MPTP hydrochloride


For research use only.

MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.

MPTP hydrochloride化学構造

CAS No. 23007-85-4

サイズ 価格(税別)
10mM (1mL in DMSO) JPY 16200
JPY 18100
JPY 51300

代表番号: 03-5615-9297|電子メール:[email protected]



Dopamine Receptor阻害剤の選択性比較

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製品説明 MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.

The morphology of N2AB-1 and glioma cells was unaltered when these cells were exposed to all doses of MPTP. And, C6 glioma cell proliferation was also unaffected by MPTP treatment[3]. MPTP Promotes Apoptosis and Tau Phosphorylation in Human Neuroblastoma M17 Cells. MPTP significantly promotes Tau phosphorylation at Ser262 in human neuroblastoma M17 cells. MPTP caused a dose-dependent increase in the intracellular α-synuclein level in our M17 human neuroblastoma cells. MPTP appears to promote Tau phosphorylation in the brain by activating both PKA and GSK3β[4].

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells M2fF[2Z2dmO2aX;uJIF{e2G7 M17MZlEzOCCvaX7z M{PE[2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiTVHPRUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIF{e2W|c3XkJIF{KG:6aXTheIlwdiCxZjDrfY52emGvaX7lJJN2[nO2cnH0[UBifCB3MDD1UUBu\WG|dYLl[EBi\nSncjDh[IRqfGmxbnHsJIVvgnmvZTDh[IRm\CCjZoTldkAyOjBibXnud{BqdmO3YnH0bY9v NYS4SWNIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwO|g1OTBpPkKyNFc5PDFyPD;hQi=>
insect cells NXn6V49UTnWwY4Tpc44h[XO|YYm= NXfKTYJYQTBibXnudy=> MXrJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KE2DT1Gg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczDhd5Nme3OnZDDhd{BwgGmmYYTpc44hd2Zia4nueZJidWmwZTDzeYJ{fHKjdHWgZZQhPTBidV2gcYVie3W{ZXSgZYZ1\XJiYXTkbZRqd26jbDDzeYJ{fHKjdHWgZYRl\WRiYX\0[ZIhQTBibXnud{BqdmO3YnH0bY9v M37vdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEe4OFExLz5{MkC3PFQyODxxYU6=
Methods Test Index PMID
Western blot TH / Actin ; pCaMKIIβ / pCaMKIIα / CaMKIIβ / CaMKIIα / β-Actin ; TH / p-α-Syn / α-Syn / β-actin / CDK5 / LC3-I / LC3-II / p62 / NLRP3 / ASC / Casp1 p20 / Procasp1 ; p-ERK1/2 / ERK1/2 / GAPDH ; GDH2 / GDH1 / GFAP / GAPDH 23391753 31427934 33717653 32927363 33093440
IHC tyrosine hydroxylase (TH) ; tyrosine hydroxylase (TH) ; SNpc ; tyrosine hydroxylase (TH) ; Substantia nigra 31427934 33717653 33093440 11724929 17336077
Immunofluorescence tyrosine hydroxylase (TH) / miR-188-3p ; α-Syn ; tyrosine hydroxylase (TH) / Tunel ; tyrosine hydroxylase (TH) / Tunel ; tyrosine hydroxylase (TH) ; GFAP 33717653 33093440
体内試験 The number of tyrosine hydroxylase-positive neurons was decreased in the substantia nigra pars compacta of MPTP-treated mice. MPTP decreased thioredoxin reductase 1 expression and thioredoxin reductase activity in the mouse midbrain, reduced the number of thioredoxin reductase 1-positive cells in the substantia nigra pars compacta of mice. Administration of the toxin MPTP can cause neurochemical, behavioral and histopathological alterations in human and nonhuman primates that are similar to those observed in Parkinsonian patients. Compared with primates, rodents are insensitive to MPTP. MPTP can be administered by various routes, such as gavage and stereotactic injection, but the most common and reproducible route is systemic administration, including subcutaneous, intravenous, intraperitoneal and intramuscular injection. MPTP is a lipophilic protoxin that can rapidly cross the blood-brain barrier following systemic injection. Once it enters the brain, MPTP is converted to 1-methyl-4-phenylpyridine by monoamine oxidase B[1]. MPTP has been shown to be toxic to dopaminergic neurons of the nigrostriatal system in humans, monkeys, and mice and to produce long-lasting depletion of DA and its metabolites in the striatum[2].




  • 細胞株:N2AB-1 neural cell line and the C6 glioma cell line
  • 濃度: 47.7, 4.77 and 0.477 μM
  • 反応時間:1, 2, 3 days
  • 実験の流れ:

    N2AB-1 and C6 glioma cells were plated in 24-well costar dishes (16 mm diameter) at 50,000 cells per well with the culture medium described above. After 24 h medium was removed and medium with varying concentrations of MPTP or MPP+ was added in duplicate. Control and treated cells were then trypsinized and counted with a hemocytometer every day for 3 days following treatment.



  • 動物モデル:C57BL/6 mice
  • 投薬量:20 mg/kg
  • 投与方法:i.p.

溶解度 (25°C)



分子量 209.72


CAS No. 23007-85-4
Storage 3年 -20°C
2年 -80°C in solvent
Smiles CN1CCC(=CC1)C2=CC=CC=C2.Cl



mg/kg g μL


% DMSO % % Tween 80 % ddH2O


投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。



質量 濃度 体積 分子量



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