BMS-754807

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.

BMS-754807化学構造

CAS No. 1001350-96-4

サイズ 価格(税別) 在庫状況
10mM (1mL in DMSO) JPY 40800 国内在庫あり
JPY 31800 国内在庫あり
JPY 46800 国内在庫あり
JPY 129800 国内在庫なし(納期7~10日)

代表番号: 045-509-1970|電子メール:[email protected]
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シグナル伝達経路

IGF-1R阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
M109 Growth inhibitory assay ~5 μM IC50=1.055 μM 19996272
HCT116 Growth inhibitory assay ~5 μM IC50=0.852 μM 19996272
DU4475 2.431 Growth inhibitory assay ~5 μM IC50=2.431 μM 19996272
H526 0.044 Growth inhibitory assay ~5 μM IC50=0.044 μM 19996272
HT1080/S Growth inhibitory assay ~5 μM IC50=0.531 μM 19996272
MDA-MB-231T Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
H209 Growth inhibitory assay ~5 μM IC50=1.193 μM 19996272
SW-684 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
MDA-MB-231 Growth inhibitory assay ~5 μM IC50=1.648 μM 19996272
Calu-6 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
SW1990 Growth inhibitory assay ~5 μM IC50=0.826 μM 19996272
MDA-MB-468 Growth inhibitory assay ~5 μM IC50=0.504 μM 19996272
H1299 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
SU.86.86 Growth inhibitory assay ~5 μM IC50=2.672 μM 19996272
JJN3 Growth inhibitory assay ~5 μM IC50=2.433 μM 19996272
NCI-H383 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
PL45 Growth inhibitory assay ~5 μM IC50=2.255 μM 19996272
H929 Growth inhibitory assay ~5 μM IC50=0.014 μM 19996272
NCI-446 Growth inhibitory assay ~5 μM IC50=1.154 μM 19996272
Hs700t Growth inhibitory assay ~5 μM IC50=0.231 μM 19996272
U266 B1 Growth inhibitory assay ~5 μM IC50=1.669 μM 19996272
SHP-77 Growth inhibitory assay ~5 μM IC50=1.888 μM 19996272
HPAF-II Growth inhibitory assay ~5 μM IC50=0.644 μM 19996272
RPMI 8226 Growth inhibitory assay ~5 μM IC50=1.293 μM 19996272
SA-4 Growth inhibitory assay ~5 μM IC50=1.301 μM 19996272
PANC-1 BM Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
OCI-LY19 (B-cell) Growth inhibitory assay ~5 μM IC50=0.4 μM 19996272
To184.T Growth inhibitory assay ~5 μM IC50=0.469 μM 19996272
PANC-1 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
OCI-LY10 (B-cell) Growth inhibitory assay ~5 μM IC50=0.45 μM 19996272
HTB-92 Growth inhibitory assay ~5 μM IC50=1.02 μM 19996272
Bxpc-3 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
Bxpc-1 Growth inhibitory assay ~5 μM IC50=1.924 μM 19996272
U937 (Histioocytic) Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
SHSY5Y Growth inhibitory assay ~5 μM IC50=0.106 μM 19996272
Capan-2 Growth inhibitory assay ~5 μM IC50=1.774 μM 19996272
MEC-1 (Chronic B cell) Growth inhibitory assay ~5 μM IC50=2.637 μM 19996272
SK-NSH Growth inhibitory assay ~5 μM IC50=0.139 μM 19996272
Aspc-1 Growth inhibitory assay ~5 μM IC50=0.379 μM 19996272
Daudi (Burkitt's) Growth inhibitory assay ~5 μM IC50=2.637 μM 19996272
IMR-32 Growth inhibitory assay ~5 μM IC50=0.261 μM 19996272
HS766T Growth inhibitory assay ~5 μM IC50=2.001 μM 19996272
ST486 Growth inhibitory assay ~5 μM IC50=1.19 μM 19996272
LAN-1 Growth inhibitory assay ~5 μM IC50=0.04 μM 19996272
HTB-47 Growth inhibitory assay ~5 μM IC50=2.056 μM 19996272
CTLL2 Growth inhibitory assay ~5 μM IC50>1.00 μM 19996272
SK-NAS Growth inhibitory assay ~5 μM IC50=0.497 μM 19996272
HTB-46 Growth inhibitory assay ~5 μM IC50=5.25 μM 19996272
SET2 Growth inhibitory assay ~5 μM IC50=0.298 μM 19996272
DAOY Growth inhibitory assay ~5 μM IC50=1.979 μM 19996272
HEK293 Growth inhibitory assay ~5 μM IC50=0.915 μM 19996272
THP-1 Growth inhibitory assay ~5 μM IC50=6.58 μM 19996272
PFSK-1 Growth inhibitory assay ~5 μM IC50=0.132 μM 19996272
151-B Growth inhibitory assay ~5 μM IC50=2.67 μM 19996272
TALL-1 (T-cell) Growth inhibitory assay ~5 μM IC50=1.28 μM 19996272
A673 Growth inhibitory assay ~5 μM IC50=0.408 μM 19996272
786-O Growth inhibitory assay ~5 μM IC50=1.647 μM 19996272
OCI-AML 2 (acute myeloid) Growth inhibitory assay ~5 μM IC50=3.33 μM 19996272
RD1 Growth inhibitory assay ~5 μM IC50=0.068 μM 19996272
ovcar-5 Growth inhibitory assay ~5 μM IC50=0.05 μM 19996272
Mutz 2 (acute myeloid) Growth inhibitory assay ~5 μM IC50=1.15 μM 19996272
Rh41 Growth inhibitory assay ~5 μM IC50=0.005 μM 19996272
ovcar-4 Growth inhibitory assay ~5 μM IC50=1 μM 19996272
MOLM-13 (acute myeloid) Growth inhibitory assay ~5 μM IC50=0.42 μM 19996272
Rh36 Growth inhibitory assay ~5 μM IC50=1.432 μM 19996272
ovcar-3 Growth inhibitory assay ~5 μM IC50=5 μM 19996272
ML2 (Myelomonocytic) Growth inhibitory assay ~5 μM IC50=0.09 μM 19996272
CTR Growth inhibitory assay ~5 μM IC50=0.253 μM 19996272
sw-626 Growth inhibitory assay ~5 μM IC50=2.306 μM 19996272
L1210 (Murine lymphocytic) Growth inhibitory assay ~5 μM IC50=2.39 μM 19996272
ME Growth inhibitory assay ~5 μM IC50=0.015 μM 19996272
sk-ov-3 Growth inhibitory assay ~5 μM IC50=5.1 μM 19996272
Kasumi-1 (acute myeloid) Growth inhibitory assay ~5 μM IC50=0.16 μM 19996272
Rh1 Growth inhibitory assay ~5 μM IC50=0.027 μM 19996272
A2780R Growth inhibitory assay ~5 μM IC50=1.564 μM 19996272
HPN-ALL (T-cell) Growth inhibitory assay ~5 μM IC50=0.52 μM 19996272
TC71 Growth inhibitory assay ~5 μM IC50=0.014 μM 19996272
TOV 21G Growth inhibitory assay ~5 μM IC50=4.279 μM 19996272
HL60 (acute myelocytic) Growth inhibitory assay ~5 μM IC50=0.12 μM 19996272
TC32 Growth inhibitory assay ~5 μM IC50=0.008 μM 19996272
TOV 112D Growth inhibitory assay ~5 μM IC50=2.146 μM 19996272
B6-T315I (Murine B-ALL) Growth inhibitory assay ~5 μM IC50=2.83 μM 19996272
RDES Growth inhibitory assay ~5 μM IC50=0.012 μM 19996272
A2780/S Growth inhibitory assay ~5 μM IC50=0.122 μM 19996272
P388 (Murine) Growth inhibitory assay ~5 μM IC50=4.27 μM 19996272
5838 Growth inhibitory assay ~5 μM IC50=0.034 μM 19996272
22-r-1 Growth inhibitory assay ~5 μM IC50=0.175 μM 19996272
RS411 (B cell precursor-ALL) Growth inhibitory assay ~5 μM IC50=0.102 μM 19996272
LG Growth inhibitory assay ~5 μM IC50=0.038 μM 19996272
MDA-PCa-2b Growth inhibitory assay ~5 μM IC50=0.098 μM 19996272
MV411 (B Myelomonocytic) Growth inhibitory assay ~5 μM IC50=0.33 μM 19996272
VW Growth inhibitory assay ~5 μM IC50=0.019 μM 19996272
LN CAP-FGC Growth inhibitory assay ~5 μM IC50=1.434 μM 19996272
B6-P210 (Murine ALL) Growth inhibitory assay ~5 μM IC50=1.293 μM 19996272
K-562 (CML) Growth inhibitory assay ~5 μM IC50=2.302 μM 19996272
KAG Growth inhibitory assay ~5 μM IC50=1.665 μM 19996272
DU145 Growth inhibitory assay ~5 μM IC50=1.465 μM 19996272
JD Growth inhibitory assay ~5 μM IC50=0.391 μM 19996272
PC3 Growth inhibitory assay ~5 μM IC50=0.965 μM 19996272
CCRF-CEM (ALL) Growth inhibitory assay ~5 μM IC50=1.239 μM 19996272
BT549 Growth inhibitory assay ~5 μM IC50=1.645 μM 19996272
HCT116/VM46 Growth inhibitory assay ~5 μM IC50=1.702 μM 19996272
H460 Growth inhibitory assay ~5 μM IC50=0.795 μM 19996272
MCF-7 Growth inhibitory assay ~5 μM IC50=0.016 μM 19996272
GEO Growth inhibitory assay ~5 μM IC50=0.356 μM 19996272
H441 0.646 Growth inhibitory assay ~5 μM IC50=0.646 μM 19996272
MCF-7-807R Growth inhibitory assay ~5 μM IC50=0.49 μM 19996272
Colo205 Growth inhibitory assay ~5 μM IC50=0.104 μM 19996272
H292 Growth inhibitory assay ~5 μM IC50=0.788 μM 19996272
BT474 (S) Growth inhibitory assay ~5 μM IC50=2.403 μM 19996272
HT-29 Growth inhibitory assay ~5 μM IC50=2.103 μM 19996272
A549 Growth inhibitory assay ~5 μM IC50=0.675 μM 19996272
BT474-M1 Growth inhibitory assay ~5 μM IC50=2.365 μM 19996272
SW480 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
L2987 Growth inhibitory assay ~5 μM IC50=0.442 μM 19996272
AU565 Growth inhibitory assay ~5 μM IC50=4.97 μM 19996272
SW403 Growth inhibitory assay ~5 μM IC50=0.22 μM 19996272
H1437 Growth inhibitory assay ~5 μM IC50=0.523 μM 19996272
BT-20 Growth inhibitory assay ~5 μM IC50=3.562 μM 19996272
Colo320HSR Growth inhibitory assay ~5 μM IC50=0.011 μM 19996272
H2087 Growth inhibitory assay ~5 μM IC50>1.00 μM 19996272
HCC1419 Growth inhibitory assay ~5 μM IC50=2.517 μM 19996272
WiDr Growth inhibitory assay ~5 μM IC50=0.076 μM 19996272
H661 0.573 Growth inhibitory assay ~5 μM IC50=0.573 μM 19996272
HCC-38 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
LS174T Growth inhibitory assay ~5 μM IC50=0.535 μM 19996272
H211 Growth inhibitory assay ~5 μM IC50=0.733 μM 19996272
HCC70 Growth inhibitory assay ~5 μM IC50=1.55 μM 19996272
SW116 Growth inhibitory assay ~5 μM IC50=0.067 μM 19996272
H513 Growth inhibitory assay ~5 μM IC50=4.448 μM 19996272
MDA-MB-157 Growth inhibitory assay ~5 μM IC50=0.036 μM 19996272
H2052 Growth inhibitory assay ~5 μM IC50=1.05 μM 19996272
MDA-MB-415 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
DLD-1 Growth inhibitory assay ~5 μM IC50=0.909 μM 19996272
H2595 Growth inhibitory assay ~5 μM IC50=4.475 μM 19996272
MDA-MB-435S Growth inhibitory assay ~5 μM IC50=1.869 μM 19996272
HCT15 Growth inhibitory assay ~5 μM IC50>1.00 μM 19996272
SK-Hep1 Growth inhibitory assay ~5 μM IC50=0.146 μM 19996272
MDA-MB-436 Growth inhibitory assay ~5 μM IC50=5.502 μM 19996272
KM12C Growth inhibitory assay ~5 μM IC50=0.054 μM 19996272
HEPG2 Growth inhibitory assay ~5 μM IC50=0.025 μM 19996272
MDA-MB-453 Growth inhibitory assay ~5 μM IC50=1.869 μM 19996272
KM12SM Growth inhibitory assay ~5 μM IC50=0.059 μM 19996272
1483 Growth inhibitory assay ~5 μM IC50=2.19 μM 19996272
Hs578t Growth inhibitory assay ~5 μM IC50=1.287 μM 19996272
LS180 Growth inhibitory assay ~5 μM IC50=0.696 μM 19996272
FaDu Growth inhibitory assay ~5 μM IC50=1.27 μM 19996272
ZR-75-1 Growth inhibitory assay ~5 μM IC50=2.084 μM 19996272
LS513 Growth inhibitory assay ~5 μM IC50=0.135 μM 19996272
Detroit.562 Growth inhibitory assay ~5 μM IC50=1.14 μM 19996272
ZR-75-30 Growth inhibitory assay ~5 μM IC50>5.00 μM 19996272
RKO-PM Growth inhibitory assay ~5 μM IC50=0.232 μM 19996272
Cal.27 Growth inhibitory assay ~5 μM IC50=2 μM 19996272
KPL4 Growth inhibitory assay ~5 μM IC50=1.252 μM 19996272
PKO-RM13 Growth inhibitory assay ~5 μM IC50=0.425 μM 19996272
HS.53.T Growth inhibitory assay ~5 μM IC50=0.79 μM 19996272
EMT6 Growth inhibitory assay ~5 μM IC50=0.806 μM 19996272
SNU-C1 Growth inhibitory assay ~5 μM IC50=0.007 μM 19996272
SQCCY1 Growth inhibitory assay ~5 μM IC50=0.79 μM 19996272
SW480 Growth inhibitory assay ~5 μM IC50=0.037 μM 19996272
SCC9 Growth inhibitory assay ~5 μM IC50=0.75 μM 19996272
SK-LMS-1 Growth inhibitory assay ~5 μM IC50=0.687 μM 19996272
SCC25 Growth inhibitory assay ~5 μM IC50=0.68 μM 19996272
U87 Growth inhibitory assay ~5 μM IC50=0.95 μM 19996272
SCC15 Growth inhibitory assay ~5 μM IC50=0.67 μM 19996272
T98G Growth inhibitory assay ~5 μM IC50=1.218 μM 19996272
SCC4 Growth inhibitory assay ~5 μM IC50=0.63 μM 19996272
U118 Growth inhibitory assay ~5 μM IC50=1.618 μM 19996272
TU167 Growth inhibitory assay ~5 μM IC50=4.52 μM 19996272
NCI-H727 Growth inhibitory assay ~10 μM IC50=428 nM 20385747
NCI-H720 Growth inhibitory assay ~10 μM IC50=2.8 μM 20385747
NCI-H835 Growth inhibitory assay ~10 μM IC50=1 μM 20385747
NCI-H727 Kinase assay ~10 μM inhibits constitutive IGF1R autophosphorylation 20385747
RD Growth inhibitory assay ~10 μM IC50=1.12 µM 21298745
Rh41 Growth inhibitory assay ~10 μM IC50=0.07 µM 21298745
Rh18 Growth inhibitory assay ~10 μM IC50=4.96 µM 21298745
Rh30 Growth inhibitory assay ~10 μM IC50=0.19 µM 21298745
BT-12 Growth inhibitory assay ~10 μM IC50=0.78 µM 21298745
CHLA-266 Growth inhibitory assay ~10 μM IC50=0.89 µM 21298745
TC-71 Growth inhibitory assay ~10 μM IC50=0.11 µM 21298745
CHLA-9 Growth inhibitory assay ~10 μM IC50=0.12 µM 21298745
CHLA-10 Growth inhibitory assay ~10 μM IC50=0.62 µM 21298745
CHLA-258 Growth inhibitory assay ~10 μM IC50=0.27 µM 21298745
GBM2 Growth inhibitory assay ~10 μM IC50=1.47 µM 21298745
NB-1643 Growth inhibitory assay ~10 μM IC50=0.12 µM 21298745
NB-EBc1 Growth inhibitory assay ~10 μM IC50=0.35 µM 21298745
CHLA-90 Growth inhibitory assay ~10 μM IC50=0.77 µM 21298745
CHLA-136 Growth inhibitory assay ~10 μM IC50=0.52 µM 21298745
NALM-6 Growth inhibitory assay ~10 μM IC50=0.49 µM 21298745
COG-LL-317 Growth inhibitory assay ~10 μM IC50=1.38 µM 21298745
RS4;11 Growth inhibitory assay ~10 μM IC50=0.38 µM 21298745
MOLT-4 Growth inhibitory assay ~10 μM IC50=0.53 µM 21298745
CCRF-CEM Growth inhibitory assay ~10 μM IC50=1.13 µM 21298745
Kasumi-1 Growth inhibitory assay ~10 μM IC50=1.2 µM 21298745
Karpas-299 Growth inhibitory assay ~10 μM IC50=1.64 µM 21298745
Ramos-RA1 Growth inhibitory assay ~10 μM IC50=1.31 µM 21298745
A549 Kinase assay 0.5 μM inhibits IGF-IR/IR activation 26928578
NCI-H358 Kinase assay 0.5 μM inhibits IGF-IR/IR activation 26928578
A549 Function assay 0.5 μM causes a concurrent decrease in phosphorylated AKT and ERK 26928578
NCI-H358 Function assay 0.5 μM causes a concurrent decrease in phosphorylated AKT and ERK 26928578
A549 Growth inhibitory assay ~10 μM IC50=0.76 μM 26928578
NCI-H358 Growth inhibitory assay ~10 μM IC50=1.09 μM 26928578
A549 Apoptosis assay 0.5 μM induces Apoptosis 26928578
NCI-H358 Apoptosis assay 0.5 μM induces Apoptosis 26928578
A549 Function assay 0.5 μM reduces wound closure 26928578
NCI-H358 Function assay 0.5 μM reduces wound closure 26928578
IGF-Sal Growth inhibitory assay IC50=7 nM 19778024
IGF-Sal Kinase assay inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) 19778024
Rh30  Function assay induces an increase of SFK phosphorylation 25925378
Rh41 Function assay induces an increase of SFK phosphorylation 25925378
RD Function assay induces an increase of SFK phosphorylation 25925378
IGF1R-SAL Function assay Inhibition of IGF1R in IGF1R-SAL cells, IC50 = 0.0021 μM. 20675137
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells 29435139
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
wild type fibroblast cells qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
NB1643 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells 29435139
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) 29435139
LAN-5 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells 29435139
NB-EBc1 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells 29435139
BT-37 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells 29435139
TC32 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells 29435139
MG 63 (6-TG R) qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells 29435139
wild type fibroblast cells qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells 29435139
U-2 OS qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells 29435139
Rh41 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells 29435139
Rh18 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells 29435139
Saos-2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells 29435139
OHS-50 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells 29435139
SK-N-SH qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells 29435139
COLO-205 Growth Inhibition Assay Inhibition of human COLO-205 cell growth in a cell viability assay, IC50 = 0.002243 μM. SANGER
EW-1 Growth Inhibition Assay Inhibition of human EW-1 cell growth in a cell viability assay, IC50 = 0.003998 μM. SANGER
TE-11 Growth Inhibition Assay Inhibition of human TE-11 cell growth in a cell viability assay, IC50 = 0.004197 μM. SANGER
A4-Fuk Growth Inhibition Assay Inhibition of human A4-Fuk cell growth in a cell viability assay, IC50 = 0.0057 μM. SANGER
PANC-08-13 Growth Inhibition Assay Inhibition of human PANC-08-13 cell growth in a cell viability assay, IC50 = 0.008604 μM. SANGER
Saos-2 Growth Inhibition Assay Inhibition of human Saos-2 cell growth in a cell viability assay, IC50 = 0.00962 μM. SANGER
HT-29 Growth Inhibition Assay Inhibition of human HT-29 cell growth in a cell viability assay, IC50 = 0.01226 μM. SANGER
NCI-H1355 Growth Inhibition Assay Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50 = 0.01401 μM. SANGER
NCI-H2122 Growth Inhibition Assay Inhibition of human NCI-H2122 cell growth in a cell viability assay, IC50 = 0.01458 μM. SANGER
ES1 Growth Inhibition Assay Inhibition of human ES1 cell growth in a cell viability assay, IC50 = 0.01594 μM. SANGER
KS-1 Growth Inhibition Assay Inhibition of human KS-1 cell growth in a cell viability assay, IC50 = 0.01594 μM. SANGER
EW-16 Growth Inhibition Assay Inhibition of human EW-16 cell growth in a cell viability assay, IC50 = 0.02095 μM. SANGER
LB771-HNC Growth Inhibition Assay Inhibition of human LB771-HNC cell growth in a cell viability assay, IC50 = 0.02296 μM. SANGER
NCI-H650 Growth Inhibition Assay Inhibition of human NCI-H650 cell growth in a cell viability assay, IC50 = 0.02652 μM. SANGER
NCI-H727 Growth Inhibition Assay Inhibition of human NCI-H727 cell growth in a cell viability assay, IC50 = 0.03011 μM. SANGER
NOS-1 Growth Inhibition Assay Inhibition of human NOS-1 cell growth in a cell viability assay, IC50 = 0.03084 μM. SANGER
T84 Growth Inhibition Assay Inhibition of human T84 cell growth in a cell viability assay, IC50 = 0.03359 μM. SANGER
SNU-387 Growth Inhibition Assay Inhibition of human SNU-387 cell growth in a cell viability assay, IC50 = 0.03578 μM. SANGER
TE-8 Growth Inhibition Assay Inhibition of human TE-8 cell growth in a cell viability assay, IC50 = 0.03654 μM. SANGER
ML-2 Growth Inhibition Assay Inhibition of human ML-2 cell growth in a cell viability assay, IC50 = 0.03695 μM. SANGER
HT-144 Growth Inhibition Assay Inhibition of human HT-144 cell growth in a cell viability assay, IC50 = 0.03791 μM. SANGER
LCLC-97TM1 Growth Inhibition Assay Inhibition of human LCLC-97TM1 cell growth in a cell viability assay, IC50 = 0.04354 μM. SANGER
LS-1034 Growth Inhibition Assay Inhibition of human LS-1034 cell growth in a cell viability assay, IC50 = 0.04606 μM. SANGER
BFTC-905 Growth Inhibition Assay Inhibition of human BFTC-905 cell growth in a cell viability assay, IC50 = 0.04727 μM. SANGER
SIG-M5 Growth Inhibition Assay Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50 = 0.04819 μM. SANGER
GDM-1 Growth Inhibition Assay Inhibition of human GDM-1 cell growth in a cell viability assay, IC50 = 0.05338 μM. SANGER
GP5d Growth Inhibition Assay Inhibition of human GP5d cell growth in a cell viability assay, IC50 = 0.05404 μM. SANGER
NCI-H358 Growth Inhibition Assay Inhibition of human NCI-H358 cell growth in a cell viability assay, IC50 = 0.05571 μM. SANGER
EW-11 Growth Inhibition Assay Inhibition of human EW-11 cell growth in a cell viability assay, IC50 = 0.0558 μM. SANGER
KM12 Growth Inhibition Assay Inhibition of human KM12 cell growth in a cell viability assay, IC50 = 0.05722 μM. SANGER
EW-7 Growth Inhibition Assay Inhibition of human EW-7 cell growth in a cell viability assay, IC50 = 0.06101 μM. SANGER
A375 Growth Inhibition Assay Inhibition of human A375 cell growth in a cell viability assay, IC50 = 0.06678 μM. SANGER
G-401 Growth Inhibition Assay Inhibition of human G-401 cell growth in a cell viability assay, IC50 = 0.06781 μM. SANGER
IGROV-1 Growth Inhibition Assay Inhibition of human IGROV-1 cell growth in a cell viability assay, IC50 = 0.06857 μM. SANGER
MFH-ino Growth Inhibition Assay Inhibition of human MFH-ino cell growth in a cell viability assay, IC50 = 0.07149 μM. SANGER
MEL-JUSO Growth Inhibition Assay Inhibition of human MEL-JUSO cell growth in a cell viability assay, IC50 = 0.07154 μM. SANGER
EW-18 Growth Inhibition Assay Inhibition of human EW-18 cell growth in a cell viability assay, IC50 = 0.07157 μM. SANGER
HCC2998 Growth Inhibition Assay Inhibition of human HCC2998 cell growth in a cell viability assay, IC50 = 0.0719 μM. SANGER
ES4 Growth Inhibition Assay Inhibition of human ES4 cell growth in a cell viability assay, IC50 = 0.07293 μM. SANGER
SK-N-DZ Growth Inhibition Assay Inhibition of human SK-N-DZ cell growth in a cell viability assay, IC50 = 0.07792 μM. SANGER
PSN1 Growth Inhibition Assay Inhibition of human PSN1 cell growth in a cell viability assay, IC50 = 0.07822 μM. SANGER
CAL-39 Growth Inhibition Assay Inhibition of human CAL-39 cell growth in a cell viability assay, IC50 = 0.08259 μM. SANGER
SNU-C1 Growth Inhibition Assay Inhibition of human SNU-C1 cell growth in a cell viability assay, IC50 = 0.08617 μM. SANGER
CMK Growth Inhibition Assay Inhibition of human CMK cell growth in a cell viability assay, IC50 = 0.09283 μM. SANGER
MCF7 Growth Inhibition Assay Inhibition of human MCF7 cell growth in a cell viability assay, IC50 = 0.09299 μM. SANGER
ES8 Growth Inhibition Assay Inhibition of human ES8 cell growth in a cell viability assay, IC50 = 0.10016 μM. SANGER
RS4-11 Growth Inhibition Assay Inhibition of human RS4-11 cell growth in a cell viability assay, IC50 = 0.1024 μM. SANGER
NCI-H1437 Growth Inhibition Assay Inhibition of human NCI-H1437 cell growth in a cell viability assay, IC50 = 0.10534 μM. SANGER
SJRH30 Growth Inhibition Assay Inhibition of human SJRH30 cell growth in a cell viability assay, IC50 = 0.10982 μM. SANGER
GCIY Growth Inhibition Assay Inhibition of human GCIY cell growth in a cell viability assay, IC50 = 0.11182 μM. SANGER
ABC-1 Growth Inhibition Assay Inhibition of human ABC-1 cell growth in a cell viability assay, IC50 = 0.11695 μM. SANGER
MHH-ES-1 Growth Inhibition Assay Inhibition of human MHH-ES-1 cell growth in a cell viability assay, IC50 = 0.12206 μM. SANGER
NCI-H2228 Growth Inhibition Assay Inhibition of human NCI-H2228 cell growth in a cell viability assay, IC50 = 0.12427 μM. SANGER
COR-L105 Growth Inhibition Assay Inhibition of human COR-L105 cell growth in a cell viability assay, IC50 = 0.13232 μM. SANGER
NCI-H810 Growth Inhibition Assay Inhibition of human NCI-H810 cell growth in a cell viability assay, IC50 = 0.13707 μM. SANGER
CHP-212 Growth Inhibition Assay Inhibition of human CHP-212 cell growth in a cell viability assay, IC50 = 0.15162 μM. SANGER
LB647-SCLC Growth Inhibition Assay Inhibition of human LB647-SCLC cell growth in a cell viability assay, IC50 = 0.1549 μM. SANGER
NCI-H1648 Growth Inhibition Assay Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50 = 0.16075 μM. SANGER
RH-1 Growth Inhibition Assay Inhibition of human RH-1 cell growth in a cell viability assay, IC50 = 0.16629 μM. SANGER
CAL-85-1 Growth Inhibition Assay Inhibition of human CAL-85-1 cell growth in a cell viability assay, IC50 = 0.16738 μM. SANGER
NB10 Growth Inhibition Assay Inhibition of human NB10 cell growth in a cell viability assay, IC50 = 0.17084 μM. SANGER
RPMI-2650 Growth Inhibition Assay Inhibition of human RPMI-2650 cell growth in a cell viability assay, IC50 = 0.17567 μM. SANGER
NTERA-S-cl-D1 Growth Inhibition Assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50 = 0.17778 μM. SANGER
NH-12 Growth Inhibition Assay Inhibition of human NH-12 cell growth in a cell viability assay, IC50 = 0.17943 μM. SANGER
COLO-320-HSR Growth Inhibition Assay Inhibition of human COLO-320-HSR cell growth in a cell viability assay, IC50 = 0.17958 μM. SANGER
MC-IXC Growth Inhibition Assay Inhibition of human MC-IXC cell growth in a cell viability assay, IC50 = 0.17996 μM. SANGER
HMV-II Growth Inhibition Assay Inhibition of human HMV-II cell growth in a cell viability assay, IC50 = 0.18325 μM. SANGER
LS-411N Growth Inhibition Assay Inhibition of human LS-411N cell growth in a cell viability assay, IC50 = 0.18349 μM. SANGER
RD Growth Inhibition Assay Inhibition of human RD cell growth in a cell viability assay, IC50 = 0.18531 μM. SANGER
DOK Growth Inhibition Assay Inhibition of human DOK cell growth in a cell viability assay, IC50 = 0.19484 μM. SANGER
SK-CO-1 Growth Inhibition Assay Inhibition of human SK-CO-1 cell growth in a cell viability assay, IC50 = 0.19724 μM. SANGER
LAN-6 Growth Inhibition Assay Inhibition of human LAN-6 cell growth in a cell viability assay, IC50 = 0.19876 μM. SANGER
NCI-H747 Growth Inhibition Assay Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50 = 0.19905 μM. SANGER
Capan-2 Growth Inhibition Assay Inhibition of human Capan-2 cell growth in a cell viability assay, IC50 = 0.20635 μM. SANGER
NMC-G1 Growth Inhibition Assay Inhibition of human NMC-G1 cell growth in a cell viability assay, IC50 = 0.20852 μM. SANGER
ES6 Growth Inhibition Assay Inhibition of human ES6 cell growth in a cell viability assay, IC50 = 0.21402 μM. SANGER
MZ1-PC Growth Inhibition Assay Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50 = 0.21584 μM. SANGER
SW1710 Growth Inhibition Assay Inhibition of human SW1710 cell growth in a cell viability assay, IC50 = 0.216 μM. SANGER
PANC-10-05 Growth Inhibition Assay Inhibition of human PANC-10-05 cell growth in a cell viability assay, IC50 = 0.21713 μM. SANGER
ES3 Growth Inhibition Assay Inhibition of human ES3 cell growth in a cell viability assay, IC50 = 0.22285 μM. SANGER
SK-PN-DW Growth Inhibition Assay Inhibition of human SK-PN-DW cell growth in a cell viability assay, IC50 = 0.22786 μM. SANGER
SK-NEP-1 Growth Inhibition Assay Inhibition of human SK-NEP-1 cell growth in a cell viability assay, IC50 = 0.22835 μM. SANGER
A427 Growth Inhibition Assay Inhibition of human A427 cell growth in a cell viability assay, IC50 = 0.24322 μM. SANGER
SK-LU-1 Growth Inhibition Assay Inhibition of human SK-LU-1 cell growth in a cell viability assay, IC50 = 0.2433 μM. SANGER
MIA-PaCa-2 Growth Inhibition Assay Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay, IC50 = 0.25262 μM. SANGER
SK-MEL-3 Growth Inhibition Assay Inhibition of human SK-MEL-3 cell growth in a cell viability assay, IC50 = 0.25834 μM. SANGER
LC-2-ad Growth Inhibition Assay Inhibition of human LC-2-ad cell growth in a cell viability assay, IC50 = 0.27037 μM. SANGER
MG-63 Growth Inhibition Assay Inhibition of human MG-63 cell growth in a cell viability assay, IC50 = 0.27622 μM. SANGER
HUTU-80 Growth Inhibition Assay Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50 = 0.27884 μM. SANGER
HCC70 Growth Inhibition Assay Inhibition of human HCC70 cell growth in a cell viability assay, IC50 = 0.28448 μM. SANGER
SJSA-1 Growth Inhibition Assay Inhibition of human SJSA-1 cell growth in a cell viability assay, IC50 = 0.3261 μM. SANGER
SIMA Growth Inhibition Assay Inhibition of human SIMA cell growth in a cell viability assay, IC50 = 0.34069 μM. SANGER
LK-2 Growth Inhibition Assay Inhibition of human LK-2 cell growth in a cell viability assay, IC50 = 0.34124 μM. SANGER
EKVX Growth Inhibition Assay Inhibition of human EKVX cell growth in a cell viability assay, IC50 = 0.35075 μM. SANGER
NCI-H441 Growth Inhibition Assay Inhibition of human NCI-H441 cell growth in a cell viability assay, IC50 = 0.35395 μM. SANGER
A431 Growth Inhibition Assay Inhibition of human A431 cell growth in a cell viability assay, IC50 = 0.35421 μM. SANGER
HCC2157 Growth Inhibition Assay Inhibition of human HCC2157 cell growth in a cell viability assay, IC50 = 0.35686 μM. SANGER
TGBC24TKB Growth Inhibition Assay Inhibition of human TGBC24TKB cell growth in a cell viability assay, IC50 = 0.35705 μM. SANGER
TE-12 Growth Inhibition Assay Inhibition of human TE-12 cell growth in a cell viability assay, IC50 = 0.35841 μM. SANGER
GB-1 Growth Inhibition Assay Inhibition of human GB-1 cell growth in a cell viability assay, IC50 = 0.3628 μM. SANGER
NB69 Growth Inhibition Assay Inhibition of human NB69 cell growth in a cell viability assay, IC50 = 0.36369 μM. SANGER
NCI-H292 Growth Inhibition Assay Inhibition of human NCI-H292 cell growth in a cell viability assay, IC50 = 0.36962 μM. SANGER
CAL-12T Growth Inhibition Assay Inhibition of human CAL-12T cell growth in a cell viability assay, IC50 = 0.37216 μM. SANGER
GI-ME-N Growth Inhibition Assay Inhibition of human GI-ME-N cell growth in a cell viability assay, IC50 = 0.37933 μM. SANGER
L-363 Growth Inhibition Assay Inhibition of human L-363 cell growth in a cell viability assay, IC50 = 0.38703 μM. SANGER
SK-MM-2 Growth Inhibition Assay Inhibition of human SK-MM-2 cell growth in a cell viability assay, IC50 = 0.39516 μM. SANGER
CAL-51 Growth Inhibition Assay Inhibition of human CAL-51 cell growth in a cell viability assay, IC50 = 0.40269 μM. SANGER
NCI-H2171 Growth Inhibition Assay Inhibition of human NCI-H2171 cell growth in a cell viability assay, IC50 = 0.41171 μM. SANGER
SK-MEL-2 Growth Inhibition Assay Inhibition of human SK-MEL-2 cell growth in a cell viability assay, IC50 = 0.41805 μM. SANGER
COLO-668 Growth Inhibition Assay Inhibition of human COLO-668 cell growth in a cell viability assay, IC50 = 0.42737 μM. SANGER
TCCSUP Growth Inhibition Assay Inhibition of human TCCSUP cell growth in a cell viability assay, IC50 = 0.43088 μM. SANGER
CHP-126 Growth Inhibition Assay Inhibition of human CHP-126 cell growth in a cell viability assay, IC50 = 0.43102 μM. SANGER
LU-99A Growth Inhibition Assay Inhibition of human LU-99A cell growth in a cell viability assay, IC50 = 0.44655 μM. SANGER
SBC-5 Growth Inhibition Assay Inhibition of human SBC-5 cell growth in a cell viability assay, IC50 = 0.47041 μM. SANGER
BB49-HNC Growth Inhibition Assay Inhibition of human BB49-HNC cell growth in a cell viability assay, IC50 = 0.47733 μM. SANGER
SW982 Growth Inhibition Assay Inhibition of human SW982 cell growth in a cell viability assay, IC50 = 0.47869 μM. SANGER
OVCAR-5 Growth Inhibition Assay Inhibition of human OVCAR-5 cell growth in a cell viability assay, IC50 = 0.50207 μM. SANGER
CCF-STTG1 Growth Inhibition Assay Inhibition of human CCF-STTG1 cell growth in a cell viability assay, IC50 = 0.51374 μM. SANGER
KYSE-510 Growth Inhibition Assay Inhibition of human KYSE-510 cell growth in a cell viability assay, IC50 = 0.51755 μM. SANGER
TE-1 Growth Inhibition Assay Inhibition of human TE-1 cell growth in a cell viability assay, IC50 = 0.54963 μM. SANGER
CPC-N Growth Inhibition Assay Inhibition of human CPC-N cell growth in a cell viability assay, IC50 = 0.55598 μM. SANGER
KGN Growth Inhibition Assay Inhibition of human KGN cell growth in a cell viability assay, IC50 = 0.55892 μM. SANGER
LB996-RCC Growth Inhibition Assay Inhibition of human LB996-RCC cell growth in a cell viability assay, IC50 = 0.56224 μM. SANGER
TE-441-T Growth Inhibition Assay Inhibition of human TE-441-T cell growth in a cell viability assay, IC50 = 0.56355 μM. SANGER
BC-1 Growth Inhibition Assay Inhibition of human BC-1 cell growth in a cell viability assay, IC50 = 0.58745 μM. SANGER
5637 Growth Inhibition Assay Inhibition of human 5637 cell growth in a cell viability assay, IC50 = 0.60092 μM. SANGER
A673 Growth Inhibition Assay Inhibition of human A673 cell growth in a cell viability assay, IC50 = 0.60486 μM. SANGER
OPM-2 Growth Inhibition Assay Inhibition of human OPM-2 cell growth in a cell viability assay, IC50 = 0.61161 μM. SANGER
DK-MG Growth Inhibition Assay Inhibition of human DK-MG cell growth in a cell viability assay, IC50 = 0.61751 μM. SANGER
HGC-27 Growth Inhibition Assay Inhibition of human HGC-27 cell growth in a cell viability assay, IC50 = 0.62379 μM. SANGER
TE-10 Growth Inhibition Assay Inhibition of human TE-10 cell growth in a cell viability assay, IC50 = 0.63065 μM. SANGER
VA-ES-BJ Growth Inhibition Assay Inhibition of human VA-ES-BJ cell growth in a cell viability assay, IC50 = 0.63247 μM. SANGER
KOSC-2 Growth Inhibition Assay Inhibition of human KOSC-2 cell growth in a cell viability assay, IC50 = 0.63721 μM. SANGER
LB1047-RCC Growth Inhibition Assay Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50 = 0.64357 μM. SANGER
NCI-H1299 Growth Inhibition Assay Inhibition of human NCI-H1299 cell growth in a cell viability assay, IC50 = 0.64814 μM. SANGER
AN3-CA Growth Inhibition Assay Inhibition of human AN3-CA cell growth in a cell viability assay, IC50 = 0.65646 μM. SANGER
MKN45 Growth Inhibition Assay Inhibition of human MKN45 cell growth in a cell viability assay, IC50 = 0.65987 μM. SANGER
BB30-HNC Growth Inhibition Assay Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50 = 0.66381 μM. SANGER
HSC-3 Growth Inhibition Assay Inhibition of human HSC-3 cell growth in a cell viability assay, IC50 = 0.66843 μM. SANGER
SNB75 Growth Inhibition Assay Inhibition of human SNB75 cell growth in a cell viability assay, IC50 = 0.67377 μM. SANGER
NCI-H1770 Growth Inhibition Assay Inhibition of human NCI-H1770 cell growth in a cell viability assay, IC50 = 0.67403 μM. SANGER
SW948 Growth Inhibition Assay Inhibition of human SW948 cell growth in a cell viability assay, IC50 = 0.6926 μM. SANGER
NCI-H2141 Growth Inhibition Assay Inhibition of human NCI-H2141 cell growth in a cell viability assay, IC50 = 0.69819 μM. SANGER
SK-OV-3 Growth Inhibition Assay Inhibition of human SK-OV-3 cell growth in a cell viability assay, IC50 = 0.71264 μM. SANGER
GI-1 Growth Inhibition Assay Inhibition of human GI-1 cell growth in a cell viability assay, IC50 = 0.72502 μM. SANGER
NCI-H2342 Growth Inhibition Assay Inhibition of human NCI-H2342 cell growth in a cell viability assay, IC50 = 0.72829 μM. SANGER
NB1 Growth Inhibition Assay Inhibition of human NB1 cell growth in a cell viability assay, IC50 = 0.73121 μM. SANGER
NCI-H1618 Growth Inhibition Assay Inhibition of human NCI-H1618 cell growth in a cell viability assay, IC50 = 0.73903 μM. SANGER
DMS-273 Growth Inhibition Assay Inhibition of human DMS-273 cell growth in a cell viability assay, IC50 = 0.74175 μM. SANGER
SW48 Growth Inhibition Assay Inhibition of human SW48 cell growth in a cell viability assay, IC50 = 0.74963 μM. SANGER
RT-112 Growth Inhibition Assay Inhibition of human RT-112 cell growth in a cell viability assay, IC50 = 0.75108 μM. SANGER
NCI-H1734 Growth Inhibition Assay Inhibition of human NCI-H1734 cell growth in a cell viability assay, IC50 = 0.7629 μM. SANGER
SNG-M Growth Inhibition Assay Inhibition of human SNG-M cell growth in a cell viability assay, IC50 = 0.78394 μM. SANGER
LS-513 Growth Inhibition Assay Inhibition of human LS-513 cell growth in a cell viability assay, IC50 = 0.78587 μM. SANGER
SCC-4 Growth Inhibition Assay Inhibition of human SCC-4 cell growth in a cell viability assay, IC50 = 0.78676 μM. SANGER
LCLC-103H Growth Inhibition Assay Inhibition of human LCLC-103H cell growth in a cell viability assay, IC50 = 0.78834 μM. SANGER
SW954 Growth Inhibition Assay Inhibition of human SW954 cell growth in a cell viability assay, IC50 = 0.79303 μM. SANGER
COLO-680N Growth Inhibition Assay Inhibition of human COLO-680N cell growth in a cell viability assay, IC50 = 0.79945 μM. SANGER
NCI-H1651 Growth Inhibition Assay Inhibition of human NCI-H1651 cell growth in a cell viability assay, IC50 = 0.80182 μM. SANGER
SW620 Growth Inhibition Assay Inhibition of human SW620 cell growth in a cell viability assay, IC50 = 0.80713 μM. SANGER
KYSE-270 Growth Inhibition Assay Inhibition of human KYSE-270 cell growth in a cell viability assay, IC50 = 0.80989 μM. SANGER
NCI-H1882 Growth Inhibition Assay Inhibition of human NCI-H1882 cell growth in a cell viability assay, IC50 = 0.81014 μM. SANGER
YKG-1 Growth Inhibition Assay Inhibition of human YKG-1 cell growth in a cell viability assay, IC50 = 0.83103 μM. SANGER
A2780 Growth Inhibition Assay Inhibition of human A2780 cell growth in a cell viability assay, IC50 = 0.86327 μM. SANGER
MES-SA Growth Inhibition Assay Inhibition of human MES-SA cell growth in a cell viability assay, IC50 = 0.87372 μM. SANGER
BCPAP Growth Inhibition Assay Inhibition of human BCPAP cell growth in a cell viability assay, IC50 = 0.87737 μM. SANGER
H4 Growth Inhibition Assay Inhibition of human H4 cell growth in a cell viability assay, IC50 = 0.90356 μM. SANGER
EW-13 Growth Inhibition Assay Inhibition of human EW-13 cell growth in a cell viability assay, IC50 = 0.909 μM. SANGER
HSC-2 Growth Inhibition Assay Inhibition of human HSC-2 cell growth in a cell viability assay, IC50 = 0.91076 μM. SANGER
TE-15 Growth Inhibition Assay Inhibition of human TE-15 cell growth in a cell viability assay, IC50 = 0.95556 μM. SANGER
COR-L23 Growth Inhibition Assay Inhibition of human COR-L23 cell growth in a cell viability assay, IC50 = 0.9653 μM. SANGER
786-0 Growth Inhibition Assay Inhibition of human 786-0 cell growth in a cell viability assay, IC50 = 0.96904 μM. SANGER
A101D Growth Inhibition Assay Inhibition of human A101D cell growth in a cell viability assay, IC50 = 0.97646 μM. SANGER
G-402 Growth Inhibition Assay Inhibition of human G-402 cell growth in a cell viability assay, IC50 = 0.97855 μM. SANGER
639-V Growth Inhibition Assay Inhibition of human 639-V cell growth in a cell viability assay, IC50 = 0.99007 μM. SANGER
SW872 Growth Inhibition Assay Inhibition of human SW872 cell growth in a cell viability assay, IC50 = 0.99324 μM. SANGER
MZ2-MEL Growth Inhibition Assay Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50 = 0.99816 μM. SANGER
HL-60 Growth Inhibition Assay Inhibition of human HL-60 cell growth in a cell viability assay, IC50 = 1.01305 μM. SANGER
NCI-H1304 Growth Inhibition Assay Inhibition of human NCI-H1304 cell growth in a cell viability assay, IC50 = 1.02172 μM. SANGER
GAMG Growth Inhibition Assay Inhibition of human GAMG cell growth in a cell viability assay, IC50 = 1.02372 μM. SANGER
G-361 Growth Inhibition Assay Inhibition of human G-361 cell growth in a cell viability assay, IC50 = 1.03515 μM. SANGER
LU-134-A Growth Inhibition Assay Inhibition of human LU-134-A cell growth in a cell viability assay, IC50 = 1.04553 μM. SANGER
IGR-1 Growth Inhibition Assay Inhibition of human IGR-1 cell growth in a cell viability assay, IC50 = 1.06361 μM. SANGER
SW962 Growth Inhibition Assay Inhibition of human SW962 cell growth in a cell viability assay, IC50 = 1.08487 μM. SANGER
KINGS-1 Growth Inhibition Assay Inhibition of human KINGS-1 cell growth in a cell viability assay, IC50 = 1.08504 μM. SANGER
DEL Growth Inhibition Assay Inhibition of human DEL cell growth in a cell viability assay, IC50 = 1.10005 μM. SANGER
NB5 Growth Inhibition Assay Inhibition of human NB5 cell growth in a cell viability assay, IC50 = 1.11259 μM. SANGER
HuCCT1 Growth Inhibition Assay Inhibition of human HuCCT1 cell growth in a cell viability assay, IC50 = 1.117 μM. SANGER
MS-1 Growth Inhibition Assay Inhibition of human MS-1 cell growth in a cell viability assay, IC50 = 1.13564 μM. SANGER
CAKI-1 Growth Inhibition Assay Inhibition of human CAKI-1 cell growth in a cell viability assay, IC50 = 1.14346 μM. SANGER
ATN-1 Growth Inhibition Assay Inhibition of human ATN-1 cell growth in a cell viability assay, IC50 = 1.14642 μM. SANGER
NCI-H1792 Growth Inhibition Assay Inhibition of human NCI-H1792 cell growth in a cell viability assay, IC50 = 1.15225 μM. SANGER
NCI-H522 Growth Inhibition Assay Inhibition of human NCI-H522 cell growth in a cell viability assay, IC50 = 1.16468 μM. SANGER
HOP-62 Growth Inhibition Assay Inhibition of human HOP-62 cell growth in a cell viability assay, IC50 = 1.16571 μM. SANGER
AGS Growth Inhibition Assay Inhibition of human AGS cell growth in a cell viability assay, IC50 = 1.16817 μM. SANGER
SW1088 Growth Inhibition Assay Inhibition of human SW1088 cell growth in a cell viability assay, IC50 = 1.16879 μM. SANGER
COLO-679 Growth Inhibition Assay Inhibition of human COLO-679 cell growth in a cell viability assay, IC50 = 1.16945 μM. SANGER
PANC-03-27 Growth Inhibition Assay Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50 = 1.17005 μM. SANGER
Detroit562 Growth Inhibition Assay Inhibition of human Detroit562 cell growth in a cell viability assay, IC50 = 1.1769 μM. SANGER
SK-N-FI Growth Inhibition Assay Inhibition of human SK-N-FI cell growth in a cell viability assay, IC50 = 1.18752 μM. SANGER
SW626 Growth Inhibition Assay Inhibition of human SW626 cell growth in a cell viability assay, IC50 = 1.19561 μM. SANGER
Daoy Growth Inhibition Assay Inhibition of human Daoy cell growth in a cell viability assay, IC50 = 1.20848 μM. SANGER
OS-RC-2 Growth Inhibition Assay Inhibition of human OS-RC-2 cell growth in a cell viability assay, IC50 = 1.22299 μM. SANGER
8305C Growth Inhibition Assay Inhibition of human 8305C cell growth in a cell viability assay, IC50 = 1.23744 μM. SANGER
RKO Growth Inhibition Assay Inhibition of human RKO cell growth in a cell viability assay, IC50 = 1.24389 μM. SANGER
DBTRG-05MG Growth Inhibition Assay Inhibition of human DBTRG-05MG cell growth in a cell viability assay, IC50 = 1.26195 μM. SANGER
HOS Growth Inhibition Assay Inhibition of human HOS cell growth in a cell viability assay, IC50 = 1.27425 μM. SANGER
D-542MG Growth Inhibition Assay Inhibition of human D-542MG cell growth in a cell viability assay, IC50 = 1.27994 μM. SANGER
ST486 Growth Inhibition Assay Inhibition of human ST486 cell growth in a cell viability assay, IC50 = 1.28117 μM. SANGER
NY Growth Inhibition Assay Inhibition of human NY cell growth in a cell viability assay, IC50 = 1.28965 μM. SANGER
NCI-H838 Growth Inhibition Assay Inhibition of human NCI-H838 cell growth in a cell viability assay, IC50 = 1.2914 μM. SANGER
BB65-RCC Growth Inhibition Assay Inhibition of human BB65-RCC cell growth in a cell viability assay, IC50 = 1.3022 μM. SANGER
MEL-HO Growth Inhibition Assay Inhibition of human MEL-HO cell growth in a cell viability assay, IC50 = 1.31336 μM. SANGER
HTC-C3 Growth Inhibition Assay Inhibition of human HTC-C3 cell growth in a cell viability assay, IC50 = 1.31847 μM. SANGER
CAPAN-1 Growth Inhibition Assay Inhibition of human CAPAN-1 cell growth in a cell viability assay, IC50 = 1.32561 μM. SANGER
SK-UT-1 Growth Inhibition Assay Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50 = 1.32799 μM. SANGER
KALS-1 Growth Inhibition Assay Inhibition of human KALS-1 cell growth in a cell viability assay, IC50 = 1.32907 μM. SANGER
LB831-BLC Growth Inhibition Assay Inhibition of human LB831-BLC cell growth in a cell viability assay, IC50 = 1.34639 μM. SANGER
KE-37 Growth Inhibition Assay Inhibition of human KE-37 cell growth in a cell viability assay, IC50 = 1.35266 μM. SANGER
8505C Growth Inhibition Assay Inhibition of human 8505C cell growth in a cell viability assay, IC50 = 1.35994 μM. SANGER
BHY Growth Inhibition Assay Inhibition of human BHY cell growth in a cell viability assay, IC50 = 1.37413 μM. SANGER
ONS-76 Growth Inhibition Assay Inhibition of human ONS-76 cell growth in a cell viability assay, IC50 = 1.37892 μM. SANGER
BxPC-3 Growth Inhibition Assay Inhibition of human BxPC-3 cell growth in a cell viability assay, IC50 = 1.38403 μM. SANGER
SK-HEP-1 Growth Inhibition Assay Inhibition of human SK-HEP-1 cell growth in a cell viability assay, IC50 = 1.39441 μM. SANGER
SK-LMS-1 Growth Inhibition Assay Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50 = 1.3969 μM. SANGER
SNU-423 Growth Inhibition Assay Inhibition of human SNU-423 cell growth in a cell viability assay, IC50 = 1.41951 μM. SANGER
SF295 Growth Inhibition Assay Inhibition of human SF295 cell growth in a cell viability assay, IC50 = 1.43606 μM. SANGER
J82 Growth Inhibition Assay Inhibition of human J82 cell growth in a cell viability assay, IC50 = 1.43959 μM. SANGER
SW837 Growth Inhibition Assay Inhibition of human SW837 cell growth in a cell viability assay, IC50 = 1.46365 μM. SANGER
TE-9 Growth Inhibition Assay Inhibition of human TE-9 cell growth in a cell viability assay, IC50 = 1.47786 μM. SANGER
LoVo Growth Inhibition Assay Inhibition of human LoVo cell growth in a cell viability assay, IC50 = 1.51747 μM. SANGER
NKM-1 Growth Inhibition Assay Inhibition of human NKM-1 cell growth in a cell viability assay, IC50 = 1.52468 μM. SANGER
A172 Growth Inhibition Assay Inhibition of human A172 cell growth in a cell viability assay, IC50 = 1.52721 μM. SANGER
A388 Growth Inhibition Assay Inhibition of human A388 cell growth in a cell viability assay, IC50 = 1.52944 μM. SANGER
TK10 Growth Inhibition Assay Inhibition of human TK10 cell growth in a cell viability assay, IC50 = 1.52958 μM. SANGER
MPP-89 Growth Inhibition Assay Inhibition of human MPP-89 cell growth in a cell viability assay, IC50 = 1.54338 μM. SANGER
SF126 Growth Inhibition Assay Inhibition of human SF126 cell growth in a cell viability assay, IC50 = 1.55086 μM. SANGER
OVCAR-4 Growth Inhibition Assay Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50 = 1.55193 μM. SANGER
OCUB-M Growth Inhibition Assay Inhibition of human OCUB-M cell growth in a cell viability assay, IC50 = 1.55373 μM. SANGER
K5 Growth Inhibition Assay Inhibition of human K5 cell growth in a cell viability assay, IC50 = 1.58531 μM. SANGER
OE33 Growth Inhibition Assay Inhibition of human OE33 cell growth in a cell viability assay, IC50 = 1.59842 μM. SANGER
EFO-21 Growth Inhibition Assay Inhibition of human EFO-21 cell growth in a cell viability assay, IC50 = 1.60098 μM. SANGER
NB13 Growth Inhibition Assay Inhibition of human NB13 cell growth in a cell viability assay, IC50 = 1.62119 μM. SANGER
SH-4 Growth Inhibition Assay Inhibition of human SH-4 cell growth in a cell viability assay, IC50 = 1.62851 μM. SANGER
ETK-1 Growth Inhibition Assay Inhibition of human ETK-1 cell growth in a cell viability assay, IC50 = 1.6299 μM. SANGER
SW1573 Growth Inhibition Assay Inhibition of human SW1573 cell growth in a cell viability assay, IC50 = 1.64332 μM. SANGER
NCI-H2170 Growth Inhibition Assay Inhibition of human NCI-H2170 cell growth in a cell viability assay, IC50 = 1.64499 μM. SANGER
NCI-H1417 Growth Inhibition Assay Inhibition of human NCI-H1417 cell growth in a cell viability assay, IC50 = 1.67323 μM. SANGER
HuO-3N1 Growth Inhibition Assay Inhibition of human HuO-3N1 cell growth in a cell viability assay, IC50 = 1.68209 μM. SANGER
NCI-H526 Growth Inhibition Assay Inhibition of human NCI-H526 cell growth in a cell viability assay, IC50 = 1.69318 μM. SANGER
CP66-MEL Growth Inhibition Assay Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50 = 1.69608 μM. SANGER
LS-123 Growth Inhibition Assay Inhibition of human LS-123 cell growth in a cell viability assay, IC50 = 1.69741 μM. SANGER
SCC-15 Growth Inhibition Assay Inhibition of human SCC-15 cell growth in a cell viability assay, IC50 = 1.70193 μM. SANGER
HuP-T4 Growth Inhibition Assay Inhibition of human HuP-T4 cell growth in a cell viability assay, IC50 = 1.72836 μM. SANGER
HuP-T3 Growth Inhibition Assay Inhibition of human HuP-T3 cell growth in a cell viability assay, IC50 = 1.76211 μM. SANGER
IST-MES1 Growth Inhibition Assay Inhibition of human IST-MES1 cell growth in a cell viability assay, IC50 = 1.76781 μM. SANGER
A204 Growth Inhibition Assay Inhibition of human A204 cell growth in a cell viability assay, IC50 = 1.77017 μM. SANGER
NCI-H2126 Growth Inhibition Assay Inhibition of human NCI-H2126 cell growth in a cell viability assay, IC50 = 1.77157 μM. SANGER
NCI-H2087 Growth Inhibition Assay Inhibition of human NCI-H2087 cell growth in a cell viability assay, IC50 = 1.7974 μM. SANGER
SK-MES-1 Growth Inhibition Assay Inhibition of human SK-MES-1 cell growth in a cell viability assay, IC50 = 1.80324 μM. SANGER
GT3TKB Growth Inhibition Assay Inhibition of human GT3TKB cell growth in a cell viability assay, IC50 = 1.80864 μM. SANGER
OAW-42 Growth Inhibition Assay Inhibition of human OAW-42 cell growth in a cell viability assay, IC50 = 1.85365 μM. SANGER
KYSE-410 Growth Inhibition Assay Inhibition of human KYSE-410 cell growth in a cell viability assay, IC50 = 1.85455 μM. SANGER
NEC8 Growth Inhibition Assay Inhibition of human NEC8 cell growth in a cell viability assay, IC50 = 1.85475 μM. SANGER
22RV1 Growth Inhibition Assay Inhibition of human 22RV1 cell growth in a cell viability assay, IC50 = 1.85754 μM. SANGER
Becker Growth Inhibition Assay Inhibition of human Becker cell growth in a cell viability assay, IC50 = 1.86663 μM. SANGER
OE19 Growth Inhibition Assay Inhibition of human OE19 cell growth in a cell viability assay, IC50 = 1.87707 μM. SANGER
ACHN Growth Inhibition Assay Inhibition of human ACHN cell growth in a cell viability assay, IC50 = 1.87709 μM. SANGER
RXF393 Growth Inhibition Assay Inhibition of human RXF393 cell growth in a cell viability assay, IC50 = 1.87802 μM. SANGER
NCI-H187 Growth Inhibition Assay Inhibition of human NCI-H187 cell growth in a cell viability assay, IC50 = 1.89063 μM. SANGER
PC-3 Growth Inhibition Assay Inhibition of human PC-3 cell growth in a cell viability assay, IC50 = 1.92634 μM. SANGER
DU-145 Growth Inhibition Assay Inhibition of human DU-145 cell growth in a cell viability assay, IC50 = 1.92988 μM. SANGER
ESS-1 Growth Inhibition Assay Inhibition of human ESS-1 cell growth in a cell viability assay, IC50 = 1.9306 μM. SANGER
NCI-H716 Growth Inhibition Assay Inhibition of human NCI-H716 cell growth in a cell viability assay, IC50 = 1.94349 μM. SANGER
SUP-T1 Growth Inhibition Assay Inhibition of human SUP-T1 cell growth in a cell viability assay, IC50 = 1.96941 μM. SANGER
SNU-449 Growth Inhibition Assay Inhibition of human SNU-449 cell growth in a cell viability assay, IC50 = 1.99372 μM. SANGER
BEN Growth Inhibition Assay Inhibition of human BEN cell growth in a cell viability assay, IC50 = 2.00569 μM. SANGER
LB2241-RCC Growth Inhibition Assay Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50 = 2.01324 μM. SANGER
MDA-MB-468 Growth Inhibition Assay Inhibition of human MDA-MB-468 cell growth in a cell viability assay, IC50 = 2.01868 μM. SANGER
8-MG-BA Growth Inhibition Assay Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50 = 2.01969 μM. SANGER
NCI-H2052 Growth Inhibition Assay Inhibition of human NCI-H2052 cell growth in a cell viability assay, IC50 = 2.04159 μM. SANGER
CAL-120 Growth Inhibition Assay Inhibition of human CAL-120 cell growth in a cell viability assay, IC50 = 2.05591 μM. SANGER
M059J Growth Inhibition Assay Inhibition of human M059J cell growth in a cell viability assay, IC50 = 2.06014 μM. SANGER
U-266 Growth Inhibition Assay Inhibition of human U-266 cell growth in a cell viability assay, IC50 = 2.06897 μM. SANGER
MFE-296 Growth Inhibition Assay Inhibition of human MFE-296 cell growth in a cell viability assay, IC50 = 2.07128 μM. SANGER
SCC-25 Growth Inhibition Assay Inhibition of human SCC-25 cell growth in a cell viability assay, IC50 = 2.08184 μM. SANGER
SCLC-21H Growth Inhibition Assay Inhibition of human SCLC-21H cell growth in a cell viability assay, IC50 = 2.0999 μM. SANGER
A3-KAW Growth Inhibition Assay Inhibition of human A3-KAW cell growth in a cell viability assay, IC50 = 2.10206 μM. SANGER
KYSE-140 Growth Inhibition Assay Inhibition of human KYSE-140 cell growth in a cell viability assay, IC50 = 2.11619 μM. SANGER
MEG-01 Growth Inhibition Assay Inhibition of human MEG-01 cell growth in a cell viability assay, IC50 = 2.11642 μM. SANGER
SK-MEL-30 Growth Inhibition Assay Inhibition of human SK-MEL-30 cell growth in a cell viability assay, IC50 = 2.12309 μM. SANGER
MONO-MAC-6 Growth Inhibition Assay Inhibition of human MONO-MAC-6 cell growth in a cell viability assay, IC50 = 2.13231 μM. SANGER
KYSE-450 Growth Inhibition Assay Inhibition of human KYSE-450 cell growth in a cell viability assay, IC50 = 2.13843 μM. SANGER
NCI-H2009 Growth Inhibition Assay Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50 = 2.14893 μM. SANGER
LU-65 Growth Inhibition Assay Inhibition of human LU-65 cell growth in a cell viability assay, IC50 = 2.15051 μM. SANGER
MHH-NB-11 Growth Inhibition Assay Inhibition of human MHH-NB-11 cell growth in a cell viability assay, IC50 = 2.1569 μM. SANGER
KYSE-180 Growth Inhibition Assay Inhibition of human KYSE-180 cell growth in a cell viability assay, IC50 = 2.16631 μM. SANGER
NOMO-1 Growth Inhibition Assay Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50 = 2.16852 μM. SANGER
ALL-PO Growth Inhibition Assay Inhibition of human ALL-PO cell growth in a cell viability assay, IC50 = 2.18649 μM. SANGER
CTV-1 Growth Inhibition Assay Inhibition of human CTV-1 cell growth in a cell viability assay, IC50 = 2.22588 μM. SANGER
KYSE-150 Growth Inhibition Assay Inhibition of human KYSE-150 cell growth in a cell viability assay, IC50 = 2.25119 μM. SANGER
T-24 Growth Inhibition Assay Inhibition of human T-24 cell growth in a cell viability assay, IC50 = 2.25544 μM. SANGER
AM-38 Growth Inhibition Assay Inhibition of human AM-38 cell growth in a cell viability assay, IC50 = 2.27715 μM. SANGER
NCI-H1092 Growth Inhibition Assay Inhibition of human NCI-H1092 cell growth in a cell viability assay, IC50 = 2.30326 μM. SANGER
SW1783 Growth Inhibition Assay Inhibition of human SW1783 cell growth in a cell viability assay, IC50 = 2.3107 μM. SANGER
EFE-184 Growth Inhibition Assay Inhibition of human EFE-184 cell growth in a cell viability assay, IC50 = 2.3336 μM. SANGER
A704 Growth Inhibition Assay Inhibition of human A704 cell growth in a cell viability assay, IC50 = 2.345 μM. SANGER
COLO-800 Growth Inhibition Assay Inhibition of human COLO-800 cell growth in a cell viability assay, IC50 = 2.35695 μM. SANGER
DMS-153 Growth Inhibition Assay Inhibition of human DMS-153 cell growth in a cell viability assay, IC50 = 2.38808 μM. SANGER
TGW Growth Inhibition Assay Inhibition of human TGW cell growth in a cell viability assay, IC50 = 2.40252 μM. SANGER
U031 Growth Inhibition Assay Inhibition of human U031 cell growth in a cell viability assay, IC50 = 2.41075 μM. SANGER
ACN Growth Inhibition Assay Inhibition of human ACN cell growth in a cell viability assay, IC50 = 2.45048 μM. SANGER
KP-N-YN Growth Inhibition Assay Inhibition of human KP-N-YN cell growth in a cell viability assay, IC50 = 2.46004 μM. SANGER
EGI-1 Growth Inhibition Assay Inhibition of human EGI-1 cell growth in a cell viability assay, IC50 = 2.49591 μM. SANGER
UMC-11 Growth Inhibition Assay Inhibition of human UMC-11 cell growth in a cell viability assay, IC50 = 2.51219 μM. SANGER
SK-N-AS Growth Inhibition Assay Inhibition of human SK-N-AS cell growth in a cell viability assay, IC50 = 2.54232 μM. SANGER
SF268 Growth Inhibition Assay Inhibition of human SF268 cell growth in a cell viability assay, IC50 = 2.55044 μM. SANGER
KARPAS-45 Growth Inhibition Assay Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50 = 2.56467 μM. SANGER
VMRC-RCZ Growth Inhibition Assay Inhibition of human VMRC-RCZ cell growth in a cell viability assay, IC50 = 2.57247 μM. SANGER
NCCIT Growth Inhibition Assay Inhibition of human NCCIT cell growth in a cell viability assay, IC50 = 2.60543 μM. SANGER
HOP-92 Growth Inhibition Assay Inhibition of human HOP-92 cell growth in a cell viability assay, IC50 = 2.61037 μM. SANGER
MDA-MB-231 Growth Inhibition Assay Inhibition of human MDA-MB-231 cell growth in a cell viability assay, IC50 = 2.61419 μM. SANGER
NB6 Growth Inhibition Assay Inhibition of human NB6 cell growth in a cell viability assay, IC50 = 2.62328 μM. SANGER
CAL-62 Growth Inhibition Assay Inhibition of human CAL-62 cell growth in a cell viability assay, IC50 = 2.66243 μM. SANGER
HO-1-N-1 Growth Inhibition Assay Inhibition of human HO-1-N-1 cell growth in a cell viability assay, IC50 = 2.66336 μM. SANGER
NCI-H2405 Growth Inhibition Assay Inhibition of human NCI-H2405 cell growth in a cell viability assay, IC50 = 2.68417 μM. SANGER
MKN28 Growth Inhibition Assay Inhibition of human MKN28 cell growth in a cell viability assay, IC50 = 2.69293 μM. SANGER
HAL-01 Growth Inhibition Assay Inhibition of human HAL-01 cell growth in a cell viability assay, IC50 = 2.74249 μM. SANGER
COLO-824 Growth Inhibition Assay Inhibition of human COLO-824 cell growth in a cell viability assay, IC50 = 2.76602 μM. SANGER
HT-1080 Growth Inhibition Assay Inhibition of human HT-1080 cell growth in a cell viability assay, IC50 = 2.76838 μM. SANGER
NCI-H226 Growth Inhibition Assay Inhibition of human NCI-H226 cell growth in a cell viability assay, IC50 = 2.80694 μM. SANGER
BFTC-909 Growth Inhibition Assay Inhibition of human BFTC-909 cell growth in a cell viability assay, IC50 = 2.88386 μM. SANGER
LB2518-MEL Growth Inhibition Assay Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50 = 2.92298 μM. SANGER
HC-1 Growth Inhibition Assay Inhibition of human HC-1 cell growth in a cell viability assay, IC50 = 2.92852 μM. SANGER
NCI-H661 Growth Inhibition Assay Inhibition of human NCI-H661 cell growth in a cell viability assay, IC50 = 3.01168 μM. SANGER
DoTc2-4510 Growth Inhibition Assay Inhibition of human DoTc2-4510 cell growth in a cell viability assay, IC50 = 3.1079 μM. SANGER
KG-1 Growth Inhibition Assay Inhibition of human KG-1 cell growth in a cell viability assay, IC50 = 3.1079 μM. SANGER
OAW-28 Growth Inhibition Assay Inhibition of human OAW-28 cell growth in a cell viability assay, IC50 = 3.11075 μM. SANGER
VM-CUB-1 Growth Inhibition Assay Inhibition of human VM-CUB-1 cell growth in a cell viability assay, IC50 = 3.13715 μM. SANGER
HCC1569 Growth Inhibition Assay Inhibition of human HCC1569 cell growth in a cell viability assay, IC50 = 3.16762 μM. SANGER
MMAC-SF Growth Inhibition Assay Inhibition of human MMAC-SF cell growth in a cell viability assay, IC50 = 3.1697 μM. SANGER
RERF-LC-MS Growth Inhibition Assay Inhibition of human RERF-LC-MS cell growth in a cell viability assay, IC50 = 3.17549 μM. SANGER
HCT-116 Growth Inhibition Assay Inhibition of human HCT-116 cell growth in a cell viability assay, IC50 = 3.20817 μM. SANGER
C-4-II Growth Inhibition Assay Inhibition of human C-4-II cell growth in a cell viability assay, IC50 = 3.25771 μM. SANGER
GMS-10 Growth Inhibition Assay Inhibition of human GMS-10 cell growth in a cell viability assay, IC50 = 3.31731 μM. SANGER
OVCAR-8 Growth Inhibition Assay Inhibition of human OVCAR-8 cell growth in a cell viability assay, IC50 = 3.34206 μM. SANGER
HLE Growth Inhibition Assay Inhibition of human HLE cell growth in a cell viability assay, IC50 = 3.34577 μM. SANGER
CHL-1 Growth Inhibition Assay Inhibition of human CHL-1 cell growth in a cell viability assay, IC50 = 3.34883 μM. SANGER
NCI-H2030 Growth Inhibition Assay Inhibition of human NCI-H2030 cell growth in a cell viability assay, IC50 = 3.37653 μM. SANGER
ES7 Growth Inhibition Assay Inhibition of human ES7 cell growth in a cell viability assay, IC50 = 3.39911 μM. SANGER
GOTO Growth Inhibition Assay Inhibition of human GOTO cell growth in a cell viability assay, IC50 = 3.41732 μM. SANGER
NCI-H1623 Growth Inhibition Assay Inhibition of human NCI-H1623 cell growth in a cell viability assay, IC50 = 3.42053 μM. SANGER
COLO-678 Growth Inhibition Assay Inhibition of human COLO-678 cell growth in a cell viability assay, IC50 = 3.44564 μM. SANGER
Ca-Ski Growth Inhibition Assay Inhibition of human Ca-Ski cell growth in a cell viability assay, IC50 = 3.46887 μM. SANGER
EW-3 Growth Inhibition Assay Inhibition of human EW-3 cell growth in a cell viability assay, IC50 = 3.51436 μM. SANGER
LOXIMVI Growth Inhibition Assay Inhibition of human LOXIMVI cell growth in a cell viability assay, IC50 = 3.51627 μM. SANGER
LC4-1 Growth Inhibition Assay Inhibition of human LC4-1 cell growth in a cell viability assay, IC50 = 3.55663 μM. SANGER
CTB-1 Growth Inhibition Assay Inhibition of human CTB-1 cell growth in a cell viability assay, IC50 = 3.56175 μM. SANGER
ChaGo-K-1 Growth Inhibition Assay Inhibition of human ChaGo-K-1 cell growth in a cell viability assay, IC50 = 3.58434 μM. SANGER
NCI-H1581 Growth Inhibition Assay Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50 = 3.64943 μM. SANGER
HT-3 Growth Inhibition Assay Inhibition of human HT-3 cell growth in a cell viability assay, IC50 = 3.66857 μM. SANGER
DV-90 Growth Inhibition Assay Inhibition of human DV-90 cell growth in a cell viability assay, IC50 = 3.67678 μM. SANGER
MRK-nu-1 Growth Inhibition Assay Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50 = 3.70735 μM. SANGER
RPMI-8402 Growth Inhibition Assay Inhibition of human RPMI-8402 cell growth in a cell viability assay, IC50 = 3.71196 μM. SANGER
HCE-T Growth Inhibition Assay Inhibition of human HCE-T cell growth in a cell viability assay, IC50 = 3.71981 μM. SANGER
BPH-1 Growth Inhibition Assay Inhibition of human BPH-1 cell growth in a cell viability assay, IC50 = 3.8199 μM. SANGER
D-263MG Growth Inhibition Assay Inhibition of human D-263MG cell growth in a cell viability assay, IC50 = 3.84417 μM. SANGER
U-118-MG Growth Inhibition Assay Inhibition of human U-118-MG cell growth in a cell viability assay, IC50 = 4.02428 μM. SANGER
SN12C Growth Inhibition Assay Inhibition of human SN12C cell growth in a cell viability assay, IC50 = 4.04292 μM. SANGER
KURAMOCHI Growth Inhibition Assay Inhibition of human KURAMOCHI cell growth in a cell viability assay, IC50 = 4.05467 μM. SANGER
COLO-829 Growth Inhibition Assay Inhibition of human COLO-829 cell growth in a cell viability assay, IC50 = 4.1346 μM. SANGER
GR-ST Growth Inhibition Assay Inhibition of human GR-ST cell growth in a cell viability assay, IC50 = 4.17635 μM. SANGER
NCI-H2081 Growth Inhibition Assay Inhibition of human NCI-H2081 cell growth in a cell viability assay, IC50 = 4.28007 μM. SANGER
KNS-81-FD Growth Inhibition Assay Inhibition of human KNS-81-FD cell growth in a cell viability assay, IC50 = 4.40655 μM. SANGER
Calu-6 Growth Inhibition Assay Inhibition of human Calu-6 cell growth in a cell viability assay, IC50 = 4.41101 μM. SANGER
U251 Growth Inhibition Assay Inhibition of human U251 cell growth in a cell viability assay, IC50 = 4.44884 μM. SANGER
KP-4 Growth Inhibition Assay Inhibition of human KP-4 cell growth in a cell viability assay, IC50 = 4.49305 μM. SANGER
HuH-7 Growth Inhibition Assay Inhibition of human HuH-7 cell growth in a cell viability assay, IC50 = 4.49657 μM. SANGER
NCI-H2347 Growth Inhibition Assay Inhibition of human NCI-H2347 cell growth in a cell viability assay, IC50 = 4.5022 μM. SANGER
SK-MEL-24 Growth Inhibition Assay Inhibition of human SK-MEL-24 cell growth in a cell viability assay, IC50 = 4.53506 μM. SANGER
HEL Growth Inhibition Assay Inhibition of human HEL cell growth in a cell viability assay, IC50 = 4.54405 μM. SANGER
NCI-H460 Growth Inhibition Assay Inhibition of human NCI-H460 cell growth in a cell viability assay, IC50 = 4.5776 μM. SANGER
CA46 Growth Inhibition Assay Inhibition of human CA46 cell growth in a cell viability assay, IC50 = 4.59584 μM. SANGER
NCI-H1755 Growth Inhibition Assay Inhibition of human NCI-H1755 cell growth in a cell viability assay, IC50 = 4.62915 μM. SANGER
CESS Growth Inhibition Assay Inhibition of human CESS cell growth in a cell viability assay, IC50 = 4.65205 μM. SANGER
MHH-CALL-2 Growth Inhibition Assay Inhibition of human MHH-CALL-2 cell growth in a cell viability assay, IC50 = 4.68861 μM. SANGER
UM-UC-3 Growth Inhibition Assay Inhibition of human UM-UC-3 cell growth in a cell viability assay, IC50 = 4.71548 μM. SANGER
LXF-289 Growth Inhibition Assay Inhibition of human LXF-289 cell growth in a cell viability assay, IC50 = 4.74443 μM. SANGER
T47D Growth Inhibition Assay Inhibition of human T47D cell growth in a cell viability assay, IC50 = 4.76635 μM. SANGER
TE-6 Growth Inhibition Assay Inhibition of human TE-6 cell growth in a cell viability assay, IC50 = 4.81703 μM. SANGER
ECC4 Growth Inhibition Assay Inhibition of human ECC4 cell growth in a cell viability assay, IC50 = 4.83833 μM. SANGER
CAL-33 Growth Inhibition Assay Inhibition of human CAL-33 cell growth in a cell viability assay, IC50 = 4.84825 μM. SANGER
SW13 Growth Inhibition Assay Inhibition of human SW13 cell growth in a cell viability assay, IC50 = 4.87146 μM. SANGER
769-P Growth Inhibition Assay Inhibition of human 769-P cell growth in a cell viability assay, IC50 = 4.88193 μM. SANGER
U-2-OS Growth Inhibition Assay Inhibition of human U-2-OS cell growth in a cell viability assay, IC50 = 4.90779 μM. SANGER
LAMA-84 Growth Inhibition Assay Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50 = 4.92749 μM. SANGER
NCI-H345 Growth Inhibition Assay Inhibition of human NCI-H345 cell growth in a cell viability assay, IC50 = 4.96365 μM. SANGER
NCI-H1694 Growth Inhibition Assay Inhibition of human NCI-H1694 cell growth in a cell viability assay, IC50 = 4.96855 μM. SANGER
C2BBe1 Growth Inhibition Assay Inhibition of human C2BBe1 cell growth in a cell viability assay, IC50 = 4.98155 μM. SANGER
COLO-684 Growth Inhibition Assay Inhibition of human COLO-684 cell growth in a cell viability assay, IC50 = 5.06788 μM. SANGER
LC-1F Growth Inhibition Assay Inhibition of human LC-1F cell growth in a cell viability assay, IC50 = 5.0921 μM. SANGER
A2058 Growth Inhibition Assay Inhibition of human A2058 cell growth in a cell viability assay, IC50 = 5.26272 μM. SANGER
MOLT-16 Growth Inhibition Assay Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50 = 5.32484 μM. SANGER
DU-4475 Growth Inhibition Assay Inhibition of human DU-4475 cell growth in a cell viability assay, IC50 = 5.36197 μM. SANGER
SNU-C2B Growth Inhibition Assay Inhibition of human SNU-C2B cell growth in a cell viability assay, IC50 = 5.44771 μM. SANGER
TUR Growth Inhibition Assay Inhibition of human TUR cell growth in a cell viability assay, IC50 = 5.51595 μM. SANGER
Daudi Growth Inhibition Assay Inhibition of human Daudi cell growth in a cell viability assay, IC50 = 5.51694 μM. SANGER
IMR-5 Growth Inhibition Assay Inhibition of human IMR-5 cell growth in a cell viability assay, IC50 = 5.6021 μM. SANGER
IST-MEL1 Growth Inhibition Assay Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50 = 5.63247 μM. SANGER
NCI-H1650 Growth Inhibition Assay Inhibition of human NCI-H1650 cell growth in a cell viability assay, IC50 = 5.64209 μM. SANGER
LOUCY Growth Inhibition Assay Inhibition of human LOUCY cell growth in a cell viability assay, IC50 = 5.66174 μM. SANGER
NCI-H1963 Growth Inhibition Assay Inhibition of human NCI-H1963 cell growth in a cell viability assay, IC50 = 5.66692 μM. SANGER
KMOE-2 Growth Inhibition Assay Inhibition of human KMOE-2 cell growth in a cell viability assay, IC50 = 5.7626 μM. SANGER
HCE-4 Growth Inhibition Assay Inhibition of human HCE-4 cell growth in a cell viability assay, IC50 = 5.78117 μM. SANGER
SF539 Growth Inhibition Assay Inhibition of human SF539 cell growth in a cell viability assay, IC50 = 5.81309 μM. SANGER
GCT Growth Inhibition Assay Inhibition of human GCT cell growth in a cell viability assay, IC50 = 5.99711 μM. SANGER
BHT-101 Growth Inhibition Assay Inhibition of human BHT-101 cell growth in a cell viability assay, IC50 = 6.0215 μM. SANGER
MV-4-11 Growth Inhibition Assay Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50 = 6.10704 μM. SANGER
D-283MED Growth Inhibition Assay Inhibition of human D-283MED cell growth in a cell viability assay, IC50 = 6.17633 μM. SANGER
HH Growth Inhibition Assay Inhibition of human HH cell growth in a cell viability assay, IC50 = 6.20084 μM. SANGER
IA-LM Growth Inhibition Assay Inhibition of human IA-LM cell growth in a cell viability assay, IC50 = 6.23432 μM. SANGER
LP-1 Growth Inhibition Assay Inhibition of human LP-1 cell growth in a cell viability assay, IC50 = 6.27356 μM. SANGER
QIMR-WIL Growth Inhibition Assay Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50 = 6.29707 μM. SANGER
M14 Growth Inhibition Assay Inhibition of human M14 cell growth in a cell viability assay, IC50 = 6.58861 μM. SANGER
HT-1376 Growth Inhibition Assay Inhibition of human HT-1376 cell growth in a cell viability assay, IC50 = 6.62249 μM. SANGER
RPMI-7951 Growth Inhibition Assay Inhibition of human RPMI-7951 cell growth in a cell viability assay, IC50 = 6.64003 μM. SANGER
NCI-H1563 Growth Inhibition Assay Inhibition of human NCI-H1563 cell growth in a cell viability assay, IC50 = 6.64282 μM. SANGER
Ca9-22 Growth Inhibition Assay Inhibition of human Ca9-22 cell growth in a cell viability assay, IC50 = 6.6908 μM. SANGER
NCI-H2227 Growth Inhibition Assay Inhibition of human NCI-H2227 cell growth in a cell viability assay, IC50 = 6.72244 μM. SANGER
L-540 Growth Inhibition Assay Inhibition of human L-540 cell growth in a cell viability assay, IC50 = 6.97353 μM. SANGER
NALM-6 Growth Inhibition Assay Inhibition of human NALM-6 cell growth in a cell viability assay, IC50 = 7.12163 μM. SANGER
HCC1143 Growth Inhibition Assay Inhibition of human HCC1143 cell growth in a cell viability assay, IC50 = 7.1789 μM. SANGER
CAL-54 Growth Inhibition Assay Inhibition of human CAL-54 cell growth in a cell viability assay, IC50 = 7.30834 μM. SANGER
CAS-1 Growth Inhibition Assay Inhibition of human CAS-1 cell growth in a cell viability assay, IC50 = 7.37047 μM. SANGER
RCC10RGB Growth Inhibition Assay Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50 = 7.54014 μM. SANGER
NCI-H1573 Growth Inhibition Assay Inhibition of human NCI-H1573 cell growth in a cell viability assay, IC50 = 7.56522 μM. SANGER
697 Growth Inhibition Assay Inhibition of human 697 cell growth in a cell viability assay, IC50 = 7.58666 μM. SANGER
LNCaP-Clone-FGC Growth Inhibition Assay Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay, IC50 = 7.85618 μM. SANGER
HT55 Growth Inhibition Assay Inhibition of human HT55 cell growth in a cell viability assay, IC50 = 8.02849 μM. SANGER
KARPAS-422 Growth Inhibition Assay Inhibition of human KARPAS-422 cell growth in a cell viability assay, IC50 = 8.03517 μM. SANGER
BT-20 Growth Inhibition Assay Inhibition of human BT-20 cell growth in a cell viability assay, IC50 = 8.42844 μM. SANGER
MDA-MB-361 Growth Inhibition Assay Inhibition of human MDA-MB-361 cell growth in a cell viability assay, IC50 = 8.54339 μM. SANGER
DMS-114 Growth Inhibition Assay Inhibition of human DMS-114 cell growth in a cell viability assay, IC50 = 8.66749 μM. SANGER
EoL-1-cell Growth Inhibition Assay Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50 = 8.66955 μM. SANGER
NB12 Growth Inhibition Assay Inhibition of human NB12 cell growth in a cell viability assay, IC50 = 8.86699 μM. SANGER
HDLM-2 Growth Inhibition Assay Inhibition of human HDLM-2 cell growth in a cell viability assay, IC50 = 9.16845 μM. SANGER
ME-180 Growth Inhibition Assay Inhibition of human ME-180 cell growth in a cell viability assay, IC50 = 9.25521 μM. SANGER
PFSK-1 Growth Inhibition Assay Inhibition of human PFSK-1 cell growth in a cell viability assay, IC50 = 9.38893 μM. SANGER
NCI-H1522 Growth Inhibition Assay Inhibition of human NCI-H1522 cell growth in a cell viability assay, IC50 = 9.63917 μM. SANGER
SR Growth Inhibition Assay Inhibition of human SR cell growth in a cell viability assay, IC50 = 9.8234 μM. SANGER
LU-165 Growth Inhibition Assay Inhibition of human LU-165 cell growth in a cell viability assay, IC50 = 9.835 μM. SANGER
EB2 Growth Inhibition Assay Inhibition of human EB2 cell growth in a cell viability assay, IC50 = 9.8583 μM. SANGER
C3A Growth Inhibition Assay Inhibition of human C3A cell growth in a cell viability assay, IC50 = 9.87709 μM. SANGER
NCI-H1793 Growth Inhibition Assay Inhibition of human NCI-H1793 cell growth in a cell viability assay, IC50 = 9.90289 μM. SANGER
NCI-H28 Growth Inhibition Assay Inhibition of human NCI-H28 cell growth in a cell viability assay, IC50 = 10.1407 μM. SANGER
UACC-257 Growth Inhibition Assay Inhibition of human UACC-257 cell growth in a cell viability assay, IC50 = 10.4166 μM. SANGER
MDA-MB-134-VI Growth Inhibition Assay Inhibition of human MDA-MB-134-VI cell growth in a cell viability assay, IC50 = 10.6056 μM. SANGER
IST-SL2 Growth Inhibition Assay Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50 = 10.6583 μM. SANGER
CGTH-W-1 Growth Inhibition Assay Inhibition of human CGTH-W-1 cell growth in a cell viability assay, IC50 = 10.7825 μM. SANGER
C-33-A Growth Inhibition Assay Inhibition of human C-33-A cell growth in a cell viability assay, IC50 = 10.7975 μM. SANGER
Hs-578-T Growth Inhibition Assay Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50 = 10.8458 μM. SANGER
MZ7-mel Growth Inhibition Assay Inhibition of human MZ7-mel cell growth in a cell viability assay, IC50 = 11.0898 μM. SANGER
KP-N-YS Growth Inhibition Assay Inhibition of human KP-N-YS cell growth in a cell viability assay, IC50 = 11.4914 μM. SANGER
LB373-MEL-D Growth Inhibition Assay Inhibition of human LB373-MEL-D cell growth in a cell viability assay, IC50 = 11.8696 μM. SANGER
NCI-H520 Growth Inhibition Assay Inhibition of human NCI-H520 cell growth in a cell viability assay, IC50 = 11.9407 μM. SANGER
CAL-148 Growth Inhibition Assay Inhibition of human CAL-148 cell growth in a cell viability assay, IC50 = 12.0776 μM. SANGER
KYSE-70 Growth Inhibition Assay Inhibition of human KYSE-70 cell growth in a cell viability assay, IC50 = 12.1046 μM. SANGER
OVCAR-3 Growth Inhibition Assay Inhibition of human OVCAR-3 cell growth in a cell viability assay, IC50 = 12.1331 μM. SANGER
SBC-1 Growth Inhibition Assay Inhibition of human SBC-1 cell growth in a cell viability assay, IC50 = 12.1884 μM. SANGER
NCI-H1993 Growth Inhibition Assay Inhibition of human NCI-H1993 cell growth in a cell viability assay, IC50 = 12.2994 μM. SANGER
Calu-1 Growth Inhibition Assay Inhibition of human Calu-1 cell growth in a cell viability assay, IC50 = 12.3415 μM. SANGER
WSU-NHL Growth Inhibition Assay Inhibition of human WSU-NHL cell growth in a cell viability assay, IC50 = 12.3788 μM. SANGER
J-RT3-T3-5 Growth Inhibition Assay Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay, IC50 = 12.4848 μM. SANGER
PA-1 Growth Inhibition Assay Inhibition of human PA-1 cell growth in a cell viability assay, IC50 = 12.5451 μM. SANGER
IM-9 Growth Inhibition Assay Inhibition of human IM-9 cell growth in a cell viability assay, IC50 = 12.7138 μM. SANGER
KM-H2 Growth Inhibition Assay Inhibition of human KM-H2 cell growth in a cell viability assay, IC50 = 12.7654 μM. SANGER
U-87-MG Growth Inhibition Assay Inhibition of human U-87-MG cell growth in a cell viability assay, IC50 = 13.0415 μM. SANGER
HPAF-II Growth Inhibition Assay Inhibition of human HPAF-II cell growth in a cell viability assay, IC50 = 13.4808 μM. SANGER
DB Growth Inhibition Assay Inhibition of human DB cell growth in a cell viability assay, IC50 = 13.7045 μM. SANGER
BOKU Growth Inhibition Assay Inhibition of human BOKU cell growth in a cell viability assay, IC50 = 13.8328 μM. SANGER
HCC38 Growth Inhibition Assay Inhibition of human HCC38 cell growth in a cell viability assay, IC50 = 13.8335 μM. SANGER
MDA-MB-157 Growth Inhibition Assay Inhibition of human MDA-MB-157 cell growth in a cell viability assay, IC50 = 13.9601 μM. SANGER
FTC-133 Growth Inhibition Assay Inhibition of human FTC-133 cell growth in a cell viability assay, IC50 = 14.139 μM. SANGER
MC-CAR Growth Inhibition Assay Inhibition of human MC-CAR cell growth in a cell viability assay, IC50 = 14.5038 μM. SANGER
THP-1 Growth Inhibition Assay Inhibition of human THP-1 cell growth in a cell viability assay, IC50 = 14.614 μM. SANGER
HCT-15 Growth Inhibition Assay Inhibition of human HCT-15 cell growth in a cell viability assay, IC50 = 14.7066 μM. SANGER
NCI-H1155 Growth Inhibition Assay Inhibition of human NCI-H1155 cell growth in a cell viability assay, IC50 = 14.7657 μM. SANGER
D-392MG Growth Inhibition Assay Inhibition of human D-392MG cell growth in a cell viability assay, IC50 = 15.198 μM. SANGER
HT-1197 Growth Inhibition Assay Inhibition of human HT-1197 cell growth in a cell viability assay, IC50 = 15.2627 μM. SANGER
T98G Growth Inhibition Assay Inhibition of human T98G cell growth in a cell viability assay, IC50 = 16.2469 μM. SANGER
BC-3 Growth Inhibition Assay Inhibition of human BC-3 cell growth in a cell viability assay, IC50 = 16.3723 μM. SANGER
DMS-53 Growth Inhibition Assay Inhibition of human DMS-53 cell growth in a cell viability assay, IC50 = 16.4241 μM. SANGER
PC-14 Growth Inhibition Assay Inhibition of human PC-14 cell growth in a cell viability assay, IC50 = 16.496 μM. SANGER
NCI-H1703 Growth Inhibition Assay Inhibition of human NCI-H1703 cell growth in a cell viability assay, IC50 = 16.5926 μM. SANGER
ARH-77 Growth Inhibition Assay Inhibition of human ARH-77 cell growth in a cell viability assay, IC50 = 16.9307 μM. SANGER
NCI-H1436 Growth Inhibition Assay Inhibition of human NCI-H1436 cell growth in a cell viability assay, IC50 = 17.2361 μM. SANGER
RCM-1 Growth Inhibition Assay Inhibition of human RCM-1 cell growth in a cell viability assay, IC50 = 17.9934 μM. SANGER
CAL-72 Growth Inhibition Assay Inhibition of human CAL-72 cell growth in a cell viability assay, IC50 = 18.1382 μM. SANGER
JiyoyeP-2003 Growth Inhibition Assay Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay, IC50 = 18.3276 μM. SANGER
AsPC-1 Growth Inhibition Assay Inhibition of human AsPC-1 cell growth in a cell viability assay, IC50 = 18.8638 μM. SANGER
OCI-AML2 Growth Inhibition Assay Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50 = 19.0924 μM. SANGER
RO82-W-1 Growth Inhibition Assay Inhibition of human RO82-W-1 cell growth in a cell viability assay, IC50 = 19.2558 μM. SANGER
NCI-H209 Growth Inhibition Assay Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50 = 19.2741 μM. SANGER
RPMI-6666 Growth Inhibition Assay Inhibition of human RPMI-6666 cell growth in a cell viability assay, IC50 = 19.3018 μM. SANGER
P30-OHK Growth Inhibition Assay Inhibition of human P30-OHK cell growth in a cell viability assay, IC50 = 19.6604 μM. SANGER
SW1990 Growth Inhibition Assay Inhibition of human SW1990 cell growth in a cell viability assay, IC50 = 19.7833 μM. SANGER
A498 Growth Inhibition Assay Inhibition of human A498 cell growth in a cell viability assay, IC50 = 20.0041 μM. SANGER
Calu-3 Growth Inhibition Assay Inhibition of human Calu-3 cell growth in a cell viability assay, IC50 = 20.0694 μM. SANGER
SW1463 Growth Inhibition Assay Inhibition of human SW1463 cell growth in a cell viability assay, IC50 = 20.0705 μM. SANGER
YT Growth Inhibition Assay Inhibition of human YT cell growth in a cell viability assay, IC50 = 20.687 μM. SANGER
MDA-MB-175-VII Growth Inhibition Assay Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay, IC50 = 20.7094 μM. SANGER
NUGC-3 Growth Inhibition Assay Inhibition of human NUGC-3 cell growth in a cell viability assay, IC50 = 20.8286 μM. SANGER
COLO-792 Growth Inhibition Assay Inhibition of human COLO-792 cell growth in a cell viability assay, IC50 = 20.8786 μM. SANGER
NCI-H748 Growth Inhibition Assay Inhibition of human NCI-H748 cell growth in a cell viability assay, IC50 = 20.9574 μM. SANGER
SW1417 Growth Inhibition Assay Inhibition of human SW1417 cell growth in a cell viability assay, IC50 = 21.0448 μM. SANGER
REH Growth Inhibition Assay Inhibition of human REH cell growth in a cell viability assay, IC50 = 21.0864 μM. SANGER
HEC-1 Growth Inhibition Assay Inhibition of human HEC-1 cell growth in a cell viability assay, IC50 = 21.8654 μM. SANGER
no-10 Growth Inhibition Assay Inhibition of human no-10 cell growth in a cell viability assay, IC50 = 22.6912 μM. SANGER
EM-2 Growth Inhibition Assay Inhibition of human EM-2 cell growth in a cell viability assay, IC50 = 23.3021 μM. SANGER
LN-405 Growth Inhibition Assay Inhibition of human LN-405 cell growth in a cell viability assay, IC50 = 23.4328 μM. SANGER
RVH-421 Growth Inhibition Assay Inhibition of human RVH-421 cell growth in a cell viability assay, IC50 = 23.6492 μM. SANGER
CAMA-1 Growth Inhibition Assay Inhibition of human CAMA-1 cell growth in a cell viability assay, IC50 = 24.0797 μM. SANGER
MDA-MB-453 Growth Inhibition Assay Inhibition of human MDA-MB-453 cell growth in a cell viability assay, IC50 = 24.4188 μM. SANGER
EFO-27 Growth Inhibition Assay Inhibition of human EFO-27 cell growth in a cell viability assay, IC50 = 24.4381 μM. SANGER
LU-139 Growth Inhibition Assay Inhibition of human LU-139 cell growth in a cell viability assay, IC50 = 24.4583 μM. SANGER
YAPC Growth Inhibition Assay Inhibition of human YAPC cell growth in a cell viability assay, IC50 = 25.4403 μM. SANGER
CCRF-CEM Growth Inhibition Assay Inhibition of human CCRF-CEM cell growth in a cell viability assay, IC50 = 25.4533 μM. SANGER
DJM-1 Growth Inhibition Assay Inhibition of human DJM-1 cell growth in a cell viability assay, IC50 = 26.0811 μM. SANGER
SNU-475 Growth Inhibition Assay Inhibition of human SNU-475 cell growth in a cell viability assay, IC50 = 26.345 μM. SANGER
Ramos-2G6-4C10 Growth Inhibition Assay Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50 = 26.4762 μM. SANGER
HCC1187 Growth Inhibition Assay Inhibition of human HCC1187 cell growth in a cell viability assay, IC50 = 26.7959 μM. SANGER
EFM-19 Growth Inhibition Assay Inhibition of human EFM-19 cell growth in a cell viability assay, IC50 = 26.8204 μM. SANGER
HT Growth Inhibition Assay Inhibition of human HT cell growth in a cell viability assay, IC50 = 27.169 μM. SANGER
NCI-H64 Growth Inhibition Assay Inhibition of human NCI-H64 cell growth in a cell viability assay, IC50 = 28.2381 μM. SANGER
JEG-3 Growth Inhibition Assay Inhibition of human JEG-3 cell growth in a cell viability assay, IC50 = 28.3241 μM. SANGER
CAL-27 Growth Inhibition Assay Inhibition of human CAL-27 cell growth in a cell viability assay, IC50 = 28.4822 μM. SANGER
HSC-4 Growth Inhibition Assay Inhibition of human HSC-4 cell growth in a cell viability assay, IC50 = 28.7306 μM. SANGER
HCC1599 Growth Inhibition Assay Inhibition of human HCC1599 cell growth in a cell viability assay, IC50 = 29.235 μM. SANGER
TE-5 Growth Inhibition Assay Inhibition of human TE-5 cell growth in a cell viability assay, IC50 = 30.5378 μM. SANGER
IPC-298 Growth Inhibition Assay Inhibition of human IPC-298 cell growth in a cell viability assay, IC50 = 30.9652 μM. SANGER
EHEB Growth Inhibition Assay Inhibition of human EHEB cell growth in a cell viability assay, IC50 = 31.1889 μM. SANGER
NCI-H322M Growth Inhibition Assay Inhibition of human NCI-H322M cell growth in a cell viability assay, IC50 = 33.5237 μM. SANGER
A253 Growth Inhibition Assay Inhibition of human A253 cell growth in a cell viability assay, IC50 = 34.0349 μM. SANGER
NCI-H596 Growth Inhibition Assay Inhibition of human NCI-H596 cell growth in a cell viability assay, IC50 = 34.8541 μM. SANGER
MN-60 Growth Inhibition Assay Inhibition of human MN-60 cell growth in a cell viability assay, IC50 = 35.9922 μM. SANGER
C32 Growth Inhibition Assay Inhibition of human C32 cell growth in a cell viability assay, IC50 = 37.6212 μM. SANGER
SCC-9 Growth Inhibition Assay Inhibition of human SCC-9 cell growth in a cell viability assay, IC50 = 37.8733 μM. SANGER
COR-L279 Growth Inhibition Assay Inhibition of human COR-L279 cell growth in a cell viability assay, IC50 = 37.9052 μM. SANGER
MOLT-4 Growth Inhibition Assay Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50 = 38.4987 μM. SANGER
RT4 Growth Inhibition Assay Inhibition of human RT4 cell growth in a cell viability assay, IC50 = 39.105 μM. SANGER
MLMA Growth Inhibition Assay Inhibition of human MLMA cell growth in a cell viability assay, IC50 = 39.1717 μM. SANGER
KYSE-520 Growth Inhibition Assay Inhibition of human KYSE-520 cell growth in a cell viability assay, IC50 = 39.3112 μM. SANGER
NCI-H2196 Growth Inhibition Assay Inhibition of human NCI-H2196 cell growth in a cell viability assay, IC50 = 40.0071 μM. SANGER
MKN1 Growth Inhibition Assay Inhibition of human MKN1 cell growth in a cell viability assay, IC50 = 40.2345 μM. SANGER
HN Growth Inhibition Assay Inhibition of human HN cell growth in a cell viability assay, IC50 = 40.5211 μM. SANGER
MFE-280 Growth Inhibition Assay Inhibition of human MFE-280 cell growth in a cell viability assay, IC50 = 41.3794 μM. SANGER
647-V Growth Inhibition Assay Inhibition of human 647-V cell growth in a cell viability assay, IC50 = 41.8832 μM. SANGER
PF-382 Growth Inhibition Assay Inhibition of human PF-382 cell growth in a cell viability assay, IC50 = 42.0242 μM. SANGER
IST-SL1 Growth Inhibition Assay Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50 = 42.3247 μM. SANGER
MKN7 Growth Inhibition Assay Inhibition of human MKN7 cell growth in a cell viability assay, IC50 = 42.4977 μM. SANGER
CP50-MEL-B Growth Inhibition Assay Inhibition of human CP50-MEL-B cell growth in a cell viability assay, IC50 = 42.6901 μM. SANGER
K052 Growth Inhibition Assay Inhibition of human K052 cell growth in a cell viability assay, IC50 = 43.0698 μM. SANGER
23132-87 Growth Inhibition Assay Inhibition of human 23132-87 cell growth in a cell viability assay, IC50 = 43.5286 μM. SANGER
GAK Growth Inhibition Assay Inhibition of human GAK cell growth in a cell viability assay, IC50 = 44.127 μM. SANGER
Mewo Growth Inhibition Assay Inhibition of human Mewo cell growth in a cell viability assay, IC50 = 45.5878 μM. SANGER
RMG-I Growth Inhibition Assay Inhibition of human RMG-I cell growth in a cell viability assay, IC50 = 45.7372 μM. SANGER
BE-13 Growth Inhibition Assay Inhibition of human BE-13 cell growth in a cell viability assay, IC50 = 45.9392 μM. SANGER
SW684 Growth Inhibition Assay Inhibition of human SW684 cell growth in a cell viability assay, IC50 = 47.4969 μM. SANGER
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生物活性

製品説明 BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
特性 Muti-inhibitor of the IGR-1R/IR family.
Targets
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
TrkB [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
TrkA [1]
(Cell-free assay)
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1.7 nM 1.8 nM 4.1 nM 5.6 nM 7.4 nM
In Vitro
In vitro BMS-754807 effectively inhibits the growth of a broad range of human tumor cell lines of different histologic origins including mesenchymal (Ewing's, rhabdomyosarcoma, neuroblastoma, and liposarcoma), epithelial (breast, lung, pancreatic, colon, and gastric), and hematopoietic (multiple myeloma and leukemia), the IC50 values range from 5 nM to 365 nM for the most sensitive cell lines. BMS-754807 inhibits proliferation of IGF-1R-Sal cells and RH41 cells with IC50 of 7 nM and 5 nM. BMS-754807 inhibits phosphorylation of IGF-1R in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 13 nM, 6 nM and 21 nM. BMS-754807 inhibits phosphorylation of Akt in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 22 nM, 13 nM and 16 nM. BMS-754807 induces greater apoptosis in Rh41 cells by 24 hours as indicated by an increased sub-G1 peak (23.1%), compared with control (2.4%). [1] BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) in the IGF-Sal cell line with IC50 consistent with the antiproliferative IC50 (7 nM) in this cell line. The crystal structure of BMS-754807 cocrystallized with the kinase domain of IGF-1R shows that the donor/acceptor/donor hydrogen bond triad with Met1052 and Glu1050 within the hinge region of the kinase. [2] BMS-754807 shows a median EC50 value of 0.62 μM against 23 cell lines in the pediatric preclinical testing program (PPTP). [3]
Kinase Assay Kinase inhibition assays
The primary screen for BMS-754807 is an in vitro kinase assay using recombinant human IGF-1 receptor enzyme in biochemical assays using synthetic peptide KKSRGDYMTMQIG as a phosphoacceptor substrate. The selectivity profile is evaluated against multiple recombinant enzymes that are generated at BMS or purchased externally. The enzymatic assays are performed in Ubottom 384-well plates using a 30 μL reaction volume in assay buffer (100 mM Hepes pH 7.4, 10 mM MgCl2, 0.015% Brij35 and 4 mM DTT). The 60 minute reactions are initiated by combining ATP (concentration equivalent to Km ATP), 1.5 μM fluoresceinlabeled peptide substrate, enzyme and BMS-754807. The reactions are terminated with EDTA. The reaction mixtures are analyzed on the Caliper LabChip 3000 by electrophoretic separation of the fluorescent substrate and phosphorylated product. Inhibition data are calculated by comparison to enzyme-free control reactions for 100% inhibition and vehicle-only reactions for 0% inhibition. Compounds are dissolved in dimethylsulfoxide (DMSO, 10mM stock) and evaluated at eleven concentrations. IC50 values are derived by non-linear regression analysis of the dose response curves.
細胞実験 細胞株 IGF-1R-Sal, RH41 and Geo cell lines
濃度 365 nM
反応時間 72 hours
実験の流れ Cells are grown at their optimal density in RPMI +GlutaMax supplemented with 10% heat-inactivated fetal bovine serum (FBS), 10 mM Hepes, penicillin, and streptomycin. Cell proliferation is evaluated by incorporation of 3H-thymidine into DNA after exposure of cells to BMS-754807 for 72 hours. Results are expressed as an IC50, which is the drug concentration required to inhibit cell proliferation by 50% compared with untreated control cells.
実験結果図 Methods Biomarkers 結果図 PMID
Growth inhibition assay Cell viability 30754629
Western blot p-IGFIRRβ/InsRβ / IGFIRβ / p-AKT / AKT / p-ERK / ERK 26136493
In Vivo
In Vivo BMS-754807 (12.5mg/kg, orally) inhibits IGF-1R phosphorylation in tumor and serum in IGF-1R-Sal tumor–bearing nude mice. BMS-754807 inhibits tumor growth in a selected group of epithelial (IGF-1R-Sal, GEO, and Colo205), hematopoietic (JJN3), and mesenchymal (RD1 and Rh41) xenograft tumor models with TGI ranging from 53% to 115%. [1] BMS-754807 (6.25 mg/kg) achieves complete tumor growth inhibition in the transgenic-derived IGF-Sal tumor mouse model with correlated inhibition of pIGF-1R and pAKT. The protein binding for BMS-754807 ranges from of 98.5% in mouse plasma to 95.9% in human plasma. BMS-754807 results in clearance of 113 (mL/min)/kg, 20 (mL/min)/kg, 3.5 (mL/min)/kg and 41 (mL/min)/kg. [2] BMS-754807 (25 mg/kg) significantly inhibits tumor in KT-5 (Wilms), KT-14 (rhabdoid), Rh28 (rhabdomyosarcoma), and OS-1 xenografts mice model. [3]
動物実験 動物モデル IGF-1R-Sal, GEO, Colo205, JJN3, RD1 or Rh41 tumor–bearing nude mice
投与量 150 mg/kg
投与経路 Orally
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01525823 Completed
Healthy Volunteers
Bristol-Myers Squibb
February 2012 Phase 1
NCT00908024 Terminated
Colorectal Cancer|Head and Neck Cancer|Neoplasm Metastasis
Bristol-Myers Squibb
October 2009 Phase 1|Phase 2
NCT00898716 Completed
Neoplasms
Bristol-Myers Squibb
September 2009 Phase 1
NCT00788333 Completed
Breast Cancer
Bristol-Myers Squibb
July 2009 Phase 1|Phase 2

化学情報

分子量 461.49 化学式

C23H24FN9O

CAS No. 1001350-96-4 SDF Download BMS-754807 SDFをダウンロードする
Smiles CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F
保管

In vitro
Batch:

DMSO : 92 mg/mL ( (199.35 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Ethanol : 92 mg/mL

Water : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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Tags: BMS-754807を買う | BMS-754807 ic50 | BMS-754807供給者 | BMS-754807を購入する | BMS-754807費用 | BMS-754807生産者 | オーダーBMS-754807 | BMS-754807化学構造 | BMS-754807分子量 | BMS-754807代理店