Elamipretide (SS-31, MTP-131)

製品コード：S9803 純度：98.83%

Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Amino-acid Sequence

D-Arg-Dmt-Lys-Phe-NH2

CAS No. 736992-21-5

サイズ	価格(税別)	在庫状況
5mg	JPY 20800	国内在庫なし(納期7~10日)
25mg	JPY 62500	国内在庫あり
100mg	JPY 145500	国内在庫なし(納期7~10日)
1g	JPY 343500	国内在庫あり
バルクサイズ	バルク特価あり

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製品安全説明書

現在のバッチを見る：純度： 98.83%

98.83

化学情報

保管	3 years -20°C powder	溶液の保管冷凍と解凍の繰り返しを避けるため小分けにしてください	1年-80°Cin solvent
			１ケ月-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

生物活性

製品説明

Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Targets

cytochrome c peroxidase

In vitro
In vitro	Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex of this compound with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.^[1]
細胞実験	細胞株	feline kidney cells
	濃度	0.1-10 μM
	反応時間	1 hour
	実験の流れ	Intracellular targeting of Elamipretide (SS-31, MTP-131) is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated compound for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.

In Vivo
In vivo	Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.^[1]
動物実験	動物モデル	male Sprague–Dawley rats
	投与量	2.0 mg/kg
	投与経路	SC

参考
https://pubmed.ncbi.nlm.nih.gov/23813215/ https://pubmed.ncbi.nlm.nih.gov/31747905/

参考

https://pubmed.ncbi.nlm.nih.gov/23813215/
https://pubmed.ncbi.nlm.nih.gov/31747905/

製品情報

Molecular Formula	C₃₂H₄₉N₉O₅
Molecular Weight	639.79
CAS No.	736992-21-5
Storage (From the date of receipt)	3 years -20°C powder
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)