STAT

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号	製品カタログ	溶解度(25°C)
カタログ番号	製品カタログ	水	DMSO	アルコール
S1155	S3I-201	<1 mg/mL	73 mg/mL	'<1 mg/mL
S1014	Bosutinib (SKI-606)	<1 mg/mL	100 mg/mL	2 mg/mL
S1491	Fludarabine (NSC 118218)	<1 mg/mL	57 mg/mL	''''<1 mg/mL
S2796	WP1066	<1 mg/mL	71 mg/mL	<1 mg/mL
S1396	Resveratrol (SRT501)	<1 mg/mL	45 mg/mL	''<1 mg/mL
E2398	STAT5-IN-2	<1 mg/mL	80 mg/mL	40 mg/mL
E1124	Narciclasine	-1 mg/mL	61 mg/mL	-1 mg/mL
E0485	Stafia-1	<1 mg/mL	100 mg/mL	100 mg/mL
S9920	GYY4137	5 mg/mL	75 mg/mL	''<1 mg/mL
S8152	Cucurbitacin I	<1 mg/mL	100 mg/mL	''''100 mg/mL
E0011	Linderalactone	<1 mg/mL	49 mg/mL	''''''49 mg/mL
S7024	Stattic	<1 mg/mL	42 mg/mL	<1 mg/mL
S2824	TPCA-1	<1 mg/mL	56 mg/mL	<1 mg/mL
S3030	Niclosamide (BAY2353)	<1 mg/mL	<1 mg/mL	'''''<1 mg/mL
S4182	Nifuroxazide	<1 mg/mL	55 mg/mL	<1 mg/mL
S7337	SH-4-54	<1 mg/mL	100 mg/mL	50 mg/mL
S0918	Ginkgolic acid C17:1	<1 mg/mL	75 mg/mL	'''''75 mg/mL
S3267	Kaempferol-3-O-rutinoside	-1 mg/mL	100 mg/mL	-1 mg/mL
S0818	STAT3-IN-1	<1 mg/mL	95 mg/mL	5 mg/mL
S6898	RCM-1	<1 mg/mL	60 mg/mL	<1 mg/mL
S8685	AS1517499	<1 mg/mL	79 mg/mL	36 mg/mL
S7977	Napabucasin (BBI608)	<1 mg/mL	10 mg/mL	'<1 mg/mL
S0981	BD750	<1 mg/mL	30 mg/mL	'''27 mg/mL
S0986	SC-1	<1 mg/mL	86 mg/mL	86 mg/mL
S2265	Artesunate (WR-256283)	<1 mg/mL	77 mg/mL	77 mg/mL
S7769	BP-1-102	<1 mg/mL	100 mg/mL	<1 mg/mL
S2285	Cryptotanshinone	<1 mg/mL	5 mg/mL	1 mg/mL
S6919	Brevilin A	-1 mg/mL	69 mg/mL	-1 mg/mL
S7923	SH5-07 (SH-5-07)	<1 mg/mL	100 mg/mL	100 mg/mL
S9015	Homoharringtonine (CGX-635)	-1 mg/mL	100 mg/mL	''''-1 mg/mL
S7951	Ochromycinone (STA-21)	<1 mg/mL	21 mg/mL	2 mg/mL
S3292	Falcarindiol	-1 mg/mL	52 mg/mL	-1 mg/mL
S8561	HJC0152	<1 mg/mL	88 mg/mL	<1 mg/mL
S3810	Scutellarin	-1 mg/mL	50 mg/mL	-1 mg/mL
S8197	APTSTAT3-9R	98 mg/mL	<1 mg/mL	<1 mg/mL
S4358	Pimozide	<1 mg/mL	92 mg/mL	''9 mg/mL
S0445	SC-43	<1 mg/mL	86 mg/mL	25 mg/mL
S8605	C188-9	<1 mg/mL	94 mg/mL	'6 mg/mL
S7501	HO-3867	<1 mg/mL	13 mg/mL	6 mg/mL
S6784	STAT5-IN-1	<1 mg/mL	20 mg/mL	<1 mg/mL
S9664	Colivelin	100 mg/mL	-1 mg/mL	''-1 mg/mL
S4842	Balsalazide	71 mg/mL	71 mg/mL	'''<1 mg/mL
S3745	Balsalazide disodium	87 mg/mL	87 mg/mL	<1 mg/mL

亜型選択性的な製品

STAT製品

All (45) STAT阻害剤(42) STAT活性剤(1) STATモジュレータ(2)

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1155	S3I-201 S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.	Cell Death Differ, 2022, 10.1038/s41418-021-00926-5 Cancer Commun (Lond), 2022, 42(3):205-222 Oncoimmunology, 2022, 11(1):2021619	The inhibitors U0126, PP1 and S3I-201 reduce the colony-forming ability of KIF5B-RET positive cells. A549 cells carrying KIF5B-RET were diluted and seeded in 6-well plates, treated with DMSO, U0126 (MEK inhibitor) 10 uM, PP1 (SRC inhibitors) 5 uM or S3I-201(STAT3 inhibitors) 100 uM for 14 days. The total numbers of colonies, each containing more than 40 cells, were determined. (P < 0.05, P < 0.01, **P < 0.001, Student's t test).
S1014	Bosutinib (SKI-606) Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.	J Immunother Cancer, 2022, 10(1)e003766 Front Oncol, 2022, 12:802482 Mol Pharmacol, 2022, MOLPHARM-AR-2021-000287	A,IC50 of Bosutinib that block ANDV-induced EC permeability. Endothelial cells were ANDV infected, and 3 days postinfection the permeability of cells in response to VEGF addition was determined in the presence or absence of increasing amounts of kinase inhibitor. The effect of inhibitors is presented as the percentage of ANDV-induced permeability of inhibitor-treated monolayers 3 days postinfection and 30 min post-VEGF and FITC-dextran addition. B, VEGFR2-Src inhibitors block ANDV-induced permeability. Endothelial cells were plated on vitronectin-coated Transwell inserts and infected at an MOI of 0.5 in triplicate with ANDV. Three days postinfection, the permeability of ANDV- and mock-infected endothelial cell monolayers was determined as described for Fig. 1 at indicated times in the presence or absence of Bosutinib .
S1491	Fludarabine (NSC 118218) Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Signal Transduct Target Ther, 2022, 7(1):80 J Neuroinflammation, 2022, 19(1):109 J Biomed Sci, 2022, 29(1):20	Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
S2796	WP1066 WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.	Cell Biosci, 2022, 12(1):43 Commun Biol, 2022, 5(1):105 Evid Based Complement Alternat Med, 2022, 2022:3492058	Effects of selective STAT3 inhibitors on adherent glioma CSCs. Cells were treated with WP1066 (50 uM for 2 h) or vehicle, and colocalization of STAT3 and p65 was determined by immunostaining.
S1396	Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Placenta, 2022, 122:56-65 Int Immunopharmacol, 2022, 103:108489 Eur J Neurosci, 2022, 10.1111/ejn.15596	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
E2398^新	STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
E1124^新	Narciclasine Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
E0485^新	Stafia-1 Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
S9920^新	GYY4137 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
S8152^新	Cucurbitacin I Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
E0011^新	Linderalactone Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
S7024	Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.	Nat Commun, 2022, 13(1):791 Haematologica, 2022, 10.3324/haematol.2021.279957 Br J Cancer, 2022, 10.1038/s41416-022-01794-7	Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.
S2824	TPCA-1 TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.	Nat Cell Biol, 2022, 24(5):766-782 Sci Adv, 2022, 8(12):eabh4050 Proc Natl Acad Sci U S A, 2022, 119(3)e2114134119	AGS cells were treated with cwith IL-1β in the presence of the IKK inhibitor TPCA-1, the p38 MAPK inhibitor BIX02188 and the JNK inhibitor SP600125. Cell lysates were obtained 24 h after IL-1β treatment and immunoblotted with PTEN antibodies.
S3030	Niclosamide (BAY2353) Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).	Cell Death Differ, 2021, 10.1038/s41418-021-00781-4 Cell Death Dis, 2021, 12(9):799 Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080	Effects of some confirmed hits on IRF7 transcription level in response to IFN-α2a treatment (1 h) in SH-SY5Y cells. Data represent mean expression fold±SEM relative to GAPDH, measured from three independent experiments, each in triplicates. P<0.05, P<0.01, and **P<0.001 compared to IFN-α2a treated cells.
S4182	Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.	J Immunother Cancer, 2021, 9(6)e002305 Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00019-9 Signal Transduct Target Ther, 2020,	(A) and (B) NSCs were transfected with vector or shRNA against miR-200a, and then the miR-200a-silenced cells were treated with or without Nifuroxazide. p-STAT1, STAT1, p-STAT3, STAT3 and c-Myc expression levels were determined by Western blotting.
S7337	SH-4-54 SH-4-54 is a potent STAT inhibitor with K_D of 300 nM and 464 nM for STAT3 and STAT5, respectively.	Cell Death Dis, 2022, 13(5):424 Diabetes Res Clin Pract, 2022, S0168-8227(22)00588-5 Endocrinology, 2022, 163(5)bqac031	Expression of indicated proteins in PRL-stimulated INS-1 cells without (control, white bars) or with (black bars) STAT inhibitor (SH-4-54).
S0918	Ginkgolic acid C17:1 Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S3267	Kaempferol-3-O-rutinoside Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
S5554	Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S0949	Cucurbitacin IIb Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
S0818	STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.	Theranostics, 2022, 12(2):842-858
S6898	RCM-1 RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.
S8685	AS1517499 AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.	BMC Med, 2022, 20(1):148 Cell Death Dis, 2022, 13(1):66 Theranostics, 2021, 11(9):4251-4261
S7977	Napabucasin (BBI608) Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.	Cell Rep Med, 2022, 3(2):100526 Oncogene, 2021, 10.1038/s41388-021-01817-2 Br J Cancer, 2021, 10.1038/s41416-021-01270-8
S0981	BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
S0986	SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.	Proc Natl Acad Sci U S A, 2021, 118(40)e2103623118 Antibiotics (Basel), 2021, 10(10)1223
S2265	Artesunate (WR-256283) Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.	Front Pharmacol, 2021, 12:615889 Sci Rep, 2021, 11(1):14571 Oncol Lett, 2021, 22(2):597
S7769	BP-1-102 BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.	Cell Death Dis, 2022, 13(5):424 Front Immunol, 2021, 12:779667 J Drug Target, 2021, 1-25	WT and 4E-BP1/2 DKO cells were treated for 4 h with 10 ng/ml LPS with or without 2 μM BP-1-102 (A) and relative amounts of Nfil3 and sIl1ra mRNAs were quantified using RT-qPCR (normalized to Rpl19).
S2285	Cryptotanshinone Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.	Adv Sci (Weinh), 2022, e2200263 Cancer Cell Int, 2022, 22(1):147 Front Immunol, 2021, 12:712781	(a) Effect on STAT3 DNA binding activity of the STAT3 inhibitors cryptotanshinone (CTN) and S31-201 in STAT3 mutant cell lines OCI-Ly12 and OCI-Ly13.2. (b) Effect on cell viability at 48 h of the STAT3 inhibitors cryptotanshinone and S31-201 in OCI-Ly12 and OCI-Ly13.2 cells.
S6919	Brevilin A Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.	Front Pharmacol, 2022, 13:795613
S7923	SH5-07 (SH-5-07) SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
S9015	Homoharringtonine (CGX-635) Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.	Autophagy, 2022, 1-19 Elife, 2022, 11e71880 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S7951	Ochromycinone (STA-21) Ochromycinone (STA-21) is a selective STAT3 inhibitor.	Biochem Pharmacol, 2021, 192:114688 Cell Death Dis, 2020, 19;11(2):135 Cell Death Discov, 2020, 2;6:42
S3292	Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.	Front Pharmacol, 2021, 12:656697
S8561	HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.	Cancer Lett, 2019, 10.1016/j.canlet.2019.02.029 Cancer Manag Res, 2018, 10:6857-6867
S3810	Scutellarin Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
S8197	APTSTAT3-9R APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.	Sci Rep, 2022, 12(1):7 Toxicol Mech Methods, 2021, 1-11 Clin Transl Med, 2021, 11(2):e295
S4358	Pimozide Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at α2-adrenoceptor and 5-HT1A with Ki of 360 nM and 310 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.	Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
S0445	SC-43 SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
S8605	C188-9 C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.	Cancer Cell, 2022, S1535-6108(21)00662-0 Cancer Immunol Res, 2022, 10(1):56-69 Int J Mol Sci, 2022, 23(4)2019	(E) Hep3B cells were pre-infected with flag-CEP55 for 24 h and were then infected with 10 nM JAK2 inhibitor XL019 or 10 nM STAT3 inhibitor C188-9 for 48 h. Cells’ invasion ability was determined by trans-well assays. Representative microscope images are plotted. Bars, 50 μm;
S7501	HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.	Sci Rep, 2022, 12(1):7 Nature, 2021, 600(7888):314-318 Acta Pharm Sin B, 2021, 11(2):394-405	Cell apoptosis as measured by TUNEL. Representative sections as determined at 12 hours after reperfusion (3100 magnification). Apoptotic nuclei were stained red, and the software of Image J was used to analyse quantity of TUNEL-positive cells in the livers. Scale bars5100 lm. P<0.05, P<0.01, **P<0.001 compared with IR group.
S6784	STAT5-IN-1 STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.	Fish Shellfish Immunol, 2022, 124:472-479 Biomed Pharmacother, 2021, 143:112204 Am J Transl Res, 2021, 13(3):1422-1431
S9664	Colivelin Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	Thromb J, 2022, 20(1):24 J Reprod Immunol, 2022, 151:103623 Exp Eye Res, 2021, 213:108823
S4842	Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S3745	Balsalazide disodium Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.	Front Microbiol, 2020, 10:2936

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S1155	S3I-201 S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.	Cell Death Differ, 2022, 10.1038/s41418-021-00926-5 Cancer Commun (Lond), 2022, 42(3):205-222 Oncoimmunology, 2022, 11(1):2021619	The inhibitors U0126, PP1 and S3I-201 reduce the colony-forming ability of KIF5B-RET positive cells. A549 cells carrying KIF5B-RET were diluted and seeded in 6-well plates, treated with DMSO, U0126 (MEK inhibitor) 10 uM, PP1 (SRC inhibitors) 5 uM or S3I-201(STAT3 inhibitors) 100 uM for 14 days. The total numbers of colonies, each containing more than 40 cells, were determined. (P < 0.05, P < 0.01, **P < 0.001, Student's t test).
S1014	Bosutinib (SKI-606) Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.	J Immunother Cancer, 2022, 10(1)e003766 Front Oncol, 2022, 12:802482 Mol Pharmacol, 2022, MOLPHARM-AR-2021-000287	A,IC50 of Bosutinib that block ANDV-induced EC permeability. Endothelial cells were ANDV infected, and 3 days postinfection the permeability of cells in response to VEGF addition was determined in the presence or absence of increasing amounts of kinase inhibitor. The effect of inhibitors is presented as the percentage of ANDV-induced permeability of inhibitor-treated monolayers 3 days postinfection and 30 min post-VEGF and FITC-dextran addition. B, VEGFR2-Src inhibitors block ANDV-induced permeability. Endothelial cells were plated on vitronectin-coated Transwell inserts and infected at an MOI of 0.5 in triplicate with ANDV. Three days postinfection, the permeability of ANDV- and mock-infected endothelial cell monolayers was determined as described for Fig. 1 at indicated times in the presence or absence of Bosutinib .
S1491	Fludarabine (NSC 118218) Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Signal Transduct Target Ther, 2022, 7(1):80 J Neuroinflammation, 2022, 19(1):109 J Biomed Sci, 2022, 29(1):20	Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
S2796	WP1066 WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.	Cell Biosci, 2022, 12(1):43 Commun Biol, 2022, 5(1):105 Evid Based Complement Alternat Med, 2022, 2022:3492058	Effects of selective STAT3 inhibitors on adherent glioma CSCs. Cells were treated with WP1066 (50 uM for 2 h) or vehicle, and colocalization of STAT3 and p65 was determined by immunostaining.
S1396	Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Placenta, 2022, 122:56-65 Int Immunopharmacol, 2022, 103:108489 Eur J Neurosci, 2022, 10.1111/ejn.15596	Cellular senescence and SIRT1 phosphorylation was monitored in PAECs (P2) incubated in DMEM containing HDL (50 mg/L), LDL (50 mg/L), or resveratrol (100 μM) for 24 hours.
E2398^新	STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
E1124^新	Narciclasine Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
E0485^新	Stafia-1 Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
S9920^新	GYY4137 GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
S8152^新	Cucurbitacin I Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
E0011^新	Linderalactone Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
S7024	Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.	Nat Commun, 2022, 13(1):791 Haematologica, 2022, 10.3324/haematol.2021.279957 Br J Cancer, 2022, 10.1038/s41416-022-01794-7	Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.
S2824	TPCA-1 TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.	Nat Cell Biol, 2022, 24(5):766-782 Sci Adv, 2022, 8(12):eabh4050 Proc Natl Acad Sci U S A, 2022, 119(3)e2114134119	AGS cells were treated with cwith IL-1β in the presence of the IKK inhibitor TPCA-1, the p38 MAPK inhibitor BIX02188 and the JNK inhibitor SP600125. Cell lysates were obtained 24 h after IL-1β treatment and immunoblotted with PTEN antibodies.
S3030	Niclosamide (BAY2353) Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).	Cell Death Differ, 2021, 10.1038/s41418-021-00781-4 Cell Death Dis, 2021, 12(9):799 Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080	Effects of some confirmed hits on IRF7 transcription level in response to IFN-α2a treatment (1 h) in SH-SY5Y cells. Data represent mean expression fold±SEM relative to GAPDH, measured from three independent experiments, each in triplicates. P<0.05, P<0.01, and **P<0.001 compared to IFN-α2a treated cells.
S4182	Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.	J Immunother Cancer, 2021, 9(6)e002305 Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00019-9 Signal Transduct Target Ther, 2020,	(A) and (B) NSCs were transfected with vector or shRNA against miR-200a, and then the miR-200a-silenced cells were treated with or without Nifuroxazide. p-STAT1, STAT1, p-STAT3, STAT3 and c-Myc expression levels were determined by Western blotting.
S7337	SH-4-54 SH-4-54 is a potent STAT inhibitor with K_D of 300 nM and 464 nM for STAT3 and STAT5, respectively.	Cell Death Dis, 2022, 13(5):424 Diabetes Res Clin Pract, 2022, S0168-8227(22)00588-5 Endocrinology, 2022, 163(5)bqac031	Expression of indicated proteins in PRL-stimulated INS-1 cells without (control, white bars) or with (black bars) STAT inhibitor (SH-4-54).
S0918	Ginkgolic acid C17:1 Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S3267	Kaempferol-3-O-rutinoside Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
S5554	Lanatoside C Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
S0949	Cucurbitacin IIb Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
S0818	STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.	Theranostics, 2022, 12(2):842-858
S6898	RCM-1 RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.
S8685	AS1517499 AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.	BMC Med, 2022, 20(1):148 Cell Death Dis, 2022, 13(1):66 Theranostics, 2021, 11(9):4251-4261
S7977	Napabucasin (BBI608) Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.	Cell Rep Med, 2022, 3(2):100526 Oncogene, 2021, 10.1038/s41388-021-01817-2 Br J Cancer, 2021, 10.1038/s41416-021-01270-8
S0981	BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
S0986	SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.	Proc Natl Acad Sci U S A, 2021, 118(40)e2103623118 Antibiotics (Basel), 2021, 10(10)1223
S2265	Artesunate (WR-256283) Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.	Front Pharmacol, 2021, 12:615889 Sci Rep, 2021, 11(1):14571 Oncol Lett, 2021, 22(2):597
S7769	BP-1-102 BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.	Cell Death Dis, 2022, 13(5):424 Front Immunol, 2021, 12:779667 J Drug Target, 2021, 1-25	WT and 4E-BP1/2 DKO cells were treated for 4 h with 10 ng/ml LPS with or without 2 μM BP-1-102 (A) and relative amounts of Nfil3 and sIl1ra mRNAs were quantified using RT-qPCR (normalized to Rpl19).
S2285	Cryptotanshinone Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.	Adv Sci (Weinh), 2022, e2200263 Cancer Cell Int, 2022, 22(1):147 Front Immunol, 2021, 12:712781	(a) Effect on STAT3 DNA binding activity of the STAT3 inhibitors cryptotanshinone (CTN) and S31-201 in STAT3 mutant cell lines OCI-Ly12 and OCI-Ly13.2. (b) Effect on cell viability at 48 h of the STAT3 inhibitors cryptotanshinone and S31-201 in OCI-Ly12 and OCI-Ly13.2 cells.
S6919	Brevilin A Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.	Front Pharmacol, 2022, 13:795613
S7923	SH5-07 (SH-5-07) SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.
S9015	Homoharringtonine (CGX-635) Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.	Autophagy, 2022, 1-19 Elife, 2022, 11e71880 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S7951	Ochromycinone (STA-21) Ochromycinone (STA-21) is a selective STAT3 inhibitor.	Biochem Pharmacol, 2021, 192:114688 Cell Death Dis, 2020, 19;11(2):135 Cell Death Discov, 2020, 2;6:42
S3292	Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.	Front Pharmacol, 2021, 12:656697
S8561	HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.	Cancer Lett, 2019, 10.1016/j.canlet.2019.02.029 Cancer Manag Res, 2018, 10:6857-6867
S3810	Scutellarin Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
S8197	APTSTAT3-9R APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.	Sci Rep, 2022, 12(1):7 Toxicol Mech Methods, 2021, 1-11 Clin Transl Med, 2021, 11(2):e295
S4358	Pimozide Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at α2-adrenoceptor and 5-HT1A with Ki of 360 nM and 310 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.	Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
S0445	SC-43 SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
S8605	C188-9 C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.	Cancer Cell, 2022, S1535-6108(21)00662-0 Cancer Immunol Res, 2022, 10(1):56-69 Int J Mol Sci, 2022, 23(4)2019	(E) Hep3B cells were pre-infected with flag-CEP55 for 24 h and were then infected with 10 nM JAK2 inhibitor XL019 or 10 nM STAT3 inhibitor C188-9 for 48 h. Cells’ invasion ability was determined by trans-well assays. Representative microscope images are plotted. Bars, 50 μm;
S7501	HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.	Sci Rep, 2022, 12(1):7 Nature, 2021, 600(7888):314-318 Acta Pharm Sin B, 2021, 11(2):394-405	Cell apoptosis as measured by TUNEL. Representative sections as determined at 12 hours after reperfusion (3100 magnification). Apoptotic nuclei were stained red, and the software of Image J was used to analyse quantity of TUNEL-positive cells in the livers. Scale bars5100 lm. P<0.05, P<0.01, **P<0.001 compared with IR group.
S6784	STAT5-IN-1 STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.	Fish Shellfish Immunol, 2022, 124:472-479 Biomed Pharmacother, 2021, 143:112204 Am J Transl Res, 2021, 13(3):1422-1431

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S9664	Colivelin Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	Thromb J, 2022, 20(1):24 J Reprod Immunol, 2022, 151:103623 Exp Eye Res, 2021, 213:108823

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S9664

Colivelin

Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.

Thromb J, 2022, 20(1):24

J Reprod Immunol, 2022, 151:103623

Exp Eye Res, 2021, 213:108823

製品コード	製品説明	文献中Selleckの製品使用例	お客様のフィードバック
S4842	Balsalazide Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S3745	Balsalazide disodium Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.	Front Microbiol, 2020, 10:2936

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S4842

Balsalazide

Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

S3745

Balsalazide disodium

Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

Front Microbiol, 2020, 10:2936