逆転写酵素

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1401 Tenofovir 2 mg/mL 4 mg/mL <1 mg/mL
S1400 Tenofovir (GS 1278) Disoproxil Fumarate <1 mg/mL 100 mg/mL ''''44 mg/mL
S1704 Emtricitabine (BW 1592) 49 mg/mL 49 mg/mL ''''9 mg/mL
S1252 Entecavir Hydrate <1 mg/mL 59 mg/mL '<1 mg/mL
S1718 Adefovir Dipivoxil (GS 0840) <1 mg/mL 100 mg/mL ''100 mg/mL
S5959 Tenofovir Disoproxil <1 mg/mL 100 mg/mL ''100 mg/mL
S4879 Tenofovir hydrate 10 mg/mL <1 mg/mL ''<1 mg/mL
S4427 Tenofovir alafenamide hemifumarate 50 mg/mL 100 mg/mL '100 mg/mL
S4428 Tenofovir alafenamide fumarate 10 mg/mL 100 mg/mL '100 mg/mL
S3273 Hypericin -1 mg/mL 100 mg/mL -1 mg/mL
S1742 Nevirapine (NSC 641530) <1 mg/mL 53 mg/mL '<1 mg/mL
S1702 Didanosine <1 mg/mL 47 mg/mL <1 mg/mL
S1706 Lamivudine (BCH-189) 46 mg/mL 46 mg/mL ''<1 mg/mL
S1398 Stavudine (d4T) <1 mg/mL 45 mg/mL 15 mg/mL
S1651 Telbivudine 48 mg/mL 48 mg/mL 2 mg/mL
S3080 Etravirine (TMC125) <1 mg/mL 42 mg/mL <1 mg/mL
S2579 Zidovudine 53 mg/mL 53 mg/mL 18 mg/mL
S1719 Zalcitabine 42 mg/mL 7 mg/mL <1 mg/mL
S3165 Abacavir sulfate 36 mg/mL <1 mg/mL <1 mg/mL
S2914 Dapivirine (TMC120) <1 mg/mL 34 mg/mL <1 mg/mL
S3076 Foscarnet Sodium 3 mg/mL 7 mg/mL '<1 mg/mL
S7303 Rilpivirine <1 mg/mL 73 mg/mL '<1 mg/mL
S4890 Bifendate -1 mg/mL 83 mg/mL -1 mg/mL
S5215 Abacavir (1592U89) -1 mg/mL 57 mg/mL '-1 mg/mL
S5246 Entecavir <1 mg/mL 55 mg/mL <1 mg/mL
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 20 mg/mL 49 mg/mL ''40 mg/mL
S4187 Salicylanilide <1 mg/mL 43 mg/mL '18 mg/mL
S4685 Efavirenz <1 mg/mL 63 mg/mL '63 mg/mL
S3606 Fangchinoline <1 mg/mL 100 mg/mL 4 mg/mL
S6452 Delavirdine (mesylate) <1 mg/mL 100 mg/mL 4 mg/mL
S7856 Tenofovir Alafenamide (GS-7340) <1 mg/mL 95 mg/mL 95 mg/mL
S8055 Lersivirine (UK-453061) <1 mg/mL 62 mg/mL '''62 mg/mL
S5423 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride -1 mg/mL 52 mg/mL -1 mg/mL
S5068 Adefovir 0.1 mg/mL <1 mg/mL <1 mg/mL
S6492 Doravirine (MK-1439) <1 mg/mL 85 mg/mL <1 mg/mL

亜型選択性的な製品

Reverse Transcriptase製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir (GS 1278) Disoproxil Fumarate

Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine (BW 1592)

Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil (GS 0840)

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S5959

Tenofovir Disoproxil

Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.

S4879

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S4427

Tenofovir alafenamide hemifumarate

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S4428

Tenofovir alafenamide fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S3273

Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

S1742

Nevirapine (NSC 641530)

Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine (BCH-189)

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

S1719

Zalcitabine

Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir (1592U89)

Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S6848

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S4187

Salicylanilide

Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S6452

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S8055

Lersivirine (UK-453061)

Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

S6492

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1401

Tenofovir

Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir (GS 1278) Disoproxil Fumarate

Tenofovir Disoproxil Fumarate (GS-1278, Tenofovir DF) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine (BW 1592)

Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.

S1252

Entecavir Hydrate

Entecavir Hydrate (ETV, Baraclude), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil (GS 0840)

Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S5959

Tenofovir Disoproxil

Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.

S4879

Tenofovir hydrate

Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.

S4427

Tenofovir alafenamide hemifumarate

Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S4428

Tenofovir alafenamide fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

S3273

Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

S1742

Nevirapine (NSC 641530)

Nevirapine (NSC 641530) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine (BCH-189)

Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

S1398

Stavudine (d4T)

Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

S1719

Zalcitabine

Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4890

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.

S5215

Abacavir (1592U89)

Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

S5246

Entecavir

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S6848

3'-Fluoro-3'-deoxythymidine (Alovudine)

3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.

S4187

Salicylanilide

Salicylanilides (WR10019) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S4685

Efavirenz

Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S3606

Fangchinoline

Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.

S6452

Delavirdine (mesylate)

Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

S8055

Lersivirine (UK-453061)

Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.

S5423

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.

S5068

Adefovir

Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

S6492

Doravirine (MK-1439)

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.

Tags: reverse transcriptase inhibition | reverse transcriptase reaction | hiv reverse transcriptase | reverse transcriptase protocol | reverse transcriptase function | reverse transcriptase assay | reverse transcriptase activity | reverse transcriptase drugs | reverse transcriptase mechanism | reverse transcriptase in humans | reverse transcriptase inhibitor review