ホームページ Neuronal Signaling -GPCR & G Protein -Transmembrane Transporters GluR mGluR4 選択性 作動薬
  • NMDA receptor
  • AMPA receptor
  • mGluR2
  • mGluR3
  • mGluR4
  • mGluR5

mGluR4 選択性 作動薬

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S8035 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. Selective mGluR4, EC50: 19.8 nM
S2892 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS. Selective mGluR4 (Human), EC50: 240 nM; mGluR4 (Rat ), EC50: 110 nM
S2862 VU 0364770 VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. Selective mGlu4, EC50: 1.1 μM