Z-VAD-FMK

For research use only. Not for use in humans.

製品コードS7023 別名:Z-VAD(OH)-FMK

Z-VAD-FMK化学構造

CAS No. 187389-52-2

Z-VAD-FMK (Z-VAD(OH)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

サイズ 価格(税別)  
JPY 21400
JPY 80000
JPY 173300
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バルク問合せ

文献中Selleckの製品使用例(645)

製品安全説明書

Caspase阻害剤の選択性比較

生物活性

製品説明 Z-VAD-FMK (Z-VAD(OH)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
特性 A key compound for apoptosis studies.
ターゲット
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外試験

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

細胞データ
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U937 M2TkVmFxd3C2b4Ppd{BCe3OjeR?= MmTVOVDPxE1? MoKzOFhp MWXy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> NGTkXZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyOFA1Oyd-MkW4NlQxPDN:L3G+
HL-60 M2TSXWFxd3C2b4Ppd{BCe3OjeR?= M2izUFUx|ryP NXq5U5lRPDiq M{jDfZJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh NIPseJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyOFA1Oyd-MkW4NlQxPDN:L3G+
DTK-SME MXPBdI9xfG:|aYOgRZN{[Xl? M{HpUlUx|ryP Ml\uNog> MnyzSG1UVw>? MVvwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHL1dIl3[WOjaX7l MlXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NEO4PVcoRjJ3OESzPFk4RC:jPh?=
HCT116  NXP6OI5jSXCxcITvd4l{KEG|c3H5 MkHiOVDPxE1? M{G4OlJp M2XsNIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgSGRXWA>? M{DWe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[4PFE5Lz5{NUi2PFgyQDxxYU6=
SGN M{W1b2Fxd3C2b4Ppd{BCe3OjeR?= NXTQeIgxOjCvTR?= M3jPdlQ5cA>? MmrCbIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5NE[zN{c,OjV6N{S2N|M9N2F-
A549/V16 MnHRRZBweHSxc3nzJGF{e2G7 M4L6XlUx|ryP MWmxbC=> NHPZUHJz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl2NkCzN{c,OjV7NE[wN|M9N2F-
U1 MknBT4lv[XOnIFHzd4F6 MmHGNVAx|ryP NHTuUVEzcA>? MnPFbY5pcWKrdIOgZ4F{eGG|ZT2z M4DIc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
ACH-2 NHPIXJdCeG:ydH;zbZMhSXO|YYm= MVGwMVIxOM7:TR?= M3flRlJp M3fQOJJm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M2H2[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
U1 MVPBdI9xfG:|aYOgRZN{[Xl? Ml[yNE0yODEQvF2= MoS3Nog> NUS2XIxxemWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NX3pS|UxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFA6PDJpPkK1PVgxQTR{PD;hQi=>
HUVEC-2c MUTBdI9xfG:|aYOgRZN{[Xl? M4Tj[FUx|ryP MX[2bC=> NHXvU5Nl\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? MkLnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyMkG3NlkoRjJ4MEKxO|I6RC:jPh?=
SP2/0 M3TEXGFxd3C2b4Ppd{BCe3OjeR?= MYmxNFDPxE1? NVP2U5E4OWh? NGG0dXVFVVOR Mo\wZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= M1LhZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEe0O|MzLz5{NkC3OFc{OjxxYU6=
CEF NG\YdI1McW6jc3WgRZN{[Xl? NX3zeIh6OCx|Mzy2O{wyODEQvF2= NY[wV5Y3OTWvaX6= MUPkc5dvNXKnZ4XsZZRmeyCSUjDlcpp6dWViYXP0bZZqfHlidH:gOFDwxIViYYSgNVAx|ryP NF:1NZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNlM{QSd-Mk[xNFI{Ozl:L3G+
BEL-7402 NVjZcGRiSXCxcITvd4l{KEG|c3H5 M1exeVIx|ryP MoS1NYg> M4XNZoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4NEe5OUc,OjZzNkS3PVU9N2F-
HepG2 NETmdppCeG:ydH;zbZMhSXO|YYm= Mm\6NlDPxE1? M3HzN|Fp NEOxOXlifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh NHLUelA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2OFc6PSd-Mk[xOlQ4QTV:L3G+
HGL5 M1fxU2Fxd3C2b4Ppd{BCe3OjeR?= M1;ae|Ux|ryP Mn\mNlRp NHSzOIxqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4OUC3OUc,OjZzNkmwO|U9N2F-
GC1a NVvuWWh{SXCxcITvd4l{KEG|c3H5 M4PqflUx|ryP MlLBNlRp MoHHbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NIrNfnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2PVA4PSd-Mk[xOlkxPzV:L3G+
A549 NHixWnpCeG:ydH;zbZMhSXO|YYm= M{LqPFIxKM7:TR?= MmfSNlRp Mkf3doVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBJTkOSIITy[YF1dWWwdB?= MnHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUSxOFkoRjJ3N{m0NVQ6RC:jPh?=
HeLa NEH2fphCeG:ydH;zbZMhSXO|YYm= NV\KUmpzOTEQvF2= M2LYblQ5cA>? M3fIb4Rm[2yrbnXzJJRp\SC{YYTlJI9nKGGyb4D0c5NqeyCmcnHtZZRq[2GubIm= MlK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{K1OFUoRjJ3N{eyOVQ2RC:jPh?=
SGC-7901 MWDBdI9xfG:|aYOgRZN{[Xl? MnnmNlDDqM7:TR?= MmDINYg> MmfCbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4N{C3Okc,OjV5NkewO|Y9N2F-
MCF-7 MmXjRZBweHSxc3nzJGF{e2G7 MnLoNVDPxE1? NHzueoszcA>? MUXpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC NIP3bmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUeyNlEyPCd-MkW3NlIyOTR:L3G+
A549 M{LQcGFxd3C2b4Ppd{BCe3OjeR?= NXHqWG9[OTBizszN NEjMfZYzPGh? MVHEUXNQ NH[0NIRxem:vb4Tld{BJSkNvdILlZZRm\CCDNUS5JINmdGxic4Xyeol3[WxiJjDheJRmdnWjdHXzJJRp\SClbHXheoVlKFCDUmCg[ZhxemW|c3nvci=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6M{W2PEc,OjV4OEO1Olg9N2F-
U87 Mn\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L1SlUx|ryP Mmj3NYg> MYry[YNwfmW{czDj[YxtKGe{b4f0bEBnem:vIGTNXkB1emWjdH3lcpQ> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6MU[2PEc,OjV4OEG2Olg9N2F-
Neocortical Neuron MXfO[ZVzd3SxeHnjbZR6KEG|c3H5 NV;HdG5{OTByzszN M33rTlFp MlHlZY51[Wexbnn6[ZMhUG:rYX3p[IUhSS2LbnT1Z4VlKE6ndYLveI95cWOrdIm= Mn7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{WwNFEoRjJ3Nke1NFAyRC:jPh?=
Primary human placental cytotrophoblasts MUPBdI9xfG:|aYOgRZN{[Xl? MWizNO69VQ>? M4fqW|I1cA>? NY\zfmZlTE2VTx?= MXHy[ZZmenOnczD0bIUhcW6qaXLpeIlwdiCxZjCxNe6zNUiVREKgZpkhfHKrY3zvd4FvyqB? M37VTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkSyOVkzLz5{NU[0NlU6OjxxYU6=
MM MorORZBweHSxc3nzJGF{e2G7 MlqxOVDPxE1? MUGyNI1qdg>? M{XoNpBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? NYPORZl3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1N|AxQThpPkK1OVMxODl6PD;hQi=>
DLD1 NGC0VVdCeG:ydH;zbZMhSXO|YYm= M1[yXFIxyqEQvF2= NUTlNnRUOWh? M2X3eJBienSueTDy[ZZmenOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliV2PQNS=> MnTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkSyOFYoRjJ3NUK0NlQ3RC:jPh?=
MDA-MB-231 NYHnTos4S3m2b4TvfIlkcXS7IFHzd4F6 MXKxNO69VQ>? MmD2NYg> MXXheYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 MmC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkG1NFEoRjJ3NUKxOVAyRC:jPh?=
MKN28 NEXqSZFCeG:ydH;zbZMhSXO|YYm= M4PBc|Ex|ryP NWjCW4J1OzCvaX6= NYHydXE4TE2VTx?= MV3pcohq[mm2czDUUmYu|rFicHz1d{BEUFhvaX7keYNm\CCjcH;weI9{cXN? NXz0cGRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVM6PjBpPkK1OVE{QTZyPD;hQi=>
HL-60 Mn\3R5l1d3SxeHnjbZR6KEG|c3H5 M{S4dFExOM7:TR?= M{C4NVFp MnzvSG1UVw>? MX|CpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyMkmzNkc,OjV3MEK5N|I9N2F-
AGS MlzKRZBweHSxc3nzJGF{e2G7 M3rEcVEx|ryP NX[wb25lOWh? Mme4dJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkKxOEc,OjV2OUKyNVQ9N2F-
A549  MoDCRZBweHSxc3nzJGF{e2G7 NXXa[Fg6OTEQvF2= M4LFXFI1cA>? NYXpNFZm[myxY3vzJGROSVNvaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgZY5lKGGyb4D0c5Rq[yClZXzsJIRm[XSq NYCydZhoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0N|Q6QDlpPkK1OFM1QTh7PD;hQi=>
INS-1 MmX2RZBweHSxc3nzJGF{e2G7 NVz2dpVbPTEQvF2= NFTZSIo3cA>? NWfCV2lOTE2VTx?= MmrW[IVkemWjc3XzJJRp\SCycn;wc5J1cW:wIH;mJIViemy7IHHwc5B1d3SrYzDj[Yxte8Li M2r4eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEOwPFk4Lz5{NUSzNFg6PzxxYU6=
Primary hepatocytes  M4LJcGFxd3C2b4Ppd{BCe3OjeR?= NXzLb4d[PTEQvF2= MVSxPIg> M2TXeolvcGmkaYTzJIFxd3C2b4Ppd{Bw\iCqZYDheI9kgXSnczDpcoR2[2WmIHL5JGFkfCCGIHHu[EBVVkZvzsG= NIP4U5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSwO|U{QCd-MkW0NFc2Ozh:L3G+
L929-A  MmrxR5l1d3SxeHnjbZR6KEG|c3H5 MYOyNOKh|ryP M2XKd|I1cA>? MWfpcohq[mm2czDUUmbPuS2rbnT1Z4VlKGOnbHyg[IVifGh? MkLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OUi1OFAoRjJ3M{m4OVQxRC:jPh?=
L929-N NHr0[GpEgXSxdH;4bYNqfHliQYPzZZk> NEHobHAzOMLizszN M{C2ZlI1cA>? M4\jZYVvcGGwY3XzJIRm[XSqII\pZUBifXSxY4LpcoUhXE6IzsGgdJJw\HWldHnvci=> MljEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OUi1OFAoRjJ3M{m4OVQxRC:jPh?=
Cytotoxicity Assay MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NET4eHozOM7:TR?= NITpSpc1QGh? NGG3c29xemW4ZX70JG1JVURvaX7keYNm\CClZXzsJIRm[XSq NGfMRmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5NlEyPid-MkWzPVIyOTZ:L3G+
COS7 NFHBSZFMcW6jc3WgRZN{[Xl? M3n6V|Ex|ryP NF;iNGYzPGh? NYTZdHc{cW6lcnXhd4V{KGOjc4Dhd4UhOy95IHHjeIl3cXSrZYO= Mn;qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OESwNlUoRjJ3M{i0NFI2RC:jPh?=
COS7 MofYRZBweHSxc3nzJGF{e2G7 M3:2S|Ex|ryP MnjhOFhp MYnwZZJ1cWGubImgdJJmfmWwdHXkJGZEOTBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NUC3WGVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPFQxOjVpPkK1N|g1ODJ3PD;hQi=>
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A549 NFizOJdCeG:ydH;zbZMhSXO|YYm= MXi1NO69VQ>? M4G1e|I1cA>? MVXy[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN2OUe4NUc,OjV|NEm3PFE9N2F-
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A375 MUPBdI9xfG:|aYOgRZN{[Xl? MVqyNO69VQ>? NHjzN|QzPGh? NUfmWGdTemW4ZYLz[ZMh\GmlaYTybY5wdmViQj3pcoR2[2WmIHHwc5B1d3Orcx?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ7OUGxNUc,OjR4OUmxNVE9N2F-
HDPC MXLBdI9xfG:|aYOgRZN{[Xl? NInnT3Q2OML3TR?= M3TXNFI1cA>? MlzXbY5pcWKrdIOgUm8ucW6mdXPl[EBieG:ydH;zbZM> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|NEW5N{c,OjR4M{S1PVM9N2F-
A549 MW\BdI9xfG:|aYOgRZN{[Xl? NF3i[mM2OML3TR?= NH64XW0zcA>? NFvaWZFFVVOR NYLuRY1yeHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= M3;KUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi4NVM2Lz5{NEW4PFE{PTxxYU6=
 BV-2 NXvpO3pDSXCxcITvd4l{KEG|c3H5 MXGyNO69VQ>? M2fJfVJp MkPtd5VxeHKnc4Pld{BWXi2rbnT1Z4VlKGOqcn;tZZRqdiCneITyeZNqd25iYX7kJIRqdGG2aX;uJI9nKHSqZTDueYNt\WG{IHXueoVtd3Cn NUPiU5F4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OVgyOThpPkK0OVU5OTF6PD;hQi=>
HT-29  NH;4cpdCeG:ydH;zbZMhSXO|YYm= MlXCOVDPxE1? Mln0OFhp NVTjSWJP[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s MoPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NEmxO|UoRjJ2NUS5NVc2RC:jPh?=
A549 MYXBdI9xfG:|aYOgRZN{[Xl? MX[1{txO MWmyOIg> NXLKZmZ[e3WycILld5NmeyB4ZdMgLGJMOTByNECpMYlv\HWlZXSgZZBweHSxc3nzxsA> NGDzfI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyPVg4OSd-MkS1Nlk5PzF:L3G+
MIA-PaCa-2 MVTBdI9xfG:|aYOgRZN{[Xl? M33oV|I1cA>? MXjicI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVzMEm5Nkc,OjR3MUC5PVI9N2F-
Caki-1 NUGyZWhxSXCxcITvd4l{KEG|c3H5 M{LFdFIx|ryP Moe2NYg> NFn6d|hqdmirYnn0d{BUS1BvaX7keYNm\CCjcH;weI9{cXN? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyNE[4NUc,OjR3MES2PFE9N2F-
CLL M3;aemFxd3C2b4Ppd{BCe3OjeR?= MUiyOe69VQ>? MnO2NYg> MlrXdIFzfGmjbHz5JIJtd2OtczDNUG4zOjN6LXnu[JVk\WRiY3XscEBieG:ydH;zbZM> M1e2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NE[3OlM1Lz5{NES2O|Y{PDxxYU6=
SGC-7901 Mm\WRZBweHSxc3nzJGF{e2G7 MX:xNO69VQ>? NUTQSG1bOjSq M3\a[JBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? NUXJNotCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OVQ1QDhpPkK0OFU1PDh6PD;hQi=>
k1735 M1frfGFxd3C2b4Ppd{BCe3OjeR?= M2C0cFIx6oDLzszt M3XOSVRp MnXxbY5pcWKrdIRCpHNidG2xbnXscIEucW6mdXPl[EBieG:ydH;zbZM> NVS4clJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OVEyOTZpPkK0OFUyOTF4PD;hQi=>
HaCaT  MV\BdI9xfG:|aYOgRZN{[Xl? MXexNFDPxE1? NFHOW3UycA>? Ml20Zox2dnS|IGXWRk1qdmS3Y3XkJIFxd3C2b4Ppd{BqdiCKYVPhWEBk\Wyucx?= M17wdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W2PVk4Lz5{NEO1Olk6PzxxYU6=
podocytes NYSwWpJ6SXCxcITvd4l{KEG|c3H5 MWKyNFDPxE1? NEjidGY3cA>? NIHiemJqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSB|LEStSGdG NHmzWlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOzO|c4Pyd-MkSzN|c4Pzd:L3G+
 KB MljtRZBweHSxc3nzJGF{e2G7 M2r0W|Ux|ryP NIm1SXQzPGh? NUnmS|cxcW6qaXLpeJMhVGmlbz3BMYlv\HWlZXSgZ4F{eGG|ZT2zJIFv\CCSQWLQJIFkfGm4YYTpc44> NGj5ZYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOzO|Q6Oid-MkSzN|c1QTJ:L3G+
 HepG2  MUDBdI9xfG:|aYOgRZN{[Xl? NXjUO443OTEQvF2= NG\UcIQzPGh? NVvrVGhCemWmdXPld{B3cW2nboTpckBkdGWjdnHn[UBk[XW|ZXSgZpkhVFCV M{THblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{K1PFE3Lz5{NEOyOVgyPjxxYU6=
fetal rat lung fibroblasts  NY\qSnJIU2mwYYPlJGF{e2G7 MlTwPFDPxE4EoB?= MmL4NYg> MUfpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> NFjTfXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOxOFE{PSd-MkSzNVQyOzV:L3G+
PDL fibroblasts Mn7ST4lv[XOnIFHzd4F6 M1vuXlgx|ryPwrC= MnW2NYg> Ml3mbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> NESwNGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEOxOFE{PSd-MkSzNVQyOzV:L3G+
MB49 NEW5b45CeG:ydH;zbZMhSXO|YYm= MkS0NlDPxE1? MV2xbC=> M4XkWJJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NXrscIVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFI1OzNpPkK0NlgzPDN|PD;hQi=>
5637 MXvBdI9xfG:|aYOgRZN{[Xl? MoLaNlDPxE1? NEfHXYQycA>? M2C0T5JmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MkSzN{c,OjR{OEK0N|M9N2F-
A549  NVXocHBNSXCxcITvd4l{KEG|c3H5 MlPNNVAx|ryP NW[5[HljPDiq NUjrUVRoe3WycILld5NmeyC2aHWgZZBweHSxc3nzJINifXOnZDDifUBxcXCncnnu[eKh NYjRTYRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyO|IzODFpPkK0NlczOjBzPD;hQi=>
MCC-2 MlniRZBweHSxc3nzJGF{e2G7 NGfRelEzOCEQvF2= MknCOog> NYLFU4lqTE2VTx?= NX3QdmJ3[myxY3vzJIlv\HWlZXSgZpkhe3SjdYLvd5BwemmwZTDhdI9xfG:|aYOgZ4VtdCCmZXH0bC=> NH\UeFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK2NlY2QCd-MkSyOlI3PTh:L3G+
ADF NVnpb49kSXCxcITvd4l{KEG|c3H5 NUH1flNWPDEQvF2= Mmn6Oog> M1\FPYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy NHzCZWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKyPFI{Oid-MkSyNlgzOzJ:L3G+
 U373  MWXBdI9xfG:|aYOgRZN{[Xl? NVzqVnBwPDEQvF2= MWe2bC=> M1\VXYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy M3TCWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkK4NlMzLz5{NEKyPFI{OjxxYU6=
RKO-HIPK2i MmriRZBweHSxc3nzJGF{e2G7 MWW0NO69VQ>? MYC2bC=> NIW0Z2pqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> M2TlSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkK4NlMzLz5{NEKyPFI{OjxxYU6=
HEC-1B NVHxc3JsSXCxcITvd4l{KEG|c3H5 NVvEO3JpOjEQvF2= NF\iW2wycA>? MnTTdoVlfWOnczDUVE1qdmS3Y3XkJIFxd3C2b4Ppd:Kh[2G|cHHz[U0{KGGwZDDjZZNx[XOnLUm= NUG2[Ix1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVM{PThpPkK0NlE{OzV6PD;hQi=>
4T1 NIrqZXZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MVWyMlUuOTEQvF2= MY[0bC=> NF7MN2ZFVVOR MmfEdoV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= NVXBfpNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNFYyPjFpPkK0NlA3OTZzPD;hQi=>
OS  NHf4[nhCeG:ydH;zbZMhSXO|YYm= NF3kdlUzOM7:TR?= NUTLbFgzPGh? NVfoUlFScW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEmzO{c,OjR{MES5N|c9N2F-
RPE Mn;ERZBweHSxc3nzJGF{e2G7 M165N|ExOM7:TR?= NYf5UpdVPDiq NGHRe5Fx[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? NX[wRYtiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNFIxPTJpPkK0NlAzODV{PD;hQi=>
UD29a NH3LV4NCeG:ydH;zbZMhSXO|YYm= NEO5NXM2OM7:TR?= MlyzNlRp