逆転写酵素

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1401	Tenofovir	2 mg/mL	4 mg/mL	<1 mg/mL
S1400	Tenofovir Disoproxil Fumarate	<1 mg/mL	100 mg/mL	44 mg/mL
S1704	Emtricitabine	49 mg/mL	49 mg/mL	9 mg/mL
S1252	Entecavir Hydrate	<1 mg/mL	59 mg/mL	<1 mg/mL
S1718	Adefovir Dipivoxil	<1 mg/mL	100 mg/mL	100 mg/mL
S6452	Delavirdine (mesylate)	<1 mg/mL	100 mg/mL	4 mg/mL
S5068	Adefovir	0.1 mg/mL	<1 mg/mL	<1 mg/mL
S5423	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride	-1 mg/mL	52 mg/mL	-1 mg/mL
S5246	Entecavir	<1 mg/mL	55 mg/mL	<1 mg/mL
S5215	Abacavir	-1 mg/mL	57 mg/mL	-1 mg/mL
S4890	Bifendate	-1 mg/mL	83 mg/mL	-1 mg/mL
S1742	Nevirapine	<1 mg/mL	53 mg/mL	<1 mg/mL
S1702	Didanosine	<1 mg/mL	47 mg/mL	<1 mg/mL
S1706	Lamivudine	46 mg/mL	46 mg/mL	<1 mg/mL
S1398	Stavudine (d4T)	<1 mg/mL	45 mg/mL	15 mg/mL
S1651	Telbivudine	48 mg/mL	48 mg/mL	2 mg/mL
S3080	Etravirine (TMC125)	<1 mg/mL	42 mg/mL	<1 mg/mL
S2579	Zidovudine	53 mg/mL	53 mg/mL	18 mg/mL
S1719	Zalcitabine	42 mg/mL	7 mg/mL	<1 mg/mL
S3165	Abacavir sulfate	36 mg/mL	<1 mg/mL	<1 mg/mL
S2914	Dapivirine (TMC120)	<1 mg/mL	34 mg/mL	<1 mg/mL
S3076	Foscarnet Sodium	3 mg/mL	7 mg/mL	<1 mg/mL
S7303	Rilpivirine	<1 mg/mL	73 mg/mL	<1 mg/mL
S4187	Salicylanilide	<1 mg/mL	43 mg/mL	18 mg/mL
S4685	Efavirenz	<1 mg/mL	63 mg/mL	63 mg/mL
S3606	Fangchinoline	<1 mg/mL	100 mg/mL	4 mg/mL
S7856	Tenofovir Alafenamide (GS-7340)	<1 mg/mL	95 mg/mL	95 mg/mL

Reverse Transcriptase製品

All (27) Reverse Transcriptase阻害剤(27) 新Reverse Transcriptase製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1401	Tenofovir Tenofovir blocks reverse transcriptase and hepatitis B virus infections.	Sci Transl Med, 2014, 6(262):262ra157 Sci Signal, 2015, 8(399):ra104 Retrovirology, 2015, 10.1186/s12977-015-0139-7	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S1400	Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.	Sci Transl Med, 2014, 6(262):262ra157 Nanoscale, 2017, 9(44):17263-17273 Retrovirology, 2015, 10.1186/s12977-015-0139-7	Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
S1704	Emtricitabine Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.	J Immunol, 2014, 193(7):3577-89
S1252	Entecavir Hydrate Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).	J Hepatol, 2015, 10.1016/j.jhep.2015.02.048
S1718	Adefovir Dipivoxil Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
S6452^新	Delavirdine (mesylate)
S5068^新	Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5423^新	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5246^新	Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
S5215^新	Abacavir Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.	Antiviral Res, 2015, 123:62-9 Antiviral Res, 2017, 142:123-135 Antimicrob Agents Chemother, 2014, 58(8):4804-13
S4890^新	Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S1742	Nevirapine Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.	Sci Transl Med, 2014, 6(262):262ra157	Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
S1702	Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
S1706	Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.		The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
S1398	Stavudine (d4T) Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
S1651	Telbivudine Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.	Sci Rep, 2013, 3:2105
S3080	Etravirine (TMC125) Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.	Antiviral Res, 2017, 145:103-113 Biochemistry, 2016, 55(28):3864-73	1D 19F NMR spectra of RT181tfmF and several RT181tfmF mutants in the absence (black) and presence of NVP (pink), EFV (green), ETR (blue) and RPV (orange). (A) Superposition of the 19F spectra of apo-RT181tfmF and the 19F spectra of RT181tfmF in the presence of each NNRTI, (B) Superposition of the 19F spectra of apo-RT181tfmF-V108I and the 19F spectra of RT181tfmF in the presence of each NNRTI, (C) Superposition of the 19F spectra of apo-RT181tfmF-K103N and the 19F spectra of RT181tfmF-K103N in the presence of each NNRTI, (D) Superposition of the 19F spectra of apo-RT181tfmF-E138K(p51) and the 19F spectra of RT181tfmF-E138K(p51) in the presence of each NNRTI. The 19F spectra in the presence of each NNRTI at 1:1 and 1:5 molar ratios are shown in light and dark colors, respectively. Chemical formulae for each inhibitor are depicted in the individual panels.
S2579	Zidovudine Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.
S1719	Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
S3165	Abacavir sulfate Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
S2914	Dapivirine (TMC120) Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
S3076	Foscarnet Sodium Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
S7303	Rilpivirine Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.	Antiviral Res, 2017, 145:103-113
S4187	Salicylanilide Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
S4685	Efavirenz Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
S3606	Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
S7856	Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1401	Tenofovir Tenofovir blocks reverse transcriptase and hepatitis B virus infections.	Sci Transl Med, 2014, 6(262):262ra157 Sci Signal, 2015, 8(399):ra104 Retrovirology, 2015, 10.1186/s12977-015-0139-7	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S1400	Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.	Sci Transl Med, 2014, 6(262):262ra157 Nanoscale, 2017, 9(44):17263-17273 Retrovirology, 2015, 10.1186/s12977-015-0139-7	Human PBMCs containing indicated concentrations of Tenofovir disoproxil fumarate were inoculated with 5 ng mock-exposed or semen-exposed R5-HIV-luciferase, or 50 ng R5-HIV-luciferase as infectivity matched control. Infection rates were determined 3 days post inoculation.
S1704	Emtricitabine Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.	J Immunol, 2014, 193(7):3577-89
S1252	Entecavir Hydrate Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).	J Hepatol, 2015, 10.1016/j.jhep.2015.02.048
S1718	Adefovir Dipivoxil Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
S6452^新	Delavirdine (mesylate)
S5068^新	Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
S5423^新	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S5246^新	Entecavir Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
S5215^新	Abacavir Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.	Antiviral Res, 2015, 123:62-9 Antiviral Res, 2017, 142:123-135 Antimicrob Agents Chemother, 2014, 58(8):4804-13
S4890^新	Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
S1742	Nevirapine Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.	Sci Transl Med, 2014, 6(262):262ra157	Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 d post infection by measuring β-galactosidase. Left: the mean enzyme activities. Middle: normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of nevirapine were set at 100%. Right: IC50 values.
S1702	Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
S1706	Lamivudine Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.		The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.
S1398	Stavudine (d4T) Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
S1651	Telbivudine Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.	Sci Rep, 2013, 3:2105
S3080	Etravirine (TMC125) Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.	Antiviral Res, 2017, 145:103-113 Biochemistry, 2016, 55(28):3864-73	1D 19F NMR spectra of RT181tfmF and several RT181tfmF mutants in the absence (black) and presence of NVP (pink), EFV (green), ETR (blue) and RPV (orange). (A) Superposition of the 19F spectra of apo-RT181tfmF and the 19F spectra of RT181tfmF in the presence of each NNRTI, (B) Superposition of the 19F spectra of apo-RT181tfmF-V108I and the 19F spectra of RT181tfmF in the presence of each NNRTI, (C) Superposition of the 19F spectra of apo-RT181tfmF-K103N and the 19F spectra of RT181tfmF-K103N in the presence of each NNRTI, (D) Superposition of the 19F spectra of apo-RT181tfmF-E138K(p51) and the 19F spectra of RT181tfmF-E138K(p51) in the presence of each NNRTI. The 19F spectra in the presence of each NNRTI at 1:1 and 1:5 molar ratios are shown in light and dark colors, respectively. Chemical formulae for each inhibitor are depicted in the individual panels.
S2579	Zidovudine Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.
S1719	Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
S3165	Abacavir sulfate Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
S2914	Dapivirine (TMC120) Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
S3076	Foscarnet Sodium Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
S7303	Rilpivirine Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.	Antiviral Res, 2017, 145:103-113
S4187	Salicylanilide Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
S4685	Efavirenz Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
S3606	Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
S7856	Tenofovir Alafenamide (GS-7340) Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

研究分野別

製品類型

逆転写酵素

シグナル伝達経路

研究分野

阻害剤の選択性比較

Reverse Transcriptase製品