SGLT

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1548 Dapagliflozin <1 mg/mL 82 mg/mL ''17 mg/mL
S8022 Empagliflozin (BI 10773) <1 mg/mL 90 mg/mL <1 mg/mL
S8103 Sotagliflozin (LX4211) <1 mg/mL 84 mg/mL 17 mg/mL
S8558 Tofogliflozin(CSG 452) 4 mg/mL 84 mg/mL '84 mg/mL
S0994 Ipragliflozin L-Proline <1 mg/mL 35 mg/mL ''''6 mg/mL
S8938 KGA-2727 100 mg/mL 100 mg/mL ''45 mg/mL
S8939 Mizagliflozin 100 mg/mL 100 mg/mL '100 mg/mL
S5566 Dapagliflozin propanediol monohydrate <1 mg/mL 100 mg/mL 100 mg/mL
S8637 Ipragliflozin (ASP1941) <1 mg/mL 80 mg/mL 80 mg/mL
S2342 Phloretin <1 mg/mL 54 mg/mL 54 mg/mL
S2343 Phlorizin <1 mg/mL 87 mg/mL 9 mg/mL
S5413 Ertugliflozin 87 mg/mL 87 mg/mL '87 mg/mL

亜型選択性的な製品

SGLT製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1548

Dapagliflozin

Dapagliflozin (BMS-512148) is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.

S8022

Empagliflozin (BI 10773)

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

S8103

Sotagliflozin (LX4211)

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.

S8558

Tofogliflozin(CSG 452)

Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively.

S0994

Ipragliflozin L-Proline

Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.

S8938

KGA-2727

KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.

S8939

Mizagliflozin

Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.

S5566

Dapagliflozin propanediol monohydrate

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.

S8637

Ipragliflozin (ASP1941)

Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.

S2342

Phloretin

Phloretin (Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

S2343

Phlorizin

Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.

S5413

Ertugliflozin

Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1548

Dapagliflozin

Dapagliflozin (BMS-512148) is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.

S8022

Empagliflozin (BI 10773)

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

S8103

Sotagliflozin (LX4211)

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.

S8558

Tofogliflozin(CSG 452)

Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively.

S0994

Ipragliflozin L-Proline

Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.

S8938

KGA-2727

KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.

S8939

Mizagliflozin

Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.

S5566

Dapagliflozin propanediol monohydrate

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.

S8637

Ipragliflozin (ASP1941)

Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.

S2342

Phloretin

Phloretin (Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

S2343

Phlorizin

Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.

S5413

Ertugliflozin

Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.