-3'-deoxythymidine (Alovudine)3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
||
| S1742 |
NevirapineNevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
|
|
| S1702 |
DidanosineDidanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
||
| S1706 |
LamivudineLamivudine (GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
|
|
| S1398 |
Stavudine (d4T)Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
||
| S1651 |
TelbivudineTelbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection. |
||
| S3080 |
Etravirine (TMC125)Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
1D 19F NMR spectra of RT181tfmF and several RT181tfmF mutants in the absence (black) and presence of NVP (pink), EFV (green), ETR (blue) and RPV (orange). (A) Superposition of the 19F spectra of apo-RT181tfmF and the 19F spectra of RT181tfmF in the presence of each NNRTI, (B) Superposition of the 19F spectra of apo-RT181tfmF-V108I and the 19F spectra of RT181tfmF in the presence of each NNRTI, (C) Superposition of the 19F spectra of apo-RT181tfmF-K103N and the 19F spectra of RT181tfmF-K103N in the presence of each NNRTI, (D) Superposition of the 19F spectra of apo-RT181tfmF-E138K(p51) and the 19F spectra of RT181tfmF-E138K(p51) in the presence of each NNRTI. The 19F spectra in the presence of each NNRTI at 1:1 and 1:5 molar ratios are shown in light and dark colors, respectively. Chemical formulae for each inhibitor are depicted in the individual panels.
|
|
| S2579 |
ZidovudineZidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. |
||
| S1719 |
ZalcitabineZalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
||
| S3165 |
Abacavir sulfateAbacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
||
| S2914 |
Dapivirine (TMC120)Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
||
| S3076 |
Foscarnet SodiumFoscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
||
| S7303 |
RilpivirineRilpivirine (R278474, TMC27) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
||
| S4890 |
BifendateBifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B. |
||
| S5215 |
AbacavirAbacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
||
| S5246 |
EntecavirEntecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
||
| S4187 |
SalicylanilideSalicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
||
| S4685 |
EfavirenzEfavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
||
| S3606 |
FangchinolineFangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities. |
||
| S6452 |
Delavirdine (mesylate)Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
||
| S7856 |
Tenofovir Alafenamide (GS-7340)Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. |
||
| S5423 |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
||
| S5068 |
AdefovirAdefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
||
| S6492 |
Doravirine (MK-1439)Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
