Sirtuin

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1541	Selisistat (EX 527)	<1 mg/mL	49 mg/mL	18 mg/mL
S2804	Sirtinol	<1 mg/mL	23 mg/mL	<1 mg/mL
S1899	Nicotinamide (Vitamin B3)	24 mg/mL	24 mg/mL	24 mg/mL
S7845	SirReal2	<1 mg/mL	84 mg/mL	<1 mg/mL
S5914	AK 7	<1 mg/mL	87 mg/mL	3 mg/mL
S4900	Tenovin-6	98 mg/mL	98 mg/mL	<1 mg/mL
S8245	Thiomyristoyl	<1 mg/mL	100 mg/mL	100 mg/mL
S8460	Salermide	<1 mg/mL	78 mg/mL	7 mg/mL
S8627	OSS_128167	<1 mg/mL	73 mg/mL	<1 mg/mL
S8628	3-TYP	5 mg/mL	29 mg/mL	29 mg/mL
S1129	SRT1720 HCl	<1 mg/mL	38 mg/mL	<1 mg/mL
S5918	CAY10602	<1 mg/mL	56 mg/mL	<1 mg/mL
S4735	Salvianolic acid B	100 mg/mL	100 mg/mL	100 mg/mL
S8270	SRT2183	<1 mg/mL	93 mg/mL	3 mg/mL
S7792	SRT2104 (GSK2245840)	<1 mg/mL	16 mg/mL	<1 mg/mL
S2391	Quercetin	<1 mg/mL	61 mg/mL	10 mg/mL
S2298	Fisetin	<1 mg/mL	57 mg/mL	3 mg/mL
S8481	SRT3025	<1 mg/mL	100 mg/mL	5 mg/mL

亜型選択性的な製品

Sirtuin製品

All (18) Sirtuin阻害剤(10) Sirtuin活性剤(8) 新Sirtuin製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1541	Selisistat (EX 527) Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.	Blood, 2014, 124(1):121-33 J Pineal Res, 2014, 57(2):228-38 Cancer Res, 2014, 74(1):298-308	The eect of Melatonin, luzindole, and EX527 treatment on apoptotic index, infarct size, lactate dehydrogenase (LDH) release, and CK release in IR-injured hearts. Representative photomicrographs of in situ detection of apoptotic myocytes by TUNEL staining. Green ﬂuorescence shows TUNEL-positive nuclei; blue ﬂuorescence shows nuclei of total cardiomyocytes; original magniﬁcation 9x400. Sacle bar: 100 um.
S2804	Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Nat Biotechnol, 2015, 10.1038/nbt.3130 Oxid Med Cell Longev, 2017, 2017:1035702 Sci Rep, 2016, 6:21857	Effects of Cap pretreatment with or without coadministration of sirtinol on the activities of caspase-3 in the rat primary cardiomyocytes after A/R. A/R induced a significant increase in the activities of caspase-3. Cap significantly decreased the change in the activities of caspase-3 caused by A/R, and sirtinol significantly blocked the effects of Cap. Values were expressed as the mean ± SEM (n = 6). ∗∗P < 0.01 versus the control group; ▲▲P < 0.01 versus the A/R group; ##P < 0.01 versus the Cap + A/R group.
S1899	Nicotinamide (Vitamin B3) Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.	Cancer Cell, 2014, 26(4):534-48 PLoS Biol, 2013, 12(1):e1001758	Immunoprecipitation-western blot for analyzing acetylated Snail in Snail-transfected 293T cells (upper) and FaDu-Snail cells (lower) treated with a vehicle control (Ctrl), a HDAC inhibitor TSA 5 nM for 8 hr, a SIRT1 inhibitor NAM(Nicotinamide) 10 mM for 8 hr, or in combination.
S7845	SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.	J Steroid Biochem Mol Biol, 2019, 185:27-38
S5914^新	AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S4900	Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.	Nat Biotechnol, 2015, 10.1038/nbt.3130
S8245	Thiomyristoyl Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
S8460	Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
S8627	OSS_128167 OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
S8628	3-TYP 3-TYP is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	CNS Neurosci Ther, 2018, 10.1111/cns.13053	Effects of HNK or 3‐TYP on surgery/anesthesia‐induced an increased expression of pro‐inflammatory cytokines in hippocampus. (A, E) Representative blots at postoperative 1 and 3 d, respectively. (B, F) MCP‐1 relative expression. (C, G) TNF‐α relative expression. (D, H) IL‐1β relative expression. The data are presented as the mean ±standard error of the mean for each group (n = 6 per group). *P < 0.05 vs the control group; #P < 0.05 vs the surgery+vehicle group; $P < 0.05 vs the honokiol group
S1129	SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.	Nat Med, 2015, 10.1038/nm.3821 EMBO J, 2013, 32(6):791-804 Cancer Res, 2016, 76(5):1225-36
S5918^新	CAY10602 CAY10602 is a potent SIRT1 activator.
S4735	Salvianolic acid B Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
S8270	SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
S7792	SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
S2391	Quercetin Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.	Mol Nutr Food Res, 2017, 61(4) Clin Cancer Res, 2018, 10.1158/1078-0432	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2298	Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.	Alcohol Clin Exp Res, 2016, 40(10):2076-2084	Liver pathology and serum markers of liver injury in mice fed control (Ctrl), or ethanol (EtOH), or ethanol combined with fisetin (E/Fisetin) diet for 4 weeks. (A) Light microscopy with hematoxylin and eosin staining shows lipid accumulation (arrows) in the liver of mice after alcohol exposure, which was alleviated by fisetin administration. (B) Plasma alanine aminotransferase (ALT) and (C) aspartate aminotransferase (AST) activities. Infinity ALT and AST reagents were used formeasuring ALT and AST activities. Scale bar: 50 lm. Results are mean±SD (n = 3 to 6). Results for bars that do not share a letter differed significantly among groups (p < 0.05). Significant differences among groups are determined by analysis of variance followed by Tukey’s test.
S8481	SRT3025 SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1541	Selisistat (EX 527) Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.	Blood, 2014, 124(1):121-33 J Pineal Res, 2014, 57(2):228-38 Cancer Res, 2014, 74(1):298-308	The eect of Melatonin, luzindole, and EX527 treatment on apoptotic index, infarct size, lactate dehydrogenase (LDH) release, and CK release in IR-injured hearts. Representative photomicrographs of in situ detection of apoptotic myocytes by TUNEL staining. Green ﬂuorescence shows TUNEL-positive nuclei; blue ﬂuorescence shows nuclei of total cardiomyocytes; original magniﬁcation 9x400. Sacle bar: 100 um.
S2804	Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.	Nat Biotechnol, 2015, 10.1038/nbt.3130 Oxid Med Cell Longev, 2017, 2017:1035702 Sci Rep, 2016, 6:21857	Effects of Cap pretreatment with or without coadministration of sirtinol on the activities of caspase-3 in the rat primary cardiomyocytes after A/R. A/R induced a significant increase in the activities of caspase-3. Cap significantly decreased the change in the activities of caspase-3 caused by A/R, and sirtinol significantly blocked the effects of Cap. Values were expressed as the mean ± SEM (n = 6). ∗∗P < 0.01 versus the control group; ▲▲P < 0.01 versus the A/R group; ##P < 0.01 versus the Cap + A/R group.
S1899	Nicotinamide (Vitamin B3) Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.	Cancer Cell, 2014, 26(4):534-48 PLoS Biol, 2013, 12(1):e1001758	Immunoprecipitation-western blot for analyzing acetylated Snail in Snail-transfected 293T cells (upper) and FaDu-Snail cells (lower) treated with a vehicle control (Ctrl), a HDAC inhibitor TSA 5 nM for 8 hr, a SIRT1 inhibitor NAM(Nicotinamide) 10 mM for 8 hr, or in combination.
S7845	SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.	J Steroid Biochem Mol Biol, 2019, 185:27-38
S5914^新	AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S4900	Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.	Nat Biotechnol, 2015, 10.1038/nbt.3130
S8245	Thiomyristoyl Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
S8460	Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
S8627	OSS_128167 OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
S8628	3-TYP 3-TYP is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.	CNS Neurosci Ther, 2018, 10.1111/cns.13053	Effects of HNK or 3‐TYP on surgery/anesthesia‐induced an increased expression of pro‐inflammatory cytokines in hippocampus. (A, E) Representative blots at postoperative 1 and 3 d, respectively. (B, F) MCP‐1 relative expression. (C, G) TNF‐α relative expression. (D, H) IL‐1β relative expression. The data are presented as the mean ±standard error of the mean for each group (n = 6 per group). *P < 0.05 vs the control group; #P < 0.05 vs the surgery+vehicle group; $P < 0.05 vs the honokiol group

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1129	SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.	Nat Med, 2015, 10.1038/nm.3821 EMBO J, 2013, 32(6):791-804 Cancer Res, 2016, 76(5):1225-36
S5918^新	CAY10602 CAY10602 is a potent SIRT1 activator.
S4735	Salvianolic acid B Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
S8270	SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
S7792	SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
S2391	Quercetin Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.	Mol Nutr Food Res, 2017, 61(4) Clin Cancer Res, 2018, 10.1158/1078-0432	After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
S2298	Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.	Alcohol Clin Exp Res, 2016, 40(10):2076-2084	Liver pathology and serum markers of liver injury in mice fed control (Ctrl), or ethanol (EtOH), or ethanol combined with fisetin (E/Fisetin) diet for 4 weeks. (A) Light microscopy with hematoxylin and eosin staining shows lipid accumulation (arrows) in the liver of mice after alcohol exposure, which was alleviated by fisetin administration. (B) Plasma alanine aminotransferase (ALT) and (C) aspartate aminotransferase (AST) activities. Infinity ALT and AST reagents were used formeasuring ALT and AST activities. Scale bar: 50 lm. Results are mean±SD (n = 3 to 6). Results for bars that do not share a letter differed significantly among groups (p < 0.05). Significant differences among groups are determined by analysis of variance followed by Tukey’s test.
S8481	SRT3025 SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

Tags: Sirtuin activation | SIRT1 inhibition | SIRT1 activation | SIRT1 protein | SIRT1 cancer | SIRT1 activity | SIRT1 pathway | SIRT1 assay | Sirtuin protein | Sirtuin activity | SIRT activation | SIRT assay | Sirtuin cancer | Sirtuin pathway | SIRT1 phosphorylation | Sirtuin assay | SIRT2 cancer | SIRT pathway | SIRT2 protein | SIRT2 assay | SIRT1 inhibitor review

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輸送温度 :冷凍（-15℃—-20℃）
お薦めの保存温度 : -20℃以下

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