ATPase

シグナル伝達経路

研究分野

阻害剤の選択性比較

カタログ番号 製品カタログ 溶解度(25°C)
DMSO アルコール
S1478 Oligomycin A <1 mg/mL 10 mg/mL <1 mg/mL
S7046 Brefeldin A <1 mg/mL 4 mg/mL <1 mg/mL
S7099 (-)-Blebbistatin <1 mg/mL 58 mg/mL <1 mg/mL
S2000 Sodium orthovanadate 36 mg/mL <1 mg/mL <1 mg/mL
S7821 Bufalin ˂1 mg/mL 78 mg/mL 40 mg/mL
S8828 Gboxin 2 mg/mL 39 mg/mL 79 mg/mL
S2528 Ciclopirox <1 mg/mL 42 mg/mL 42 mg/mL
S3019 Ciclopirox ethanolamine <1 mg/mL 6 mg/mL 30 mg/mL
S2233 Esomeprazole Sodium 73 mg/mL 73 mg/mL 73 mg/mL
S7266 Golgicide A <1 mg/mL 57 mg/mL 4 mg/mL
S2222 PF-3716556 <1 mg/mL 79 mg/mL 79 mg/mL
S7460 BTB06584 <1 mg/mL 84 mg/mL <1 mg/mL
S3699 2,3-Butanedione-2-monoxime 20 mg/mL 20 mg/mL 20 mg/mL
S8101 CB-5083 <1 mg/mL 82 mg/mL 13 mg/mL
S4166 Chlorpropamide <1 mg/mL 55 mg/mL 55 mg/mL
S3628 BHQ <1 mg/mL 10 mg/mL 40 mg/mL
S8276 FCCP <1 mg/mL 50 mg/mL 50 mg/mL
S5623 Bedaquiline <1 mg/mL 12 mg/mL 3 mg/mL
S3924 Ginsenoside Rb1 -1 mg/mL 100 mg/mL -1 mg/mL
S5454 Saikosaponin D <1 mg/mL 100 mg/mL <1 mg/mL
S2623 Omecamtiv mecarbil (CK-1827452) <1 mg/mL 80 mg/mL 6 mg/mL
S6815 CDN1163 <1 mg/mL 64 mg/mL 64 mg/mL
S9181 Periplocin -1 mg/mL 100 mg/mL -1 mg/mL

ATPase製品

新ATPase製品
製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1478

Oligomycin A

Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

S7046

Brefeldin A

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis.

S7099

(-)-Blebbistatin

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

S2000

Sodium orthovanadate

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

S7821

Bufalin

Bufalin is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.

S8828

Gboxin

Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.

S2528

Ciclopirox

Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.

S3019

Ciclopirox ethanolamine

Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.

S2233

Esomeprazole Sodium

Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

S7266

Golgicide A

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

S2222

PF-3716556

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

S7460

BTB06584

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.

S5554

Lanatoside C

Lanatoside C, a cardiac glycoside which belongs to a class of compounds derived from plants called foxglove, possesses the ability to inhibit the interchange of Na+ and K+ across cell membrane and is widely used to treat anti-arrhythmias and heart failure.

S3699

2,3-Butanedione-2-monoxime

2,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.

S8101

CB-5083

CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.

S4166

Chlorpropamide

Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.

S3628

BHQ

BHQ is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

S8276

FCCP

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

S5623

Bedaquiline

Bedaquiline, a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

S5454

Saikosaponin D

Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.

S2623

Omecamtiv mecarbil (CK-1827452)

Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.

S6815

CDN1163

CDN1163 is a small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) that improves Ca2+ homeostasis.

S4707

Oleic Acid

Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent.

S9181

Periplocin

Periplocin, extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S1478

Oligomycin A

Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

S7046

Brefeldin A

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis.

S7099

(-)-Blebbistatin

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

S2000

Sodium orthovanadate

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

S7821

Bufalin

Bufalin is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.

S8828

Gboxin

Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.

S2528

Ciclopirox

Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator.

S3019

Ciclopirox ethanolamine

Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.

S2233

Esomeprazole Sodium

Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

S7266

Golgicide A

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

S2222

PF-3716556

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

S7460

BTB06584

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.

S5554

Lanatoside C

Lanatoside C, a cardiac glycoside which belongs to a class of compounds derived from plants called foxglove, possesses the ability to inhibit the interchange of Na+ and K+ across cell membrane and is widely used to treat anti-arrhythmias and heart failure.

S3699

2,3-Butanedione-2-monoxime

2,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.

S8101

CB-5083

CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.

S4166

Chlorpropamide

Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.

S3628

BHQ

BHQ is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

S8276

FCCP

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

S5623

Bedaquiline

Bedaquiline, a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

S5454

Saikosaponin D

Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.

製品コード 製品説明 文献中Selleckの製品使用例 お客様のフィードバック
S2623

Omecamtiv mecarbil (CK-1827452)

Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.

2019, 10.1161/CIRCRESAHA.118.314505

2019, 49(6):920-935

2018, 27(3):602-615

S6815

CDN1163

CDN1163 is a small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) that improves Ca2+ homeostasis.

S4707

Oleic Acid

Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent.

S9181

Periplocin

Periplocin, extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.

Tags: ATPase inhibition | ATPase pump | ATPase activity | ATPase assay | sodium potassium ATPase pump | Na K-ATPase pump | Na K-ATPase activity | mitochondrial ATPase | Ca-ATPase pump | Na K-ATPase inhibition | myosin ATPase activity | H-ATPase pump | ATPase phosphorylation | ATPase assay protocol | HK-ATPase pump | Ca-ATPase activity | V-ATPase pump | sodium potassium ATPase activity | actomyosin ATPase activity | P-type ATPase pump