IκB/IKK

シグナル伝達経路

研究分野

  • 阻害剤の選択性比較
  • 溶解度
カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1274 BX-795 <1 mg/mL 100 mg/mL <1 mg/mL
S2882 IKK-16 (IKK Inhibitor VII) <1 mg/mL 97 mg/mL <1 mg/mL
S2824 TPCA-1 <1 mg/mL 56 mg/mL <1 mg/mL
S2864 IMD 0354 <1 mg/mL 10 mg/mL 77 mg/mL
S8044 BMS-345541 <1 mg/mL 9 mg/mL <1 mg/mL
S3615 Dehydrocostus Lactone <1 mg/mL 46 mg/mL 46 mg/mL
S3612 Rosmarinic acid 24 mg/mL 72 mg/mL 72 mg/mL
S4907 SC-514 <1 mg/mL 45 mg/mL <1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S7851 AZD3264 <1 mg/mL 88 mg/mL 2 mg/mL
S7697 LY2409881 <1 mg/mL 20 mg/mL <1 mg/mL
S7691 PS-1145 <1 mg/mL 64 mg/mL 2 mg/mL
S7948 MRT67307 HCl 92 mg/mL 92 mg/mL 92 mg/mL
S1274 BX-795 <1 mg/mL 100 mg/mL <1 mg/mL
S2882 IKK-16 (IKK Inhibitor VII) <1 mg/mL 97 mg/mL <1 mg/mL
S2824 TPCA-1 <1 mg/mL 56 mg/mL <1 mg/mL
S2864 IMD 0354 <1 mg/mL 10 mg/mL 77 mg/mL
S8044 BMS-345541 <1 mg/mL 9 mg/mL <1 mg/mL
S3615 Dehydrocostus Lactone <1 mg/mL 46 mg/mL 46 mg/mL
S3612 Rosmarinic acid 24 mg/mL 72 mg/mL 72 mg/mL
S4907 SC-514 <1 mg/mL 45 mg/mL <1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S7851 AZD3264 <1 mg/mL 88 mg/mL 2 mg/mL
S7697 LY2409881 <1 mg/mL 20 mg/mL <1 mg/mL
S7691 PS-1145 <1 mg/mL 64 mg/mL 2 mg/mL
S7948 MRT67307 HCl 92 mg/mL 92 mg/mL 92 mg/mL

亜型選択性的な製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1274

BX-795

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

S2882

IKK-16 (IKK Inhibitor VII)

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

S2824

TPCA-1

TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.

S2864

IMD 0354

IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.

S8044

BMS-345541

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.

S3615

Dehydrocostus Lactone

Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

S3612

Rosmarinic acid

Rosmarinic acid (RA) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.

S4907

SC-514

SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

S1681

Mesalamine

Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

S7851

AZD3264

AZD3264 is a novel IKK2 inhibitor.

S7697

LY2409881

LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.

S7691

PS-1145

PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

S7948

MRT67307 HCl

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.

S1274

BX-795

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

S2882

IKK-16 (IKK Inhibitor VII)

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

S2824

TPCA-1

TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.

S2864

IMD 0354

IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.

S8044

BMS-345541

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.

S3615

Dehydrocostus Lactone

Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

S3612

Rosmarinic acid

Rosmarinic acid (RA) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.

S4907

SC-514

SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

S1681

Mesalamine

Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

S7851

AZD3264

AZD3264 is a novel IKK2 inhibitor.

S7697

LY2409881

LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.

S7691

PS-1145

PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

S7948

MRT67307 HCl

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.