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研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1614 Riluzole (PK 26124) <1 mg/mL 46 mg/mL '46 mg/mL
S2454 Bupivacaine HCl 23 mg/mL 65 mg/mL 65 mg/mL
S1811 Amiloride (MK-870) HCl 6 mg/mL 53 mg/mL '''5 mg/mL
S1256 Rufinamide <1 mg/mL 18 mg/mL <1 mg/mL
S1445 Zonisamide <1 mg/mL 42 mg/mL 5 mg/mL
S5181 Levobupivacaine <1 mg/mL 58 mg/mL ''58 mg/mL
S5789 Propafenone <1 mg/mL 68 mg/mL ''41 mg/mL
S6920 SEA0400 <1 mg/mL 74 mg/mL '74 mg/mL
S2524 Phenytoin Sodium 3 mg/mL 32 mg/mL 11 mg/mL
S1693 Carbamazepine <1 mg/mL 47 mg/mL 18 mg/mL
S2785 A-803467 <1 mg/mL 72 mg/mL 11 mg/mL
S2560 Amiloride HCl dihydrate 17 mg/mL 0 mg/mL 0 mg/mL
S2525 Phenytoin <1 mg/mL 50 mg/mL 13 mg/mL
S2874 Camostat Mesilate 10 mg/mL 99 mg/mL '<1 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S3024 Lamotrigine <1 mg/mL 10 mg/mL 3 mg/mL
S1965 Primidone <1 mg/mL 44 mg/mL 3 mg/mL
S3064 Ambroxol HCl <1 mg/mL 4 mg/mL <1 mg/mL
S2041 Dyclonine HCl 6 mg/mL 15 mg/mL 36 mg/mL
S4229 Oxybuprocaine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S3155 Mepivacaine HCl 57 mg/mL 3 mg/mL 8 mg/mL
S2500 Propafenone HCl <1 mg/mL 69 mg/mL <1 mg/mL
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S1619 Prilocaine <1 mg/mL 44 mg/mL 44 mg/mL
S5274 GS967 <1 mg/mL 45 mg/mL 46 mg/mL
S4038 Dibucaine HCl 76 mg/mL 76 mg/mL 76 mg/mL
S5490 Disopyramide -1 mg/mL 67 mg/mL -1 mg/mL
S1391 Oxcarbazepine <1 mg/mL 7 mg/mL <1 mg/mL
S4657 Eslicarbazepine Acetate <1 mg/mL 59 mg/mL 11 mg/mL
S4058 Ropivacaine HCl 46 mg/mL 62 mg/mL ''<1 mg/mL
S4180 Nefopam HCl 21 mg/mL 1 mg/mL <1 mg/mL
S4061 Levobupivacaine HCl 64 mg/mL 64 mg/mL 57 mg/mL
S5814 cariporide <1 mg/mL 87 mg/mL 3 mg/mL
S4080 Triamterene <1 mg/mL 20 mg/mL <1 mg/mL
S5710 Ambroxol -1 mg/mL 76 mg/mL -1 mg/mL
S4200 Tolperisone HCl 56 mg/mL 56 mg/mL 56 mg/mL
S4210 Benzocaine <1 mg/mL 33 mg/mL 33 mg/mL
S4669 Benzocaine hydrochloride <1 mg/mL 40 mg/mL '40 mg/mL
S4668 Procaine <1 mg/mL 47 mg/mL 47 mg/mL
S4339 Meticrane <1 mg/mL 55 mg/mL '<1 mg/mL
S4225 Mexiletine HCl 43 mg/mL 43 mg/mL 43 mg/mL
S4235 Phenazopyridine HCl <1 mg/mL 50 mg/mL <1 mg/mL
S3751 Quinidine sulfate 9 mg/mL 100 mg/mL '100 mg/mL
S0016 SN-6 <1 mg/mL 80 mg/mL '''<1 mg/mL
S3907 Bulleyaconi cine A -1 mg/mL 7 mg/mL -1 mg/mL
S4284 Chloroprocaine HCl 61 mg/mL 61 mg/mL <1 mg/mL
S5749 Chlorpromazine -1 mg/mL 64 mg/mL -1 mg/mL
S2110 Vinpocetine <1 mg/mL 3 mg/mL
S2118 Ibutilide Fumarate 89 mg/mL 89 mg/mL ''89 mg/mL
S4294 Procainamide HCl 54 mg/mL 54 mg/mL 54 mg/mL
S3911 Veratramine -1 mg/mL 63 mg/mL -1 mg/mL
S1828 Proparacaine HCl 66 mg/mL 12 mg/mL <1 mg/mL

Sodium Channel製品

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1614

Riluzole (PK 26124)

Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.

S2454

Bupivacaine HCl

Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.

S1811

Amiloride (MK-870) HCl

Amiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

S1256

Rufinamide

Rufinamide (CGP 33101) is a voltage-gated sodium channel blocker, used an anticonvulsant medication.

S1445

Zonisamide

Zonisamide (CI-912) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

S5181

Levobupivacaine

Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. Levobupivacaine exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.

S5789

Propafenone

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.

S6920

SEA0400

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.

S2524

Phenytoin Sodium

Phenytoin Sodium (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

S1693

Carbamazepine

Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.

S2785

A-803467

A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.

S2560

Amiloride HCl dihydrate

Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.

S2525

Phenytoin

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

S2874

Camostat Mesilate

Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

S2114

Dronedarone HCl

Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S3024

Lamotrigine

Lamotrigine (BW-430C) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.

S1965

Primidone

Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.

S3064

Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

S2041

Dyclonine HCl

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.

S4229

Oxybuprocaine HCl

Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions

S3155

Mepivacaine HCl

Mepivacaine is a tertiary amine used as a local anesthetic.

S2500

Propafenone HCl

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

S9142

Sparteine

Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.

S4023

Procaine HCl

Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S1619

Prilocaine

Prilocaine (NSC 40027) is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

S5556

(-)-Sparteine Sulfate

Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.

S5274

GS967

GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.

S4038

Dibucaine HCl

Dibucaine HCl (Cinchocaine) is a local anesthetics.

S5490

Disopyramide

Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.

S1391

Oxcarbazepine

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

S4657

Eslicarbazepine Acetate

Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom) is an antiepileptic drug.

S4058

Ropivacaine HCl

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

S4180

Nefopam HCl

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.

S4061

Levobupivacaine HCl

Levobupivacaine HCl ((S)-(-)-Bupivacaine), the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

S5814

cariporide

Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.

S4080

Triamterene

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

S5710

Ambroxol

Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

S2318

Lappaconitine

Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.

S4200

Tolperisone HCl

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.

S4210

Benzocaine

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.

S4669

Benzocaine hydrochloride

Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

S4668

Procaine

Procaine (Novocaine, Vitamin H3, Duracaine, Spinocaine) is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.

S4339

Meticrane

Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.

S4225

Mexiletine HCl

Mexiletine HCl (KO1173) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

S4235

Phenazopyridine HCl

Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.

S3751

Quinidine sulfate

Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

S0016

SN-6

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.

S3907

Bulleyaconi cine A

Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.

S4284

Chloroprocaine HCl

Chloroprocaine HCl is a local anesthetic during surgical procedures.

S5749

Chlorpromazine

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

S2110

Vinpocetine

Vinpocetine (RGH-4405) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

S2118

Ibutilide Fumarate

Ibutilide Fumarate (U-70226E) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

S4294

Procainamide HCl

Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.

S3250

Veratrine

Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.

S3911

Veratramine

Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.

S1828

Proparacaine HCl

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1614

Riluzole (PK 26124)

Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.

S2454

Bupivacaine HCl

Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.

S1811

Amiloride (MK-870) HCl

Amiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

S1256

Rufinamide

Rufinamide (CGP 33101) is a voltage-gated sodium channel blocker, used an anticonvulsant medication.

S1445

Zonisamide

Zonisamide (CI-912) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

S5181

Levobupivacaine

Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. Levobupivacaine exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.

S5789

Propafenone

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.

S6920

SEA0400

SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.

S2524

Phenytoin Sodium

Phenytoin Sodium (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

S1693

Carbamazepine

Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.

S2785

A-803467

A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.

S2560

Amiloride HCl dihydrate

Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.

S2525

Phenytoin

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

S2874

Camostat Mesilate

Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

S2114

Dronedarone HCl

Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S3024

Lamotrigine

Lamotrigine (BW-430C) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.

S1965

Primidone

Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.

S3064

Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

S2041

Dyclonine HCl

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.

S4229

Oxybuprocaine HCl

Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions

S3155

Mepivacaine HCl

Mepivacaine is a tertiary amine used as a local anesthetic.

S2500

Propafenone HCl

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

S9142

Sparteine

Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.

S4023

Procaine HCl

Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

S1619

Prilocaine

Prilocaine (NSC 40027) is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.

S5556

(-)-Sparteine Sulfate

Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.

S5274

GS967

GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.

S4038

Dibucaine HCl

Dibucaine HCl (Cinchocaine) is a local anesthetics.

S5490

Disopyramide

Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.

S1391

Oxcarbazepine

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

S4657

Eslicarbazepine Acetate

Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom) is an antiepileptic drug.

S4058

Ropivacaine HCl

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

S4180

Nefopam HCl

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.

S4061

Levobupivacaine HCl

Levobupivacaine HCl ((S)-(-)-Bupivacaine), the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.

S5814

cariporide

Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.

S4080

Triamterene

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

S5710

Ambroxol

Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

S2318

Lappaconitine

Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.

S4200

Tolperisone HCl

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.

S4210

Benzocaine

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.

S4669

Benzocaine hydrochloride

Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

S4668

Procaine

Procaine (Novocaine, Vitamin H3, Duracaine, Spinocaine) is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.

S4339

Meticrane

Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.

S4225

Mexiletine HCl

Mexiletine HCl (KO1173) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

S4235

Phenazopyridine HCl

Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.

S3751

Quinidine sulfate

Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

S0016

SN-6

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.

S3907

Bulleyaconi cine A

Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.

S4284

Chloroprocaine HCl

Chloroprocaine HCl is a local anesthetic during surgical procedures.

S5749

Chlorpromazine

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

S2110

Vinpocetine

Vinpocetine (RGH-4405) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

S2118

Ibutilide Fumarate

Ibutilide Fumarate (U-70226E) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

S4294

Procainamide HCl

Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S3250

Veratrine

Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S3911

Veratramine

Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.

S1828

Proparacaine HCl

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.