TAE684 (NVP-TAE684)

TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM of 3 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.

TAE684 (NVP-TAE684)化学構造

CAS No. 761439-42-3

サイズ 価格(税別) 在庫状況
JPY 28500 国内在庫あり
JPY 50100 国内在庫あり
JPY 129800 国内在庫あり

代表番号: 045-509-1970|電子メール:[email protected]
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TAE684 (NVP-TAE684)関連製品

シグナル伝達経路

ALK阻害剤の選択性比較

Cell Data

Cell Lines Assay Type Concentration Incubation Time 活性情報 PMID
SCC-3 Growth Inhibition Assay IC50=0.0000603 μM SANGER
SF539 Growth Inhibition Assay IC50=0.000564 μM SANGER
DEL Growth Inhibition Assay IC50=0.000927 μM SANGER
NB1 Growth Inhibition Assay IC50=0.00162 μM SANGER
SR Growth Inhibition Assay IC50=0.00277 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.02384 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=0.02952 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=0.04865 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.05565 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.10256 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.10294 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.10568 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.16096 μM SANGER
SW982 Growth Inhibition Assay IC50=0.16478 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.17443 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.17835 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.19343 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.19631 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.19692 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.19776 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.22669 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.23524 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.24524 μM SANGER
CMK Growth Inhibition Assay IC50=0.2553 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.27855 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=0.29159 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.30218 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.31204 μM SANGER
NB69 Growth Inhibition Assay IC50=0.31787 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.32523 μM SANGER
KP-N-RT-BM-1 Growth Inhibition Assay IC50=0.33123 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.33291 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.33303 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.33396 μM SANGER
L-540 Growth Inhibition Assay IC50=0.36988 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.38867 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.39446 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.39561 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.40569 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.41292 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=0.41609 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.4288 μM SANGER
697 Growth Inhibition Assay IC50=0.43215 μM SANGER
NB14 Growth Inhibition Assay IC50=0.43826 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.47116 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=0.47375 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.48142 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.48328 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.49031 μM SANGER
ES4 Growth Inhibition Assay IC50=0.49109 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.4989 μM SANGER
RL95-2 Growth Inhibition Assay IC50=0.50112 μM SANGER
TE-15 Growth Inhibition Assay IC50=0.51124 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.53349 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.54549 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.55023 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.55184 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.55624 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.55794 μM SANGER
SW872 Growth Inhibition Assay IC50=0.56724 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.57884 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.63526 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.6358 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.63725 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.65033 μM SANGER
KGN Growth Inhibition Assay IC50=0.66168 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.66169 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.67462 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.69074 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=0.69389 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.71496 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=0.72664 μM SANGER
ES8 Growth Inhibition Assay IC50=0.74975 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.76695 μM SANGER
ES6 Growth Inhibition Assay IC50=0.77559 μM SANGER
L-363 Growth Inhibition Assay IC50=0.82375 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.83233 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.83912 μM SANGER
SF268 Growth Inhibition Assay IC50=0.84042 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.84263 μM SANGER
TGW Growth Inhibition Assay IC50=0.85863 μM SANGER
CHP-126 Growth Inhibition Assay IC50=0.85957 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.87589 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.89757 μM SANGER
NALM-6 Growth Inhibition Assay IC50=0.90739 μM SANGER
GCIY Growth Inhibition Assay IC50=0.95526 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.98824 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.9884 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.99535 μM SANGER
NB17 Growth Inhibition Assay IC50=1.00639 μM SANGER
LXF-289 Growth Inhibition Assay IC50=1.03076 μM SANGER
TK10 Growth Inhibition Assay IC50=1.05063 μM SANGER
K5 Growth Inhibition Assay IC50=1.06274 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=1.07259 μM SANGER
HCE-T Growth Inhibition Assay IC50=1.08819 μM SANGER
GI-1 Growth Inhibition Assay IC50=1.09798 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=1.10022 μM SANGER
TE-9 Growth Inhibition Assay IC50=1.11328 μM SANGER
SF126 Growth Inhibition Assay IC50=1.11568 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=1.13112 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=1.13338 μM SANGER
HEL Growth Inhibition Assay IC50=1.14895 μM SANGER
HAL-01 Growth Inhibition Assay IC50=1.15283 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=1.15974 μM SANGER
SW954 Growth Inhibition Assay IC50=1.19567 μM SANGER
D-283MED Growth Inhibition Assay IC50=1.22379 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=1.2389 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=1.25208 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=1.26348 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=1.29117 μM SANGER
A704 Growth Inhibition Assay IC50=1.32689 μM SANGER
KALS-1 Growth Inhibition Assay IC50=1.3408 μM SANGER
ETK-1 Growth Inhibition Assay IC50=1.34489 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=1.34986 μM SANGER
OCUB-M Growth Inhibition Assay IC50=1.36143 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=1.36378 μM SANGER
NB13 Growth Inhibition Assay IC50=1.37293 μM SANGER
GR-ST Growth Inhibition Assay IC50=1.38757 μM SANGER
DU-4475 Growth Inhibition Assay IC50=1.45853 μM SANGER
HCC2157 Growth Inhibition Assay IC50=1.46659 μM SANGER
RKO Growth Inhibition Assay IC50=1.49922 μM SANGER
LS-123 Growth Inhibition Assay IC50=1.51594 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=1.55811 μM SANGER
SW962 Growth Inhibition Assay IC50=1.5613 μM SANGER
PF-382 Growth Inhibition Assay IC50=1.5696 μM SANGER
A101D Growth Inhibition Assay IC50=1.57113 μM SANGER
NB10 Growth Inhibition Assay IC50=1.57392 μM SANGER
NB5 Growth Inhibition Assay IC50=1.58476 μM SANGER
HCE-4 Growth Inhibition Assay IC50=1.6085 μM SANGER
HT-144 Growth Inhibition Assay IC50=1.6319 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=1.64307 μM SANGER
NKM-1 Growth Inhibition Assay IC50=1.6866 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=1.69573 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=1.70036 μM SANGER
U-266 Growth Inhibition Assay IC50=1.73842 μM SANGER
BL-41 Growth Inhibition Assay IC50=1.76272 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=1.78309 μM SANGER
Daudi Growth Inhibition Assay IC50=1.78967 μM SANGER
CPC-N Growth Inhibition Assay IC50=1.85096 μM SANGER
EM-2 Growth Inhibition Assay IC50=1.851 μM SANGER
HCC1187 Growth Inhibition Assay IC50=1.86241 μM SANGER
LP-1 Growth Inhibition Assay IC50=1.87143 μM SANGER
CAS-1 Growth Inhibition Assay IC50=1.98299 μM SANGER
NB7 Growth Inhibition Assay IC50=2.00555 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=2.01513 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=2.03351 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=2.06786 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=2.11559 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=2.12445 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=2.17683 μM SANGER
TE-6 Growth Inhibition Assay IC50=2.1905 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=2.19141 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=2.20041 μM SANGER
LS-513 Growth Inhibition Assay IC50=2.22269 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=2.33256 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=2.37493 μM SANGER
GT3TKB Growth Inhibition Assay IC50=2.39972 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=2.42341 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=2.43674 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=2.47467 μM SANGER
DMS-114 Growth Inhibition Assay IC50=2.61524 μM SANGER
ONS-76 Growth Inhibition Assay IC50=2.63641 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=2.65414 μM SANGER
BOKU Growth Inhibition Assay IC50=2.72764 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=2.79912 μM SANGER
ES1 Growth Inhibition Assay IC50=2.81804 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=2.82012 μM SANGER
A388 Growth Inhibition Assay IC50=2.9617 μM SANGER
NCCIT Growth Inhibition Assay IC50=3.08862 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=3.13203 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=3.18943 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=3.2002 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=3.26859 μM SANGER
SH-4 Growth Inhibition Assay IC50=3.28797 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=3.32849 μM SANGER
KM12 Growth Inhibition Assay IC50=3.33544 μM SANGER
ST486 Growth Inhibition Assay IC50=3.53883 μM SANGER
HC-1 Growth Inhibition Assay IC50=3.62028 μM SANGER
BV-173 Growth Inhibition Assay IC50=3.64088 μM SANGER
EW-24 Growth Inhibition Assay IC50=3.66434 μM SANGER
LU-65 Growth Inhibition Assay IC50=3.6871 μM SANGER
ECC4 Growth Inhibition Assay IC50=3.7756 μM SANGER
ARH-77 Growth Inhibition Assay IC50=4.11067 μM SANGER
BC-3 Growth Inhibition Assay IC50=4.13068 μM SANGER
SNB75 Growth Inhibition Assay IC50=4.2619 μM SANGER
MEG-01 Growth Inhibition Assay IC50=4.27419 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=4.28443 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=4.30601 μM SANGER
Becker Growth Inhibition Assay IC50=4.47336 μM SANGER
DMS-153 Growth Inhibition Assay IC50=4.66475 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=4.68515 μM SANGER
EW-3 Growth Inhibition Assay IC50=4.76248 μM SANGER
KE-37 Growth Inhibition Assay IC50=4.86196 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=4.87227 μM SANGER
MC116 Growth Inhibition Assay IC50=4.94126 μM SANGER
NH-12 Growth Inhibition Assay IC50=4.96439 μM SANGER
CTB-1 Growth Inhibition Assay IC50=4.97721 μM SANGER
KM-H2 Growth Inhibition Assay IC50=5.05323 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=5.1183 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=5.14268 μM SANGER
EB-3 Growth Inhibition Assay IC50=5.17504 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=5.26322 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=5.43633 μM SANGER
no-11 Growth Inhibition Assay IC50=5.47087 μM SANGER
CESS Growth Inhibition Assay IC50=5.58034 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=5.58659 μM SANGER
REH Growth Inhibition Assay IC50=6.25618 μM SANGER
KU812 Growth Inhibition Assay IC50=6.42791 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=6.60674 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=7.06492 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=7.22977 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=7.33335 μM SANGER
NB6 Growth Inhibition Assay IC50=7.54899 μM SANGER
MN-60 Growth Inhibition Assay IC50=7.69215 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=8.01734 μM SANGER
EKVX Growth Inhibition Assay IC50=8.47066 μM SANGER
D-263MG Growth Inhibition Assay IC50=8.55396 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=8.64006 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=8.89892 μM SANGER
ACN Growth Inhibition Assay IC50=9.19157 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=9.21219 μM SANGER
EW-11 Growth Inhibition Assay IC50=9.65396 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=9.7877 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=10.2347 μM SANGER
EVSA-T Growth Inhibition Assay IC50=10.3192 μM SANGER
DSH1 Growth Inhibition Assay IC50=10.3972 μM SANGER
COLO-824 Growth Inhibition Assay IC50=10.8669 μM SANGER
K052 Growth Inhibition Assay IC50=10.9322 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=10.9939 μM SANGER
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生物活性

製品説明 TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM of 3 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.
Targets
ALK [1]
(Cell lines)
2-10 nM
In Vitro
In vitro

TAE684 does not exhibit significant cross-reactivity against other kinases. TAE684 potently inhibits the proliferation of Ba/F3 NPM-ALK cells with IC50 of 3 nM, without affecting the survival of Ba/F3 cells even at 1 μM. TAE684 also inhibits proliferation of NPM-ALK-expressing human ALCL cell lines including Karpas-299 and SU-DHL-1 with IC50 of 2–5 nM. Molecular modeling reveals that L258 may be one of the major kinase-selectivity determinants for TAE684. TAE684 treatment results in a rapid and sustained inhibition of phosphorylation of NPM-ALK. TAE684 induces apoptosis and G1 phase arrest in NPM-ALK-expressing Ba/F3 cells and ALCL patient cell lines. [1] TAE684 markedly overcomes Crizotinib-resistance in H3122 CR cells, harboring the fusion oncogene EML4-ALK, decreasing cell growth, suppressing ALK phosphorylation and inducing apoptosis.[2] Neurite outgrowth induced by expression of the mALK R1279Q mutant could be completely inhibited by TAE684 at 30 nM. [3]

Kinase Assay In vitro Enzyme Assays.
All in vitro enzyme assays are done at Upstate Biotechnology with the exception of InsR and IGF-1R. To determine the IC50 of TAE684 against InsR and IGF-1R a homogeneous time-resolved fluorescence assay is performed. ATP (10 mM) and 20 mg/ml biotinylated PolyEY (Glu, Tyr 4:1) are combined with 50 nL of serial dilutions of TAE684 (10-500 nM) and 4 ng of InsR enzyme in the presence of the kinase reaction buffer (20 mM Tris譎Cl, pH 7.5/10 mM MgCl2/3 mM MnCl2/1 mM DTT/10 mM NaVO4/0.1 mg/ml of BSA). Assays are incubated for 1 hour at ambient temperature. Reactions are terminated by adding 10 mL of the detection solution containing 50 mM EDTA, 500 mM KF, 0.5 mg/ml of BSA, 5 mg/mL Eu3+ cryptate-labeled anti-phosphotyrosine antibody Mab PT66-K, and 5 mg/mL Streptavidin-XLent. The reaction is incubated for half an hour, and fluorescence signals are read on Analyst GT.
細胞実験 細胞株 Luciferase-expressing Karpas-299, SU-DHL-1, and Ba/F3 cells and transformed Ba/F3 stably expressing NPM-ALK, Bcr-Abl, or TEL-kinase fusion constructs.
濃度 1 nM-10 μM
反応時間 2–3 days
実験の流れ

Cells are seeded in 384-well plates (2.5×104 cells per well) and incubated with serial dilutions of TAE684 or DMSO for 2–3 days. Luciferase expression is used as a measure of cell proliferation/survival and is evaluated with the Bright-Glo Luciferase Assay System. IC50 values are generated by using XLFit software.

実験結果図 Methods Biomarkers 結果図 PMID
Growth inhibition assay Cell viability 18594010
Western blot p-ROS1 / ROS1 p-ALK / ALK / p-STAT3 / STAT3 / p-ERK / ERK / p-AKT / AKT / Survivin / BIM / PARP 25351743
In Vivo
In Vivo

After 4 weeks of treatment with TAE684 at 3 and 10 mg/kg, there is a significant delay in lymphoma development and 100- to 1,000-fold reduction in luminescence signal, without any signs of compound- or disease-related toxicity in Karpas-299 lymphoma model. TAE684 treatment also induces disease regression in established Karpas-299 lymphomas and down-regulates CD30 expression. [1] TAE684 also shows impressive antitumor activity against H3122 CR xenograft tumors. [2] Furthermore, treatment with TAE684 improves the rough eye phenotype of both ALK mutants, especially that seen with ALKR1275Q, whereas Crizotinib has little effect on either phenotype. [3]

動物実験 動物モデル Karpas-299 xenografts are established in 4- to 6-week old female Fox Chase SCIDBeige mice.
投与量 1, 3, and 10 mg/kg
投与経路 Once daily by oral gavage for 3 weeks

化学情報

分子量 614.2 化学式

C30H40ClN7O3S

CAS No. 761439-42-3 SDF Download TAE684 (NVP-TAE684) SDFをダウンロードする
Smiles CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
保管

In vitro
Batch:

DMSO : 10 mg/mL ( (16.28 mM); 吸湿したDMSOは溶解度を減少させます。新しいDMSOをご使用ください。)

Water : Insoluble

Ethanol : Insoluble

モル濃度計算器

in vivo
Batch:

Add solvents to the product individually and in order.

投与溶液組成計算機

実験計算

モル濃度計算器

質量 濃度 体積 分子量

投与溶液組成計算機(クリア溶液)

ステップ1:実験データを入力してください。(実験操作によるロスを考慮し、動物数を1匹分多くして計算・調製することを推奨します)

mg/kg g μL

ステップ2:投与溶媒の組成を入力してください。(ロット毎に適した溶解組成が異なる場合があります。詳細については弊社までお問い合わせください)

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結果:

投与溶媒濃度: mg/ml;

DMSOストック溶液調製方法: mg 試薬を μL DMSOに溶解する(濃度 mg/mL, 注:濃度が当該ロットのDMSO溶解度を超える場合はご連絡ください。 )

投与溶媒調製方法:Take μL DMSOストック溶液に μL PEG300,を加え、完全溶解後μL Tween 80,を加えて完全溶解させた後 μL ddH2O,を加え完全に溶解させます。

投与溶媒調製方法:μL DMSOストック溶液に μL Corn oil,を加え、完全溶解。

注意:1.ストック溶液に沈殿、混濁などがないことをご確認ください;
2.順番通りに溶剤を加えてください。次のステップに進む前に溶液に沈殿、混濁などがないことを確認してから加えてください。ボルテックス、ソニケーション、水浴加熱など物理的な方法で溶解を早めることは可能です。

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