ドーパミン受容体
阻害剤の選択性比較
カタログ番号 | 製品カタログ | 溶解度(25°C) | ||
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水 | DMSO | アルコール | ||
S3163 | Benztropine mesylate | 81 mg/mL | 50 mg/mL | 81 mg/mL |
S2456 | Chlorpromazine HCl | 71 mg/mL | 71 mg/mL | 71 mg/mL |
S2452 | Amfebutamone (Bupropion) HCl | <1 mg/mL | 8 mg/mL | <1 mg/mL |
S3201 | Trifluoperazine 2HCl | 96 mg/mL | 88 mg/mL | 96 mg/mL |
S2461 | Domperidone | <1 mg/mL | 48 mg/mL | 1 mg/mL |
S4569 | Fluphenazine dihydrochloride | 100 mg/mL | 100 mg/mL | '30 mg/mL |
S1642 | Methyldopa | <1 mg/mL | 2 mg/mL | <1 mg/mL |
S5796 | Vanoxerine dihydrochloride | 5 mg/mL | 17 mg/mL | 2 mg/mL |
S3854 | Tetrahydropalmatine hydrochloride | -1 mg/mL | 12 mg/mL | -1 mg/mL |
S3189 | Ropinirole HCl | 60 mg/mL | 10 mg/mL | <1 mg/mL |
S2493 | Olanzapine | <1 mg/mL | 62 mg/mL | 9 mg/mL |
S1763 | Quetiapine Fumarate | <1 mg/mL | 36 mg/mL | <1 mg/mL |
S1444 | Ziprasidone HCl | <1 mg/mL | 90 mg/mL | <1 mg/mL |
S0476 | SCH-23390 hydrochloride | 20 mg/mL | 65 mg/mL | '25 mg/mL |
S1280 | Amisulpride | <1 mg/mL | 73 mg/mL | 73 mg/mL |
S1724 | Paliperidone | <1 mg/mL | 4 mg/mL | <1 mg/mL |
S1920 | Haloperidol | <1 mg/mL | 75 mg/mL | 8 mg/mL |
S1771 | Chlorprothixene | <1 mg/mL | 6 mg/mL | 28 mg/mL |
S4251 | Phenothiazine | <1 mg/mL | 40 mg/mL | <1 mg/mL |
S4096 | Droperidol | <1 mg/mL | 76 mg/mL | <1 mg/mL |
S3044 | Lurasidone HCl | <1 mg/mL | 1 mg/mL | <1 mg/mL |
S2104 | Levosulpiride | <1 mg/mL | 69 mg/mL | <1 mg/mL |
S4086 | Loxapine Succinate | <1 mg/mL | 89 mg/mL | 2 mg/mL |
S5741 | Quetiapine | -1 mg/mL | 77 mg/mL | '-1 mg/mL |
S5559 | Tetrahydropalmatine | <1 mg/mL | 16 mg/mL | <1 mg/mL |
S4731 | Perphenazine | <1 mg/mL | 74 mg/mL | '74 mg/mL |
S5153 | Tetrahydroberberine | -1 mg/mL | 6 mg/mL | -1 mg/mL |
S5324 | Oxidopamine (hydrobromide) | 50 mg/mL | 50 mg/mL | '50 mg/mL |
S4889 | Perospirone hydrochloride | -1 mg/mL | 92 mg/mL | '-1 mg/mL |
S5399 | Chlorprothixene hydrochloride | -1 mg/mL | 70 mg/mL | -1 mg/mL |
S5565 | Triflupromazine hydrochloride | -1 mg/mL | 78 mg/mL | -1 mg/mL |
S4151 | Penfluridol | <1 mg/mL | 100 mg/mL | 100 mg/mL |
S5481 | Molindone hydrochloride | -1 mg/mL | 9 mg/mL | -1 mg/mL |
S2437 | Rotundine | <1 mg/mL | 8 mg/mL | <1 mg/mL |
S4631 | Prochlorperazine dimaleate salt | <1 mg/mL | 74 mg/mL | '2 mg/mL |
S4257 | Alizapride HCl | 70 mg/mL | 42 mg/mL | <1 mg/mL |
S4655 | Sulpiride | <1 mg/mL | 68 mg/mL | '<1 mg/mL |
S5714 | lurasidone | <1 mg/mL | 7 mg/mL | <1 mg/mL |
S5034 | Melitracen hydrochloride | 65 mg/mL | 65 mg/mL | '65 mg/mL |
S1789 | Tetrabenazine (Xenazine) | <1 mg/mL | 58 mg/mL | 32 mg/mL |
S6410 | Clemizole | -1 mg/mL | 65 mg/mL | -1 mg/mL |
S4219 | Azaperone | <1 mg/mL | 65 mg/mL | 34 mg/mL |
S6455 | Clebopride (malate) | 33 mg/mL | 100 mg/mL | 12 mg/mL |
S5428 | Promazine hydrochloride | -1 mg/mL | 64 mg/mL | -1 mg/mL |
S5624 | Paliperidone Palmitate | <1 mg/mL | 1 mg/mL | '3 mg/mL |
S5749 | Chlorpromazine | -1 mg/mL | 64 mg/mL | -1 mg/mL |
S9509 | Tiapride Hydrochloride | -1 mg/mL | 35 mg/mL | -1 mg/mL |
S4289 | Metoclopramide HCl | 67 mg/mL | 67 mg/mL | 67 mg/mL |
S5862 | Metoclopramide | <1 mg/mL | 60 mg/mL | <1 mg/mL |
S6887 | Clozapine N-oxide | 68 mg/mL | 68 mg/mL | 8 mg/mL |
S0104 | Pardoprunox (SLV-308) hydrochloride | <1 mg/mL | 30 mg/mL | '<1 mg/mL |
S1726 | Levodopa | <1 mg/mL | <1 mg/mL | <1 mg/mL |
S2451 | Amantadine HCl | 38 mg/mL | 38 mg/mL | 38 mg/mL |
S2011 | Pramipexole 2HCl Monohydrate | 60 mg/mL | 41 mg/mL | <1 mg/mL |
S2460 | Pramipexole | <1 mg/mL | 42 mg/mL | 42 mg/mL |
S2529 | Dopamine HCl | 38 mg/mL | 38 mg/mL | <1 mg/mL |
S5849 | Cariprazine HCl | 3 mg/mL | 5 mg/mL | '4 mg/mL |
S3664 | Flupentixol dihydrochloride | 100 mg/mL | 100 mg/mL | '''30 mg/mL |
S3821 | Nuciferine | <1 mg/mL | 2 mg/mL | <1 mg/mL |
S4618 | Fenoldopam mesylate | <1 mg/mL | 80 mg/mL | '<1 mg/mL |
S7993 | SKF38393 HCl | <1 mg/mL | 58 mg/mL | 6 mg/mL |
S4639 | Brexpiprazole | <1 mg/mL | 24 mg/mL | '<1 mg/mL |
S3656 | Piribedil | <1 mg/mL | 59 mg/mL | '59 mg/mL |
S2168 | PD128907 HCl | 50 mg/mL | 12 mg/mL | <1 mg/mL |
S5842 | Cabergoline | <1 mg/mL | 90 mg/mL | 90 mg/mL |
S4274 | Rotigotine | <1 mg/mL | 63 mg/mL | 63 mg/mL |
S5066 | Pramipexole dihydrochloride | -1 mg/mL | 56 mg/mL | -1 mg/mL |
S4933 | Lithium carbonate | ' mg/mL | ||
S4732 | MPTP hydrochloride | 41 mg/mL | 20 mg/mL | 41 mg/mL |
S8097 | C-DIM12 | <1 mg/mL | 71 mg/mL | 71 mg/mL |
S3188 | (+,-)-Octopamine HCl | 38 mg/mL | 38 mg/mL | 11 mg/mL |
亜型選択性的な製品
Dopamine Receptor製品
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S3163 |
Benztropine mesylateBenztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. |
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S2456 |
Chlorpromazine HClChlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents. |
![]() ![]() Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given. |
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S2452 |
Amfebutamone (Bupropion) HClAmfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. |
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S3201 |
Trifluoperazine 2HClTrifluoperazine (SKF5019) is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
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S2461 |
DomperidoneDomperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. |
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S4569 |
Fluphenazine dihydrochlorideFluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. |
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S5856 |
TrifluoperazineTrifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. |
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S1642 |
MethyldopaMethyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
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S5796 |
Vanoxerine dihydrochlorideVanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex. |
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S3854 |
Tetrahydropalmatine hydrochlorideTetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant. |
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S3189 |
Ropinirole HClRopinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM. |
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S2493 |
OlanzapineOlanzapine (LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
![]() ![]() Punctuates of LC3 proteins in olanzapine-treated T98 and LN229 cells. Cells were incubated with olanzapine (0, 0.1M, 0.2mM) for 48h and then stained with the anti-LC3 antibody. Cells were examined by fluorescence confocal microscopy. Green: FITC-labeled LC3; Blue: DAPI-labeled nucleus. Magnification: x 400
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S1763 |
Quetiapine FumarateQuetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors. |
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S1444 |
Ziprasidone HClZiprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
![]() ![]() a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.
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S0476新 |
SCH-23390 hydrochlorideSCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM. |
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S1280 |
AmisulprideAmisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
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S1724 |
PaliperidonePaliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia. |
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S1920 |
HaloperidolHaloperidol (Haldol) is an antipsychotic and butyrophenone. |
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S1771 |
ChlorprothixeneChlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
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S4251 |
PhenothiazinePhenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
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S4096 |
DroperidolDroperidol (NSC 169874) is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
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S3044 |
Lurasidone HClLurasidone (SM-13496) is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. |
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S2104 |
LevosulpirideLevosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
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S4086 |
Loxapine SuccinateLoxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. |
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S5741 |
QuetiapineQuetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55. |
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S5559 |
TetrahydropalmatineTetrahydropalmatine (Rotundine), a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. |
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S4731 |
PerphenazinePerphenazine (Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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S5153 |
TetrahydroberberineTetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. |
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S5324 |
Oxidopamine (hydrobromide)Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. |
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S4889 |
Perospirone hydrochloridePerospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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S5399 |
Chlorprothixene hydrochlorideChlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. |
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S5565 |
Triflupromazine hydrochlorideTriflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class. |
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S4151 |
PenfluridolPenfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. |
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S5481 |
Molindone hydrochlorideMolindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
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S2437 |
RotundineRotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
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S4631 |
Prochlorperazine dimaleate saltProchlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist. |
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S4257 |
Alizapride HClAlizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting. |
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S4655 |
SulpirideSulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. |
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S5714 |
lurasidoneLurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
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S5034 |
Melitracen hydrochlorideMelitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties. |
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S1789 |
Tetrabenazine (Xenazine)Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. |
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S6410 |
ClemizoleClemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. |
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S4219 |
AzaperoneAzaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
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S6455 |
Clebopride (malate)Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting. |
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S5428 |
Promazine hydrochloridePromazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. |
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S5624 |
Paliperidone PalmitatePaliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. |
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S5749 |
ChlorpromazineChlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM. |
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S9509 |
Tiapride HydrochlorideTiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders. |
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S4289 |
Metoclopramide HClMetoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
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S5862 |
MetoclopramideMetoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting. |
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S6887新 |
Clozapine N-oxideClozapine N-oxide (CNO) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist. |
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S0104新 |
Pardoprunox (SLV-308) hydrochloridePardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively. |
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S1726 |
LevodopaLevodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms. |
![]() ![]() (A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
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S2451 |
Amantadine HClAmantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus. |
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S2011 |
Pramipexole 2HCl MonohydratePramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. |
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S2460 |
PramipexolePramipexole (SND 919) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
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S2529 |
Dopamine HClDopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
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S5849 |
Cariprazine HClCariprazine (RGH-188), a novel second-generation antipsychotic, is a D3-preferring dopamine D2/D3 receptor partial agonist. |
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S3664 |
Flupentixol dihydrochlorideFlupentixol (Flupenthixol) dihydrochloride, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist. |
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S3821 |
NuciferineNuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
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S4618 |
Fenoldopam mesylateFenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
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S7993 |
SKF38393 HClSKF38393 HCl is a selective dopamine D1/D5 receptor agonist. |
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S4639 |
BrexpiprazoleBrexpiprazole (OPC-34712) is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. |
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S3656 |
PiribedilPiribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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S2168 |
PD128907 HClPD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
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S5842 |
CabergolineCabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. |
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S4274 |
RotigotineRotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome. |
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S5066 |
Pramipexole dihydrochloridePramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor. |
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S4933新 |
Lithium carbonateLithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). Lithium carbonate is able to alter D2 dopamine receptors response. |
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S4732 |
MPTP hydrochlorideMPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis. |
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S8097 |
C-DIM12C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. |
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S3188 |
(+,-)-Octopamine HClOctopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S3163 |
Benztropine mesylateBenztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. |
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S2456 |
Chlorpromazine HClChlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents. |
![]() ![]() Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given. |
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S2452 |
Amfebutamone (Bupropion) HClAmfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. |
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S3201 |
Trifluoperazine 2HClTrifluoperazine (SKF5019) is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. |
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S2461 |
DomperidoneDomperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. |
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S4569 |
Fluphenazine dihydrochlorideFluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. |
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S5856 |
TrifluoperazineTrifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. |
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S1642 |
MethyldopaMethyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. |
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S5796 |
Vanoxerine dihydrochlorideVanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex. |
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S3854 |
Tetrahydropalmatine hydrochlorideTetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant. |
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S3189 |
Ropinirole HClRopinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S2493 |
OlanzapineOlanzapine (LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
2020, S0092-8674(20)31394-5 2020, 10.1038/s41401-020-0378-6 2019, 560:294-305 |
![]() ![]() Punctuates of LC3 proteins in olanzapine-treated T98 and LN229 cells. Cells were incubated with olanzapine (0, 0.1M, 0.2mM) for 48h and then stained with the anti-LC3 antibody. Cells were examined by fluorescence confocal microscopy. Green: FITC-labeled LC3; Blue: DAPI-labeled nucleus. Magnification: x 400
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S1763 |
Quetiapine FumarateQuetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors. |
2019, 145(6):1495-1507 2019, 313:77-90 |
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S1444 |
Ziprasidone HClZiprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
2018, 560(7718):372-376 2018, 8(1):15753 2017, 7(1):8491 |
![]() ![]() a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.
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S0476新 |
SCH-23390 hydrochlorideSCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM. |
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S1280 |
AmisulprideAmisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
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S1724 |
PaliperidonePaliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia. |
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S1920 |
HaloperidolHaloperidol (Haldol) is an antipsychotic and butyrophenone. |
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S1771 |
ChlorprothixeneChlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
2018, 8(1):15753 |
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S4251 |
PhenothiazinePhenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
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S4096 |
DroperidolDroperidol (NSC 169874) is a potent antagonist of dopamine subtype 2 receptors in the limbic system. |
2018, 8(1):15753 |
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S3044 |
Lurasidone HClLurasidone (SM-13496) is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. |
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S2104 |
LevosulpirideLevosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
2018, 8(1):15753 |
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S4086 |
Loxapine SuccinateLoxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. |
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S5741 |
QuetiapineQuetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55. |
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S5559 |
TetrahydropalmatineTetrahydropalmatine (Rotundine), a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. |
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S4731 |
PerphenazinePerphenazine (Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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S5153 |
TetrahydroberberineTetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. |
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S5324 |
Oxidopamine (hydrobromide)Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. |
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S4889 |
Perospirone hydrochloridePerospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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S5399 |
Chlorprothixene hydrochlorideChlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. |
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S5565 |
Triflupromazine hydrochlorideTriflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class. |
2020, 2020/9/20.4.7.30734 |
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S4151 |
PenfluridolPenfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. |
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S5481 |
Molindone hydrochlorideMolindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
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S2437 |
RotundineRotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
2019, 91(8):1440-1447 |
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S4631 |
Prochlorperazine dimaleate saltProchlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist. |
2016, 5:150 |
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S4257 |
Alizapride HClAlizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting. |
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S4655 |
SulpirideSulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. |
2020, 11(1):941 |
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S5714 |
lurasidoneLurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
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S5034 |
Melitracen hydrochlorideMelitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties. |
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S1789 |
Tetrabenazine (Xenazine)Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2. |
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S6410 |
ClemizoleClemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. |
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S4219 |
AzaperoneAzaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
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S6455 |
Clebopride (malate)Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting. |
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S5428 |
Promazine hydrochloridePromazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. |
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S5624 |
Paliperidone PalmitatePaliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. |
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S5749 |
ChlorpromazineChlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM. |
2020, 232:119701 2020, 48(8):613-621 2020, 2020/9/20.4.7.30734 |
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S9509 |
Tiapride HydrochlorideTiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders. |
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S4289 |
Metoclopramide HClMetoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
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S5862 |
MetoclopramideMetoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S6887新 |
Clozapine N-oxideClozapine N-oxide (CNO) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist. |
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S0104新 |
Pardoprunox (SLV-308) hydrochloridePardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively. |
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S1726 |
LevodopaLevodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms. |
2017, 12(3):e0173240 |
![]() ![]() (A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
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S2451 |
Amantadine HClAmantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus. |
2020, 2000034 |
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S2011 |
Pramipexole 2HCl MonohydratePramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. |
2016, 12(12):2374-2385 |
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S2460 |
PramipexolePramipexole (SND 919) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
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S2529 |
Dopamine HClDopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist. |
2020, 10.1002/cac2.12103 2019, 142(3):700-718 |
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S5849 |
Cariprazine HClCariprazine (RGH-188), a novel second-generation antipsychotic, is a D3-preferring dopamine D2/D3 receptor partial agonist. |
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S3664 |
Flupentixol dihydrochlorideFlupentixol (Flupenthixol) dihydrochloride, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist. |
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S3821 |
NuciferineNuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
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S4618 |
Fenoldopam mesylateFenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
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S7993 |
SKF38393 HClSKF38393 HCl is a selective dopamine D1/D5 receptor agonist. |
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S4639 |
BrexpiprazoleBrexpiprazole (OPC-34712) is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. |
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S3656 |
PiribedilPiribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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S2168 |
PD128907 HClPD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
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S5842 |
CabergolineCabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. |
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S4274 |
RotigotineRotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome. |
2019, 10(9):649 |
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S5066 |
Pramipexole dihydrochloridePramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S4933新 |
Lithium carbonateLithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). Lithium carbonate is able to alter D2 dopamine receptors response. |
製品コード | 製品説明 | 文献中Selleckの製品使用例 | お客様のフィードバック |
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S4732 |
MPTP hydrochlorideMPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis. |
2020, 17(1):272 |
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S8097 |
C-DIM12C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells. |
2020, 23724 2018, 9(3):411 |
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S3188 |
(+,-)-Octopamine HClOctopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. |