Teicoplanin

Teicoplanin is associated with small increases in the GI colonization by C. albicans. ^[1] The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell. ^[2] Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis. ^[3] Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. ^[4]

Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. ^[5]