Z-VAD-FMK

For research use only. Not for use in humans.

製品コードS7023

Z-VAD-FMK化学構造

CAS No. 187389-52-2

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

サイズ 価格(税別) 在庫  
JPY 21400 あり
JPY 80000 あり
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文献中Selleckの製品使用例(564)

製品安全説明書

Caspase阻害剤の選択性比較

生物活性

製品説明 Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
特性 A key compound for apoptosis studies.
ターゲット
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外試験

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NX3DSW84SXCxcITvd4l{KEG|c3H5 NFrEco02OM7:TR?= NWKySWk5OjSq NIfhZ5lqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? MXSyOlE3QTB5NR?=
HGL5 NFTtWJRCeG:ydH;zbZMhSXO|YYm= MlrmOVDPxE1? MkfUNlRp NXvGb5gycW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? MXyyOlE3QTB5NR?=
HepG2 MmXtRZBweHSxc3nzJGF{e2G7 M1njflIx|ryP M1;lV|Fp M1\ieoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> M4T0elI3OTZ2N{m1
BEL-7402 M4TyRmFxd3C2b4Ppd{BCe3OjeR?= NF3iV|MzOM7:TR?= M3m0[VFp NHvRWmFifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh M3XyOlI3OTZ2N{m1
CEF NVyyVIsxU2mwYYPlJGF{e2G7 NWDObllQOCx|Mzy2O{wyODEQvF2= M1;rcFE2dWmw M1fTSYRwf25vcnXneYxifGW|IGDSJIVvgnmvZTDhZ5Rqfmm2eTD0c{A1OO,:hTDheEAyODEQvF2= NHTJWGozPjFyMkOzPS=>
SP2/0 M1LlW2Fxd3C2b4Ppd{BCe3OjeR?= NXrEbGdEOTByzszN NU\UPYRFOWh? NHnIToxFVVOR Mn7BZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= NIHGNnYzPjB5NEezNi=>
HUVEC-2c MlXFRZBweHSxc3nzJGF{e2G7 Mnf0OVDPxE1? NV7EUGZmPmh? MnPF[IVkemWjc3XkJJRp\SCxeD3MSGwucW6mdXPl[EBifXSxcHjh[5k> NIjteFczPjB{MUeyPS=>
U1 NHfSOJFCeG:ydH;zbZMhSXO|YYm= NVj5TGtoOC1zMEFOwG0> MnvJNog> NX\SVIJ3emWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M4HEXlI2QThyOUSy
ACH-2 MWTBdI9xfG:|aYOgRZN{[Xl? M37vfFAuOjByzszN NWToXIJZOmh? M4XWbpJm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MmWyNlU6QDB7NEK=
U1 NIflVWxMcW6jc3WgRZN{[Xl? Mm\kNVAx|ryP MYGybC=> M1zHWolvcGmkaYTzJINie3Cjc3WtNy=> M4nSblI2QThyOUSy
A549/V16 MoHZRZBweHSxc3nzJGF{e2G7 M2DveFUx|ryP NWTicGFGOWh? MUfy[ZBz\XO|ZYOgWGcwXE1vaX7keYNm\CCjcH;weI9{cXN? M2[3ZlI2QTR4MEOz
SGN MlPmRZBweHSxc3nzJGF{e2G7 NUHwWnpSOjCvTR?= M3HSdVQ5cA>? M3zweohieyCwbzDpcoZtfWWwY3Wgc44hSUmILDDjZYxx[WmwIHX4dJJme3Orb36gc5Ih[2WubDDhdI9xfG:|aYO= MliwNlU5PzR4M{O=
HCT116  M1XBWmFxd3C2b4Ppd{BCe3OjeR?= MXW1NO69VQ>? M4rR[FJp NFXVbZVqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JGRFXlB? M2PS[FI2QDZ6OEG4
DTK-SME NITNcYtCeG:ydH;zbZMhSXO|YYm= MVW1NO69VQ>? M1rQTlJp NHvsTFJFVVOR Mn7zdIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> MV2yOVg1Ozh7Nx?=
HL-60 MkDvRZBweHSxc3nzJGF{e2G7 M{HNWFUx|ryP NF;2dZA1QGh? MoDEdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> NGXENlMzPTh{NEC0Ny=>
U937 NEfSelhCeG:ydH;zbZMhSXO|YYm= MXG1NO69VQ>? MnS2OFhp NYLJVWJEemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? MXmyOVgzPDB2Mx?=
A549 NGO5enJCeG:ydH;zbZMhSXO|YYm= NFzs[XQzOCEQvF2= NGTld3MzPGh? NV6we5QzemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCKRlPQJJRz\WG2bXXueC=> M1;3d|I2Pzl2MUS5
HeLa MXvBdI9xfG:|aYOgRZN{[Xl? MUKxNO69VQ>? MlzwOFhp NHK3OXhl\WOuaX7ld{B1cGVicnH0[UBw\iCjcH;weI9{cXNiZILhcYF1cWOjbHz5 NFzPdFQzPTd5MkW0OS=>
SGC-7901 MXzBdI9xfG:|aYOgRZN{[Xl? NFPERoUzOMLizszN MkfCNYg> M4fSXIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgc5hidGmybHH0bY4> Mn3uNlU4PjdyN{[=
MCF-7 NX23fmpCSXCxcITvd4l{KEG|c3H5 NF7FVnYyOM7:TR?= MXqybC=> M3X4UolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgN2I> M{jmfFI2PzJ{MUG0
A549 MoW4RZBweHSxc3nzJGF{e2G7 MXexNEDPxE1? NE\4V5UzPGh? NGjMVmtFVVOR NX\IUVdkeHKxbX;0[ZMhUEKFLYTy[YF1\WRiQUW0PUBk\WyuIIP1dpZqfmGuID[gZZR1\W63YYTld{B1cGViY3zlZZZm\CCSQWLQJIV5eHKnc4Ppc44> NVnRfHQxOjV4OEO1Olg>
U87 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPQOVDPxE1? M1HYdVFp M4Pmd5Jm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? NYfXTZhDOjV4OEG2Olg>
Neocortical Neuron M3Kwb25mfXKxdH;4bYNqfHliQYPzZZk> NH;FPZoyODEQvF2= MkCyNYg> NHm5cVZidnSjZ3;ubZpmeyCKb3nhcYll\SCDLVnu[JVk\WRiTnX1do91d3irY3n0fS=> NXfWfINKOjV4N{WwNFE>
Primary human placental cytotrophoblasts NFj1NHFCeG:ydH;zbZMhSXO|YYm= MUezNO69VQ>? MkLDNlRp MYLEUXNQ NWroSmQzemW4ZYLz[ZMhfGinIHnubIljcXSrb36gc4YhOTIQsj3IV2QzKGK7IITybYNtd3OjbtMg NWjOfVlEOjV4NEK1PVI>
MM NHTaVlVCeG:ydH;zbZMhSXO|YYm= NUWyRZhGPTEQvF2= Ml\aNlBucW5? MoTTdIFzfGy7IHnubIljcXS|IGPIT{1qdmS3Y3XkJEBk\WyuIHTlZZRp MVWyOVU{ODB7OB?=
DLD1 Mn7kRZBweHSxc3nzJGF{e2G7 M3LwfFIxyqEQvF2= NV;Se3VoOWh? NUPPfWRreGG{dHz5JJJmfmW{c3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDXV3Ay MY[yOVUzPDJ2Nh?=
MDA-MB-231 NYH2VmRPS3m2b4TvfIlkcXS7IFHzd4F6 Mnv3NVDPxE1? MlrKNYg> NHn6eJZifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 MYeyOVUzOTVyMR?=
MKN28 MVzBdI9xfG:|aYOgRZN{[Xl? NEGxd|cyOM7:TR?= NX70c5F[OzCvaX6= MnrPSG1UVw>? NEj4bHBqdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= MnnvNlU2OTN7NkC=
HL-60 MYTDfZRwfG:6aXPpeJkhSXO|YYm= MUCxNFDPxE1? MYKxbC=> NVK5[4llTE2VTx?= MXtCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MlHhNlU2ODJ7M{K=
AGS M1;BTmFxd3C2b4Ppd{BCe3OjeR?= MX:xNO69VQ>? M3nHPFFp NYDHPXJ4eHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= MWWyOVQ6OjJzNB?=
A549  NWjoclVTSXCxcITvd4l{KEG|c3H5 NUTHXmhMOTEQvF2= NYHhW|FYOjSq NGLQd|VjdG:la4OgSG1CWy2rbnT1Z4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDhcoQh[XCxcITveIlkKGOnbHyg[IVifGh? NFy4SY4zPTR|NEm4PS=>
INS-1 M3vOPWFxd3C2b4Ppd{BCe3OjeR?= NYfCR5dTPTEQvF2= NEj1[oo3cA>? MnTvSG1UVw>? NYTtZYtK\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGWjcnz5JIFxd3C2b4TpZ{Bk\Wyuc9Mg NHPhSoIzPTR|MEi5Oy=>
Primary hepatocytes  MXHBdI9xfG:|aYOgRZN{[Xl? NEH5[Gs2OM7:TR?= NIXkXYsyQGh? MmD2bY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= MX:yOVQxPzV|OB?=
L929-A  M37XdWN6fG:2b4jpZ4l1gSCDc4PhfS=> NIPZRYMzOMLizszN M3HPVlI1cA>? MUnpcohq[mm2czDUUmbPuS2rbnT1Z4VlKGOnbHyg[IVifGh? Mne1NlU{QTh3NEC=
L929-N M3PvZWN6fG:2b4jpZ4l1gSCDc4PhfS=> NF[wV|YzOMLizszN MknNNlRp MVrlcohidmOnczDk[YF1cCC4aXGgZZV1d2O{aX7lJHRPTs7zIIDyc4R2[3Srb36= NF:5eI8zPTN7OEW0NC=>
Cytotoxicity Assay MXTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MYOyNO69VQ>? NHnLU5U1QGh? MljKdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? NIjJdZAzPTN7MkGxOi=>
COS7 MUjLbY5ie2ViQYPzZZk> NUL3SHdMOTEQvF2= MXWyOIg> MWPpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? M1fqeFI2Ozh2MEK1
COS7 MnjBRZBweHSxc3nzJGF{e2G7 Ml3pNVDPxE1? NUnHNJV6PDiq MoTydIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= NX3V[m5YOjV|OESwNlU>
A375 M{PudGFxd3C2b4Ppd{BCe3OjeR?= NVfW[4hQOzEQvF2= NHTsUWkzcA>? M13D[pBz\X[nboTzJJRp\SCmcoXnMYlv\HWlZXSgVGFTWCClbHXheoFo\Q>? NEjRNHMzPTN5NkGxOS=>
A549 MYTBdI9xfG:|aYOgRZN{[Xl? MkD0OVDPxE1? M4e0eFI1cA>? NXrT[3JHemW4ZYLz[ZMhemmkb4PvcYUh[mmxZ3Xu[ZNqeyCjbnSgZZBweHSxc3nzJINifXOnZDDifUAhS2iran;u[4Ridg>? NIrMUlgzPTN2OUe4NS=>
A549 MkL5RZBweHSxc3nzJGF{e2G7 M3HySlIvPS1{Nd88US=> MYmxbC=> M{XpUIRm[3KnYYPld{B1cGVicH;weYxifGmxbjDv[kBieG:ydH;0bYMh[2WubIOg[IVx\W6mIH;uJINwdmOnboTyZZRqd26| M1XuT|I2OzR{NEK3
 NBL-W-S  MXHBdI9xfG:|aYOgRZN{[Xl? MWS1NO69VQ>? M3;oTFFp MmPa[pVtdHlicnXzZ5VmeyClZXzsJJZq[WKrbHn0fUBi\nSncjDHRW5VNTZzIITy[YF1dWWwdB?= MYKyOVMzOzJ{Mh?=
Caki-1  MWnBdI9xfG:|aYOgRZN{[Xl? MX[0NO69VQ>? NXHPVYd[PDiq M4\MfJJm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> M{DXPFI2Ojd7MUmx
769-P MlzlRZBweHSxc3nzJGF{e2G7 MojBOFDPxE1? NFXacW01QGh? MoLsdoVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> NGH5emQzPTJ5OUG5NS=>
H9c2 M4OyOGFxd3C2b4Ppd{BCe3OjeR?= MnzaOVDPxE1? NUnLcI54OWh? MnfIbY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? MX[yOVI5OzhzOR?=
K562 MVHBdI9xfG:|aYOgRZN{[Xl? M3rPcVUx|ryP Mm[4OIg> M4[y[YlvcGmkaYTzJGpi[y2DLXnu[JVk\WRiY3XscEBieG:ydH;zbZM> NIPETWgzPTJ2MU[xPS=>
L929 MoP2RZBweHSxc3nzJGF{e2G7 MkHmNVDPxE1? NWnLXWdkPmh? MV;pcoR2[2W|IH7lZ5JweHSxc3nzJJdqfGhiVF7G MojWNlUyQTV4NkC=
A549 NV2wdmFxSXCxcITvd4l{KEG|c3H5 M3;ab|Ex|ryP NXnFR5luO2h? MXry[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= NHHzXYEzPTF4MU[5PS=>
MCF-7 NEexW4RCeG:ydH;zbZMhSXO|YYm= MYKyNO69VQ>? NUC2OmFSOmh? MYLk[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz MXSyOVE5OjJ2MB?=
OS NIfkUpNCeG:ydH;zbZMhSXO|YYm= M3XSRVIxNzRyzszN MUO3Nog> NVjwXWo2cW6qaXLpeJMhV1NiY3XscEB3cWGkaXzpeJkhemWmdXP0bY9vKGK7IFO2JINmemGvaXTl MUKyOVE2OjN7OR?=
HUVECs NUjwRWZUSXCxcITvd4l{KEG|c3H5 M3rBflEx|ryP NUT5fXJuOmh? MonjxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBJXV[HQ4O= MWSyOVE{QDdyMx?=
EA.hy926 M4rIXmFxd3C2b4Ppd{BCe3OjeR?= MmL2NVDPxE1? NIKzUGozcA>? M1jwcOKhcW6qaXLpeJMh[XCxcITvd4l{KGGwZDDmZYNqdGm2YYTld{BifXSxcHjh[5khcW5iRFXOWlIucW6oZXP0[YQhTUFwaIm5NlY> NX6z[HlVOjVzM{i3NFM>
Ebs MkK0RZBweHSxc3nzJGF{e2G7 M3rHNFExNTFyMN88US=> NWfqTXhWOjSq NGK5[GvDqE2PVGOg[4Vv\XKjdHnvckBz[XSnIHTlZ5Jm[XOnZDDhd{B1cGViY3;uZ4VvfHKjdHnvckBw\iC8LW\BSE5ndWtiaX7jdoVie2Wm MUiyOVE{PDhzNx?=
Jurkat M4fRTmFxd3C2b4Ppd{BCe3OjeR?= NYLlbVJMOjEQvF2= Ml\JNlRp M2PsdmROW09? M3vqbZBienSrYXzsfUBqdmirYnn0JINmdGxiZHXheIghd2ZiSoXyb4F1KGOnbHzzJIlv\HWlZXSgZpkhOTByNUitSlQh[2:vYnnu[YQhf2m2aDDWVGHDqA>? MUGyOVEzODd{Mx?=
K562 MnvGRZBweHSxc3nzJGF{e2G7 Mkm2NE4yNTIQvF2= NWKxN3pbOWh? MkjVbY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MYmyOVEyQTF6OB?=
IMR-32 M4mwSmFxd3C2b4Ppd{BCe3OjeR?= M{PqNFQxyqEQvF5CpC=> MUeybC=> MWHk[YNz\WG|ZTDpckBieG:ydH;0bYMh[2WubIOgZ49ueGG{ZXSgeI8hXC1{IITvfIlv MmDjNlUxQDR5NUW=
RPMI 8226 MVzBdI9xfG:|aYOgRZN{[Xl? M2LmUlExOM7:TR?= M{LKRlFp Ml3jZYxud3O2IHPvcZBt\XSnbImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? NFLsXG8zPTB|N{i1NS=>
U266  NV\MTYFKSXCxcITvd4l{KEG|c3H5 NXvnb3JYOTByzszN MmriNYg> Mo\qdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NVLmOoxbOjVyM{e4OVE>
H929  NYDTOXNbSXCxcITvd4l{KEG|c3H5 NH62SHEyODEQvF2= NImwbpIycA>? NF;kWnNx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= MViyOVA{Pzh3MR?=
MM.1S  NXfaT5RRSXCxcITvd4l{KEG|c3H5 M4TFVlExOM7:TR?= MnzhNYg> NEHyS2Vm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z NIiwd5gzPTB|N{i1NS=>
C6 MVjBdI9xfG:|aYOgRZN{[Xl? MmfDOVDPxE1? MYO0PIg> MXXwdoV3\W62czD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDjZZV{\WRiYomgdJJm\26nbn;sc45m MVGyOVAyOzR5OR?=
AGS MoT4RZBweHSxc3nzJGF{e2G7 NV\BUXBbPTEQvF2= NESycJkzPGh? NXq3PVNK[WKxbHnzbJMh|rJvbHHwZYNpd26nLXnu[JVk\WRiY3XscEBl\WG2aDDhcoQhcW6qaXLpeIVlKGe{b4f0bC=> NFjpSWgzPTByOU[5PC=>
HeLa  NEnY[plCeG:ydH;zbZMhSXO|YYm= Mn3YOFDPxE1? NEfEWFQzPGh? MVLpcohq[mm2czD0bIUhcW6lcnXhd4VlKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPpVm5HOTJz MmnINlQ6Ojh4OEW=
THP-1  Moq0RZBweHSxc3nzJGF{e2G7 NEfVNGkyOM7:TR?= NIDnfVUycA>? M361O5Jm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSUyDLWPEWOKh NYLnOGZ7OjR7MkO2OVM>
P815  MoDkRZBweHSxc3nzJGF{e2G7 NXO5S3FjOTByINM1US=> MlHLNVJp MWjEUXNQ NW\aS5MycW6qaXLpeJMhfmm{dYOtbY5lfWOnZDDhdI9xfG:|aYO= MUeyOFkzOzJ5Mx?=
HCT116 NH;qSIdCeG:ydH;zbZMhSXO|YYm= NXnabpkxOjEQvF2= NWK3O4JDOjSq NXGxc5M{[WK{b3fheIV{KG:oIGTRMYlv\HWlZXSgZZBweHSxc3m= M4HydFI1QDlyNES5
SW1116  M4rEOWFxd3C2b4Ppd{BCe3OjeR?= M1mxWlExKML3TR?= NXHXfWd{OWh? NF20OHZFVVOR MnKydoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= NYjJNVdTOjR6N{SyPFY>
LOVO NUjEPIVJSXCxcITvd4l{KEG|c3H5 MVWxNEDDvU1? NH\s[24ycA>? NHrIXGxFVVOR NVHsfpgxemW|dILhbY5{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkh\2WoaYTpcoljKHCudYOg[IVkcXSjYnnu[S=> MoHwNlQ5PzR{OE[=
SNU449  MmrQRZBweHSxc3nzJGF{e2G7 NIL0OHkzOM7:TR?= MYS0PIg> NYLzNpV5TE2VTx?= M1rF[oRm[3KnYYPld{BucVJvNEWxMYlv\HWlZXSgZZBweHSxdHnj MYCyOFg1OTZ|OB?=
Caco-2 NVzR[|lkSXCxcITvd4l{KEG|c3H5 M{jWTVQx6oDLzszN M4\WXlRp NYDnVmM4eHKndnXueJMhW1RvNz3pcoR2[2WmIGrPMVEh[2ijbnfld{BidmRiVFXSJIRzd3B? MoH5NlQ5OjJzOEO=
macrophage M3f0NWNmdGxiVnnhZoltcXS7IFHzd4F6 MV[wMVIxOM7:TR?= NGfEbXozPGh? MmjEbY5lfWOnczDUUmYuKGGwZDDSbZA{NWSncHXu[IVvfCCwZXPyc5B1d3OrczDpckBu[WO{b4DoZYdm NXLU[XA1OjR5OUm1OlU>
AGS  NGqy[oVCeG:ydH;zbZMhSXO|YYm= M3:2OlIx|ryP NIq4XW0yOmh? MYDEUXNQ NXe1WW5CemWmdXPld{B1cGViaX7keYN1cW:wIH;mJIFxd3C2b4Ppd{BqdiC{ZYPwc45{\SC2bzD0bIUhTXSRQXOg[pJi[3Srb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MmLBNlQ4QDl5MEO=
LCC9  MoT3R4VtdCCYaXHibYxqfHliQYPzZZk> NHPsS|QyODEQvF2= MoLxOYQ> MYTicI9kc3NiY3XscEBl\WG2aDDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKExzNzDhcoQh[2iub4LvdZVqdmV? MkmwNlQ4QDV{NU[=
U937  MnO3coVkem:ydH;zbZMhSXO|YYm= MWKxNOKh|ryP MofsN|DDqG2rbh?= M1:x[4lv\HWlZYOgcoVkem:ydH;zbZMh[2:vYnnu[UB4cXSqIGTOSi=> NFnEb3QzPDd5M{e1Oi=>
T cell MUTD[YxtKHC{b3zp[oVz[XSrb36gZZN{[Xl? NXW2UHJvOC1zMEFOwG0> NF3YUHk4Omh? M{S2e2lEPTB;N{Cg{txONCCrbnjpZol1eyCjboTpMWNFOy2rbnT1Z4VlKFRiY3XscEBxem:uaX\ldoF1cW:wIHnuJHBDVUO| MUCyOFc3QDdyNx?=
HeLa  Mn3IRZBweHSxc3nzJGF{e2G7 MUm1NO69VQ>? M1vkd|czcA>? M2fLOWROW09? NV;CXW92eHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3;tdI92dmS|wrCx5qCUPQ>? NUHJbnl2OjR5NUS3PFY>
HeLa  NXq3fVNPSXCxcITvd4l{KEG|c3H5 NVHhW25POTByzszN NYe1PYxDOjSq Mm\Td5VxeHKnc4Pld{Bz[XSnIH;mJINmdGxiZHXheIghcW6mdXPl[EBjgSCxdnXy[ZhxemW|c3nvckBw\iCJNUnTJI9zKEd5MWKgdFE2OGeudXXkxsA> MXeyOFczOjR4OB?=
IEC-6  MoGzRZBweHSxc3nzJGF{e2G7 Mn3JNVDPxE1? MV2yOIg> NVjMZ4s{eHKndnXueJMhXGOmQT3pcoR2[2WmIHPhd5Bie2VvMzDjcIVifmGpZTDhcoQh|rJvY3H0[Y5qdiCmZXfyZYRifGmxbh?= NXH6UHVbOjR5MUG1O|E>
HCT116 MmnHRZBweHSxc3nzJGF{e2G7 NXftbZZYOjEQvF2= M3zJ[|I1cA>? M3PudIlvcGmkaYTzJJRp\SClZXzsJIFxd3C2b4TpZ{BqdmS3Y3XkJIJ6KFmOVEKwOS=> M4qxXFI1PzF|OEGy
L02 MkHLRZBweHSxc3nzJGF{e2G7 M13Oc|Ix|ryP MnH1NYg> M2XmXJBz\X[nboTzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE2HSGC= NELMbYczPDdyNkS2NS=>
A375 MU\BdI9xfG:|aYOgRZN{[Xl? MnL1NlDPxE1? Mki1NlRp NUjPXow5emW4ZYLz[ZMh\GmlaYTybY5wdmViQj3pcoR2[2WmIHHwc5B1d3Orcx?= MkL1NlQ3QTlzMUG=
HDPC Mlm1RZBweHSxc3nzJGF{e2G7 MmLiOVDDvU1? NFX6WIUzPGh? MYPpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> NEDCU4gzPDZ|NEW5Ny=>
A549 MWfBdI9xfG:|aYOgRZN{[Xl? M1;0UVUxyrWP NF;OWW4zcA>? M3fEbWROW09? M2C4d5Bz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw NIrjNXUzPDV6OEGzOS=>
 BV-2 M3\qWWFxd3C2b4Ppd{BCe3OjeR?= M33yZlIx|ryP NVHHS|ZVOmh? MXrzeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? MoLzNlQ2PThzMUi=
HT-29  MVPBdI9xfG:|aYOgRZN{[Xl? MUe1NO69VQ>? NF7hOVg1QGh? NX7HXXdy[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s MoHmNlQ2PDlzN{W=
A549 MkjsRZBweHSxc3nzJGF{e2G7 M3\QO|XPxE1? Mle3NlRp NF\4Z5Z{fXCycnXzd4V{KD[nwrCoRmsyODB2MDmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> MofkNlQ2Ojl6N{G=
MIA-PaCa-2 MlfVRZBweHSxc3nzJGF{e2G7 NFW1T3gzPGh? MoLTZoxw[2u|IHPs[YF3[WenIH;mJINie3Cjc3WtN{BqdmS3Y3XkJIJ6KGKxdHigRU01PDN4NUSgZY5lKHCjY3zpeIF5\Wx? NWP6eXpqOjR3MUC5PVI>
Caki-1 M4HWTGFxd3C2b4Ppd{BCe3OjeR?= MnTaNlDPxE1? Mnz5NYg> NIe1OItqdmirYnn0d{BUS1BvaX7keYNm\CCjcH;weI9{cXN? MXSyOFUxPDZ6MR?=
CLL MoX0RZBweHSxc3nzJGF{e2G7 MnfJNlXPxE1? MXqxbC=> NF\td3Fx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? MWCyOFQ3PzZ|NB?=
SGC-7901 MojTRZBweHSxc3nzJGF{e2G7 NVnCXnZ5OTEQvF2= MWeyOIg> MUHwdo9ud3SnczD0bIUhS0eLST3pcohq[mm2ZXSgZ4VtdCCpcn;3eIghcW5iU1fDMVc6ODFiY3XscJM> MlPjNlQ1PTR2OEi=
k1735 M3Xac2Fxd3C2b4Ppd{BCe3OjeR?= NUHWdmt[OjEkgJpOwI0> NFrKUms1cA>? MmfUbY5pcWKrdIRCpHNidG2xbnXscIEucW6mdXPl[EBieG:ydH;zbZM> M4DEPFI1PDVzMUG2
HaCaT  MlXBRZBweHSxc3nzJGF{e2G7 Mlq1NVAx|ryP NXTVWlN1OWh? NHi4T4ljdHWwdIOgWXZDNWmwZIXj[YQh[XCxcITvd4l{KGmwIFjhR4FVKGOnbHzz NWnzS2RlOjR|NU[5PVc>
podocytes NW\PZXRwSXCxcITvd4l{KEG|c3H5 NEHOXWwzODEQvF2= M1X6dVZp NYOySmdQcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? NF7zSnQzPDN|N{e3Oy=>
 KB NXTJSYJESXCxcITvd4l{KEG|c3H5 M{Ta[VUx|ryP MonMNlRp MnHCbY5pcWKrdIOgUIlkdy2DLXnu[JVk\WRiY3HzdIF{\S1|IHHu[EBRSVKSIHHjeIl3[XSrb36= MUKyOFM{PzR7Mh?=
 HepG2  MnH4RZBweHSxc3nzJGF{e2G7 NWHxV2xxOTEQvF2= MVqyOIg> NUHTbnBremWmdXPld{B3cW2nboTpckBkdGWjdnHn[UBk[XW|ZXSgZpkhVFCV NEm3SJozPDN{NUixOi=>
fetal rat lung fibroblasts  MVnLbY5ie2ViQYPzZZk> NVj5SWVkQDEQvF5CpC=> MYCxbC=> MknMbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> MoPaNlQ{OTRzM{W=
PDL fibroblasts MlTqT4lv[XOnIFHzd4F6 NFOwbnU5OM7:TdMg M{PI[|Fp NFyyZnNqdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? MWWyOFMyPDF|NR?=
MB49 NXLnelY3SXCxcITvd4l{KEG|c3H5 M3jCPVIx|ryP M3Xnc|Fp NFzhTlhz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? MWSyOFI5OjR|Mx?=
5637 NVXDWIZySXCxcITvd4l{KEG|c3H5 MUWyNO69VQ>? M1LMOVFp NIrLZnFz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? MmXENlQzQDJ2M{O=
A549  M3O0emFxd3C2b4Ppd{BCe3OjeR?= M3HHWlExOM7:TR?= NULTZ|lrPDiq M{PtOJN2eHC{ZYPz[ZMhfGinIHHwc5B1d3OrczDjZZV{\WRiYomgdIlx\XKrbnZCpC=> NIjSOoIzPDJ5MkKwNS=>
MCC-2 NUiyPGhWSXCxcITvd4l{KEG|c3H5 NYqxN5I2OjBizszN M{C4bVZp NGrBVYJFVVOR NIDwRlBjdG:la4OgbY5lfWOnZDDifUB{fGG3cn;zdI9zcW6nIHHwc5B1d3OrczDj[YxtKGSnYYTo MW[yOFI3OjZ3OB?=
ADF NEf2b5VCeG:ydH;zbZMhSXO|YYm= MlHoOFDPxE1? MXy2bC=> NETFboNqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NEDHNIgzPDJ{OEKzNi=>
 U373  NUX5TVlUSXCxcITvd4l{KEG|c3H5 Mo\2OFDPxE1? NFe3SpY3cA>? MX;pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NXvmVJJxOjR{MkiyN|I>
RKO-HIPK2i MmnnRZBweHSxc3nzJGF{e2G7 MoPPOFDPxE1? NFTOe443cA>? MXjpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NVHMPJptOjR{MkiyN|I>
HEC-1B MWjBdI9xfG:|aYOgRZN{[Xl? MoHRNlDPxE1? M4ry[FFp M2m5VZJm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 M2\ic|I1OjF|M{W4
4T1 M3n6NGNmdGxiVnnhZoltcXS7IFHzd4F6 NUDmc45DOi53LUGw{txO M4TMOFRp M4XsfWROW09? NEj0XGZz\XOldXXzJJRp\SCleYTveI95cWOrdImgc4YhPFRzIHPlcIx{KGmwZIXj[YQh[nliU2DEWEBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> NWfJZVRXOjR{ME[xOlE>
OS  NHi5cVZCeG:ydH;zbZMhSXO|YYm= M2Kwc|Ix|ryP MVq0bC=> MUXpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliUFTU Mk\wNlQzODR7M{e=
RPE NV6xOol7SXCxcITvd4l{KEG|c3H5 MWGxNFDPxE1? NIC1O401QGh? NF3E[Xhx[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? M{nDV|I1OjB{MEWy
UD29a M3m2UGFxd3C2b4Ppd{BCe3OjeR?= NELSVIQ2OM7:TR?= M4WweVI1cA>? NE\HdJpqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgUnVVOw>? NXrY[mtNOjRzOUC1O|Q>
SH-SY5Y  M4rTT2Fxd3C2b4Ppd{BCe3OjeR?= MXSxNO69VQ>? NXiyVlZrOjSq MV;heJRmdnWjdHXzJINie3Cjc3WgZYN1cX[jdHnvckBidmRiY3XscEBl\WG2aDDpcoR2[2WmIHL5JGhPTS1{RFe= MX[yOFE1PTR4Mx?=
HeLa  M1rBPWFxd3C2b4Ppd{BCe3OjeR?= M3nSTFExNzJyzszN NUflboNROjSq MVnpcohq[mm2czD0bIUh[WO2aY\peJkhd2ZidHjlJI1icm:{aYT5JI9nKHSqZTDt[Y1j\XK|IH;mJJRp\SClYYPwZZNmNW[jbXnsfS=> MUCyOFE{PzJ4Nh?=
SCCVII  NV7SdJhPSXCxcITvd4l{KEG|c3H5 MnvTNlXPxE1? MlW2NYg> NYDkSnpvcW6qaXLpeJMhfGinIHPlcIwhc2mubHnu[{Bi\nSncjDkZZNifGmwaXK= MmTQNlQyOjZ2NkS=
RAW 264.7 MUDBdI9xfG:|aYOgRZN{[Xl? M4i3T|Ix|ryP MoS5NVhp NGPRb3hqdmO{ZXHz[ZMhVEN|LVnJM:6zNWGldHnuJJJifGmxIHPvcZBiemWmIITvJGVEXFZvTV;TJJRz\WG2bXXueEBwdmy7 M{fnSVI1OTF4N{C3
A549  NHHBV5VCeG:ydH;zbZMhSXO|YYm= NXS3ZZJyOi53zszN NH7aTFEzPGh? NV;scI5F\GWlcnXhd4V{KG:{aXTvcolvNWmwZIXj[YQh[XW2b4DoZYd6KGG|IIflcIwh[W6mIFzvd5Mhd2ZizqVPjI0h[Wy|bzDvZ4N2enKnZDDkeZJqdmdiYYX0c5Bp[WerYzDwdo9k\XO| NYG4NGNuOjRzMEK1NlI>
UM-SCC-10A  NIW0NW5CeG:ydH;zbZMhSXO|YYm= NHTpWXg2OML3TR?= NETrPY0zcA>? MXry[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JIhq\2hvZH;z[UBqe2:jbHHueI9t[WO2b37l Ml3BNlQxQTh5NUO=
BGC-823 NXyzPFh2SXCxcITvd4l{KEG|c3H5 NWXX[otHOTBizszN NXLOR|BVOjSq MlnVdoVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NWXFbnFoOjRyOUi1NVE>
Nalm-6  NWTnWGhDSXCxcITvd4l{KEG|c3H5 NILYR|kzOM7:TR?= NUD0PG9xPGh? NHzVb49qdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> MkXaNlQxOzl7Nke=
KHOS  NHnCenpCeG:ydH;zbZMhSXO|YYm= M{nvUVQx|ryP M1HrRlI1cA>? M1fifIJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= NFjBWXUzPDB{NUO2NS=>
G292 NVi2Xo9xSXCxcITvd4l{KEG|c3H5 NYnCW4FwPDEQvF2= NH3MZW4zPGh? MlLWZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= NXLZ[mJxOjRyMkWzOlE>
MG-63 MmexRZBweHSxc3nzJGF{e2G7 M{nKWFQx|ryP NITWOIwzPGh? M2nkc4Jtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= Mm\4NlQxOjV|NkG=
EBV-transformed B cells M1HzR2Fxd3C2b4Ppd{BCe3OjeR?= Mmi4NlDPxE1? MY[ybC=> MVnEUXNQ MYTicI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> NEO5S4UzPDByOE[yPC=>
IM-9 B NHG1b2dCeG:ydH;zbZMhSXO|YYm= MVKyNO69VQ>? NXvpUHdqOmh? NX;1NpBTTE2VTx?= NH\tWndjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? M4LBWFI1ODB6NkK4
CNE1 Mn;1RZBweHSxc3nzJGF{e2G7 M2PVVlIx|ryP MUW0PIg> NVrOPFJE[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? NH;I[|EzOzl6NUCyPS=>
CNE2 MmDSRZBweHSxc3nzJGF{e2G7 MUWyNO69VQ>? MV20PIg> MnfWZoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> NVzK[W9yOjN7OEWwNlk>
HL-60 NUDhOnpySXCxcITvd4l{KEG|c3H5 MWK1NOK2VQ>? M4\N[|Fp NFPje4NFVVOR M1[3VolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKDMUS1 MUCyN|k1QDd3MR?=
L929 M13YT2Fxd3C2b4Ppd{BCe3OjeR?= NW\JcpJjOS5{NfMAl|XDqM7:TdMg NYntdoNEOjSq Ml7xZZVodWWwdIOgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 NXX1U3p[OjN7NEG3Olk>
Jurkat Mny5R4VtdCCYaXHibYxqfHliQYPzZZk> NXXJTo1tOs7:TR?= MX60bC=> MXry[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? NUT0N2c5OjN6OU[wOlE>
RAW264.7  MVTBdI9xfG:|aYOgRZN{[Xl? NEe2TlAyOCEQvF2= M1;EfVI1cA>? M2e0[oRm[3KnYYPld{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgS2E> NFjXNIszOzh{MEKwNy=>
A431  M{LhOGtqdmG|ZTDBd5NigQ>? MnTnOFDPxE1? NWf1b|JLOmh? MmPVZoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= M1zvNFI{QDByMEW4
Jurkat M{DuZWNmdGxiVnnhZoltcXS7IFHzd4F6 MkjNNlUuOTByzszN M3XCUFZp MVTpcohq[mm2czD6MWZCNUOPSz3pcoR2[2WmIHPlcIwh\GWjdHi= NHzEV2EzOzl|M{WzNi=>
COS-7  MmTFSpVv[3Srb36gRZN{[Xl? NWfZPXdUPTEEtV2= Ml3tNlRp MkTRZYZn\WO2czD0bIUheHKxY3Xzd4lv\yCxZjDBWG4yeyC5aYToJJBwdHmTIITyZYN1ew>? NXPZPG9{OjN7M{OyNFg>
CAL27 NGjaeFJCeG:ydH;zbZMhSXO|YYm= NYHjfm8xOTBizszN M2jVb|Jp NFfE[JV{fXCycnXzd4V{KEO3cj3OVJMuemWmdXPl[EB3cWGkaXzpeJkh[nlidYCgeI8hQTBn NEXXfJAzOzlzN{O5Oi=>
THP-1  M1XKXWFxd3C2b4Ppd{BCe3OjeR?= NXHOUHpwOTBvNUFOwG0> NWDifGVqOmh? MXrpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1emmydH;sbYRm NUnIZWlOOjN7MECyPVk>
K562 M1TFXWFxd3C2b4Ppd{BCe3OjeR?= NHS1dVEzOM7:TR?= NGLjdIg1QGh? MUDpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X NVzwNndLOjN6N{[4NlY>
HL-60 M2HNVWFxd3C2b4Ppd{BCe3OjeR?= NGrrd3IyODEQvF2= M4LoTFI1cA>? NXqyZ2VncW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliYXLp[ZRidmViZHn0[ZJx\W6nc9Mg NUXWTW9wOjN6NkW3O|g>
HeLa  M4LJPGFxd3C2b4Ppd{BCe3OjeR?= Mlr2NlDPxE1? M1\TW|Jp M2T0[IlvcGmkaYTzJGROVVBiaX7keYNm\CCjcH;weI9{cXN? MVWyN|g3Ozl4Nh?=
U251 NW\LNYcySXCxcITvd4l{KEG|c3H5 NYnIcWw2OjEQvF2= MmnvNlRp MVnpcohq[mm2czDjZZN1cWOrbjDpcoR2[2WmIFeyM20heGijc3WgZZJz\XO2IHHu[EBieG:ydH;zbZM> MViyN|gyPjhzNh?=
HL-60 MVnBdI9xfG:|aYOgRZN{[Xl? MoHlOVDDvU1? NF2yZms1cA>? NFzV[|FjdG:la4OgeIhmKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzygMVktKGGwZDDQRXJRKGmwZIXj[YQh[nliNoO= M4TCd|I{QDB2N{C2
Ec-109 NGHpTYJCeG:ydH;zbZMhSXO|YYm= Mk\nNVAh|ryP NFGwZYs1QGh? NFPHNVRz\XC{ZYPz[ZMhWEVvbXXkbYF1\WRiRXOtNVA6KGOnbHygZZBweHSxc3nz NHLpdpYzOzd6Mk[0NS=>
RKO MX3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NYfKTWtUOTBizszN MVSyOIg> NGntcIlqdmirYnn0d{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliY3H1d4VlKGK7IFTBRi=> NFPDSmIzOzd3OEC2OC=>
T98G Mm[yR4VtdCCYaXHibYxqfHliQYPzZZk> MoDlNU0yODEQvF2= M4\DdFI1cA>? NIXMSIhqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT NEjFWnUzOzd4OUK3OS=>
Jurkat NYriXFY5S2WubDDWbYFjcWyrdImgRZN{[Xl? MVixNFAuOjByzszN NHnNbXkzPGh? NIPVe2lqdmirYnn0d{BJ[UF2IHnu[JVk\XNiYYDvdJRwe2m|IHTldIVv\GWwdDDv[kBkd26lZX70doF1cW:wwrC= MVWyN|c{OjR6MR?=
Molt-3  MoLZRZBweHSxc3nzJGF{e2G7 NUXDd3dPPTEQvF2= MXeybC=> NFTBXYVz\WS3Y3XzJI1mdGG2b37pck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NXzBSpRxOjN5MkWwNVM>
hMSC12 MXPBdI9xfG:|aYOgRZN{[Xl? NH;qPIQyODEQvF2= NUTyU2M{PGR? NIDkRpBqdmirYnn0d{Bwe3Snb3flcolkKGO3bIT1doUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDjZYxkcW[rY3H0bY9v NHX5[oMzOzZ3N{iyNi=>
HM7  MUjBdI9xfG:|aYOgRZN{[Xl? NUjmUVdSOjEQvF5CpC=> NEDzNIcycA>? MYHicI9kc3NiYYDpZ5Vt[XKnbjDBJIFk\XSjdHWtbY5lfWOnZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVEBkdGWjdnHn[S=> MmLmNlM2QDN2MUK=
Hep-2  M1X3U2Fxd3C2b4Ppd{BCe3OjeR?= M{nuXlIx|ryPwrC= MojFNlRp MmXpSG1UVw>? MW\hcIxmfmmjdHXzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSCrbnT1Z4VlKGK7IIPpcIljcW6rbh?= M4T5PFI{PThyMEOy
HSCs MXjBdI9xfG:|aYOgRZN{[Xl? M1L5R|Ux|ryP NEjzRpEzPGh? NYjX[2k6TE2VTx?= NEXtO5lqdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm NGX3OI4zOzR7OUi3OC=>
HL-60  NVnGSIRiS3m2b4TvfIlkcXS7IFHzd4F6 NHvRe|YzOM7:TdMg NIDHO4szPGh? NHrOdo5z\WS3Y3XzJJRp\SCleYTveI95cWNiZX\m[YN1KG:oIFXyfVU> NVW2epp5OjN2OUS0PFA>
HA NFzq[JBCeG:ydH;zbZMhSXO|YYm= M2Ky[FUx|ryP M3znO|I1cA>? NVOyNYN3e3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD MnnKNlM1PzV7NU[=
C666-1 NF6yPZZCeG:ydH;zbZMhSXO|YYm= M4TrclUx|ryP NYjPTWtkOjSq M1nvfJN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? MX[yN|Q4PTl3Nh?=
Hepa1-6 Mne4RZBweHSxc3nzJGF{e2G7 NFfIeGE2OM7:TR?= MkLQNog> MnnJbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| MlG4NlM1PDZ5NUO=
PLC/PRF/5c MnTjRZBweHSxc3nzJGF{e2G7 M3u3SVUx|ryP MU[xbC=> MVfwdoV3\W62czDhdI9xfG:|aYOgeJJq\2encnXkJIJ6KEOLTh?= MljaNlM1Ozh6MkS=
HCT116 NHnBeo5CeG:ydH;zbZMhSXO|YYm= M3vEcFExOM7:TR?= MV2xMlVp M1r2bYlvcGmkaYTzJG9{NWmwZIXj[YQh[2WubDDk[YF1cA>? M2njTVI{PzR2M{Wz
HCEC NXjie3MzTnWwY4Tpc44hSXO|YYm= MmLIOVDPxE1? MXi3Nog> NFfLRWtFVVOR Ml32doV{fG:{ZYOgc4YhfGinIH7vdo1idCCKQ1XDJJBp\W6xdInw[S=> Mn\oNlM4PDJyMUG=
Primary rat cerebral cortical neurons M362dGFxd3C2b4Ppd{BCe3OjeR?= MVKxNFDPxE1? M1\JUlFp M1PrWJBz\X[nboTzJGNlNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDj[YxtKGSnYYTo Mmq1NlM4PDF|MUe=
MDA-MB-231  MXXBdI9xfG:|aYOgRZN{[Xl? MoDzNlXPxE1? NEK5WoMzPGh? MYrhZpJw\2G2ZYOgZ5l1d3SxeHnjbZR6KGGwZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMh[W6mIGDBVnAhcW6mdXPl[EBjgSCUZ{O= M{\FWlI2OzN5NUS0
NLRP3-Tet-on-MC/9  NEO4V49CeG:ydH;zbZMhSXO|YYm= NWO3cJcyOTBvNEFOwG0> NYLoc2pDOTKq MWXheJRmdnWjdHXzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDDRXBUNWG|c3;jbYF1\WRiTlzSVFMhdXW2YX70d{BqdiC2aHWgWIV1NW:wIIP5d5RmdQ>? NHj4NpczOzdyM{O4PS=>
KNS42  M2jRUmFxd3C2b4Ppd{BCe3OjeR?= M2SwZlUx|ryP M3TUNFFp NGLSfIdz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHPvcZBt\XSnbImgZYJwdGm|aHXkJINie3Cjc3WgN{84KGGldHn2bZR6KGmwIILld5BwdnOnIITvJGFDXC1{NkOvNmRIN22ndH\vdo1qdiClb33ibY5ifGmxbh?= MoruNlM3QTFzNEW=
MCF-7  MWTBdI9xfG:|aYOgRZN{[Xl? MX2yNO69VcLi NVz3cFd4PzKq NV23SVZzcW6qaXLpeJMh\XG3b3ytJIFv\CB2LV;IWE1u\WSrYYTl[EBieG:ydH;zbZM> M4jSSVI{Pjd3NkSz
hCMEC/D3  NXHLS5g4SXCxcITvd4l{KEG|c3H5 M{jRSlI2|ryP MYO3Nog> NIXUR2Rz\WS3Y3XzJGx1gEFiaX7keYNm\CCjcH;weI9{cXN? NGizWYIzOzZ4NUG5PC=>
Jurkat MV7BdI9xfG:|aYOgRZN{[Xl? MmrsNVIvPS13MN88US=> M37a[lFp M3;xTYRwe2ViZHXw[Y5l\W62bImgd5VxeHKnc4Pld{BUWEhvaX7keYNm\CCSYYKtOEBkdGWjdnHn[UwhWEGUUDDjcIVifmGpZTygSG5CKG[{YXft[Y51[XSrb36sJIFv\CCub4PzJI9nKH[rYXLpcIl1gQ>? NYfBNJJvOjN2NEK5O|Y>
CNE-1 NH\hTGhCeG:ydH;zbZMhSXO|YYm= NIPzXoczOM7:TdMg M3ywRlI1cA>? MnH4bY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= M{nkTFI{PDJ4OEWw
HONE-1 NETtWmxCeG:ydH;zbZMhSXO|YYm= M1zlZlIx|ryPwrC= M1S0TFI1cA>? MVPpcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq MUeyN|QzPjh3MB?=
astrocytes cell M1WxV2Fxd3C2b4Ppd{BCe3OjeR?= NXPaS5NrPDEQvF2= M4HMSFZp M2XnbZJm\HWlZYOg[YFzdHliYYDvdJRwe2m|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\Q>? NGPUV4gzOzRzMUe3PC=>
U-937 NUPnW214SXCxcITvd4l{KEG|c3H5 NWLhbItHOTEQvF2= MUGzNI1qdg>? M13FVJBz\X[nboTzJHRPTi2rbnT1Z4VlKG6nY4LvdJRwe2m| MnPsNlM1OTB5NEi=
MDA-MB-231 M4\pOGFxd3C2b4Ppd{BCe3OjeR?= Mo\qNVAx|ryP Mni1NYg> MoDqbY5pcWKrdIOgd4Vve2m2aYrheIlwdiC2bzDUVmFKVCC3cH;uJG1VTEhiZH;3ck1z\We3bHH0bY9v M3\uO|I{PDB6NEK5
HeLa  NIfRcZlCeG:ydH;zbZMhSXO|YYm= NX;6[5ExOTByzszN MkHTNog> MVTicI9kc3NiSmLTMVE2KEmwZIXj[ZMhSXCxcITveIlkKEOnbHygSIVifGh? M{LjZVI{OzR2MES1
Ec109 MWjBdI9xfG:|aYOgRZN{[Xl? MYCxNO69VQ>? MVG2bC=> MYXicI9kc3NiYYDvdJRwfGmlIHPvcYJqdmG2aX;uJI9nKFSjdD3TcYFkVjdiYX7kJJJi\GmjdHnvci=> NIP6TWwzOzN|OEW2PC=>
H460  MnvRRZBweHSxc3nzJGF{e2G7 NVPOPW1FOTEQvF2= NYnKZ3o3Pmh? MkPMZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> M3LJOlI{OzN6NU[4
HeLa  M{[4OGFxd3C2b4Ppd{BCe3OjeR?= MlTEOVDPxE1? NVfzN2h1OS53aB?= M2nNdIFjem:pYYTld:KhS2iuYX35[IliNWmwZIXj[YQh[XCxcITvd4l{ NHKxd2kzOzNyM{iwOC=>
SK-HEP1 NXfVeVY4SXCxcITvd4l{KEG|c3H5 M1XMN|ExOM7:TR?= MX6xbC=> MWXpcohq[mm2czDDdnQyKGGldHn2ZZRm\CClYYPwZZNmNTNuID23MEAuQCxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? NULpfZV[OjN|MEK2OVA>
QGY7701 NGHuOo1CeG:ydH;zbZMhSXO|YYm= NXK0THdsOjYQvF2= M4jmTlEvPWh? NVu0Unp7cW6qaXLpeJMh[WOldX31cIF1cW:wIH;mJJN2[i2JMTDwbIF{\SCrbnT1Z4VlKGK7IFTPXEAsKHG3ZYLj[ZRqdg>? NWHnNI5GOjN{NECwOlE>
HepG2 NHOwXFlCeG:ydH;zbZMhSXO|YYm= M3zvfFIx|ryP NI\GfpM{OG2rbh?= NV3tdIFEcW6qaXLpeJMhfGinIHXubIFv[2WmIHPlcIwh\GWjdHigZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIHHwbYdmdmmwIHHu[EBVWkGLTB?= NUjLWGNVOjN{MkSyN|k>
U87  MUHBdI9xfG:|aYOgRZN{[Xl? NXHrZZl2OjYQvF2= NUjKeG5{Omh? MlT3[IVkemWjc3XzJIl{d2yrcYXpdol1cWenbnnuJEhKW0xrLXnu[JVk\WRiYYDvdJRwfGmlIHPlcIwh\GWjdHisJIJ2fCCwb4SgcoVkem:2aXOgZ4VtdCCmZXH0bC=> MlnFNlMzOjl4Mk[=
HSC-2 MlzkRZBweHSxc3nzJGF{e2G7 NITOeXMzPS93MN88US=> MnHLNYg> M2LoTIlvcGmkaYTzJHNPNTN6LXnu[JVk\WRiY4n0c5RwgGmlaYT5 Mmn5NlMyPTV{NEi=
HSC-4 MVjBdI9xfG:|aYOgRZN{[Xl? MYmyOU82OM7:TR?= NU[xO5lPOWh? NWW4WJNCcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> NUS1XppROjNzNUWyOFg>
CL-1 NGn4RnVCeG:ydH;zbZMhSXO|YYm= NXroToZEOjEQvF2= MmTUNYg> NWDKPGdW[myxY3vzJG9RPDR7IHnu[JVk\WRiY3XscEBl\WG2aB?= NY\Tb45IOjNzM{G3PFI>
MEL NF;SW|VCeG:ydH;zbZMhSXO|YYm= MXuyNO69VQ>? NH65WY8zPGh? MWPEUXNQ MnPJbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? M1LSOlI{ODF2OEi3
Bel-7402  M3f0e2Nie3Cjc3WgRYN1cX[jdHnvckBCe3OjeR?= MX61NO69VQ>? MlH5Nog> MnrkbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> MoPsNlMxODh5NEK=
Eca-109 NYDLUodtSXCxcITvd4l{KEG|c3H5 M2f0NVI2|ryP M4\3NlMxdWmw M3jVNIlvcGmkaYTzJGJLNUJzMT3pcoR2[2WmIHPlcIwh\GWjdHi= MlXrNlMxPzZ7Nke=
MEL MULBdI9xfG:|aYOgRZN{[Xl? MXmyNO69VQ>? NEfoNlEycA>? NVjZSVVHTE2VTx?= NXX4VlVVcW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= NVK0TXkyOjNyMUS4PFc>
Bel-7402  MmfoRZBweHSxc3nzJGF{e2G7 MofCOVDPxE1? M2DwUVJp Mn\ubY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NXfpZ2hsOjNyMEi3OFI>
L929 M{S4VmZ2dmO2aX;uJGF{e2G7 NYizO4h3Oi53zszN NYf3dXpNOWh? NF\wbWpqdmO{ZXHz[ZMhWkmSMTDlfJBz\XO|aX;uJIFv\CCneHHj[ZJj[XSnZDDUUmbPuS2rbnT1Z4VlKG2rdH;jbI9v\HKrYXyg[Jl{\nWwY4Tpc44h[W6mIGLPV{Bxem:mdXP0bY9v NFLxb|QzOzByMEWxPC=>
RCC  NETz[ItE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGDYRW8yODEQvF2= M3vmcFI1cA>? NF7HWmpz\WOxdnXy[ZMhfGinII\pZYJqdGm2eTDv[kBk\WyuczDlfJBwe2WmIITvJFE2\C2SR1qy MVKyNlk6OTR7NB?=
NB2a/d1 NH7iNZlCeG:ydH;zbZMhSXO|YYm= NU\vPGh2OTByzszN NHfRPXo4Omh? MVjheJRmdnWjdHXzJJN1[XW{b4Pwc5JqdmVvaX7keYNm\CClYYPwZZNmKGGldHn2bZR6NCCSQWLQMEBidmRidHH1JINt\WG4YXfl MX:yNlk5QDV2MR?=
T cell NFfPN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC0NlUuOTByzszN M3rrc|I1cA>? M3HVR4Rwe2VvZHXw[Y5l\W62bImgbY5pcWKrdHXkJHQh[2WubDDwdo9tcW[ncnH0bY9vKG2nZHnheIVlKHSqcn;1[4ghfGinIHPvMZN1cW23bHH0bY9vKHerdHigZY51cS2FREOgZY5lKGGwdHmtR2QzQA>? NFPwOZUzOjl6MkWzPC=>
K562 MUPBdI9xfG:|aYOgRZN{[Xl? M375fVExOM7:TR?= MVWxbC=> NHzR[JFjdG:la4OgRYJvd2KjdnnzZ5VuyqCILXnu[JVk\WRiYYDvdJRwe2m| NHrRXFQzOjl5MkO3Ni=>
Jurkat  NGrROGhCeG:ydH;zbZMhSXO|YYm= MXm0NO69VQ>? MUGxbC=> NUX2R3FU[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? NG[yWXEzOjl2MkezPC=>
BGC-823 MWrBdI9xfG:|aYOgRZN{[Xl? NIjPc20yODEQvF2= NXPIeIp2OWh? M17WW5BienSrYXzsfUBz\XOldXXzJINmdGy|IHHnZYlve3RiZHHtZYdmKG:oIHThbYR7\Wmw MVKyNlkzPjV2NR?=
Hep3B NUP2OFBmSXCxcITvd4l{KEG|c3H5 NHHhco02OM7:TR?= NXnNdXVlOWh? M{nRSYJtd2OtczDhdI9xfG:|aYOgbY5lfWOnZDDifUBJTUeFcx?= M2\Ic|IzQTJ|MUW0
LLC-PK1 MUDBdI9xfG:|aYOgRZN{[Xl? MWOyNO69VQ>? MUexbC=> NGP0bZpxemW4ZX70d{BkcXOybHH0bY4ucW6mdXPl[EBl\We{YXTheIlwdiCxZjDBeIc2NCCkZXPsbY4uOSxiYX7kJGF1\zF{IIDyc5RmcW6| M{TzblIzQDl4MEO3
A549 NYK0TVNOSXCxcITvd4l{KEG|c3H5 M{i5UFUx|ryP M4j6WFFp NX;qZ2RO[myxY3vzJJRp\SCEQVmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> NGr4NHYzOjh6N{KxOS=>
SGC-7901  Ml76RZBweHSxc3nzJGF{e2G7 M3vCWlEx|ryP NHfXfIwzPGh? NIXxfpZqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? MXWyNlg1QDV7Nx?=
DM6 NI\jPGRCeG:ydH;zbZMhSXO|YYm= NY\BRlVCOTByzszN NE\ONnU4Omh? MmG2Zoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? NWHFWIdlOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NEnTd4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfMOVDPxE1? Mn\IOFhp M{XSPIlvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> M3;tSFIzQDByOU[4
A2750  MmX0RZBweHSxc3nzJGF{e2G7 M{LaeVIx|ryP M3f1OVJp NFvHRo1FVVOR NX:xe4tr[myxY3vzJINie3Cjc3WgZ4xm[X[jZ3Wg[JVzcW6pIHjlcIVv[WyrbjD0doVifG2nboSgZY5lKHKnZIXj[ZMh[XW2b4DoZYdq[yClZXzsJIRm[XSq NUfJTotWOjJ5OESzOlM>
U87  NFvYXG1CeG:ydH;zbZMhSXO|YYm= MWGyNO69VQ>? MnnNNlRp NWfXc|hUemWmdXPld{B1cGViYYDvdJRwe2m|IILheIUhcW6mdXPl[EBjgSCSTFHC NGTqPVAzOjd5OEe4NC=>
HT1080 M4PoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vRTVUx|ryP MUm3[C=> MYXpcohq[mm2czD0bIUh[2WubDDndo94fGhiaX7obYJqfGmxbjDjZZV{\WRiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKESFQTDhcoQhV02S M1PXUFIzPzRyOUi0
A549  M{\rWGFxd3C2b4Ppd{BCe3OjeR?= M1voVFUx|ryP M1La[FJp NIXLdJBx[XK2aXHscJkh\GWlcnXhd4V{KHOxZHn1cUB{\Wynbnn0[U1qdmS3Y3XkJIFxd3C2b4Ppdy=> NU\HO45rOjJ5MkG4NFQ>
Primary OPC MVfBdI9xfG:|aYOgRZN{[Xl? M1e2WVHPxE1? NUDNb2N2PmhxMkTo MVvy[YR2[2W|IITo[UBx\XKlZX70ZYdmKG:oIHPlcIx{KGmwIHXhdox6NSCjbnSgcIF1\S2jcH;weI9{cXNxbnXjdo9{cXN? NYjB[opMOjJ5MEezPFU>
PMNs NHjBNZRCeG:ydH;zbZMhSXO|YYm= Mk\QOFDPxE1? MVu2bC=> NYLNWXZCTE2VTx?= NGWwOo1z\X[ncoPl[EB1cGViYX3veY51KG:oIHPs[YF3\WRiY3HzdIF{\S1|IITvJI5m[XJidnXobYNt\SCuZY\lcJM> MVGyNlY6OjV5Nx?=
A549  MkTiRZBweHSxc3nzJGF{e2G7 NGHT[oQ2OM7:TR?= MnS2NYg> MYfwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? Mk\lNlI3QDd4M{W=
AGS MVrBdI9xfG:|aYOgRZN{[Xl? NULnVXJ7OjEQvF2= MoK4NVJp Mkf6bY5pcWKrdIOgeIhmKGGldHn2ZZRqd25ib3[gdJJwNWOjc4Dhd4UuOyCrbjDy[ZNxd26|ZTD0c{B1cGViRYTPRYMh\nKjY4Tpc44> NInlZWczOjZ6N{O5PC=>
shC9  NFfjZWlCeG:ydH;zbZMhSXO|YYm= Ml7CNVDPxE1? MmHnNVZp M1nZXoJtfW62czDTTGgh\XiycnXzd4lwdiCrbjDzbGM6KGOnbHzzJIV5eG:|ZXSgeI8h\Wm2aHXyJHBCKG:{IFzQRy=> MYiyNlY1OTB7NB?=
primary MEFs NWTiPHZCTnWwY4Tpc44hSXO|YYm= NVj4dVk4OTKq M{C2XOKhcW6lcnXhd4V{KGW2b4Dvd4ll\S2rbnT1Z4VlKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWg[IVxd2yjcnn6ZZRqd25? MU[yNlYyOzd4Nx?=
3T9 MEFs NGD5cnZHfW6ldHnvckBCe3OjeR?= MlfDNVZp MoTzbY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> NH;SXYkzOjZzM{e2Oy=>
3T9 MEFs MUjGeY5kfGmxbjDBd5NigQ>? NUS5eHAxOTiq MXf1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> MUiyNlYyOzd4Nx?=
MDA-MB-231  MVvBdI9xfG:|aYOgRZN{[Xl? MmLKNlDPxE1? NWOyOpcxPGR? MorjdoVlfWOnczD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBu\XSob4LtbY4hfHKnYYTt[Y51KHejczDzbYdvcW[rY3HueIx6 M4[wRlIzPTl|NESx
C6  MnvvRZBweHSxc3nzJGF{e2G7 NIP0T3MyOM7:TR?= M3nIXVI1cA>? NH7TOGxjdG:la4OgeIhmKHO3cIDy[ZN{cX[nIHXm[oVkfCCxZjD0bIUheGWydHnk[UBwdiC4aXHibYxqfHl? MoTkNlI2QDh7OEC=
HL-60  MYnBdI9xfG:|aYOgRZN{[Xl? M{fQOlExOM7:TR?= M4Tvc|I1cA>? MnG1bY5pcWKrdIOgeIhmKGOnbHygZZBweHSxc3nzJJNmdGWldHXkJEgsMS2vZX70bJltKM7{LTix5qaTPilvZHnncJVkd3C7cnHuc5Nq\GYEoEW= MoT2NlI2PDZ4Nkm=
HL-60 NIfKWoxCeG:ydH;zbZMhSXO|YYm= MlX2NVAuQDEQvF2= MYm0bC=> M1jxe4lvcGmkaYTzJHRIUFFvaX7keYNm\CClZXzsJIFxd3C2b4Ppd:Kh M4rlelIzPTJ|MkK5
BCC NUPKXVVJSXCxcITvd4l{KEG|c3H5 M1X1V|Ux|ryP MXyxbC=> MojCbY5pcWKrdIOgSGFVWy2vZXTpZZRm\CCpcn;3eIghcW6qaXLpeIlwdg>? M123WVIzPTF7NEO2
RAW 264.7 MYnBdI9xfG:|aYOgRZN{[Xl? NGXRTlc2OC9zMEFOwG0> NEfyW40ycA>? NEDvUXlkd26lZX70doF1cW:wLXTldIVv\GWwdDDpcohq[mm2czDEU24ucW6mdXPl[EBzWk6DIHPs[YF3[Wen MknQNlI1QTF2Mk[=
K562 MW\BdI9xfG:|aYOgRZN{[Xl? M4\xSVI2|ryP NGexR5ozcA>? NUjKTY1TeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3:teJJm[XSvZX70JJdqfGhiYX31doVve2mwIFegZY5lKFSUQVnM M4S5U|IzPDh|N{e3
SGC-7901 NWfHbJhKSXCxcITvd4l{KEG|c3H5 MWiyNEDPxE4EoB?= M{HuPFJp MknIZZR1\W63YYTld{BJOk9{wrDvdkBVVkZizsGtbY5lfWOnZDDj[YxtKGGyb4D0c5NqeyCjczD3[YxtKGG|IHPhd5Bie2VvMzDhZ5Rqfmm2edMg M2CzTVIzPDdzNUi5
PC3 NVO2XnNnSXCxcITvd4l{KEG|c3H5 NFTiSZYyOM7:TR?= MVu0bC=> NH7RXXVkd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> M2[yN|IzPDdzOUe0
SMMC-7721 MXnBdI9xfG:|aYOgRZN{[Xl? NIrhclA2OM7:TR?= MlfnOFhp Moi5ZZR1\W63YYTld{BwXFJvaX7keYNm\CCjcH;weI9{cXN? NVLIRW5UOjJ2NkW4N|M>
HeLa  MonHRZBweHSxc3nzJGF{e2G7 NYf2NGd2PTEEoN88US=> NFH3fHE1Nziq MlPEbY5pcWKrdIOgV3RUNWmwZIXj[YQhdGG2ZT3wbIF{\SCjcH;weI91cWNiZY\lcpR{ MVSyNlQ3ODVyNB?=
HeLa  NYTlNHRISXCxcITvd4l{KEG|c3H5 Mlf0OVDDqM7:TR?= NIG2RVgycA>? M3X3S5N2eHC{ZYPz[ZMhfGinIF\SRXAucW6mdXPl[EBi[2O3bYXsZZRqd25ib3[gZY5v\XirbjDWJJBwe2m2aY\lJINmdGy| NWTsc4FGOjJ2NEm0OFA>
T47D  NWntRpNiSXCxcITvd4l{KEG|c3H5 NXXyO4h[OTByzszN NF3Y[|AycA>? NFO0c|NjdG:la4OgeIhmKGenbnXyZZRqd25ib3[gSU1k[WRxQ2TGNkBjgSCVVGO= NXnzSFM4OjJ2MEGxOlg>
HeLa  NF:2bmlCeG:ydH;zbZMhSXO|YYm= Mmf0N|DPxE1? MnvxOIg> M1LoS:KhcW6lcnXhd4V{KHSqZTDn[Y5memGuIHPlcIwhfmmjYnnsbZR6KDR6IHigZYZ1\XJicHjveI9lgW6jbXnjJJRz\WG2bXXueOKh NH3rU3kzOjN7NEK0PC=>
HCC NYP0N2o2SXCxcITvd4l{KEG|c3H5 NFPqbI4zOCEQvF5CpC=> NGnZZXkzcA>? MYfheJRmdnWjdHXzJJRp\SCGSFGgbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKFCDUmC= M1LVdVIzOzR{N{Oy
mESCs MnrZRZBweHSxc3nzJGF{e2G7 NXrhdpdbOi53zszN MXuybC=> MXXpcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= Mn3yNlIzQDV{N{S=
EMT-6  NVLlUll6S3m2b4TvfIlkcXS7IFHzd4F6 NFHvVHgyODEQvF2= NVTIU2dyOWh? NXrsPY9CeGG{dHnhcIx6KGKub3Pr[YQh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IIPpdoFu\XOrbnW= MWCyNlI2OTl{MR?=
MCF7 M2fofWFxd3C2b4Ppd{BCe3OjeR?= M3X4eFUxyqEQvF2= MX2xbC=> Ml\vbY5pcWKrdIOgVGEh[WO2aY\heIVlKGOjc4Dhd4UuOyxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? MUmyNlIzOzN2NR?=
K562 M4j3c2Fxd3C2b4Ppd{BCe3OjeR?= NYPMN4puOjBizszNxsA> MV60PIg> NXn3SmROTE2VTx?= MXHicI9kc3NibHHwZZRqdmmkLXnu[JVk\WRiaX7obYJqfGmxbjDv[kB3cWGkaXzpeJkh[W6mIHHwc5B1d3OrczDpcoR2[3Srb36= NXzl[4dOOjJ{MU[xOVg>
Molt4-hyg MkPRRZBweHSxc3nzJGF{e2G7 MoG2NVDPxE1? NHzmO4UxNjWq NWrhZVhb[myxY3vzJIZiem6nc3;sMYlv\HWlZXSgZ4F{eGG|ZT2zMYxqc2ViYXP0bZZqfHl? NIq3NoszPjJ5NUixNS=>
HeLa MnrGRZBweHSxc3nzJGF{e2G7 Mn;aNVDPxE1? MViwMlVp M3nFT4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHSqZTDjc41jcW6nZDD0doVifG2nboSge4l1cCCpb33pd4lvKE5iYX7kJHRTSUmO MnX5NlIyPzl4NkG=
Jurkat T NVXJTpRoSXCxcITvd4l{KEG|c3H5 NVjxWIppOzEQvF2= MnzENE42cA>? MYXEUXNQ NFn5UIJjdG:la4OgeIhmKHqrcnHtMYlv\HWlZXSgZZBweHSxc3nz NW\qPGZxOjJzNUm4PVg>
Neutrophil MkXPRZBweHSxc3nzJGF{e2G7 M2PHN|Ix|ryP M{CzfFAvPWh? MlXiZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= M{X2NlI3OTl4OES0
HCT116 MXnBdI9xfG:|aYOgRZN{[Xl? MVS1NOKh|ryP NF7ZboYzcA>? MWLy[ZZmenOnczDzfY5memerc4TpZ{BieG:ydH;zbZMh\W[oZXP0d{Bw\iClZXzlZ495cWJiYX7kJG5RSy1zNtMg NYD1VHh2OjJzNUm3OVI>
MDA-MB-231  MnvDRZBweHSxc3nzJGF{e2G7 M3LBdVIvPS15LkZOwG0> M13ad|Jp M3LPRYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? NHP3dIgzOjFzNUWyOi=>
LNCaP NHHoN5BCeG:ydH;zbZMhSXO|YYm= NIK1OVE1OM7:TR?= M2q1PFJp M{nSdIlvcGmkaYTzJIJ2fGWrbjDpcoR2[2WmIHPlcIwh[XCxcITvd4l{ NXvYdGRXOjJzMUS3OlQ>
MB231 NHn6cmFCeG:ydH;zbZMhSXO|YYm= NGr2dmYyODEQvF2= MnLBNYg> NV\TelBrTE2VTx?= NHLNdXpi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w M3jLbFIzOTF{OUSw
HCC38  MXXBdI9xfG:|aYOgRZN{[Xl? M{D0dVExOM7:TR?= MnjuNYg> M1zXTmROW09? NW\IN4U2[WK{b3fheIV{KHSqZTDpcoR2[3Srb36gc4Yh[2WubDDk[YF1cCCkeTDXSWUyKGmwaHnibZRqd25uIGTSRWlNKHS{ZXH0cYVvfCxiYX7kJJRp\SClb33ibY5ifGmxbh?= MlnINlIyOTJ7NEC=
MDA-MB231 M3TyTmFxd3C2b4Ppd{BCe3OjeR?= MlrqOVDDqM7:TR?= MoTqNlRp M4joRmROW09? NXy4O4s4[WK{b3fheIV{KGO3cnP1cYlvNWmwZIXj[YQh[2WubDDk[YF1cA>? NV3SPJpIOjJzMEGzN|U>
LNCaP M1;tWGFxd3C2b4Ppd{BCe3OjeR?= Mlm4OVDDqM7:TR?= NEO3SHkzPGh? M3XHTWROW09? NUS4RWRS[WK{b3fheIV{KGO3cnP1cYlvNWmwZIXj[YQh[2WubDDk[YF1cA>? NH;JUoQzOjFyMUOzOS=>
HCT116 NYDadmE4SXCxcITvd4l{KEG|c3H5 M4WyUVUxyqEQvF2= NYDselFMOjSq MnTjSG1UVw>? MULhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo MmXiNlIyODF|M{W=
Ishikawa  MV;BdI9xfG:|aYOgRZN{[Xl? MWSyOe69VQ>? NIrjXVczPGh? NES0OGFz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHHwc5B1d3OrczDpcoR2[2WmIHL5JGJi\iCDMR?= MUKyNlA5QDlzOB?=
 YD-8  MUPBdI9xfG:|aYOgRZN{[Xl? NX\reZh2OTByzszN M4rwXVFp MUfpcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ M1j1dFIzODh4MUiz
eosinophil  NFnWNI9CeG:ydH;zbZMhSXO|YYm= MmHOPVDPxE1? NIGydm4zPGh? MmLRbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhTmG|IHHueIljd2S7wrC= M{\BOVIzODd7M{O0
L929 M4LxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XYb|IvPc7:TR?= M1jmelI1cA>? NE\FNnBqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBxNXB|ODDhcoQhVkZvzsrCJJRwKGG3Z33lcpQhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 MW[yNlAzPzB7Nx?=
YD-8  MUDBdI9xfG:|aYOgRZN{[Xl? Mn7ZNVAx|ryP M1j3Z|Fp NGD4c25jdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> NFG1[GUzOjB{MEC3PC=>
HBx NFXQe5NCeG:ydH;zbZMhSXO|YYm= M2CzZlI2|ryP NVXrXG9IPDiq M2\TZ2ROW09? M4q4dZJm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= MUeyNlAzODB5OB?=
U937  NUnVfpliSXCxcITvd4l{KEG|c3H5 Mn\hOVDDqM7:TR?= MYmxbC=> M2jYPYlvcGmkaYTzJGhHNWmwZIXj[YQh[XCxcITvd4l{yqB? NUfBV4pPOjF7OUi3N|E>
HL60 MoTLRZBweHSxc3nzJGF{e2G7 NHO5RVU1OM7:TR?= NGfsOY81OG2rbh?= M3PlNGROW09? NWHhRnZ2[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MX2yNVk5OzJ7Nh?=
M-14 M4rhXGFxd3C2b4Ppd{BCe3OjeR?= NVHZVZBrOjYQvF2= M4\weFAvPWh? MXlCpIlvcGmkaYTzJIJwfGhidHjlJINzfWSnIHX4eJJi[3RvIHHu[EBkd22yb4Xu[E1qdmS3Y3XkJIFxd3C2b4Ppdy=> NHG5ZXczOTl3NEm1PS=>