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阻害剤の選択性比較
溶解度

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S3163	Benztropine mesylate	81 mg/mL	50 mg/mL	81 mg/mL
S2456	Chlorpromazine HCl	71 mg/mL	71 mg/mL	71 mg/mL
S2452	Amfebutamone (Bupropion) HCl	<1 mg/mL	8 mg/mL	<1 mg/mL
S3201	Trifluoperazine 2HCl	96 mg/mL	88 mg/mL	96 mg/mL
S2461	Domperidone	<1 mg/mL	48 mg/mL	1 mg/mL
S4569	Fluphenazine (dihydrochloride)	100 mg/mL	100 mg/mL	30 mg/mL
S1642	Methyldopa	<1 mg/mL	2 mg/mL	<1 mg/mL
S3189	Ropinirole HCl	60 mg/mL	10 mg/mL	<1 mg/mL
S2493	Olanzapine	<1 mg/mL	62 mg/mL	9 mg/mL
S1763	Quetiapine Fumarate	<1 mg/mL	36 mg/mL	<1 mg/mL
S1444	Ziprasidone HCl	<1 mg/mL	90 mg/mL	<1 mg/mL
S5565	Triflupromazine hydrochloride	-1 mg/mL	78 mg/mL	-1 mg/mL
S5399	Chlorprothixene hydrochloride	-1 mg/mL	70 mg/mL	-1 mg/mL
S5714	lurasidone	<1 mg/mL	7 mg/mL	<1 mg/mL
S5624	Paliperidone Palmitate	<1 mg/mL	1 mg/mL	3 mg/mL
S5559	Tetrahydropalmatine	<1 mg/mL	16 mg/mL	<1 mg/mL
S5153	Tetrahydroberberine	-1 mg/mL	6 mg/mL	-1 mg/mL
S5428	Promazine hydrochloride	-1 mg/mL	64 mg/mL	-1 mg/mL
S5481	Molindone hydrochloride	-1 mg/mL	9 mg/mL	-1 mg/mL
S5324	Oxidopamine (hydrobromide)	50 mg/mL	50 mg/mL	50 mg/mL
S4889	Perospirone hydrochloride	-1 mg/mL	92 mg/mL	-1 mg/mL
S5034	Melitracen hydrochloride	65 mg/mL	65 mg/mL	65 mg/mL
S1280	Amisulpride	<1 mg/mL	73 mg/mL	73 mg/mL
S1724	Paliperidone	<1 mg/mL	4 mg/mL	<1 mg/mL
S1920	Haloperidol	<1 mg/mL	75 mg/mL	8 mg/mL
S1771	Chlorprothixene	<1 mg/mL	6 mg/mL	28 mg/mL
S4251	Phenothiazine	<1 mg/mL	40 mg/mL	<1 mg/mL
S4096	Droperidol	<1 mg/mL	76 mg/mL	<1 mg/mL
S3044	Lurasidone HCl	<1 mg/mL	1 mg/mL	<1 mg/mL
S2104	Levosulpiride	<1 mg/mL	69 mg/mL	<1 mg/mL
S4086	Loxapine Succinate	<1 mg/mL	89 mg/mL	2 mg/mL
S4731	Perphenazine	<1 mg/mL	74 mg/mL	74 mg/mL
S4151	Penfluridol	<1 mg/mL	100 mg/mL	100 mg/mL
S2437	Rotundine	<1 mg/mL	8 mg/mL	<1 mg/mL
S4631	Prochlorperazine dimaleate salt	<1 mg/mL	74 mg/mL	2 mg/mL
S4257	Alizapride HCl	70 mg/mL	42 mg/mL	<1 mg/mL
S4655	Sulpiride	<1 mg/mL	68 mg/mL	<1 mg/mL
S1789	Tetrabenazine (Xenazine)	<1 mg/mL	58 mg/mL	32 mg/mL
S4219	Azaperone	<1 mg/mL	65 mg/mL	34 mg/mL
S4289	Metoclopramide HCl	67 mg/mL	67 mg/mL	67 mg/mL
S5066	Pramipexole dihydrochloride	-1 mg/mL	56 mg/mL	-1 mg/mL
S3664	Flupenthixol dihydrochloride	100 mg/mL	100 mg/mL	30 mg/mL
S1726	Levodopa	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2451	Amantadine HCl	38 mg/mL	38 mg/mL	38 mg/mL
S2011	Pramipexole 2HCl Monohydrate	60 mg/mL	41 mg/mL	<1 mg/mL
S2460	Pramipexole	<1 mg/mL	42 mg/mL	42 mg/mL
S2529	Dopamine HCl	38 mg/mL	38 mg/mL	<1 mg/mL
S4000	Pergolide Mesylate	82 mg/mL	10 mg/mL	<1 mg/mL
S4618	Fenoldopam (mesylate)	<1 mg/mL	80 mg/mL	<1 mg/mL
S7993	SKF38393 HCl	<1 mg/mL	58 mg/mL	6 mg/mL
S4639	Brexpiprazole	<1 mg/mL	24 mg/mL	<1 mg/mL
S3656	Piribedil	<1 mg/mL	59 mg/mL	59 mg/mL
S2168	PD128907 HCl	50 mg/mL	12 mg/mL	<1 mg/mL
S4274	Rotigotine	<1 mg/mL	63 mg/mL	63 mg/mL
S4732	MPTP hydrochloride	41 mg/mL	20 mg/mL	41 mg/mL
S8097	C-DIM12	<1 mg/mL	71 mg/mL	71 mg/mL
S3188	(+,-)-Octopamine HCl	38 mg/mL	38 mg/mL	11 mg/mL

亜型選択性的な製品

Dopamine Receptor阻害剤(58)
新Dopamine Receptor製品

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S3163	Benztropine mesylate Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
S2456	Chlorpromazine HCl Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.	Antimicrob Agents Chemother, 2014, 58(8):4875-84 Virol J, 2016, 13:25	Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.
S2452	Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.	G3 (Bethesda), 2014, 4(6):1081-9 Georgia State University, 2014, Chaquettea Felton G3 (Bethesda), 2014, 10.1534/g3.114.010819
S3201	Trifluoperazine 2HCl Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
S2461	Domperidone Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
S4569	Fluphenazine (dihydrochloride) Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor.	Methods Mol Biol, 2017, 1513:119-140
S1642	Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
S3189	Ropinirole HCl Ropinirole a selective dopamine D2 receptors agonist with K_i of 29 nM.
S2493	Olanzapine Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.	J Psychiatr Res, 2017, 88:18-27 Asian Pac J Cancer Prev, 2014, 15(19):8107-13	Olanzapine and aripiprazole differentially regulate cellular glucose uptake of PBMC. Bar graphs depict cellular glucose uptake assessed by 18F-FDG in PBMC after 72 h of stimulation with the indicated concentrations of olanzapine (Olan, A) or aripiprazole (Arip, B) relative to corresponding DMSO controls (Ctrl) and normalized to protein content. Data are depicted as mean ± SD. P-values were computed by one-way ANOVA followed by Dunnett's Multiple Comparison Test. *P < 0.001, P < 0.01, *P < 0.05 versus control; results were obtained from n ¼ 4e6 independent cell isolations measured in duplicate.
S1763	Quetiapine Fumarate Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
S1444	Ziprasidone HCl Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.	Nature, 2018, 560(7718):372-376 Sci Rep, 2017, 7(1):8491
S5565^新	Triflupromazine hydrochloride Triflupromazine hydrochloride is an antipsychotic medication of the phenothiazine class.
S9509^新	Tiapride Hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
S5399^新	Chlorprothixene hydrochloride Chlorprothixene HCl is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
S5714^新	lurasidone Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
S5624^新	Paliperidone Palmitate Paliperidone Palmitate is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
S5559^新	Tetrahydropalmatine Tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist.
S5153^新	Tetrahydroberberine Tetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S5428^新	Promazine hydrochloride Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
S5481^新	Molindone hydrochloride Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.
S5324^新	Oxidopamine (hydrobromide) Oxidopamine is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity.
S4889^新	Perospirone hydrochloride Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
S5034^新	Melitracen hydrochloride Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.
S1280	Amisulpride Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
S1724	Paliperidone Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.
S1920	Haloperidol Haloperidol (Haldol) is an antipsychotic and butyrophenone.
S1771	Chlorprothixene Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with K_i of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
S4251	Phenothiazine Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.
S4096	Droperidol Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
S3044	Lurasidone HCl Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.
S2104	Levosulpiride Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.
S4086	Loxapine Succinate Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
S4731	Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
S4151	Penfluridol Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
S2437	Rotundine Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
S4631	Prochlorperazine dimaleate salt Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.
S4257	Alizapride HCl Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
S4655	Sulpiride Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
S1789	Tetrabenazine (Xenazine) Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.
S4219	Azaperone Azaperone crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
S4289	Metoclopramide HCl Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
S5066^新	Pramipexole dihydrochloride Pramipexole dihydrochloride is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
S3664	Flupenthixol dihydrochloride Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
S1726	Levodopa Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.	PLoS One, 2017, 12(3):e0173240	(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. p < 0.05; **p < 0.001 versus the control of each group.
S2451	Amantadine HCl Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.
S2011	Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
S2460	Pramipexole Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
S2529	Dopamine HCl Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
S4000	Pergolide Mesylate Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
S4618	Fenoldopam (mesylate) Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
S7993	SKF38393 HCl SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
S4639	Brexpiprazole Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors.
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S2168	PD128907 HCl PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
S4274	Rotigotine Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
S4732	MPTP hydrochloride MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism.
S8097	C-DIM12 C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
S3188	(+,-)-Octopamine HCl Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.

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ドーパミン受容体

シグナル伝達経路

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亜型選択性的な製品