STAT3 選択性阻害剤

製品コード 製品名 製品説明 Selective / Pan IC50 / Ki
S3030 Niclosamide

Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM.

Selective STAT3, IC50: 0.7 μM
S2285 Cryptotanshinone

Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.

Selective STAT3, IC50: 4.6 μM
S7024 Stattic

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.

Selective STAT3, IC50: 5.1 μM
S1155 S3I-201

S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.

Selective STAT3, IC50: 86 μM
S7501 HO-3867

HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.

S7337 SH-4-54

SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.

Pan STAT3, Kd: 300 nM
S4182 Nifuroxazide

Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells