D2 receptor 選択性阻害剤 | 作動薬 | 拮抗剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S3044 Lurasidone HCl

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.

 Selective D2 receptor, IC50: 1.68 nM
S3189 Ropinirole HCl

Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.

 Selective D2 receptor, Ki: 29 nM
S4289 Metoclopramide HCl

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

Selective
S4251 Phenothiazine

Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.

 Selective
S2104 Levosulpiride

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

 Selective
S2493 Olanzapine

Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

 Selective
S2460 Pramipexole

Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

 Pan D2S Receptor, Ki: 3.9 nM; D2L Receptor, Ki: 2.2 nM
S2011 Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.

 Pan D2S Receptor, Ki: 3.9 nM; D2L Receptor, Ki: 2.2 nM
S1771 Chlorprothixene

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.

 Pan D2 receptor, Ki: 2.96 nM
S4086 Loxapine Succinate

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

 Pan D2 receptor (bovine), Ki: 26 nM; D2 receptor (Human), Ki: 24 nM; D2 receptor (human), Ki: 24 nM
S2437 Rotundine

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

 Pan D2 receptor, IC50: 1.47 μM
S4000 Pergolide Mesylate

Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

 Pan