アンドロゲン受容体

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1123 Abiraterone (CB-7598) 0 mg/mL 0 mg/mL '''0 mg/mL
S2246 Abiraterone Acetate (CB7630) <1 mg/mL <1 mg/mL ''''28 mg/mL
S6965 ARV-110 <1 mg/mL 100 mg/mL '''''<1 mg/mL
S9667 CCS-1477 (CBP-IN-1) <1 mg/mL 100 mg/mL '''''''100 mg/mL
S2840 Apalutamide (ARN-509) <1 mg/mL 18 mg/mL 5 mg/mL
S1353 Ketoconazole (R 41400) <1 mg/mL 5 mg/mL '''7 mg/mL
S1195 TAK-700 (Orteronel) <1 mg/mL 61 mg/mL '''8 mg/mL
S1304 Megestrol Acetate <1 mg/mL 33 mg/mL '15 mg/mL
S7040 AZD3514 <1 mg/mL 100 mg/mL 100 mg/mL
S0097 (S,R,S)-AHPC (MDK7526) 10 mg/mL 86 mg/mL 86 mg/mL
S6885 Ailanthone -1 mg/mL 100 mg/mL -1 mg/mL
S1250 Enzalutamide (MDV3100) <1 mg/mL 92 mg/mL ''<1 mg/mL
S1190 Bicalutamide (ICI-176334) <1 mg/mL 86 mg/mL '5 mg/mL
S9898 Proxalutamide (GT0918) <1 mg/mL 100 mg/mL ''25 mg/mL
S9900 JNJ-63576253 (TRC-253) <1 mg/mL 100 mg/mL '''<1 mg/mL
S2803 Galeterone <1 mg/mL 24 mg/mL 40 mg/mL
S1908 Flutamide <1 mg/mL 55 mg/mL 55 mg/mL
S2604 Dehydroepiandrosterone (DHEA) <1 mg/mL 57 mg/mL '57 mg/mL
S2042 Cyproterone Acetate <1 mg/mL 83 mg/mL 10 mg/mL
S4054 Spironolactone <1 mg/mL 83 mg/mL 20 mg/mL
S4836 Nilutamide <1 mg/mL 63 mg/mL '63 mg/mL
S4593 Chlormadinone acetate <1 mg/mL 27 mg/mL 1 mg/mL
S7559 Darolutamide (ODM-201) <1 mg/mL 80 mg/mL '38 mg/mL
S8885 UT-34 <1 mg/mL 71 mg/mL 71 mg/mL
S5285 RU58841 <1 mg/mL 73 mg/mL 73 mg/mL
S7955 EPI-001 <1 mg/mL 79 mg/mL 79 mg/mL
S9045 Triptophenolide -1 mg/mL 62 mg/mL -1 mg/mL
S6896 Clascoterone <1 mg/mL 80 mg/mL 80 mg/mL
S4728 3,3'-Diindolylmethane <1 mg/mL 49 mg/mL 18 mg/mL
S5437 4,4'-DDE -1 mg/mL 63 mg/mL '-1 mg/mL
S1140 Andarine <1 mg/mL 88 mg/mL 88 mg/mL
S2832 Epiandrosterone <1 mg/mL 29 mg/mL 58 mg/mL
S6352 Androsterone -1 mg/mL 29 mg/mL '-1 mg/mL
S5508 Dehydroepiandrosterone acetate -1 mg/mL 12 mg/mL ''-1 mg/mL
S3946 Mesterolone -1 mg/mL 13 mg/mL '-1 mg/mL
S6407 Tulobuterol hydrochloride 53 mg/mL 53 mg/mL 10 mg/mL
S4794 Drostanolone Propionate -1 mg/mL 18 mg/mL '-1 mg/mL
S4795 Trenbolone acetate -1 mg/mL 62 mg/mL -1 mg/mL
S3717 Testosterone Enanthate 9 mg/mL 80 mg/mL 80 mg/mL
S4757 Dihydrotestosterone (DHT) <1 mg/mL 58 mg/mL 58 mg/mL
S1174 Ostarine (GTx-024) <1 mg/mL 78 mg/mL 78 mg/mL
S5275 Testolone (RAD140) -1 mg/mL 78 mg/mL -1 mg/mL
S0276 GSK-2881078 ˂1 mg/mL 66 mg/mL 50 mg/mL
S8822 Ligandrol (LGD-4033) <1 mg/mL 68 mg/mL 68 mg/mL
S0839 ACP-105 <1 mg/mL 58 mg/mL '''58 mg/mL
S6630 Dimethylcurcumin (ASC-J9) <1 mg/mL 79 mg/mL <1 mg/mL

Androgen Receptor製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1123

Abiraterone (CB-7598)

Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor.

S2246

Abiraterone Acetate (CB7630)

Abiraterone Acetate (CB7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.

S6965

ARV-110

ARV-110 is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.

S9667

CCS-1477 (CBP-IN-1)

CCS1477(CBP-IN-1, CBP/p300-IN-4)is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.

S2840

Apalutamide (ARN-509)

Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.

S1353

Ketoconazole (R 41400)

Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.

S1195

TAK-700 (Orteronel)

TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 (Orteronel) is an androgen biosynthesis inhibitor. Phase 3.

S1304

Megestrol Acetate

Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.

S7040

AZD3514

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.

S0097

(S,R,S)-AHPC (MDK7526)

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.

S6885

Ailanthone

Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.

S1250

Enzalutamide (MDV3100)

Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.

S1190

Bicalutamide (ICI-176334)

Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.

S9898

Proxalutamide (GT0918)

Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.

S9900

JNJ-63576253 (TRC-253)

JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.

S2803

Galeterone

Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.

S1908

Flutamide

Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

S2042

Cyproterone Acetate

Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.

S4054

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

S4836

Nilutamide

Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.

S4593

Chlormadinone acetate

Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours.

S7559

Darolutamide (ODM-201)

Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3.

S8885

UT-34

UT-34 is a potent, selective and orally bioavailable second-generation androgen receptor (AR) pan antagonist and degrader with IC50 of 203.46 nM, 80.78 nM and 94.17 nM for wild-type, T877A and W741L AR, respectively. UT-34 is a potential next-generation therapeutic for enzalutamide-resistant prostate cancer.

S5285

RU58841

RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen.

S7955

EPI-001

EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.

S9045

Triptophenolide

Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A.

S6896

Clascoterone

Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).

S4728

3,3'-Diindolylmethane

3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

S5437

4,4'-DDE

4,4'-DDE (DDE, p,p'-DDE, p,p'-dichlorodiphenyldichloroethylene), a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.

S1140

Andarine

Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.

S2832

Epiandrosterone

Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.

S3830

Protodioscin

Protodioscin (Furostanol I), a steroidal saponin compound found in a number of plant species, is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.

S6352

Androsterone

Androsterone (5alpha-Androsterone) is a steroid metabolite derived from sex hormones, which displays weak androgenic properties.

S5508

Dehydroepiandrosterone acetate

Dehydroepiandrosterone acetate (DHEA, Androstenolone) is a kind of dehydroepiandrosterone derivatives. DHEA is an endogenous steroid hormone, which is considered to be a natural product/dietary supplement with many proposed benefits to humans.

S3946

Mesterolone

Mesterolone (Androviron, Mesteranum, Proviron) is a synthetic steroid with anabolic and androgenic activities.

S6407

Tulobuterol hydrochloride

Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities.

S4794

Drostanolone Propionate

Drostanolone Propionate (Dromostanolone propionate, NSC-12198, Drostanolone 17β-propionate) is an anabolic androgenic steroid with strong anti-estrogenic properties.

S4795

Trenbolone acetate

Trenbolone acetate (RU-1697, Trenbolone 17β), a synthetic anabolic steroid, is an androgen ester and a long-acting prodrug of trenbolone.

S3717

Testosterone Enanthate

Testosterone Enanthate (Testosterone heptanoate, NSC-17591) is an androgen and anabolic steroid used in androgen replacement therapy.

S3715

Boldenone Undecylenate

Boldenone is an agonist of the androgen receptor (AR). Boldenone Undecylenate is a derivative of testosterone, which has strong anabolic effect and only moderately androgenic.

S4757

Dihydrotestosterone (DHT)

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

S1174

Ostarine (GTx-024)

Ostarine (GTx-024, MK-2866) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.

S5275

Testolone (RAD140)

Testolone (RAD140) is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator with Ki value of 7 nM as well as good selectivity over other steroid hormone nuclear receptors.

S0276

GSK-2881078

GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.

S8822

Ligandrol (LGD-4033)

Ligandrol (LGD-4033, VK-5211) is a novel nonsteroidal, oral selective androgen receptor modulator with high affinity (Ki of ∼1 nM) and selectivity.

S0839

ACP-105

ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively.

S6630

Dimethylcurcumin (ASC-J9)

Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1123

Abiraterone (CB-7598)

Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor.

S2246

Abiraterone Acetate (CB7630)

Abiraterone Acetate (CB7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.

S6965

ARV-110

ARV-110 is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.

S9667

CCS-1477 (CBP-IN-1)

CCS1477(CBP-IN-1, CBP/p300-IN-4)is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.

S2840

Apalutamide (ARN-509)

Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.

S1353

Ketoconazole (R 41400)

Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.

S1195

TAK-700 (Orteronel)

TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 (Orteronel) is an androgen biosynthesis inhibitor. Phase 3.

S1304

Megestrol Acetate

Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.

S7040

AZD3514

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.

S0097

(S,R,S)-AHPC (MDK7526)

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.

S6885

Ailanthone

Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1250

Enzalutamide (MDV3100)

Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.

2021, 27(3):426-433

2021, 10.1038/s41591-020-01168-7

2021, 10(10):e12136

S1190

Bicalutamide (ICI-176334)

Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.

2021, 7(27)eabg2564

2021, 36(10):109625

2021, 520:172-183

S9898

Proxalutamide (GT0918)

Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.

S9900

JNJ-63576253 (TRC-253)

JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.

S2803

Galeterone

Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.

2020, 10.1007/s00280-020-04195-w

2020, 153:108534

2018, 129:24-34

S1908

Flutamide

Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.

2021, 28(6):788-801.e5

2021, 10.1007/s13577-021-00579-z

2020, 9(20):e015773

S2604

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone (DHEA, Prasterone, Dehydroisoandrosterone) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

2021, 10.1007/s12015-021-10239-2

2021, 10.2139/ssrn.3886996

2020, 9e56749

S2042

Cyproterone Acetate

Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.

2021, 11(1):5457

2017, 1863(9):2319-2332

S4054

Spironolactone

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

2021, 22(4)1638

2021, S0021-9258(21)00252-0

2020, 55(2):91-102

S4836

Nilutamide

Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.

S4593

Chlormadinone acetate

Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours.

S7559

Darolutamide (ODM-201)

Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3.

2020, 202021450

2020, molcanther.0417.2020

2020, 19;molcanther00152020

S8885

UT-34

UT-34 is a potent, selective and orally bioavailable second-generation androgen receptor (AR) pan antagonist and degrader with IC50 of 203.46 nM, 80.78 nM and 94.17 nM for wild-type, T877A and W741L AR, respectively. UT-34 is a potential next-generation therapeutic for enzalutamide-resistant prostate cancer.

S5285

RU58841

RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen.

S7955

EPI-001

EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.

2019, 79(2):206-214

S9045

Triptophenolide

Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A.

S6896

Clascoterone

Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).

S4728

3,3'-Diindolylmethane

3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

2021, 35(5):e21502

2019, 10(2):38

S5437

4,4'-DDE

4,4'-DDE (DDE, p,p'-DDE, p,p'-dichlorodiphenyldichloroethylene), a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1140

Andarine

Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.

2021, 10.1021/acs.analchem.1c01083

2020, 10.1002/dta.2917

2020, 31(11):2243-2249

S2832

Epiandrosterone

Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.

S3830

Protodioscin

Protodioscin (Furostanol I), a steroidal saponin compound found in a number of plant species, is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.

S6352

Androsterone

Androsterone (5alpha-Androsterone) is a steroid metabolite derived from sex hormones, which displays weak androgenic properties.

2019, 2019:7162976

S5508

Dehydroepiandrosterone acetate

Dehydroepiandrosterone acetate (DHEA, Androstenolone) is a kind of dehydroepiandrosterone derivatives. DHEA is an endogenous steroid hormone, which is considered to be a natural product/dietary supplement with many proposed benefits to humans.

2020, 10.1038/s41416-020-1007-3

2016, 382(2):195-202

S3946

Mesterolone

Mesterolone (Androviron, Mesteranum, Proviron) is a synthetic steroid with anabolic and androgenic activities.

S6407

Tulobuterol hydrochloride

Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities.

S4794

Drostanolone Propionate

Drostanolone Propionate (Dromostanolone propionate, NSC-12198, Drostanolone 17β-propionate) is an anabolic androgenic steroid with strong anti-estrogenic properties.

S4795

Trenbolone acetate

Trenbolone acetate (RU-1697, Trenbolone 17β), a synthetic anabolic steroid, is an androgen ester and a long-acting prodrug of trenbolone.

S3717

Testosterone Enanthate

Testosterone Enanthate (Testosterone heptanoate, NSC-17591) is an androgen and anabolic steroid used in androgen replacement therapy.

2020, 8;13:2987-2995

S3715

Boldenone Undecylenate

Boldenone is an agonist of the androgen receptor (AR). Boldenone Undecylenate is a derivative of testosterone, which has strong anabolic effect and only moderately androgenic.

S4757

Dihydrotestosterone (DHT)

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

2021, 129(4):47010

2021, 11(1):14880

2021, 81(9):508-520

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1174

Ostarine (GTx-024)

Ostarine (GTx-024, MK-2866) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.

2021, 131(10)146777

2021, 10.1021/acs.analchem.1c01083

2020, 10.1002/dta.2933

S5275

Testolone (RAD140)

Testolone (RAD140) is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator with Ki value of 7 nM as well as good selectivity over other steroid hormone nuclear receptors.

2021, 131(10)146777

2021, 10.1021/acs.analchem.1c01083

S0276

GSK-2881078

GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.

S8822

Ligandrol (LGD-4033)

Ligandrol (LGD-4033, VK-5211) is a novel nonsteroidal, oral selective androgen receptor modulator with high affinity (Ki of ∼1 nM) and selectivity.

2021, 131(10)146777

2021, 10.1021/acs.analchem.1c01083

S0839

ACP-105

ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively.

2020, 10.1002/dta.2917

S6630

Dimethylcurcumin (ASC-J9)

Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.