Sirtuin

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1541	Selisistat (EX 527)	<1 mg/mL	49 mg/mL	18 mg/mL
S1396	Resveratrol (SRT501)	<1 mg/mL	45 mg/mL	''<1 mg/mL
S2804	Sirtinol	<1 mg/mL	23 mg/mL	<1 mg/mL
S1899	Nicotinamide (NSC 13128)	24 mg/mL	24 mg/mL	'24 mg/mL
S9903	NRD167	<1 mg/mL	100 mg/mL	'''6 mg/mL
S8000	Tenovin-1	<1 mg/mL	74 mg/mL	<1 mg/mL
S7845	SirReal2	<1 mg/mL	84 mg/mL	<1 mg/mL
S4900	Tenovin-6	98 mg/mL	98 mg/mL	<1 mg/mL
S2176	Tenovin-3	<1 mg/mL	65 mg/mL	<1 mg/mL
S7577	AGK2	<1 mg/mL	10 mg/mL	<1 mg/mL
S8245	Thiomyristoyl	<1 mg/mL	100 mg/mL	'100 mg/mL
S8460	Salermide	<1 mg/mL	78 mg/mL	7 mg/mL
S8627	OSS_128167	<1 mg/mL	73 mg/mL	'<1 mg/mL
S5914	AK 7	<1 mg/mL	87 mg/mL	3 mg/mL
S8628	3-TYP	5 mg/mL	29 mg/mL	'29 mg/mL
S6744	Inauhzin	<1 mg/mL	94 mg/mL	<1 mg/mL
S1129	SRT1720 HCl	<1 mg/mL	38 mg/mL	<1 mg/mL
E0394	YK 3-237	<1 mg/mL	74 mg/mL	19 mg/mL
S3262	Scopolin	-1 mg/mL	100 mg/mL	-1 mg/mL
S2935	Nicotinamide Riboside Chloride	58 mg/mL	58 mg/mL	<1 mg/mL
S4735	Salvianolic acid B	100 mg/mL	100 mg/mL	100 mg/mL
S3168	cis-Resveratrol	<1 mg/mL	46 mg/mL	'''46 mg/mL
S8270	SRT2183	<1 mg/mL	93 mg/mL	3 mg/mL
S8909	UBCS039	<1 mg/mL	49 mg/mL	16 mg/mL
S7792	SRT2104 (GSK2245840)	<1 mg/mL	16 mg/mL	<1 mg/mL
S2391	Quercetin (NSC 9221)	<1 mg/mL	61 mg/mL	10 mg/mL
S2298	Fisetin	<1 mg/mL	57 mg/mL	3 mg/mL
S5918	CAY10602	<1 mg/mL	56 mg/mL	<1 mg/mL
S8481	SRT3025 HCl	<1 mg/mL	100 mg/mL	5 mg/mL
S6880	SRT-1460	<1 mg/mL	20 mg/mL	1.5 mg/mL
S2347	Quercetin Dihydrate	<1 mg/mL	67 mg/mL	21 mg/mL

亜型選択性的な製品

Sirtuin製品

All (33) Sirtuin阻害剤(18) Sirtuin活性剤(14) Sirtuinモジュレータ(1)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1541	Selisistat (EX 527) Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.	Cell Death Differ, 2022, 10.1038/s41418-022-00992-3 Dev Cell, 2022, 57(2):260-276.e9 Front Pharmacol, 2022, 13:797469	The eect of Melatonin, luzindole, and EX527 treatment on apoptotic index, infarct size, lactate dehydrogenase (LDH) release, and CK release in IR-injured hearts. Representative photomicrographs of in situ detection of apoptotic myocytes by TUNEL staining. Green ﬂuorescence shows TUNEL-positive nuclei; blue ﬂuorescence shows nuclei of total cardiomyocytes; original magniﬁcation 9x400. Sacle bar: 100 um.
S1396	Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Placenta, 2022, 122:56-65 Int Immunopharmacol, 2022, 103:108489 Eur J Neurosci, 2022, 10.1111/ejn.15596	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
S2804	Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Stem Cell Res Ther, 2022, 13(1):198 J Cell Sci, 2022, jcs.259207 Front Pharmacol, 2022, 13:797469	Effects of sirtinol on SIRT1 expression and HIF-1α. hMSCs were treated with sirtinol (100 uM) or equivalent concentration of DMSO (CTR) for 24 h and then exposed to 1% O2 for 6 h. All cells lysates were analyzed for SIRT1, HIF-1α, and tubulin by Western blot.
S1899	Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.	Cell Rep, 2022, 38(3):110250 Cell Death Dis, 2022, 13(1):43 Cell Metab, 2021, 33(1):110-127.e5	Immunoprecipitation-western blot for analyzing acetylated Snail in Snail-transfected 293T cells (upper) and FaDu-Snail cells (lower) treated with a vehicle control (Ctrl), a HDAC inhibitor TSA 5 nM for 8 hr, a SIRT1 inhibitor NAM(Nicotinamide) 10 mM for 8 hr, or in combination.
E1150^新	SIRT7 inhibitor 97491 In SIRT7-related cancers, SIRT7 inhibitor 97491 reduces deacetylase activity of SIRT7 in a dose-dependent manner, and induces apoptosis which is activated by p53 modification and affecting the caspase pathway.
S8942^新	Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
S9903^新	NRD167 NRD167 is a potent and selective SIRT5 inhibitor.	EMBO J, 2022, e110324
S8000	Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	J Pharm Biomed Anal, 2021, 201:114121 J Transl Med, 2019, 17(1):76 Sci Rep, 2019, 9(1):1897	The SIRT1 inhibitor (tenovin-1) partially blocked the protective effect of γ-man in L02 cells. The effect of tenovin-1 on expression and acetylation level of PGC-1α (B) in L02 cells treated with or without γ-man.
S7845	SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.	Basic Res Cardiol, 2021, 116(1):48 Cancer Lett, 2020, 501:20-30 J Cell Physiol, 2020, 10.1002
S4900	Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.	Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948 J Cell Sci, 2019, 132(6)
S2176	Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S7577	AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.	Dev Cell, 2022, 57(2):260-276.e9 Front Pharmacol, 2022, 13:797469 Cell Rep, 2021, 34(13):108921	Masson trichrome staining of tubulointerstitium areas from Sham, UUO, UUO+AGK2 mice (original magnification: × 400).
S8245	Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.	Cell Metab, 2020, 32(3):420-436.e12 Cancer Lett, 2020, 501:20-30 J Cell Physiol, 2020, 10.1002
S8460	Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.	Cancer Lett, 2020, 501:20-30 Am J Transl Res, 2019, 11(8):4789-4799 J Proteome Res, 2018, 17(4):1436-1451
S8627	OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.	Biochem Pharmacol, 2022, 199:115022 Front Cell Dev Biol, 2021, 9:625540 Front Cell Dev Biol, 2021, 9:648627
S5914	AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S8628	3-TYP 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	Dev Cell, 2022, 57(2):260-276.e9 Exp Mol Med, 2022, 10.1038/s12276-022-00745-9 Int J Mol Sci, 2022, 23(7)3740	Effects of HNK or 3‐TYP on surgery/anesthesia‐induced an increased expression of pro‐inflammatory cytokines in hippocampus. (A, E) Representative blots at postoperative 1 and 3 d, respectively. (B, F) MCP‐1 relative expression. (C, G) TNF‐α relative expression. (D, H) IL‐1β relative expression. The data are presented as the mean ±standard error of the mean for each group (n = 6 per group). *P < 0.05 vs the control group; #P < 0.05 vs the surgery+vehicle group; $P < 0.05 vs the honokiol group
S6744	Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.	Cancer Lett, 2020, 501:20-30
S1129	SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.	J Transl Med, 2022, 20(1):222 FEBS J, 2022, 10.1111/febs.16353 J Diabetes Res, 2022, 2022:1755563	PAI-1 expression in HUVECs treated with drugs as indicated.(D) senescent HUVECs were treated with SRT1720, culturing for 24, 48 hours. PAI-1 mRNA and protein (E) levels were analyzed using real-time RT–PCR and Western blotting, respectively. The RNA and protein levels were normalized to the internal control β-actin. Data are presented as the mean±SEM of three independent experiments. P < 0.05 vs. corresponding control. P < 0.01 vs. corresponding control **P < 0.001 vs. corresponding control.
E0394^新	YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
S3262	Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
S2935	Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD⁺ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.	Cell Death Differ, 2022, 10.1038/s41418-022-00992-3 PLoS One, 2021, 16(6):e0252554 Nat Metab, 2021, 3(8):1109-1124
S4735	Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.	Stem Cell Res Ther, 2021, 12(1):507 Research Square, 2021, 10.21203/rs.3.rs-372611/v1 J Cell Mol Med, 2020, 29
S3168	cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
S8270	SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.	Neuro Oncol, 2021, 23(1):53-62 Cell Death Differ, 2021, 10.1038/s41418-021-00841-9 Life Sci, 2020, S0024-3205(20)31542-3
S8909	UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.	Cell Death Discov, 2022, 8(1):96
S7792	SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.	Neuro Oncol, 2021, 23(1):53-62 Front Pharmacol, 2021, 12:653233 Hepatology, 2020, 10.1002/hep.31222
S2391	Quercetin (NSC 9221) Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Hum Mol Genet, 2022, ddac116 Mol Neurobiol, 2022, 10.1007/s12035-021-02712-3	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2298	Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Cancer Lett, 2022, S0304-3835(22)00021-0 Front Immunol, 2021, 12:692321	Liver pathology and serum markers of liver injury in mice fed control (Ctrl), or ethanol (EtOH), or ethanol combined with fisetin (E/Fisetin) diet for 4 weeks. (A) Light microscopy with hematoxylin and eosin staining shows lipid accumulation (arrows) in the liver of mice after alcohol exposure, which was alleviated by fisetin administration. (B) Plasma alanine aminotransferase (ALT) and (C) aspartate aminotransferase (AST) activities. Infinity ALT and AST reagents were used formeasuring ALT and AST activities. Scale bar: 50 lm. Results are mean±SD (n = 3 to 6). Results for bars that do not sharea letter differed significantly among groups (p < 0.05). Significant differences among groups are determined by analysis of variance followed by Tukey’s test.
S5918	CAY10602 CAY10602 is a potent SIRT1 activator.	J Med Chem, 2020, 31
S8481	SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.	Neuro Oncol, 2021, 23(1):53-62 Aging Cell, 2020, e13164 Acta Haematol, 2019, 142(3):142-148
S6880	SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
S2347	Quercetin Dihydrate Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Nucleic Acids Res, 2021, gkab538 Front Immunol, 2021, 12:649285	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1541	Selisistat (EX 527) Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.	Cell Death Differ, 2022, 10.1038/s41418-022-00992-3 Dev Cell, 2022, 57(2):260-276.e9 Front Pharmacol, 2022, 13:797469	The eect of Melatonin, luzindole, and EX527 treatment on apoptotic index, infarct size, lactate dehydrogenase (LDH) release, and CK release in IR-injured hearts. Representative photomicrographs of in situ detection of apoptotic myocytes by TUNEL staining. Green ﬂuorescence shows TUNEL-positive nuclei; blue ﬂuorescence shows nuclei of total cardiomyocytes; original magniﬁcation 9x400. Sacle bar: 100 um.
S1396	Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Placenta, 2022, 122:56-65 Int Immunopharmacol, 2022, 103:108489 Eur J Neurosci, 2022, 10.1111/ejn.15596	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
S2804	Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Stem Cell Res Ther, 2022, 13(1):198 J Cell Sci, 2022, jcs.259207 Front Pharmacol, 2022, 13:797469	Effects of sirtinol on SIRT1 expression and HIF-1α. hMSCs were treated with sirtinol (100 uM) or equivalent concentration of DMSO (CTR) for 24 h and then exposed to 1% O2 for 6 h. All cells lysates were analyzed for SIRT1, HIF-1α, and tubulin by Western blot.
S1899	Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.	Cell Rep, 2022, 38(3):110250 Cell Death Dis, 2022, 13(1):43 Cell Metab, 2021, 33(1):110-127.e5	Immunoprecipitation-western blot for analyzing acetylated Snail in Snail-transfected 293T cells (upper) and FaDu-Snail cells (lower) treated with a vehicle control (Ctrl), a HDAC inhibitor TSA 5 nM for 8 hr, a SIRT1 inhibitor NAM(Nicotinamide) 10 mM for 8 hr, or in combination.
E1150^新	SIRT7 inhibitor 97491 In SIRT7-related cancers, SIRT7 inhibitor 97491 reduces deacetylase activity of SIRT7 in a dose-dependent manner, and induces apoptosis which is activated by p53 modification and affecting the caspase pathway.
S8942^新	Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
S9903^新	NRD167 NRD167 is a potent and selective SIRT5 inhibitor.	EMBO J, 2022, e110324
S8000	Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	J Pharm Biomed Anal, 2021, 201:114121 J Transl Med, 2019, 17(1):76 Sci Rep, 2019, 9(1):1897	The SIRT1 inhibitor (tenovin-1) partially blocked the protective effect of γ-man in L02 cells. The effect of tenovin-1 on expression and acetylation level of PGC-1α (B) in L02 cells treated with or without γ-man.
S7845	SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.	Basic Res Cardiol, 2021, 116(1):48 Cancer Lett, 2020, 501:20-30 J Cell Physiol, 2020, 10.1002
S4900	Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.	Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948 J Cell Sci, 2019, 132(6)
S2176	Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S7577	AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.	Dev Cell, 2022, 57(2):260-276.e9 Front Pharmacol, 2022, 13:797469 Cell Rep, 2021, 34(13):108921	Masson trichrome staining of tubulointerstitium areas from Sham, UUO, UUO+AGK2 mice (original magnification: × 400).
S8245	Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.	Cell Metab, 2020, 32(3):420-436.e12 Cancer Lett, 2020, 501:20-30 J Cell Physiol, 2020, 10.1002
S8460	Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.	Cancer Lett, 2020, 501:20-30 Am J Transl Res, 2019, 11(8):4789-4799 J Proteome Res, 2018, 17(4):1436-1451
S8627	OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.	Biochem Pharmacol, 2022, 199:115022 Front Cell Dev Biol, 2021, 9:625540 Front Cell Dev Biol, 2021, 9:648627
S5914	AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S8628	3-TYP 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	Dev Cell, 2022, 57(2):260-276.e9 Exp Mol Med, 2022, 10.1038/s12276-022-00745-9 Int J Mol Sci, 2022, 23(7)3740	Effects of HNK or 3‐TYP on surgery/anesthesia‐induced an increased expression of pro‐inflammatory cytokines in hippocampus. (A, E) Representative blots at postoperative 1 and 3 d, respectively. (B, F) MCP‐1 relative expression. (C, G) TNF‐α relative expression. (D, H) IL‐1β relative expression. The data are presented as the mean ±standard error of the mean for each group (n = 6 per group). *P < 0.05 vs the control group; #P < 0.05 vs the surgery+vehicle group; $P < 0.05 vs the honokiol group
S6744	Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.	Cancer Lett, 2020, 501:20-30

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1129	SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.	J Transl Med, 2022, 20(1):222 FEBS J, 2022, 10.1111/febs.16353 J Diabetes Res, 2022, 2022:1755563	PAI-1 expression in HUVECs treated with drugs as indicated.(D) senescent HUVECs were treated with SRT1720, culturing for 24, 48 hours. PAI-1 mRNA and protein (E) levels were analyzed using real-time RT–PCR and Western blotting, respectively. The RNA and protein levels were normalized to the internal control β-actin. Data are presented as the mean±SEM of three independent experiments. P < 0.05 vs. corresponding control. P < 0.01 vs. corresponding control **P < 0.001 vs. corresponding control.
E0394^新	YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
S3262	Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
S2935	Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD⁺ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.	Cell Death Differ, 2022, 10.1038/s41418-022-00992-3 PLoS One, 2021, 16(6):e0252554 Nat Metab, 2021, 3(8):1109-1124
S4735	Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.	Stem Cell Res Ther, 2021, 12(1):507 Research Square, 2021, 10.21203/rs.3.rs-372611/v1 J Cell Mol Med, 2020, 29
S3168	cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
S8270	SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.	Neuro Oncol, 2021, 23(1):53-62 Cell Death Differ, 2021, 10.1038/s41418-021-00841-9 Life Sci, 2020, S0024-3205(20)31542-3
S8909	UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.	Cell Death Discov, 2022, 8(1):96
S7792	SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.	Neuro Oncol, 2021, 23(1):53-62 Front Pharmacol, 2021, 12:653233 Hepatology, 2020, 10.1002/hep.31222
S2391	Quercetin (NSC 9221) Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Hum Mol Genet, 2022, ddac116 Mol Neurobiol, 2022, 10.1007/s12035-021-02712-3	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2298	Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Cancer Lett, 2022, S0304-3835(22)00021-0 Front Immunol, 2021, 12:692321	Liver pathology and serum markers of liver injury in mice fed control (Ctrl), or ethanol (EtOH), or ethanol combined with fisetin (E/Fisetin) diet for 4 weeks. (A) Light microscopy with hematoxylin and eosin staining shows lipid accumulation (arrows) in the liver of mice after alcohol exposure, which was alleviated by fisetin administration. (B) Plasma alanine aminotransferase (ALT) and (C) aspartate aminotransferase (AST) activities. Infinity ALT and AST reagents were used formeasuring ALT and AST activities. Scale bar: 50 lm. Results are mean±SD (n = 3 to 6). Results for bars that do not sharea letter differed significantly among groups (p < 0.05). Significant differences among groups are determined by analysis of variance followed by Tukey’s test.
S5918	CAY10602 CAY10602 is a potent SIRT1 activator.	J Med Chem, 2020, 31
S8481	SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.	Neuro Oncol, 2021, 23(1):53-62 Aging Cell, 2020, e13164 Acta Haematol, 2019, 142(3):142-148
S6880	SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.

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S2347	Quercetin Dihydrate Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Nucleic Acids Res, 2021, gkab538 Front Immunol, 2021, 12:649285	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

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S2347

Quercetin Dihydrate

Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138

Nucleic Acids Res, 2021, gkab538

Front Immunol, 2021, 12:649285