JNK
シグナル伝達経路
研究分野
- 阻害剤の選択性比較
- 溶解度
| カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | アルコール | ||
| S1460 | SP600125 | <1 mg/mL | 44 mg/mL | <1 mg/mL |
| S4901 | JNK-IN-8 | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S8490 | Tanzisertib(CC-930) | 4 mg/mL | 89 mg/mL | 89 mg/mL |
| S8201 | BI-78D3 | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S7544 | Vacquinol-1 | <1 mg/mL | 70 mg/mL | <1 mg/mL |
| S7409 | Anisomycin | <1 mg/mL | 41 mg/mL | 17 mg/mL |
| S7637 | DTP3 | 100 mg/mL | 100 mg/mL | 100 mg/mL |
- JNK阻害剤(7)
| 製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
|---|---|---|---|
| S1460 |
SP600125SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. |
Loss of DUSP4 function upregulates IL-6 and IL-8 and enhances mammosphere growth. Immunoblot analysis of MDA-231 cells after treatment of 24 hours with 1 umol/L selumetinib (MEKi) or 10 umol/L SP600125 (JNKi). I, MDA-231 mammosphere formation quantitated by GelCount software 7 days after siRNA transfection. Where indicated, selumetinib (MEKi) or SP600125 (JNK1) or the combination was added to the mammosphere cultures.
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| S4901 |
JNK-IN-8JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line. |
The viability of DLBCL cell lines was assessed after 72 h of treatment with the indicated concentrations of the JNK inhibitor JNK-IN-8. Mean + SEM of at least three independent experiments is shown.
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| S8490 |
Tanzisertib(CC-930)CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. |
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| S8201 |
BI-78D3BI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. |
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| S7544 |
Vacquinol-1Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. |
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| S7409 |
AnisomycinAnisomycin is an antibiotic, which inhibits protein synthesis, and also act as a JNK activator. |
(c) Immunostaining of Cx32, ALB, CPS1, CK18 and ECAD in hESC-Heps induced with SB or anisomycin.
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| S7637 |
DTP3DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
