Sirtuin

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1541 Selisistat (EX 527) <1 mg/mL 49 mg/mL 18 mg/mL
S2804 Sirtinol <1 mg/mL 23 mg/mL <1 mg/mL
S1899 Nicotinamide (Vitamin B3) 24 mg/mL 24 mg/mL 24 mg/mL
S7845 SirReal2 <1 mg/mL 84 mg/mL <1 mg/mL
S8627 OSS_128167 <1 mg/mL 73 mg/mL <1 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S8245 Thiomyristoyl <1 mg/mL 100 mg/mL 100 mg/mL
S8460 Salermide <1 mg/mL 78 mg/mL 7 mg/mL
S8628 3-TYP 5 mg/mL 29 mg/mL 29 mg/mL
S1129 SRT1720 HCl <1 mg/mL 38 mg/mL <1 mg/mL
S4735 Salvianolic acid B 100 mg/mL 100 mg/mL 100 mg/mL
S8270 SRT2183 <1 mg/mL 93 mg/mL 3 mg/mL
S7792 SRT2104 (GSK2245840) <1 mg/mL 16 mg/mL <1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S2298 Fisetin <1 mg/mL 57 mg/mL 3 mg/mL
S8481 SRT3025 <1 mg/mL 100 mg/mL 5 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1541

Selisistat (EX 527)

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

S2804

Sirtinol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

S1899

Nicotinamide (Vitamin B3)

Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.

S7845

SirReal2

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

S8627

OSS_128167

OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.

S4900

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

S8245

Thiomyristoyl

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

S8460

Salermide

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

S8628

3-TYP

3-TYP is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.

S1129

SRT1720 HCl

SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.

S4735

Salvianolic acid B

Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.

S8270

SRT2183

SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.

S7792

SRT2104 (GSK2245840)

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

S2391

Quercetin

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

S2298

Fisetin

Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

S8481

SRT3025

SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

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【休業期間】
2018年12月29日(土)から2019年1月6日(日)
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