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研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S2228 Belnacasan (VX-765) <1 mg/mL 100 mg/mL 100 mg/mL
S2417 20-Hydroxyecdysone <1 mg/mL 96 mg/mL 96 mg/mL
S4353 Terfenadine <1 mg/mL 94 mg/mL 27 mg/mL
S7023 Z-VAD-FMK <1 mg/mL 93 mg/mL <1 mg/mL
S7314 Z-IETD-FMK <1 mg/mL 91 mg/mL <1 mg/mL
S7313 Z-LEHD-FMK 44 mg/mL 100 mg/mL 100 mg/mL
S7312 Z-DEVD-FMK <1 mg/mL 100 mg/mL '<1 mg/mL
S7311 Q-VD-OPh <1 mg/mL 100 mg/mL '100 mg/mL
S8102 Z-VAD-FMK (Caspase Inhibitor VI) <1 mg/mL 90 mg/mL 90 mg/mL
S7775 Emricasan <1 mg/mL 100 mg/mL '''100 mg/mL
S7901 Ac-DEVD-CHO 100 mg/mL -1 mg/mL -1 mg/mL
S5584 Citronellol 31 mg/mL <1 mg/mL -1 mg/mL
S2768 Dinaciclib (SCH727965) <1 mg/mL 26 mg/mL 8 mg/mL
S2738 PAC-1 <1 mg/mL 78 mg/mL 16 mg/mL
S2927 Apoptosis Activator 2 <1 mg/mL 61 mg/mL <1 mg/mL
S6501 NVP 231 <1 mg/mL 86 mg/mL 8 mg/mL
S7326 Tasisulam <1 mg/mL 83 mg/mL 83 mg/mL
S9276 Alisol B -1 mg/mL 95 mg/mL -1 mg/mL
S2448 Gambogic Acid <1 mg/mL 100 mg/mL 100 mg/mL
S9097 Alisol B Acetate -1 mg/mL 100 mg/mL -1 mg/mL
S5550 Ethyl gallate -1 mg/mL 39 mg/mL -1 mg/mL
S3865 Taurochenodeoxycholic acid -1 mg/mL 99 mg/mL -1 mg/mL

亜型選択性的な製品

Caspase製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2228

Belnacasan (VX-765)

Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.

S2417

20-Hydroxyecdysone

20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.

S4353

Terfenadine

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.

S7023

Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

S7314

Z-IETD-FMK

Z-IETD-FMK is a specific Caspase-8 inhibitor.

S7313

Z-LEHD-FMK

Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor.

S7312

Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

S7311

Q-VD-OPh

Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.

S8102

Z-VAD-FMK (Caspase Inhibitor VI)

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

S7775

Emricasan

Emricasan is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

S7901

Ac-DEVD-CHO

Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.

S5584

Citronellol

Citronellol, a constituent of rose and geranium oils, is used in perfumes and insect repellents.

S2768

Dinaciclib (SCH727965)

Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.

S2738

PAC-1

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.

S2927

Apoptosis Activator 2

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.

S6501

NVP 231

NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM.

S7326

Tasisulam

Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.

S9276

Alisol B

Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.

S2448

Gambogic Acid

Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

S9097

Alisol B Acetate

Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.

S5550

Ethyl gallate

Ethyl gallat, which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity

S3865

Taurochenodeoxycholic acid

Taurochenodeoxycholic acid, a bile acid formed in the liver of most species, is used as a cholagogue and choleretic.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2228

Belnacasan (VX-765)

Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.

S2417

20-Hydroxyecdysone

20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.

S4353

Terfenadine

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.

S7023

Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

S7314

Z-IETD-FMK

Z-IETD-FMK is a specific Caspase-8 inhibitor.

S7313

Z-LEHD-FMK

Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor.

S7312

Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

S7311

Q-VD-OPh

Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.

S8102

Z-VAD-FMK (Caspase Inhibitor VI)

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

S7775

Emricasan

Emricasan is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

S7901

Ac-DEVD-CHO

Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.

S5584

Citronellol

Citronellol, a constituent of rose and geranium oils, is used in perfumes and insect repellents.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2768

Dinaciclib (SCH727965)

Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.

2020, 13;37(4):599-617 e7

2020, 10.1158/1078-0432.CCR-19-2706

2020, 2;9:e54954

S2738

PAC-1

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.

2020, 18;396:122605

2020, 4;10(5):1585-1597

2020, 6:1

S2927

Apoptosis Activator 2

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.

S6501

NVP 231

NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM.

S7326

Tasisulam

Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.

2016, 29(6):281-290

S9276

Alisol B

Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.

S2448

Gambogic Acid

Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

2019, 10.1158/1078-0432.CCR-19-0775

S9097

Alisol B Acetate

Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.

S5550

Ethyl gallate

Ethyl gallat, which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity

S3865

Taurochenodeoxycholic acid

Taurochenodeoxycholic acid, a bile acid formed in the liver of most species, is used as a cholagogue and choleretic.

2019, 7(1):145

Tags: Caspases apoptosis | Caspase inhibition | Caspase activation | Caspase activity | Caspase pathway | Caspase phosphorylation | Caspase cleavage | Caspase activity assay | Procaspase activation | Caspase inhibitor in vivo | Caspase inhibitor clinical trial | Caspase-independent apoptosis | Caspase-dependent apoptosis | Caspase inhibitor review